| 1. |
|
|
| 2. |
- Claesson, Maria, 1985, et al.
(author)
-
Pore Spanning Lipid Bilayers on Mesoporous Silica Having Varying Pore Size
- 2011
-
In: Langmuir. - : American Chemical Society (ACS). - 1520-5827 .- 0743-7463. ; 27:14, s. 8974-8982
-
Journal article (peer-reviewed)abstract
- Synthetic lipid bilayers have similar properties as cell membranes and have been shown to be of great use in the development of novel biomimicry devices. In this study, lipid bilayer formation on mesoporous silica of varying pore size, 2, 4, and 6 nm, has been investigated using quartz crystal microbalance with dissipation monitoring (QCM-D), fluorescent recovery after photo bleaching (FRAP), and atomic force microscopy (AFM). The results show that pore-spanning lipid bilayers were successfully formed regardless of pore size. However, the mechanism of the bilayer formation was dependent on the pore size, and lower surface coverages of adsorbed lipid vesicles were required on the surface having the smallest pores. A similar trend was observed for the lateral diffusion coefficient (D) of fluorescently labeled lipid molecules in the membrane, which was lowest on the surface having the smallest pores and increased with the pore size. All of the pore size dependent observations are suggested to be due to the hydrophilicity of the surface, which decreases with increased pore size.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Claesson, Rickard, et al.
(author)
-
HbA1c as a predictor of diabetes after gestational diabetes mellitus
- 2017
-
In: Primary Care Diabetes. - : Elsevier BV. - 1751-9918. ; 11:1, s. 46-51
-
Journal article (peer-reviewed)abstract
- Aim We wanted to investigate third-trimester HbA1c as a predictor of diabetes after gestational diabetes mellitus (GDM). Methods Women with GDM were followed up prospectively for five years from pregnancy to detect the development of diabetes. The ability of HbA1c to predict diabetes was evaluated with receiver-operating characteristic (ROC) curves and logistic regression analysis. Results By five years, 73 of 196 women had been diagnosed with diabetes. An optimal cut-off point for HbA1c of 36 mmol/mol (5.4%) could predict diabetes with 45% sensitivity and 92% specificity. For HbA1c ≥39 mmol/mol (≥5.7%), sensitivity, specificity, and positive predictive value were 30%, 97%, and 91%, respectively. In logistic regression analysis, adjusting for the diagnostic glucose concentration during pregnancy, HbA1c levels in the upper quartile (≥36 mmol/mol) were associated with a 5.5-fold increased risk of diabetes. Conclusion Third-trimester HbA1c levels in the pre-diabetes range revealed women with post-partum diabetes with high specificity and high positive predictive value. HbA1c testing could be used as a strategy to select high-risk women for lifestyle interventions aimed at prevention of diabetes starting during pregnancy. The results should encourage further validation in other populations using new diagnostic criteria for GDM.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Claesson, Rickard, et al.
(author)
-
The potential impact of new diagnostic criteria on the frequency of gestational diabetes mellitus in Sweden.
- 2013
-
In: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 1600-0412 .- 0001-6349. ; 92:10, s. 1223-1226
-
Journal article (peer-reviewed)abstract
- The International Association of Diabetes and Pregnancy Study Groups (IADPSG) has suggested new diagnostic criteria for gestational diabetes mellitus. Many centers in Europe still use the World Health Organization (WHO) criteria. In southern Sweden we use the 2-h threshold of the European Association for the Study of Diabetes criteria based on universal screening with a 75-g oral glucose tolerance test. We have retrospectively scrutinized oral glucose tolerance tests in a subset of 174 women included in a previous study, diagnosed with gestational diabetes mellitus 1996-1999. A complete repeat oral glucose tolerance test was performed directly after diagnosis in 120 women. When applying the current Swedish criteria, and the IADPSG and the WHO criteria to the material, gestational diabetes mellitus was confirmed in 67% (80/120), 84% (101/120), and 80% (96/120), respectively. Hence, 26% (101/80) more women were identified by the IADPSG criteria and 20% (96/80) more women by the WHO criteria, compared with the criteria presently in use.
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
- Elfwén, Ludvig, et al.
(author)
-
Coronary angiography in out-of-hospital cardiac arrest without ST elevation on ECG-Short- and long-term survival.
