| 1. |
- Fahlke, Claudia, 1964, et al.
(författare)
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Vi har drabbats av ett systemfel
- 2013
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Ingår i: GU Journalen. - 1402-9626. ; :4
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Hagsand, Angelica, 1985, et al.
(författare)
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Alcohol, crime and memory. Intoxicated eyewitnesses delayed recall of a kidnapping.
- 2012
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Ingår i: Svenska föreningen för Alkohol- och Drogforskning, konferens 8-9 November, Norrköping.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Alcohol is involved in 50-70% of violent crimes in Sweden. Eyewitness memory is a valuable source in investigations and it is common that the police interview alcohol intoxicated eyewitnesses. There are few studies on how alcohol affects witness memory. This study investigated how different doses of alcohol affected eyewitness recall one week after witnessing a crime and potential sex differences. The participants (N = 126) were healthy adults and were randomly assigned to either a control group, 0.0 g/kg ethanol (N = 42), a lower alcohol dose group, 0.4 g/kg ethanol (N = 40), or a higher alcohol dose group, 0.7 g/kg ethanol (N = 44). After 15 minutes consumption in a laboratory, participants witnessed a film showing a kidnapping of a woman by two men. The witnesses were interviewed about the crime one week later in a sober state. Witnesses in the higher alcohol dose group recalled fewer details compared to witnesses in the lower alcohol dose group. The amount of alcohol consumed did not have an impact on accuracy. Women and men reached the same blood alcohol concentration and no sex differences were found in recall. Interestingly, although the witnesses in the high alcohol dose group reported less information, their testimony was as correct as the testimony given by witnesses in the control group and the lower alcohol dose group. Despite the interesting results, more studies are needed before recommendations to the legal system can be made.
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| 3. |
- Hagsand, Angelica, 1985, et al.
(författare)
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Alcohol intoxicated eyewitnesses´ delayed recall of a kidnapping.
- 2013
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Ingår i: Poster presented at the European Association of Psychology and Law, 5th of September 2013, Coventry, UK..
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This study investigated how different doses of alcohol affected eyewitness recall. Participants (N = 126) were randomly assigned to three groups with different blood alcohol concentration (BAC), either a control group (mean BAC 0.00%, N = 42), a lower alcohol dose group (mean BAC 0.04%, N = 40), or a higher alcohol dose group (mean BAC 0.06%, N = 44). After consumption in a laboratory, participants witnessed a film of a mock crime where a woman was kidnapped by two men. One week after, the witnesses were interviewed in a sober state, by interviewers who were blind to which beverage the witnesses had consumed the week before. The main results showed that witnesses with the higher intoxication level recalled fewer details compared to witnesses with the lower intoxication level. The amount of alcohol consumed did not have an impact on the accuracy rate. No sex differences were found. We conclude that more studies are needed before recommendations can be made to an applied setting, but this study showed that alcohol may have a negative impact on eyewitness recall.
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| 4. |
- Hagsand, Angelica, 1985, et al.
(författare)
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Alcohol-intoxicated eyewitnesses’ memory: The effects of recall format, recall time, and repeated interviewing
- 2015
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Ingår i: Annual convention for Association for Psychological Science (APS), 2015-05-22, New York City, USA.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Intoxicated eyewitnesses are common, but are often discredited by investigators and in courts. The aim was to examine how intoxication (control vs. alcohol), recall format (free vs. cued), recall time (immediate vs. one week delayed), and repeated interviewing affects witnesses’ memory. The participants (N = 99) were randomly assigned to consume either juice or alcohol (0.7 g/kg), and they then witnessed a filmed staged crime. The participants were asked for a free recall followed by cued recall, either a) immediately and after a one week delay or b) only after a one week delay. Intoxicated witnesses recalled the same amount of information as sober ones in the cued recall phase, but significantly less details than sober ones in the free recall phase. However, all witnesses recalled more details and had a higher accuracy rate in free recall compared to cued recall. Overall, there was no difference between sober and intoxicated witnesses with respect to their accuracy rate. Also, all witnesses reported more details and were more accurate at the immediate compared to the delayed recall. However, conducting two recalls were more superior to one recall, since all witnesses recalled new details with relatively high accuracy at the second recall. Results are discussed in the light of their theoretical and applied relevance.
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| 5. |
- Hagsand, Angelica, 1985, et al.
(författare)
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Alcohol-intoxicated witnesses: A review of the current literature and new steps forward.
- 2014
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Ingår i: Nordic Network for Psychology and Law (NNPL), 7-8 November 2014, Oslo, Norway.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Eyewitnesses often provide central investigative leads in many criminal cases, and are often the sole source of evidence. Many witnesses are under the influence of alcohol during the crime, and/or during the investigative interview and line-up. There is evidence that jurors and expert witnesses perceive intoxicated witnesses as more cognitively impaired and less credible than sober ones. The few studies that have examined the effects of alcohol on witness memory for events cast doubt on whether expert witnesses’ and jurors’ inferences are warranted. That is, in experimental studies, intoxicated witnesses rarely differ from sober or placebo witnesses in terms of accuracy and quantity of information recalled or in their ability to recognize a perpetrator in a lineup. At the few occasions when a detrimental effect of alcohol on witness memory has been found it resulted in small differences between alcohol and sober or placebo participants, barely of any practical significance for law enforcement personnel. The present literature review indicates that intoxicated witnesses might be better than their reputation, and that witnesses who have a low to moderate intoxication level (BAC <0.10%) can be rather reliable sources of information in criminal investigations. However, limitations in the previous studies are highlighted and new steps of further research is discussed.
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| 6. |
- Hagsand, Angelica, 1985, et al.
