| 1. |
- Abel, I, et al.
(författare)
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Overview of the JET results with the ITER-like wall
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10, s. 104002-
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Tidskriftsartikel (refereegranskat)abstract
- Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Z(eff) (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. The re-establishment of the baseline H-mode and hybrid scenarios compatible with the new wall has required an optimization of the control of metallic impurity sources and heat loads. Stable type-I ELMy H-mode regimes with H-98,H-y2 close to 1 and beta(N) similar to 1.6 have been achieved using gas injection. ELM frequency is a key factor for the control of the metallic impurity accumulation. Pedestal temperatures tend to be lower with the new wall, leading to reduced confinement, but nitrogen seeding restores high pedestal temperatures and confinement. Compared with the carbon wall, major disruptions with the new wall show a lower radiated power and a slower current quench. The higher heat loads on Be wall plasma-facing components due to lower radiation made the routine use of massive gas injection for disruption mitigation essential.
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| 2. |
- Romanelli, F, et al.
(författare)
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Overview of the JET results
- 2011
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 51:9
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Tidskriftsartikel (refereegranskat)abstract
- Since the last IAEA Conference JET has been in operation for one year with a programmatic focus on the qualification of ITER operating scenarios, the consolidation of ITER design choices and preparation for plasma operation with the ITER-like wall presently being installed in JET. Good progress has been achieved, including stationary ELMy H-mode operation at 4.5 MA. The high confinement hybrid scenario has been extended to high triangularity, lower ρ*and to pulse lengths comparable to the resistive time. The steady-state scenario has also been extended to lower ρ*and ν*and optimized to simultaneously achieve, under stationary conditions, ITER-like values of all other relevant normalized parameters. A dedicated helium campaign has allowed key aspects of plasma control and H-mode operation for the ITER non-activated phase to be evaluated. Effective sawtooth control by fast ions has been demonstrated with3He minority ICRH, a scenario with negligible minority current drive. Edge localized mode (ELM) control studies using external n = 1 and n = 2 perturbation fields have found a resonance effect in ELM frequency for specific q95values. Complete ELM suppression has, however, not been observed, even with an edge Chirikov parameter larger than 1. Pellet ELM pacing has been demonstrated and the minimum pellet size needed to trigger an ELM has been estimated. For both natural and mitigated ELMs a broadening of the divertor ELM-wetted area with increasing ELM size has been found. In disruption studies with massive gas injection up to 50% of the thermal energy could be radiated before, and 20% during, the thermal quench. Halo currents could be reduced by 60% and, using argon/deuterium and neon/deuterium gas mixtures, runaway electron generation could be avoided. Most objectives of the ITER-like ICRH antenna have been demonstrated; matching with closely packed straps, ELM resilience, scattering matrix arc detection and operation at high power density (6.2 MW m-2) and antenna strap voltages (42 kV). Coupling measurements are in very good agreement with TOPICA modelling. © 2011 IAEA, Vienna.
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| 3. |
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| 4. |
- Bécoulet, A., et al.
(författare)
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Science and technology research and development in support to ITER and the Broader Approach at CEA
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10
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Tidskriftsartikel (refereegranskat)abstract
- In parallel to the direct contribution to the procurement phase of ITER and Broader Approach, CEA has initiated research & development programmes, accompanied by experiments together with a significant modelling effort, aimed at ensuring robust operation, plasma performance, as well as mitigating the risks of the procurement phase. This overview reports the latest progress in both fusion science and technology including many areas, namely the mitigation of superconducting magnet quenches, disruption-generated runaway electrons, edge-localized modes (ELMs), the development of imaging surveillance, and heating and current drive systems for steady-state operation. The WEST (W Environment for Steady-state Tokamaks) project, turning Tore Supra into an actively cooled W-divertor platform open to the ITER partners and industries, is presented.
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| 5. |
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| 6. |
- Fenstermacher, M.E., et al.
(författare)
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DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy
- 2022
-
Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 62:4
-
Tidskriftsartikel (refereegranskat)abstract
- DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I p steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at ∼8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I p beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stability limits and regulate β N in the ITER baseline scenario, based on plasma response to probing 3D fields, was demonstrated. Finally, innovative tokamak operation using a negative triangularity shape showed many attractive features for future pilot plant operation.
