| 1. |
- Csende, F., et al.
(författare)
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Copper(II) chloride as an efficient reagent for the dehydrogenation of pyridazinone derivatives
- 1995
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Ingår i: Synthesis (Stuttgart). - : Georg Thieme Verlag KG. - 0039-7881 .- 1437-210X. ; :10, s. 1240-1242
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Tidskriftsartikel (refereegranskat)abstract
- A new procedure is described for the preparation of pyridazinones from 4,5-dihydropyridazinones under mild conditions with CuCl2 in MeCN via halogenation and spontaneous HCl elimination. For the trans-hexahydrophthalazin-8(1H)-one 1B*, the HCl elimination is five times faster than for the corresponding cis isomer 1B.
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| 2. |
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| 3. |
- Csende, F., et al.
(författare)
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Preparation and antiarrhythmic activity of hexahydroisoindol-1-one derivatives
- 1999
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Ingår i: Scientia pharmaceutica. - : MDPI. - 0036-8709 .- 2218-0532. ; 67:2, s. 149-158
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Tidskriftsartikel (refereegranskat)abstract
- The synthesis of a series of partially saturated isoindol-1-one from 2- p-toluoyl-cyclohexanecarboxylic acid is described. The compounds were evaluated for their ability to protect against chloroform-induced fibrillation in mice.
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| 4. |
- Csende, F., et al.
(författare)
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Synthesis and structural study of new saturated isoindol-1-one derivatives
- 1993
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Ingår i: Heterocycles. - : The Japan Institute of Heterocyclic Chemistry. - 0385-5414 .- 1881-0942. ; 36:8, s. 1809-1821
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Tidskriftsartikel (refereegranskat)abstract
- Condensation of 2-p-toluoylcyclohexanecarboxylic acid (1a,b) with primary amines gave the corresponding hexahydroisoindol-1-ones (2a-g) in good yield. The octahydro derivatives (4a-g) were prepared from cis- and trans-hexahydro-1(2H)-phthalazinone (3a,b) by reduction with zinc-hydrochloric acid via ring contraction. Stereoselective synthesis of cis-N-phenyloctahydroisoindol-1-one (4h) was performed starting from 2b by reduction with magnesium-methanol at room temperature. Configurational assignments of cis and trans isomers were based on 1H-and 13C-nmr spectroscopic studies.
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| 5. |
- Csende, F., et al.
(författare)
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Synthesis and structural study of novel 1,2-diazepinones and azabicyclooctane derivatives
- 1996
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Ingår i: Heterocyclic Communications. - : Walter de Gruyter GmbH. - 0793-0283 .- 2191-0197. ; 2:5, s. 453-461
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Tidskriftsartikel (refereegranskat)abstract
- Condensation of 3-toluoyl-1,2,2-trimethylcyclopentane-1-carboxylic acid 2 with hydrazine, diamines or 3-aminopropanol afforded the novel bicyclic 1,2-diazepinone 3 or various condensed azabicyclooctane derivatives 4-6, respectively. Further transformations of the 1,2-diazepinone 3 to its perhydro 7 and N-methyl 8 derivatives are also described. Compound 3 when treated with Zn/HC1 resulted in the azabicyclo[3.2.1] octanone derivative 9 by a stereoselective ring contraction. Lactone formation from 3 on treatment with acetic anhydride has also been attempted.
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