- 2018
-
In: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 200, s. 90-95
-
Journal article (peer-reviewed)abstract
- BACKGROUND: The potential benefit of early coronary angiography in out-of-hospital cardiac arrest (OHCA) patients without ST elevation on ECG is unclear. The aim of this study was to evaluate the association between early coronary angiography and survival in these patients.METHODS: Nationwide observational study between 2008 and 2013. Included were patients admitted to hospital after witnessed OHCA, with shockable rhythm, age 18 to 80 years and unconscious. Patients with ST-elevation on ECG were excluded. Patients that underwent early CAG (within 24 hours) were compared with no early CAG (later during the hospital stay or not at all). Outcomes were survival at 30 days, 1 year, and 3 years. Multivariate analysis included pre-hospital factors, comorbidity and ECG-findings.RESULTS: In total, 799 OHCA patients fulfilled the inclusion criteria, of which 275 (34%) received early CAG versus 524 (66%) with no early CAG. In the early CAG group, the proportion of patients with an occluded coronary artery was 27% and 70% had at least one significant coronary stenosis (defined as narrowing of coronary lumen diameter of ≥50%). The 30-day survival rate was 65% in early CAG group versus 52% with no early CAG (P < .001). The adjusted OR was 1.42 (95% CI 1.00-2.02). The one-year survival rate was 62% in the early CAG group versus 48% in the no early CAG group with the adjusted hazard ratio of 1.35 (95% CI 1.04-1.77).CONCLUSION: In this population of bystander-witnessed cases of out-of-hospital cardiac arrest with shockable rhythm and ECG without ST elevation, early coronary angiography may be associated with improved short and long term survival.
|
|
| 13. |
- Ignell, Claes, et al.
(author)
-
Trends in the prevalence of gestational diabetes mellitus in southern Sweden, 2003-2012.
- 2014
-
In: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 1600-0412 .- 0001-6349. ; 93:4, s. 420-424
-
Journal article (peer-reviewed)abstract
- There is accumulating evidence that gestational diabetes (GDM) is a growing problem. The lack of internationally standardized diagnostic procedures prevents consistent diagnosis and the burden of GDM must be determined in country-specific studies. In southern Sweden, GDM is defined as a 2-hour capillary plasma glucose concentration of ≥10.0 mmol/L during a universal 75 g oral glucose tolerance test. We report the crude prevalence of GDM during the years 2003-2012. Of 156 144 women who gave birth, 2.2% were diagnosed with GDM. When the effect of time on the prevalence of GDM was assessed in a log-linear Poisson model, an overall increase in prevalence of 35% was predicted, corresponding to an average annual increase of 3.4%. Predicted prevalence was 1.9 (95% CI 1.8-2.0) in 2003 and 2.6 (2.4-2.7) in 2012 (p<0.0001). Due to a simultaneous rise in birth rate, the number of women diagnosed with GDM increased by 64%. This article is protected by copyright. All rights reserved.
|
|
| 14. |
- Ingason, Haukur, et al.
(author)
-
The Metro Project : Final report
- 2012
-
Reports (other academic/artistic)abstract
- This report compiles the results from the METRO project. The different parts of theproject – design fires, evacuation, integrated fire control, smoke control, extraordinarystrain onconstructions and fire- and rescue operations – are presented separately.The most complicated and expensive part of the project was the performance of thelarge scale fire and explosion tests in the Brunsberg tunnel, where the maximum heatrelease rates measured from the metro wagon was 77 MW.The main results from the project are new recommendations regarding design firesin mass transport systems, identification of key factors for fire and smoke spread in tunnelsand at stations as well as regarding the difficulties for disabled persons to evacuatefrom trains in tunnels, new recommended types of way guiding systems, safer design incase of explosions in trains and evaluation of the fire and rescue services’ possibilitiesand limitations in underground mass transport systems.
|
|
| 15. |
|
|
| 16. |
- Ingason, Haukur, et al.