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| 7. |
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| 8. |
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| 9. |
- Kattge, Jens, et al.
(författare)
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TRY plant trait database - enhanced coverage and open access
- 2020
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Ingår i: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188
-
Tidskriftsartikel (refereegranskat)abstract
- Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
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| 10. |
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| 11. |
- Jones, G. H., et al.
(författare)
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The dust halo of Saturn's largest icy moon, Rhea
- 2008
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 319:5868, s. 1380-1384
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Tidskriftsartikel (refereegranskat)abstract
- Saturn's moon Rhea had been considered massive enough to retain a thin, externally generated atmosphere capable of locally affecting Saturn's magnetosphere. The Cassini spacecraft's in situ observations reveal that energetic electrons are depleted in the moon's vicinity. The absence of a substantial exosphere implies that Rhea's magnetospheric interaction region, rather than being exclusively induced by sputtered gas and its products, likely contains solid material that can absorb magnetospheric particles. Combined observations from several instruments suggest that this material is in the form of grains and boulders up to several decimetres in size and orbits Rhea as an equatorial debris disk. Within this disk may reside denser, discrete rings or arcs of material.
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| 12. |
- Ma, Y. J., et al.
(författare)
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Time-dependent global MHD simulations of Cassini T32 flyby : From magnetosphere to magnetosheath
- 2009
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 114:3, s. A03204-
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Tidskriftsartikel (refereegranskat)abstract
- When the Cassini spacecraft flew by Titan on 13 June 2007, at 13.6 Saturn local time, Titan was directly observed to be outside Saturn's magnetopause. Cassini observations showed dramatic changes of magnetic field orientation as well as other plasma flow parameters during the inbound and outbound segments. In this paper, we study Titan's ionospheric responses to such a sudden change in the upstream plasma conditions using a sophisticated multispecies global MHD model. Simulation results of three different cases (steady state, simple current sheet crossing, and magnetopause crossing) are presented and compared against Cassini Magnetometer, Langmuir Probe, and Cassini Plasma Spectrometer observations. The simulation results provide clear evidence for the existence of a fossil field that was induced in the ionosphere. The main interaction features, as observed by the Cassini spacecraft, are well reproduced by the time-dependent simulation cases. Simulation also reveals how the fossil field was trapped during the interaction and shows the coexistence of two pileup regions with opposite magnetic orientation, as well as the formation of a pair of new Alfven wings and tail disconnection during the magnetopause crossing process.
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| 13. |
- Garnier, Philippe, et al.
(författare)
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The influence of the secondary electrons induced by energetic electrons impacting the Cassini Langmuir probe at Saturn
- 2013
-
Ingår i: Journal of geophysical research Space Physics. - 2169-9402. ; 118:11, s. 7054-7073
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Tidskriftsartikel (refereegranskat)abstract
- The Cassini Langmuir Probe (LP) onboard the Radio and Plasma Wave Science experiment has provided much information about the Saturnian cold plasma environment since the Saturn Orbit Insertion in 2004. A recent analysis revealed that the LP is also sensitive to the energetic electrons (250–450 eV) for negative potentials. These electrons impact the surface of the probe and generate a current of secondary electrons, inducing an energetic contribution to the DC level of the current-voltage (I-V) curve measured by the LP. In this paper, we further investigated this influence of the energetic electrons and (1) showed how the secondary electrons impact not only the DC level but also the slope of the (I-V) curve with unexpected positive values of the slope, (2) explained how the slope of the (I-V) curve can be used to identify where the influence of the energetic electrons is strong, (3) showed that this influence may be interpreted in terms of the critical and anticritical temperatures concept detailed by Lai and Tautz (2008), thus providing the first observational evidence for the existence of the anticritical temperature, (4) derived estimations of the maximum secondary yield value for the LP surface without using laboratory measurements, and (5) showed how to model the energetic contributions to the DC level and slope of the (I-V) curve via several methods (empirically and theoretically). This work will allow, for the whole Cassini mission, to clean the measurements influenced by such electrons. Furthermore, the understanding of this influence may be used for other missions using Langmuir probes, such as the future missions Jupiter Icy Moons Explorer at Jupiter, BepiColombo at Mercury, Rosetta at the comet Churyumov-Gerasimenko, and even the probes onboard spacecrafts in the Earth magnetosphere.