(författare)
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Bottled memories: On how alcohol affects eyewitness recall
- 2013
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Ingår i: Scandinavian Journal of Psychology. - : Wiley. - 0036-5564 .- 1467-9450. ; 54:3, s. 188-195
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Tidskriftsartikel (refereegranskat)abstract
- This study investigated how different doses of alcohol affected eyewitness recall. Participants (N = 126) were randomly assigned to three groups with different blood alcohol concentration (BAC), either a control group (mean BAC 0.00%, N = 42), a lower alcohol dose group (mean BAC 0.04%, N = 40), or a higher alcohol dose group (mean BAC 0.06%, N = 44). After consumption, participants witnessed a movie of a mock crime and were interviewed one week later. The main results showed that witnesses with the higher intoxication level recalled fewer details compared to witnesses with the lower intoxication level. The amount of alcohol consumed did not have an impact on the accuracy rate. No sex differences were found. The results are discussed in the light of past research. We conclude that more studies are needed before recommendations can be made to an applied setting. Key words: Alcohol, eyewitness memory, recall, delayed interview, intoxicated witnesses.
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| 7. |
- Hagsand, Angelica, 1985, et al.
(författare)
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Do Sober Eyewitnesses Outperform Alcohol Intoxicated Eyewitnesses in a Lineup?
- 2013
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Ingår i: European Journal of Psychology Applied to Legal Context. - 1889-1861. ; 5:1, s. 23-47
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Tidskriftsartikel (refereegranskat)abstract
- Although alcohol intoxicated eyewitnesses are common, there are only a few studies in the area. The aim of the current study is to investigate how different doses of alcohol affect eyewitness lineup identification performance. The participants (N = 123) were randomly assigned to a 3 [Beverage: control (0.0 g/kg ethanol) vs. lower (0.4 g/kg ethanol) vs. higher alcohol dose (0.7 g(kg ethanol)] X 2 (Lineup: target-present vs. target-absent) between-subject design. Participants consumed two glasses of beverage at an even pace for 15 minutes. Five minutes after consumption the participants witnessed a film depicting a staged kidnapping. Seven days later, the participants returned to the laboratory and were asked to identify the culprit in a simultaneous lineup. The result showed that overall, the participants performed better than chance; however, their lineup performance was poor. There were no significant effects of alcohol intoxication with respect to performance, neither in target-present nor target-absent lineups. The study's results suggest that eyewitnesses who have consumed a lower (0.4 g/kg ethanol) or a higher (0.7 g/kg ethanol) dose of alcohol perform at the same level as sober eyewitnesses in a lineup. The results are discussed in relation to the alcohol myopia theory and suggestions for future research are made.
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| 8. |
- Hagsand, Angelica, 1985, et al.
(författare)
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Effect of the degree of alcohol intoxication on eyewitness memory for a violent crime: Identification accuracy in lineup
- 2011
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Ingår i: Oral presentation at The Nordic Network for Psychology and Law (NNPL), September 16-17 2011, Oslo, Norway.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Introduction and Aim. In Sweden, 50-70% of all violent crimes are alcohol related (BRÅ, 2007, 2009). Eyewitnesses are valuable to the Police since they have seen the event and many crimes lack technical evidence like DNA. Due to the limited studies in the area, this ongoing experimental study might give valuable knowledge to the legal system concerning the assessment of alcohol intoxicated eyewitnesses and the credibility of their testimonies. Methods. The participants (N = 120 when finished) consists of healthy adult students. The study uses a 3 x 2 between- participants design with random assignment to alcohol beverage (none vs. moderate vs. high dose,) and lineup presentation (target present vs. target absent). Consumption time is 15 minutes in a laboratory with living room design. A movie depicting a staged kidnapping is shown to the participants and after 30 minutes of distracting filler tasks the participants are interviewed. One week later, the participants are presented the simultaneous lineup in order to identify the culprit from the movie and are also interviewed in more detail about the crime scene. Results and Conclusions. The data collection is ongoing during the spring of 2011. To this date, data from half of the participants has been collected. Results concerning identification accuracy will be presented and discussed at the NNPL conference in Oslo in September 2011.
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| 9. |
- Hagsand, Angelica, 1985, et al.
(författare)
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Immediate or delayed recall: When is the best time to interview alcohol intoxicated eyewitnesses?
- 2013
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Ingår i: Oral presentation at The Nordic Network for Psychology and Law (NNPL), October 25-26 2013, Aarhus, Denmark.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Introduction. Many violent crimes involve alcohol intoxicated eyewitnesses, but there are only a few studies on how alcohol affects eyewitness memory. Aim. The overall aim was to examine whether eyewitnesses, intoxicated as well as sober, recall more (and more accurate) information when interviewed immediately after witnessing a crime, compared to a delayed interview. Methods. The participants (N = 99) were randomly assigned to a 2 (Beverage: control vs. alcohol) x 2 (Recall trial: immediate and delayed vs. delayed only) mixed design. After a 15 minutes consumption time, a staged kidnapping on film was shown. Half of the participants (N = 48) were interviewed immediately and all (N = 100) had a one week delayed recall. Results. There was no difference between sober and intoxicated eyewitnesses in terms of amount of details, but intoxicated witnesses were less accurate. Eyewitnesses who had an immediate recall remembered significantly more and were more accurate at the delayed recall, than eyewitnesses who did not have an immediate recall. This regardless whether the eyewitnesses had consumed alcohol or not the week before. Conclusions. This study shows the importance of conducting an immediate interview, even when the witnesses are intoxicated with a low to moderate blood alcohol concentration.
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| 10. |
- Hagsand, Angelica, 1985, et al.
(författare)
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Stumbling down memory lane: When to interview alcohol-intoxicated eyewitnesses?
- 2014
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Ingår i: Conference of European Association of Psychology and Law (EAPL), 25th of June 2014, St. Petersburg, Russia.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Introduction. Many violent crimes are observed by alcohol intoxicated eyewitnesses, but there are only a few studies on how alcohol affects witness memory. Aim. The aim was to examine to what extent alcohol, time of interview (immediate vs. delayed) and recall trial (single vs. repeated) affect the completeness and accuracy of testimonies. Methods. Participants (N = 99) were randomly assigned to a 2 (Beverage: control vs. alcohol) x 2 (Recall: immediate and delayed vs. delayed only) mixed design. After a 15 minutes consumption time, a staged kidnapping on film was shown. Half of the participants (N = 48) were interviewed immediately and all (N = 99) had a one week delayed recall. Results. Overall, alcohol reduced the accuracy of the reports, but had no effect on the completeness of the testimonies. Regardless of intoxication level, the best recall performances were found when witnesses were interviewed immediately. Conclusions. The findings from this study indicates that intoxicated witnesses might report the same amount of details to the police, but be slightly less accurate compared to sober witnesses. More studies are needed to be conducted before recommendation to the legal system can be made.