(author)
-
The Metro Project: Final Report
- 2012
-
Reports (other academic/artistic)abstract
- The report compiles the results from the METRO-project. The different parts of the project; design fires, evacuation, integrated fire control, smoke control, extraordinary strain on constructions and fire- and rescue operations are presented separately. The most complicated and expensive part of the project was the performance of the large scale fire and explosion tests in the Brunsberg tunnel. The maximum heat release rates measured from the metro carriage was 77 MW. The maximum ceiling gas temperatures was 1118 °C. These values are high, and should be put into a perspective of the situation and the type of carriages used. The project is not recommending the highest values as the design fire, but values reflected in conditions. The egress study confirm that one of the major issues related to fire evacuation in underground transportation systems is that people often are reluctant to initiate an evacuation. New data show that participants moved with an average of 0.9 meters per second in the smoke filled environment (average visibility of 1.5–3.5 meters). A way-finding installation at the emergency exit, which consisted of a loudspeaker, was found to perform particularly well in terms of attracting people to the door. Two smoke control systems were simulated for a single exit metro station. The systems consisted of a pressurizing supply air system and mechanical exhaust ventilation system with and without platform screen doors. The results show that both the pressurizing supply air system and the mechanical exhaust air system provide effective smoke control for one exit metro station. The significance of the platform screen doors was shown to be important in relation to smoke control. Experiments and simulations have provided increased confidence in ability to simulate explosion scenarios to determine the pressure inside and outside a carriage and to be able to study variations of conditions such as carriage geometry and window designs. The explosion test performed show that an explosion with a relatively minor charge can significantly change the conditions for both evacuees and the rescue service. The results show that the conditions for evacuation and rescue operations can change dramatically as a result of a relatively minor explosion. Evaluation of methods and fire and rescue tactics in metros is given. Mapping of IR imaging as a tactical resource at tunnel fires was presented.
|
|
| 17. |
- Katsarou, Anastasia, et al.
(author)
-
Seasonal Pattern in the Diagnosis of Gestational Diabetes Mellitus in Southern Sweden
- 2016
-
In: Journal of Diabetes Research. - : Hindawi Limited. - 2314-6745 .- 2314-6753. ; 2016
-
Journal article (peer-reviewed)abstract
- Aim. The aim of this study was to examine seasonal patterns in glucose tolerance and in the diagnosis of gestational diabetes mellitus (GDM). Methods. Altogether, 11 538 women underwent a 75-g oral glucose tolerance test (OGTT) in the twenty-eighth week of pregnancy during the years 2003-2005 in southern Sweden. GDM was defined by the 2-h capillary glucose concentration in the OGTT (≥8.9 mmol/L). Chi-squared test, analysis of variance, and regression analyses were used for statistical evaluations. Results. The seasonal frequency of GDM ranged from 3.3% in spring to 5.5% in summer (p<0.0001). Mean 2-h glucose concentrations followed the same seasonal trend, with a difference of 0.15 mmol/L between winter and summer (p<0.0001). The 2-h glucose level increased by 0.009 mmol/L for every degree increase in temperature (p<0.0001). In regression analysis, summer (June-August) was associated with increased 2-h glucose level (p<0.001) and increased frequency of GDM compared to the other seasons (odds ratio 1.51, 95% confidence interval 1.24-1.83, and p<0.001). Conclusions. Our findings suggest seasonal variation in the 2-h glucose concentration in the OGTT and in the proportion of women diagnosed with GDM, with a peak in the summer.
|
|
| 18. |
- Ruskeeniemi, Timo, et al.
(author)
-
Subglacial permafrost evidencing re-advance of the Greenland Ice Sheet over frozen ground
- 2018
-
In: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791 .- 1873-457X. ; 199, s. 174-187
-
Journal article (peer-reviewed)abstract
- Greenland Ice Sheet (GrIS) covers an area of 1.7 million km(2). It has been an important source of climate information and the air temperature history of Greenland is well known. However, the thermal history and temperature conditions of the Greenland bedrock are poorly known. There are only few records on the temperature of the proglacial bedrock and no records on bedrock temperature underneath the ice sheet. The Greenland Analogue Project (GAP) recently investigated hydrological, hydrogeological and geochemical processes in Kangerlussuaq, West Greenland. Because permafrost has a major hydrological impact in Arctic regions, the cryogenic structure of the bedrock was an important research topic. From previous studies it was already known that Kangerlussuaq is located within the zone of continuous permafrost. Temperature profiling in a new research borehole, extending horizontally 30 m underneath the ice sheet, revealed that permafrost is 350 m deep at the ice margin. This result raised the question how far the permafrost extends under the ice sheet? In order to investigate the thermal properties, we made a series of electromagnetic (EM) soundings at the ice margin area - on proglacial area and on the ice sheet - and detected, that subglacial permafrost extends at least 2 km from the ice margin to inland. We also observed a patchy unfrozen sediment layer between the ice and the frozen bedrock. Possible existence of subglacial sediments and their role in ice dynamics has been debated in many recent papers. Our successful campaign shows that geophysics can be used for bedrock investigations through thick ice, which is known to be challenging for electromagnetic methods. Our results provide the first direct evidence supporting the proposed Holocene ice re-advance over frozen ground, and contribute to the discussion on the rapid climate changes in past, to the future of the ice sheet under warming climate and hydrogeology at the ice margin.
|
|