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| 14. |
- Hinton, T. G., et al.
(författare)
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An invitation to contribute to a strategic research agenda in radioecology
- 2013
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Ingår i: Journal of Environmental Radioactivity. - : Elsevier BV. - 0265-931X .- 1879-1700. ; 115, s. 73-82
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Tidskriftsartikel (refereegranskat)abstract
- With intentions of integrating a portion of their respective research efforts into a trans-national programme that will enhance radioecology, eight European organisations recently formed the European Radioecology ALLIANCE (www.er-alliance.org). The ALLIANCE is an Association open to other organisations throughout the world with similar interests in promoting radioecology. The ALLIANCE members recognised that their shared radioecological research could be enhanced by efficiently pooling resources among its partner organizations and prioritising group efforts along common themes of mutual interest. A major step in this prioritisation process was to develop a Strategic Research Agenda (SRA). An EC-funded Network of Excellence in Radioecology, called STAR (Strategy for Allied Radioecology), was formed, in part, to develop the SRA. This document is the first published draft of the SRA. The SRA outlines a suggested prioritisation of research topics in radioecology, with the goal of improving research efficiency and more rapidly advancing the science. It responds to the question: What topics, if critically addressed over the next 20 years, would significantly advance radioecology? The three Scientific Challenges presented within the SRA, with their 15 associated research lines, are a strategic vision of what radioecology can achieve in the future. Meeting these challenges will require a directed effort and collaboration with many organisations the world over. Addressing these challenges is important to the advancement of radioecology and in providing scientific knowledge to decision makers. Although the development of the draft SRA has largely been a European effort, the hope is that it will initiate an open dialogue within the international radioecology community and its stakeholders. This is an abbreviated document with the intention of introducing the SRA and inviting contributions from interested stakeholders. Critique and input for improving the SRA are welcomed via a link on the STAR website (www.star-radioecology.org).
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| 15. |
- Hom, Geoffrey, et al.
(författare)
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Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
- 2008
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Ingår i: New England Journal of Medicine. - : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 358:9, s. 900-909
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which the risk of disease is influenced by complex genetic and environmental contributions. Alleles of HLA-DRB1, IRF5, and STAT4are established susceptibility genes; there is strong evidence for the existence of additional risk loci.METHODS: We genotyped more than 500,000 single-nucleotide polymorphisms (SNPs) in DNA samples from 1311 case subjects with SLE and 1783 control subjects; all subjects were North Americans of European descent. Genotypes from 1557 additional control subjects were obtained from public data repositories. We measured the association between the SNPs and SLE after applying strict quality-control filters to reduce technical artifacts and to correct for the presence of population stratification. Replication of the top loci was performed in 793 case subjects and 857 control subjects from Sweden.RESULTS: Genetic variation in the region upstream from the transcription initiation site of the gene encoding B lymphoid tyrosine kinase (BLK) and C8orf13 (chromosome 8p23.1) was associated with disease risk in both the U.S. and Swedish case–control series (rs13277113; odds ratio, 1.39; P=1×10−10) and also with altered levels of messenger RNA in B-cell lines. In addition, variants on chromosome 16p11.22, near the genes encoding integrin alpha M (ITGAM, or CD11b) and integrin alpha X (ITGAX), were associated with SLE in the combined sample (rs11574637; odds ratio, 1.33; P=3×10−11).
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| 16. |
- Ma, Y. J., et al.