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| 11. |
- Hagsand, Angelica, 1985, et al.
(författare)
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The acute effect of alcohol on memory: When is the best time to interview alcohol intoxicated eyewitnesses?
- 2013
-
Ingår i: Poster presenterad på Svenska Föreningen för Alkohol och Droger (SAD), 2013-11-21, Uppsala, Sverige..
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Introduction. Many violent crimes involve alcohol intoxicated eyewitnesses, but there are only a few studies on how alcohol affects eyewitness memory. Aim. Do eyewitnesses recall more (and more accurate) details if they are interviewed when being intoxicated immediately after a crime or at a delayed recall in a sober state when more time has passed? Methods. The participants (N = 100) were randomly assigned to a 2 (Beverage: control, 0.0 g/kg vs. alcohol, 0.7 g/kg) x 2 (Recall trial: immediate and delayed vs. delayed only) mixed design. After a 15 minutes consumption time, a staged kidnapping on film was shown. Half of the participants (N = 48) were interviewed immediately and all (N = 99) had a one week delayed recall. Results. Intoxicated eyewitnesses were less accurate than sober witnesses. Alcohol did not affect the amount of reported information. Eyewitnesses, regardless of intoxication level, remembered more and were more accurate at the immediate recall, than eyewitnesses who did only have a delayed recall. Conclusions. This study shows the importance of conducting an immediate interview, even when the witnesses are intoxicated with a low to moderate blood alcohol concentration.
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| 12. |
- Hagsand, Angelica, 1985, et al.
(författare)
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Witnesses Stumbling down Memory Lane: The Effects of Alcohol Intoxication, Retention Interval, and Repeated Interviewing
- 2017
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Ingår i: Memory. - : Informa UK Limited. - 0965-8211 .- 1464-0686. ; 25:4, s. 531-543
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Tidskriftsartikel (refereegranskat)abstract
- Intoxicated eyewitnesses are often discredited by investigators and in court, but few studies have examined how alcohol affects witnesses’ memory. The primary aim of the present study was to examine how intoxication (alcohol vs. control), retention interval (immediate vs. one week delay), and number of interviews (one vs. two interviews) affect witnesses’ memory. The participants (N = 99) were randomly assigned to consume either orange juice or alcohol mixed with orange juice, and they all witnessed a filmed mock crime afterwards. The recall took place either (a) immediately and after a one week delay or (b) after a one week delay only. No main effect of alcohol was found on the quantity or quality of the witnesses’ statements. Both intoxicated and sober witnesses recalled more details, and were more accurate, during immediate compared to delayed recall. For witnesses interviewed twice, an average of 30% new details were provided in the second compared to the first interview, and these were highly accurate. In sum, contrary to what one can expect, intoxicated witnesses with a low to moderate blood alcohol concentration (below 0.10%) were reliable witnesses.
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| 13. |
- Hildebrand Karlén, Malin, 1984, et al.
(författare)
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Alcohol intoxicated eyewitnesses’ memory of intimate partner violence
- 2015
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Ingår i: Psychology, Crime and Law. - 1068-316X. ; 21:2, s. 156-171
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Tidskriftsartikel (refereegranskat)abstract
- Alcohol affects memory in many, and mostly negative, ways. This is a problem in legal contexts as many witnesses are alcohol intoxicated when taking part of the critical event. However, research is sparse regarding how, and under what circumstances, the reports of alcohol intoxicated witnesses differ from those of sober witnesses. This study investigated if alcohol intoxicated and sober eyewitnesses differ regarding completeness, accuracy, and type of information reported, as well as if gender influenced these variables. Eighty-seven healthy men (n=44) and women (n=43) received either an alcoholic beverage (0.7g/kg) or a control (juice) in a laboratory setting before viewing a film picturing intimate partner violence. Ten minutes after viewing the film, they were interviewed. Reports by alcohol intoxicated women were less complete, but as accurate, as sober women’s. In contrast, intoxicated and sober men did not differ regarding completeness or accuracy. Furthermore, compared to sober women, intoxicated women reported fewer actions but no difference was found between the groups regarding reported objects. At this moderate dose, alcohol affected women’s reports more than men’s, which may be because alcohol affects attention and memory consolidation more clearly at a lower dose for women than for men.
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| 14. |
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| 15. |
- Hildebrand Karlén, Malin, 1984, et al.
(författare)
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Alcohol Intoxicated Witnesses: Perception of Aggression and Guilt in Intimate Partner Violence
- 2017
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Ingår i: Journal of Interpersonal Violence. - : SAGE Publications. - 0886-2605 .- 1552-6518. ; 32:22, s. 3448-3474
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Tidskriftsartikel (refereegranskat)abstract
- Many witnesses to violent crimes are alcohol intoxicated, but research is lacking regarding how alcohol affects their perception of aggression and guilt. This study investigated to what extent alcohol intoxicated eyewitnesses differed from sober witnesses regarding how aggressive and guilty they perceived the involved parts in an intimate partner violence (IPV) situation. Eighty-seven healthy men (n = 44) and women (n = 43) were randomized to an alcohol group (0.7 g/kg) or a non-alcohol group. In a laboratory setting, alcoholic/non-alcoholic drinks were consumed before viewing a film depicting IPV between a man and a woman. Ten min after viewing, in an interview, the participants rated how aggressive and guilty they perceived the involved parts to be. Alcohol intoxicated participants perceived both parts’ physically aggressive behavior as comparatively less severe, but their neutral behavior as more hostile. Sober witnesses perceived the man to be the most guilty part, whereas intoxicated witnesses distributed guilt more evenly. Alcohol had a strong but complex impact on the perception of aggression in IPV (i.e., heightened during the neutral interaction and lowered during physical aggression). These results may be explained by the cognitive consequences of alcohol’s anxiety-dampening effects. Regarding the asymmetric difference in perceived guilt, stereotypical expectations of gender-appropriate behavior in an IPV situation may need to be considered.
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| 16. |
- Hildebrand Karlén, Malin, 1984, et al.
(författare)
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To wait or not to wait? Improving results when interviewing intoxicated witnesses to violence
- 2017
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Ingår i: Scandinavian Journal of Psychology. - : Wiley. - 0036-5564. ; 58:1, s. 15-22
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Tidskriftsartikel (refereegranskat)abstract
- Witnesses to violent crimes are often alcohol intoxicated, but few studies have investigated the impact of alcohol on witness reports. This study investigated how alcohol intoxication and time of interview affected reports of intimate partner violence (IPV). One hundred thirty six healthy men (N = 66) and women (N = 70) were randomized to an alcohol group (0.8g/kg for men, 0.75g/kg for women) (N = 70) or control group (N = 66), given juice. Participants consumed drinks in a laboratory setting before they witnessed an IPV scenario. Fifty percent of the intoxicated and sober participants were interviewed ten minutes after viewing the film and all participants were interviewed one week later. For the analyses, participants in the alcohol group were divided into two groups (moderately/highly intoxicated) based on their BAC-level. Ten minutes after viewing the event, highly (BAC = 0.08-0.15) intoxicated witnesses gave shorter, but as accurate, reports as moderately intoxicated/sober witnesses. All witnesses gave shorter and less accurate reports one week later compared to immediately after. However, an immediate interview increased completeness one week later. In general, time and high intoxication made witnesses give less detailed accounts of actions and verbal information, but not of objects. Highly intoxicated witnesses reported less actions and verbal information in all interviews, while information regarding objects was reported to a similar extent. At the present BAC-level, it is beneficial to conduct an immediate free recall interview with intoxicated witnesses to obtain a maximum amount of correct information and minimize the negative effect of time.
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| 17. |
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| 18. |
- Ahlin, Lars, et al.
(författare)
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Förlegad syn på missbruksvård
- 2013
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Ingår i: Svenska Dagbladet. ; :16 februari
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 19. |
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| 20. |
- Alborn, Sven-Eric, et al.
(författare)
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Att arbeta med förändringsprocesser
- 2012
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Ingår i: Handbok i missbrukspsykologi : teori och tillämpning / Claudia Fahlke (red.) ; Sven-Eric Alborn [och 41 andra]. - Malmö : Liber. - 9789147084616 ; , s. 362-369
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 21. |
- Alborn, Sven-Eric, et al.
(författare)
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Förord
- 2006
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Ingår i: Riskbruk, missbruk och beroende - forskning och vård. - Göteborg : Göteborgs universitet och Beroendekliniken, Sahlgrenska universitetssjukhuset.
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 22. |
- Alborn, Sven-Eric, et al.
(författare)
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Riskperioder för missbruk – från barndom till ålderdom
- 2012
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Ingår i: Handbok i missbrukspsykologi : teori och tillämpning / Claudia Fahlke (red.) ; Sven-Eric Alborn [och 41 andra]. - Malmö : Liber. - 9789147084616 ; , s. 229-241
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 23. |
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| 24. |
- Anderberg, Mats, et al.
(författare)
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Mer än varannan ungdom med alkohol- och narkotikaproblem i öppenvården har erfarenhet av utsatthet i barndomen
- 2019
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Ingår i: Socialmedicinsk Tidskrift. - 0037-833X. ; 96:6, s. 786-799
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Tidskriftsartikel (refereegranskat)abstract
- Few Swedish studies investigated experiences of childhood maltreatment in adolescents with substance use problems, especially in outpatient care. This study analyzed experiences of neglect and abuse during childhood in adol- escents (mean age 18 years) who started outpatient treatment for substance use problems. The results showed that several of them had experience of child maltreatment. Child maltreatment was also related to perceived pro- blems in the upbringing family, e.g. financial difficulties, substance use pro- blems, mental illness and violence in the family. This indicate the importance to investigate experiences of child maltreatment among adolescents in tre- atment for substance use problems, especially since there is evidence to- day that psychiatric co-morbidity (e.g. trauma reaction and drug problems) should be treated simultaneously to achieve the best effect.
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| 25. |
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| 26. |
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| 27. |
- Balldin, Jan, 1935, et al.
(författare)
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Gamma-glutamyltransferase in alcohol use disorders: Modification of decision limits in relation to treatment goals?
- 2010
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Ingår i: Scandinavian journal of clinical and laboratory investigation. - : Informa UK Limited. - 1502-7686 .- 0036-5513. ; 70:2, s. 71-74
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Serum gamma-glutamyltransferase (GGT) is recommended as a marker for alcohol use disorders by the Swedish National Guidelines for Addiction, although it has a low sensitivity and specificity. GGT is inexpensive and easily accessible but additional knowledge is required on how to use the marker in patients with various levels of alcohol intake. Levels of GGT were obtained from 37 male social drinkers (< 100 grams pure alcohol weekly) and 18 former alcohol-dependent males with long-term (6 +/- 5 years) abstinence. Reproducibility was calculated through repeated blood samplings. Mean serum activity of GGT, in former alcohol-dependent males, was 0.26 microkat/L with an intra-class correlation coefficient of 0.85. In social drinkers, these figures were 0.34 microkat/L and 0.92, respectively. In treatment of males, with the goal of abstinence, upper reference limit is suggested to be 0.40 microkat/L. Goals of non-harmful drinking (< 100 grams weekly) suggest higher limits (0.62 microkat/L). Thirty percent increase of GGT should be suggestive of relapse.
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| 28. |
- Balldin, Jan, 1935, et al.