(författare)
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The importance of thermal electron heating in Titan's ionosphere : Comparison with Cassini T34 flyby
- 2011
-
Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 116, s. A10213-
-
Tidskriftsartikel (refereegranskat)abstract
- We use a new magnetohydrodynamic (MHD) model to study the effects of thermal-electron heating in Titan's ionosphere. This model improves the previously used multispecies MHD model by solving both the electron and ion pressure equations instead of a single plasma pressure equation. This improvement enables a more accurate evaluation of ion and electron temperatures inside Titan's ionosphere. The model is first applied to an idealized case, and the results are compared in detail with those of the single-pressure MHD model to illustrate the effects of the improvement. Simulation results show that the dayside ionosphere thermal pressure is larger than the upstream pressure during normal conditions, when Titan is located in the dusk region; thus Saturn's magnetic field is shielded by the highly conducting ionosphere, similar to the interaction of Venus during solar maximum conditions. This model is also applied to a special flyby of Titan, the T34 flyby, which occurred near the dusk region. It is shown that better agreement with the magnetometer data can be achieved using the two-fluid MHD model with the inclusion of the effects of thermal electron heating. The model results clearly demonstrate the importance of thermal-electron heating in Titan's ionosphere.
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| 17. |
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| 18. |
- Arthur, Rohan, et al.
(författare)
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Optimising the production cost of urea from black liquor
- 2014
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Ingår i: Pulp & paper, bioenergy, bioproducts. - Bundoora : Appita Inc. - 9780987168443 ; , s. 91-95
-
Konferensbidrag (refereegranskat)abstract
- A conceptual design of an integrated facility for the co-production of ammonia and electricity from black liquor gasification has been studied. The integrated process exchanges black and green liquor, steam, electricity and sulfur with the adjacent Kraft pulp mill. A triple bottom line analysis has indicated that a competitive ammonia price (A$516/t) can be realized for a relatively small scale production 20ktpa of NH3 with an internal rate of return of 13.7%. This is achieved through a novel process design which also produces electricity and steam for the pulp mill. The plant has a carbon footprint at 50% of the average and 33% below world best practice for NH3. Social benefits are also predicted for the regional community.
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| 19. |
- Baron, J. S., et al.
(författare)
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Synthesis Centers as Critical Research Infrastructure
- 2017
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Ingår i: Bioscience. - : Oxford University Press (OUP). - 0006-3568 .- 1525-3244. ; 67:8, s. 750-759
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Tidskriftsartikel (refereegranskat)abstract
- Synthesis centers offer a unique amalgam of culture, infrastructure, leadership, and support that facilitates creative discovery on issues crucial to science and society. The combination of logistical support, postdoctoral or senior fellowships, complex data management, informatics and computing capability or expertise, and most of all, opportunity for group discussion and reflection lowers the "activation energy" necessary to promote creativity and the cross-fertilization of ideas. Synthesis centers are explicitly created and operated as community-oriented infrastructure, with scholarly directions driven by the ever-changing interests and needs of an open and inclusive scientific community. The last decade has seen a rise in the number of synthesis centers globally but also the end of core federal funding for several, challenging the sustainability of the infrastructure for this key research strategy. Here, we present the history and rationale for supporting synthesis centers, integrate insights arising from two decades of experience, and explore the challenges and opportunities for long-term sustainability.
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| 20. |
- Bertucci, C., et al.
(författare)
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The magnetic memory of Titan's ionized atmosphere
- 2008
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 321:5895, s. 1475-1478
-
Tidskriftsartikel (refereegranskat)abstract
- After 3 years and 31 close flybys of Titan by the Cassini Orbiter, Titan was finally observed in the shocked solar wind, outside of Saturn's magnetosphere. These observations revealed that Titan's flow- induced magnetosphere was populated by "fossil" fields originating from Saturn, to which the satellite was exposed before its excursion through the magnetopause. In addition, strong magnetic shear observed at the edge of Titan's induced magnetosphere suggests that reconnection may have been involved in the replacement of the fossil fields by the interplanetary magnetic field.
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| 21. |
- Cortes Ruiz, Maria F.