(författare)
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Inverse relationship between central serotonergic neurotransmission and blood pressure in alcohol-dependent male subjects
- 2006
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Ingår i: Journal of Neural Transmission. ; 113, s. 1511-1517
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Tidskriftsartikel (refereegranskat)abstract
- Data has accumulated indicating an inverse relation between central serotonergic (5-HT) neurotransmission and blood pressure in hypertensive rats and in healthy individuals. The present study aimed to elucidate whether an inverse relation exists between systolic (SBP) and diastolic (DBP) blood pressure levels and central 5-HT neurotransmission also in a group of alcohol-dependent individuals. Central 5-HT neurotransmission was assessed by using the maximum prolactin (PRL) responses to the 5-HT probe DL-fenfluramine (DL-FEN; 60 mg po.) in 17 alcohol-dependent male subjects investigated during a period of on-going alcohol intake. BP was measured immediately before all time points for blood sampling, and readings before DL-FEN administration were used as the subjects resting BP. Results showed that there were inverse correlations between the maximum PRL responses to DL-FEN and the SBP levels (r = -0.57, p < 0.002) and with the DBP levels (r = -0.52, p < 0.05), respectively. The present study suggests the existence of an association between central 5-HT neurotransmission and blood pressure regulation also in alcohol-dependent individuals.
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| 29. |
- Balldin, Jan, 1935, et al.
(författare)
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TAQ1A1 Allele of the DRD2 Gene Region Contribute to Shorter Survival Time in Alcohol Dependent Individuals When Controlling for the Influence of Age and Gender. A Follow-up Study of 18 Years.
- 2018
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Ingår i: Alcohol and Alcoholism. - : Oxford University Press (OUP). - 1464-3502 .- 0735-0414. ; 53:3, s. 216-220
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Tidskriftsartikel (refereegranskat)abstract
- To investigate the influence of the A1 allele of the TAQ1A polymorphism in the dopamine D2 receptor (DRD2) gene region on mortality in adult individuals with alcohol dependence.The study sample consisted of 359 alcohol-dependent individuals treated for severe alcohol withdrawal symptoms in 1997. Years of survival was studied in an 18-year follow-up. In the analyses, gender and age were controlled for.At the 18-year follow-up, 53% individuals had deceased. The analyses showed that older age (P < 0.001), male gender (P < 0.05) and carrying the A1 allele (P < 0.01) all significantly and independently contributed to shorten years of survival. Among the deceased individuals, the genotype A1+ was the only significant contributor to shorten years of survival.An important contribution of the present study is that in alcohol dependence the Taq1A1 allele of the DRD2 gene region is a risk factor for premature death of similar importance as the well-known risk factors of age and gender.We investigated the influence of A1 allele of the TAQ1A polymorphism in DRD2 receptor gene region on mortality in alcohol-dependent individuals in an 18-year follow-up. Age, gender and the A1 allele contributed to shorten years of survival. Among the deceased, the A1+ was the only contributor to shorten years of survival.
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| 30. |
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| 31. |
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| 32. |
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| 33. |
- Berggren, Ulf, 1948, et al.
(författare)
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Different effects of smoking or use of smokeless tobacco on platelet MAO-B activity in type 1 alcohol-dependent subjects.
- 2007
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Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - : Oxford University Press (OUP). - 0735-0414 .- 1464-3502. ; 42:3, s. 267-71
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Low platelet monoamine oxidase (MAO)-B activity has been proposed as a marker for alcohol-dependence. Findings are, however, contradictory and the influence of confounding factors have been thoroughly investigated. Thus, it is now well established that cigarette smoking reduces platelet MAO-activity. However, not much is known about the influence of smokeless tobacco, i.e. snuff or chewing tobacco, on platelet MAO-B activity. The aim of the present study was to compare platelet MAO-B activity in type 1 alcohol-dependent subjects with concomitant use of smokeless tobacco (i.e. snuff users), use of smoking tobacco (i.e. cigarette smokers), and in those without any tobacco use. METHODS: Platelet MAO-B activity was examined in three groups of alcohol-dependent subjects: snuff users (n = 14), cigarette smokers (n = 33), and non-tobacco users (N = 46). RESULTS: In the alcohol-dependent subjects concomitant cigarette smokers, but not snuff users, were found to have significantly lower platelet MAO-B activity as compared to non-tobacco users (platelet MAO-B activity 4.0 +/- 1.5, 5.1 +/- 1.5 and 5.0 +/- 1.9 microkat/kg protein, respectively). CONCLUSIONS: The findings in the present study suggests that in the alcohol-dependent subjects the concomitant use of smokeless tobacco, i.e. snuffing, does not have an inhibitory effect on platelet MAO-B activity. This may have implications for future research. Thus, alcohol-dependent subjects with concomitant tobacco use should be grouped separately according to the form of the tobacco used, i.e. smoking or smokeless tobacco.
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| 34. |
- Berggren, Ulf, 1948, et al.
(författare)
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Dopamine D2 Receptor Genotype Is Associated with Increased Mortality at a 10-Year Follow-up of Alcohol-Dependent Individuals.
- 2010
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Ingår i: Alcohol and alcoholism. - : Oxford University Press (OUP). - 1464-3502 .- 0735-0414. ; 45:1, s. 1-5
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: Because the TAQ1 A1 allele may be associated with alcohol-related medical illnesses, and medical illnesses in alcohol-dependent individuals are associated with increased mortality, we test the hypothesis that the TAQ1 A1 allele of the DRD2 gene is associated with increased mortality in alcohol-dependent individuals. METHODS: Following an index treatment episode, a 10-year follow-up study in 366 alcohol-dependent individuals was performed. The TAQ1 A1/A2 DRD2 genotype and allele frequencies were compared between those deceased and those still living at the 10-year point. In addition, the genotype and allele frequencies of these alcohol-dependent individuals were compared to that in 578 control subjects. RESULTS: The prevalence of the A1 allele differed between the deceased and living patients and the controls: 47% of the deceased were A1+, compared to 37% of the living patients and 32% of the controls. The frequency of the TAQ1 A1/A2 genotype also differed between the groups. Thus, 43% had the A1/A2 genotype in comparison with 32% in the living patients and 29% in the controls. The TAQ 1 A1 allele frequency differed between the groups. The frequency of A1 allele was 25% in the deceased patients compared to 21% in the living patients and 17% in the controls. CONCLUSION: The TAQ I A1 allele of the DRD2 gene (or DRD2 gene region) was associated with increased mortality over a 10-year period in alcohol-dependent individuals.
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| 35. |
- Berggren, Ulf, et al.
(författare)
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Extremely long recovery time for the sedative effect of clonidine in male type 1 alcohol-dependent subjects in full sustained remission
- 2002
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Ingår i: Alcohol. - 0741-8329. ; 28, s. 181-187
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Tidskriftsartikel (refereegranskat)abstract
- The possible relation between alpha-2-adrenoceptor function - as assessed by changes in systolic and diastolic blood pressure and heart rate, as well as level of sedation, after administration of clonidine (2.0 μg/kg, i.v.) - and length of time of alcohol dependence or duration of remission was investigated in 17 male subjects with alcohol dependence in full sustained remission. Six healthy males were used as control subjects. The clonidine-induced scores for level of sedation were found to correlate with duration of time in remission (r = 0.60; P < .02). Median split of duration of remission revealed that subjects with short-term (2 ± 1 years) duration of remission had significantly lower scores for clonidine-induced level of sedation than the scores for both subjects with long-term (12 ± 5 years) duration of remission (P < .004) and control subjects (P < .02). There was also a significant correlation between duration of remission and values for clonidine-induced reduction of systolic blood pressure (r = 0.51; P < .05). Results indicate an extremely long recovery period in some aspects of alpha-2-adrenoceptor function, especially for clonidine-induced increase in level of sedation, with a normalization time of 4 to 5 years. © 2002 Elsevier Science Inc. All rights reserved.
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| 36. |
- Berggren, Ulf, et al.
(författare)
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Is long-term heavy alcohol consumption toxic for brain serotonergic neurons? Relationship between years of excessive alcohol consumption and serotonergic neurotransmission.
- 2002
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Ingår i: Drug and alcohol dependence. - 0376-8716. ; 65:2, s. 159-65
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Tidskriftsartikel (refereegranskat)abstract
- The relationship between years of excessive alcohol consumption and central serotonergic neurotransmission, as assessed by the prolactin (PRL) response to D-fenfluramine, was investigated in 22 male alcohol-dependent subjects. A negative correlation was obtained, that is, the longer duration of excessive alcohol consumption the lower PRL response to D-fenfluramine. It is therefore suggested that long duration of excessive alcohol consumption in alcohol-dependent subjects causes a reduction in central serotonergic neurotransmission, possibly by a toxic effect of alcohol on serotonin neurons. The relationship between depressive and anxiety symptoms during on-going drinking and the PRL response to D-fenfluramine was also investigated. No such correlations were obtained, suggesting that reduction in central serotonergic neurotransmission does not pre-dispose to the development of depressive and anxiety symptoms, at least in relation to on-going drinking in alcohol-dependent subjects.
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| 37. |
- Berggren, Ulf, 1948, et al.
(författare)
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Platelet monoamine oxidase-B activity in type 1 alcohol-dependent subjects in sustained full remission.
- 2002
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Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - 0735-0414. ; 37:4, s. 340-3
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Tidskriftsartikel (refereegranskat)abstract
- The present study investigated platelet monoamine oxidase-B (MAO-B) activity in male alcohol-dependent subjects in sustained full remission (minimum 1 year), to exclude possible transient changes in platelet MAO-B activity, which occur up to several months after the end of alcohol intake.MAO-B activity was examined in 16 alcohol-dependent subjects, characterized as type 1 alcoholics, with an abstinence period of 6 +/- 7 years (mean +/- SD) and in 12 healthy controls.The long-term abstinent alcohol-dependent subjects did not differ from controls in platelet MAO-B activity.Type 1 male alcohol-dependent subjects appear to have normal platelet MAO-B activity. The possibility, however, cannot be excluded that type 2 long-term abstinent alcoholics may have lower platelet MAO-B activity.
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| 38. |
- Berggren, Ulf, 1948, et al.
(författare)
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Platelet monoamine oxidase B in family history positive and family history negative type 1 alcohol-dependent subjects.
- 2002
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Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - 0735-0414. ; 37:6, s. 577-80
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Tidskriftsartikel (refereegranskat)abstract
- In the present study platelet monoamine oxidase B (MAO-B) activity was investigated in 76 male type 1 alcohol-dependent subjects with and without a family history of alcoholism.Platelet MAO-B activity did not differ between family history positive (FHP) and family history negative alcohol-dependent subjects. The smoking status of the subjects was registered and there was still no difference between the groups when possible effects of smoking were taken into account. It should, however, be noted that platelet MAO-B activity was lower in alcohol-dependent subjects with three or four alcohol-dependent first-degree relatives.Although this latter finding should be interpreted with caution due to the small number of subjects, it cannot be excluded that FHP alcohol-dependent subjects with a large number of alcohol-dependent first-degree relatives may have lower platelet MAO-B activity.
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| 39. |
- Berggren, Ulf, et al.
(författare)
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Relationship between central serotonergic neurotransmission and reduction in alcohol intake by citalopram
- 2001
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Ingår i: Drug and Alcohol Dependence. - 0376-8716. ; 63, s. 263-267
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Tidskriftsartikel (refereegranskat)abstract
- The relationship between the effect of citalopram on alcohol intake and central serotonergic neurotransmission, as assessed by prolactin (PRL) response to fenfluramine, was investigated in 17 male heavy drinkers. A positive correlation was obtained, suggesting that the status of central serotonergic neurotransmission in individuals is associated with the treatment response to citalopram. When the group of subjects were divided into those with high and low PRL response (above and below median, respectively) to fenfluramine, those with high PRL response had a significant reduction in alcohol intake during citalopram treatment, whereas those with low PRL response had no such effect. Thus, in subjects with evidence of unimpaired or only slightly impaired central serotonergic neurotransmission (high PRL response) citalopram may have beneficial effect on alcohol consumption, whereas in those with more evidently impaired serotonergic neurotransmission (low PRL response) citalopram treatment may have no effect on or may even increase the alcohol consumption. © 2001 Elsevier Science Ireland Ltd.