(författare)
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Tailoring and Characterization of Polymer-linked Fibrillar Structures
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The development of sustainable and renewable materials is paramount in today’s society. As the most abundant biopolymer on Earth, cellulose from cellulose-rich fibres is an excellent alternative for advanced and innovative material solutions. Nonetheless, competing with the impressive material properties and the low manufacturing costs of fossil-based plastics imposes great challenges. To increase the potential of cellulose fibres in a broader set of applications, the material properties of cellulose need to be tuned depending on the application. An in-depth study of the fibre structure and the application of different tailoring techniques is required to induce tailoring of the physical and chemical properties of the cellulose fibre materials. This thesis focuses on the structure-property relationship of fibrillar hydrogel networks as model structures for the delignified wet-fibre wall. First, a mathematical framework was developed to describe the characteristics of the swelling and mechanical behaviour of anisotropic fibrillar structures, considering the fibril aspect ratio, surface chemistry of the fibrils, and electrolyte concentration in the system. A chemical functionalisation was then introduced to the fibrillar structure, which provided the CNFs with colloidal stability and the ability to participate in free radical polymerisation with monomers and telechelic oligomers. As a result, fibrillar networks were crosslinked with flexible polymer links that provided the network with different mechanical and chemical properties. Additionally, by tailoring the molecular weight of the crosslinks, the ionic strength of the solution, and even the aspect ratio of the fibrils, the mechanical properties of the network were tuned to be either stiffer or more ductile. Finally, an innovative and more sustainable approach was developed to introduce charge and alkene functionality to the fibres. Following the lessons learned from the CNF model investigations, a polymerisation approach was developed in the presence of functionalised fibres. The polymers were grown from the fibre wall, followed by radical crosslinking to create strong Fibre reinforced hydrogel structures. Depending on the application, the method can be easily applied to introduce other types of molecules and functionalities to the fibres and tailor the properties of the fibres to suit a wide range of applications.
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| 22. |
- Creely, A. J., et al.
(författare)
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Overview of the SPARC tokamak
- 2020
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Ingår i: Journal of Plasma Physics. - 0022-3778 .- 1469-7807. ; 86:5
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Tidskriftsartikel (refereegranskat)abstract
- The SPARC tokamak is a critical next step towards commercial fusion energy. SPARC is designed as a high-field (B-0 = 12.2 T), compact (R-0 = 1.85 m, a = 0.57 m), superconducting, D-T tokamak with the goal of producing fusion gain Q > 2 from a magnetically confined fusion plasma for the first time. Currently under design, SPARC will continue the high-field path of the Alcator series of tokamaks, utilizing new magnets based on rare earth barium copper oxide high-temperature superconductors to achieve high performance in a compact device. The goal of Q > 2 is achievable with conservative physics assumptions (H-98,H- y2 = 0.7) and, with the nominal assumption of H-98,H- y2 = 1, SPARC is projected to attain Q approximate to 11 and P-fusion approximate to 140 MW. SPARC will therefore constitute a unique platform for burning plasma physics research with high density (< n(e)> approximate to 3 x 10(20) m(-3)), high temperature (< Te > approximate to 7 keV) and high power density (P-fusion/V-plasma approximate to 7 MWm(-3)) relevant to fusion power plants. SPARC's place in the path to commercial fusion energy, its parameters and the current status of SPARC design work are presented. This work also describes the basis for global performance projections and summarizes some of the physics analysis that is presented in greater detail in the companion articles of this collection.
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| 23. |
- Ecsedi, M, et al.
(författare)
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Use of eltrombopag in aplastic anemia in Europe
- 2019
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Ingår i: Annals of hematology. - : Springer Science and Business Media LLC. - 1432-0584 .- 0939-5555. ; 98:6, s. 1341-1350
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Tidskriftsartikel (refereegranskat)
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| 24. |
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| 25. |
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| 26. |
- Garnier-Laplace, J., et al.