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| 40. |
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| 41. |
- Berggren, Ulf, et al.
(författare)
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Subnormal alpha-2-adrenoceptor-mediated sedation during 6 months of sobriety in male type 1 alcohol-dependent subjects
- 2003
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Ingår i: Alcohol and Alcoholism. - : Oxford University Press (OUP). - 0735-0414 .- 1464-3502. ; 38, s. 321-326
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Tidskriftsartikel (refereegranskat)abstract
- Aims: In the present study, α2-adrenoceptor function was investigated over 6 months of sobriety in eight male alcohol-dependent subjects. Methods: Subjects were investigated with repeated clonidine (CLON, 2 μg/kg body weight intravenously) challenge tests at days 1 and 7, and months 2 and 6 after the end of a period of heavy alcohol intake. CLON-induced sedation was rated at challenge tests. Mental well-being was self-reported before all challenge tests. Three challenge tests were performed at 1-week intervals in six male healthy controls. Results: Sedation was significantly lower after CLON at all time-points for the challenge tests in alcohol-dependent subjects compared with mean values for three challenge tests in controls. Three dimensions of mental well-being were negatively correlated with scores of CLON-induced sedation at month 6. Conclusions: α2-Adrenoceptor function is subnormal, as assessed by CLON-induced sedation, for at least 6 months after termination of alcohol intake. Whether this subnormal receptor function is pre-existing and possibly genetically determined or is a consequence of long-term alcohol intake must be further investigated, as should this receptor status in alcohol-dependent subjects with longer time-periods of sobriety.
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| 42. |
- Berggren, U, et al.
(författare)
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Subsensitive alpha-2-adrenoceptor function in male alcohol-dependent individuals during 6 months of abstinence.
- 2000
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Ingår i: Drug and alcohol dependence. - 0376-8716. ; 57:3, s. 255-60
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Tidskriftsartikel (refereegranskat)abstract
- Postsynaptic alpha-2-receptor function, as assessed by growth hormone (GH) response to clonidine (CLON), has been shown to be downregulated in patients investigated in acute but also in late withdrawal after heavy alcohol intake. The results are however sometimes conflicting. The question whether this changed receptor function is a trait or state marker is not fully investigated so far. A total of seven male patients with alcohol dependence according to DSM-IV were assessed for the postsynaptic alpha-2-receptor function with the CLON/GH test (2.0 microg/kg body weight; i.v.) starting immediately after a period of heavy drinking. Neuroendocrine tests were repeated after 7 days, 2 and 6 months. A total of six healthy males were used as controls. The maximum GH responses to CLON were significantly lower on all four test occasions in the patient group as compared to the controls. Furthermore, in the patient group all neuroendocrine test results showed blunted GH responses to CLON. Thus, patients with downregulated alpha-2-receptor function during acute withdrawal after heavy alcohol intake showed similar subsensitive receptor function abnormality after a prolonged period of abstinence. The findings in this study indicate that alcohol dependent individuals have a persistent subsensitive alpha-2-adrenoceptor function which may constitute a trait factor for alcohol dependence.
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| 43. |
- Berggren, Ulf, 1948, et al.
(författare)
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The taqI DRD2 A1 allele is associated with alcohol-dependence although its effect size is small
- 2006
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Ingår i: Alcohol. - : Oxford University Press (OUP). - 0735-0414. ; 41:5, s. 479-85
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Numerous studies of the relationship between the TaqIA DRD2 A1 allele and alcohol-dependence have been performed and many of these have shown an association whereas others have not (Noble, 2003). This has consequently generated some controversy as to whether such an association actually exists (Noble, 2003). In the two recent meta-analyses by Noble (2003) and Young et al. (2004) some very important methodological issues have been discussed, which need to be addressed in forthcoming studies. Thus, the sample size is of great importance. In case-control studies it has been estimated that to detect the role of genes with small effect size of approximately 2, which is in the range of the DRD2 A1 allele-alcoholism relationship, case-control sets of 300-400 subjects are necessary (Noble, 2003). METHODS: In the present study, we have consequently recruited a large number of subjects, 375 alcohol-dependent individuals, who were treated as inpatients for alcohol withdrawal symptoms and out of these 357 could be evaluated. As controls, 578 individuals screened and 254 individuals unscreened for alcohol consumption were used. Thus, the total number of subjects was 1217. RESULTS: In the present study, in which the TaqI A1/A2 DRD2 polymorphism was in Hardy-Weinberg equilibrium in the patient group and the two control groups, we found that the TaqI DRD2 A1/A2 genotype frequency differed significantly between the alcohol-dependent group and both the total and screened control groups. Furthermore, the TaqI DRD2 A1 allele frequency was significantly overrepresented in the alcohol-dependent subjects as compared with both the total and screened control groups. The odds ratio for alcohol-dependency being associated with the A1 allele was 1.34. CONCLUSIONS: Consequently, the findings in this study lend further support to the notion of an association between the DRD2 A1 allele and alcohol-dependence, although the effect size of the DRD2 A1 allele is small.
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| 44. |
- Berggren, Ulf, 1948, et al.
(författare)
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Thrombocytopenia in early alcohol withdrawal is associated with development of delirium tremens or seizures.
- 2009
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Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - : Oxford University Press (OUP). - 1464-3502 .- 0735-0414. ; 44:4, s. 382-6
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: In several studies, possible risk factors/predictors for severe alcohol withdrawal syndrome (AWS), i.e. delirium tremens (DT) and/or seizures, have been investigated. We have recently observed that low blood platelet count could be such a risk factor/predictor. We therefore investigated whether such an association could be found using a large number of alcohol-dependent individuals (n = 334). METHODS: This study is a retrospectively conducted cohort study based on data from female and male patients (>20 years of age), consecutively admitted to an alcohol treatment unit. The individuals had to fulfil the discharge diagnoses alcohol dependence and alcohol withdrawal syndrome according to DSM-IV. RESULTS: During the treatment period, 3% of the patients developed DT, 2% seizures and none had co-occurrence of both conditions. Among those with DT, a higher proportion had thrombocytopenia. Those with seizures had lower blood platelet count and a higher proportion of them had thrombocytopenia. The sensitivity and specificity of thrombocytopenia for the development of DT during the treatment period was 70% and 69%, respectively. The positive predictive value (PPV) was 6% and the negative predictive value (NPV) was 99%. For the development of seizures, the figure for sensitivity was 75% and for specificity 69%. The figures for PPV and NPV were similar as those for the development of DT. CONCLUSIONS: Thrombocytopenia is more frequent in patients who develop severe AWS (DT or seizures). The findings, including the high NPV of thrombocytopenia, must be interpreted with caution due to the small number of patients who developed AWS. Further studies replicating the present finding are therefore needed before the clinical usefulness can be considered.