(författare)
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Issues and practices in the use of effects data from FREDERICA in the ERICA Integrated Approach
- 2008
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Ingår i: Journal of Environmental Radioactivity. - : Elsevier BV. - 0265-931X .- 1879-1700. ; 99:9, s. 1474-1483
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Tidskriftsartikel (refereegranskat)abstract
- The ERICA Integrated Approach requires that a risk assessment screening dose rate is defined for the risk characterisation within Tiers 1 and 2. At Tier 3, no numerical screening dose rate is used, and the risk characterisation is driven by methods that can evaluate the possible effects of ionising radiation on reproduction, mortality and morbidity. Species sensitivity distribution has been used to derive the ERICA risk assessment predicted no-effect dose rate (PNEDR). The method used was based on the mathematical processing of data from FRED (FASSET radiation effects database merged with the EPIC database to form FREDERICA) and resulted in a PNEDR of 10 mu Gy/h. This rate was assumed to ascribe sufficient protection of all ecosystems from detrimental effects on structure and function under chronic exposure. The value was weighed against a number of points of comparison: (i) PNEDR values obtained by application of the safety factor method, (ii) background levels, (iii) dose rates triggering effects on radioactively contaminated sites and (iv) former guidelines from literature reviews. In Tier 3, the effects analysis must be driven by the problem formulation and is thus highly case specific. Instead of specific recommendations on numeric values, guidance on the sorts of methods that may be applied for refined effect analysis is Provided and illustrated.
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| 27. |
- Garnier, P., et al.
(författare)
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The detection of energetic electrons with the Cassini Langmuir probe at Saturn
- 2012
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 117, s. A10202-
-
Tidskriftsartikel (refereegranskat)abstract
- The Cassini Langmuir probe, part of the Radio and Plasma Wave Science (RPWS) instrument, has provided a wealth of information about the cold and dense plasma in the Saturnian system. The analysis of the ion side current (current for negative potentials) measured by the probe from 2005 to 2008 reveals also a strong sensitivity to energetic electrons (250-450 eV). These electrons impact the surface of the probe, and generate a detectable current of secondary electrons. A broad secondary electrons current region is inferred from the observations in the dipole L Shell range of similar to 6-10, with a peak full width at half maximum (FWHM) at L = 6.4-9.4 (near the Dione and Rhea magnetic dipole L Shell values). This magnetospheric flux tube region, which displays a large day/night asymmetry, is related to the similar structure in the energetic electron fluxes as the one measured by the onboard Electron Spectrometer (ELS) of the Cassini Plasma Spectrometer (CAPS). It corresponds spatially to both the outer electron radiation belt observed by the Magnetosphere Imaging Instrument (MIMI) at high energies and to the low-energy peak which has been observed since the Voyager era. Finally, a case study suggests that the mapping of the current measured by the Langmuir probe for negative potentials can allow to identify the plasmapause-like boundary recently identified at Saturn, and thus potentially identify the separation between the closed and open magnetic field lines regions.
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| 28. |
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| 29. |
- Johansson, Mattias, et al.
(författare)
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The influence of obesity-related factors in the etiology of renal cell carcinoma—A mendelian randomization study
- 2019
-
Ingår i: PLoS Medicine. - : Public Library of Science (PLoS). - 1549-1277 .- 1549-1676. ; 16:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Several obesity-related factors have been associated with renal cell carcinoma (RCC), but it is unclear which individual factors directly influence risk. We addressed this question using genetic markers as proxies for putative risk factors and evaluated their relation to RCC risk in a mendelian randomization (MR) framework. This methodology limits bias due to confounding and is not affected by reverse causation.Methods and findings: Genetic markers associated with obesity measures, blood pressure, lipids, type 2 diabetes, insulin, and glucose were initially identified as instrumental variables, and their association with RCC risk was subsequently evaluated in a genome-wide association study (GWAS) of 10,784 RCC patients and 20,406 control participants in a 2-sample MR framework. The effect on RCC risk was estimated by calculating odds ratios (ORSD) for a standard deviation (SD) increment in each risk factor. The MR analysis indicated that higher body mass index increases the risk of RCC (ORSD: 1.56, 95% confidence interval [CI] 1.44–1.70), with comparable results for waist-to-hip ratio (ORSD: 1.63, 95% CI 1.40–1.90) and body fat percentage (ORSD: 1.66, 95% CI 1.44–1.90). This analysis further indicated that higher fasting insulin (ORSD: 1.82, 95% CI 1.30–2.55) and diastolic blood pressure (DBP; ORSD: 1.28, 95% CI 1.11–1.47), but not systolic blood pressure (ORSD: 0.98, 95% CI 0.84–1.14), increase the risk for RCC. No association with RCC risk was seen for lipids, overall type 2 diabetes, or fasting glucose.Conclusions: This study provides novel evidence for an etiological role of insulin in RCC, as well as confirmatory evidence that obesity and DBP influence RCC risk.