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| 45. |
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| 46. |
- Berggren, Ulf, 1948, et al.
(författare)
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Tobacco use is associated with more severe alcohol dependence, as assessed by the number of DSM-IV criteria, in Swedish male type 1 alcoholics.
- 2007
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Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - : Oxford University Press (OUP). - 0735-0414 .- 1464-3502. ; 42:3, s. 247-51
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: A high smoking prevalence has been reported in treatment-seeking alcohol-dependent individuals. It has also been suggested that alcohol-dependent individuals who smoke may have a more severe course and greater severity of their alcoholism. METHODS: This study evaluated the impact of tobacco use in 108 Swedish male type 1 alcohol-dependent individuals, recruited by advertisement in a local daily newspaper. They were sub-grouped into smokers (N = 50), snuffers (N = 12) and tobacco nonusers (N = 46). The number of criteria for the diagnosis of alcohol dependence was used to assess the severity of alcohol dependence. RESULTS: The smokers were significantly younger compared to the tobacco non-using group, and also younger at their onset of excessive alcohol consumption. Both smokers and snuffers fulfilled significantly more DSM-IV criteria for alcohol dependence than tobacco nonusers. Furthermore, significantly higher proportions of smokers and snuffers fulfilled the criteria no 2 (experiencing withdrawal syndrome) and no 7 (continuing to use alcohol despite problems). CONCLUSIONS: These findings indicate that not only smoking, but also snuffing, is associated with greater severity of alcohol dependence, as reflected by the greater number of DSM-IV criteria.
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| 47. |
- Berggren, Ulf, et al.
(författare)
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Tobacco use is associated with reduced central serotonergic neurotransmission in type 1 alcohol-dependent individuals
- 2003
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Ingår i: Alcoholism: Clinical and Experimental Research. - 0145-6008. ; 27, s. 1257-1261
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Tidskriftsartikel (refereegranskat)abstract
- Background: Reduced central serotonergic neurotransmission in alcohol dependence may be attributed to the effects of cigarette smoking (and possibly more specifically to nicotine) rather than to alcoholism or its subtypes. The aim of the present study was therefore to compare central serotonergic neurotransmission in tobacco-using (cigarette smokers and users of smokeless tobacco, i.e., snuffers) alcohol- dependent individuals to that of tobacco-non using alcohol-dependent individuals. Methods: The central serotonergic neurotransmission was assessed by the prolactin (PRL) response to the serotonin-releasing agent D-fenfluramine (30 mg orally). Male subjects (n = 37) aged 20- 65 years were recruited for this purpose. They were all type 1 alcohol-dependent individuals and had ended their alcohol intake the day before the D-fenfluramine challenge test. Results: There was no difference in baseline PRL concentrations between tobacco-using (n = 18) and tobacco-non using (n = 19) alcohol-dependent individuals. On the other hand, the maximum PRL response after D-fenfluramine was significantly lower in the tobacco-using group as compared to the tobacco-nonusing individuals. Conclusion: Whether the reduction in central serotonergic neurotransmission in tobacco-using alcohol-dependent individuals is pre-existing or a result of tobacco use remains to be elucidated.
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| 48. |
- Berggren, U, et al.
(författare)
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Transient increase in platelet monoamine oxidase b activity during early abstinence in alcoholics: implications for research.
- 2000
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Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - 0735-0414. ; 35:4, s. 377-80
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Tidskriftsartikel (refereegranskat)abstract
- Some earlier studies have suggested that platelet monoamine oxidase (MAO)-B activity should be determined at time points other than early in the abstinence phase. However, the optimal times for blood sampling have not been precisely defined. We therefore assessed platelet MAO-B activity repeatedly in 13 male alcohol-dependent patients over the 2 months after the end of a period of heavy alcohol intake. Twelve healthy men were used as controls. In the alcohol-dependent patients, platelet MAO-B activity was transiently increased from 2 to 6 weeks after the end of alcohol intake and the values during this time period were not different from those of controls. Platelet MAO-B activity was, however, significantly lower in the alcohol-dependent patients at 1 week and at 2 months after the end of alcohol intake, in comparison to controls. It is concluded that the transient increase in platelet MAO-B activity after the end of alcohol intake in alcohol-dependent patients may conceal a difference from a control group. Therefore, it is suggested that when platelet MAO-B activity is determined, the preferential time point for obtaining those values in alcohol-dependent patients is after 2 months of abstinence.
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| 49. |
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| 50. |
- Berglund, Kristina, 1969, et al.
(författare)
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Changes in mental well-being during Minnesota treatment.
- 2004
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Ingår i: Nordic journal of psychiatry. - : Informa UK Limited. - 0803-9488 .- 1502-4725. ; 58:5, s. 383-8
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Tidskriftsartikel (refereegranskat)abstract
- The present study assessed mental well-being daily in 28 alcohol-dependent patients who underwent 28 days of Minnesota inpatient treatment. The Swedish Mood Adjective Check List (sMACL) with six bipolar dimensions was used for daily self-reports. At start of treatment, patients had lower levels in four dimensions of mental well-being compared to those of a norm group. Moreover, patients showed significant improvements in all levels of mental well-being during treatment, and at the end of treatment patients had values within the normal range, except for one dimension (activation/deactivation), in which the levels were significantly higher. The findings may suggest a beneficial effect of this type of treatment on mental well-being, although findings may also reflect a mere effect of adjustment to treatment or the social situation.
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