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| 30. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 31. |
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| 32. |
- Leip, A., et al.
(författare)
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Impacts of European livestock production: nitrogen, sulphur, phosphorus and greenhouse gas emissions, land-use, water eutrophication and biodiversity
- 2015
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Ingår i: Environmental Research Letters. - : IOP Publishing. - 1748-9318 .- 1748-9326. ; 10:11
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Tidskriftsartikel (refereegranskat)abstract
- Livestock production systems currently occupy around 28% of the land surface of the European Union (equivalent to 65% of the agricultural land). In conjunction with other human activities, livestock production systems affect water, air and soil quality, global climate and biodiversity, altering the biogeochemical cycles of nitrogen, phosphorus and carbon. Here, we quantify the contribution of European livestock production to these major impacts. For each environmental effect, the contribution of livestock is expressed as shares of the emitted compounds and land used, as compared to the whole agricultural sector. The results show that the livestock sector contributes significantly to agricultural environmental impacts. This contribution is 78% for terrestrial biodiversity loss, 80% for soil acidification and air pollution (ammonia and nitrogen oxides emissions), 81% for global warming, and 73% for water pollution (both N and P). The agriculture sector itself is one of the major contributors to these environmental impacts, ranging between 12% for global warming and 59% for N water quality impact. Significant progress in mitigating these environmental impacts in Europe will only be possible through a combination of technological measures reducing livestock emissions, improved food choices and reduced food waste of European citizens.
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| 33. |
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| 34. |
- Shaw, DE, et al.
(författare)
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Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
- 2015
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Ingår i: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 46:5, s. 1308-1321
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Tidskriftsartikel (refereegranskat)abstract
- U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p<0.001), with worse quality of life, and higher levels of anxiety and depression. They also had a higher incidence of nasal polyps and gastro-oesophageal reflux with lower lung function. Sputum eosinophil count was higher in severe asthma compared to mild/moderate asthma (median count 2.99% versus 1.05%; p=0.004) despite treatment with higher doses of inhaled and/or oral corticosteroids.Consistent with other severe asthma cohorts, U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment. It is well suited to identify asthma phenotypes using the array of “omic” datasets that are at the core of this systems medicine approach.
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| 35. |
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| 36. |
- Svenungsson, Elisabet, et al.
(författare)
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A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus
- 2010
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 69:5, s. 834-840
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Tidskriftsartikel (refereegranskat)abstract
- Objective To investigate whether the risk allele for systemic lupus erythematosus (SLE) in the signal transducer and activator of transcription factor 4 (STAT4) gene, defined by the single nucleotide polymorphism (SNP) rs10181656(G), is associated with vascular events and/or presence of prothrombotic anti-phospholipid antibodies (aPL) in patients with SLE. Methods Two independent groups of unrelated patients with SLE of Swedish ethnicity (n=424 and 154) were genotyped, and occurrence of previous manifestations of ischaemic heart disease (IHD), ischaemic cerebrovascular disease (ICVD) and venous thromboembolic events (VTE) was tabulated. aPL values were measured by ELISA. Matched controls (n=492 and 194) were genotyped. Results The STAT4 risk allele was more frequent in patients with SLE with previous arterial events (combined OR (ORc)=1.5, 95% CI 1.1 to 2.0) compared to patients without such events. The association was mainly attributable to an accumulation of the risk allele among patients with ICVD (ORc=2.3, CI 1.6 to 3.3). There was no association with IHD or VTE. The presence of two or more aPLs was associated with the risk allele (ORc=1.6, 95% CI 1.2 to 2.0). In multivariable-adjusted logistic regression analyses treatment for hypertension, at least one STAT4 risk allele, older age, IgG anti-cardiolipin antibodies and longer SLE duration remained independently associated with previous ICVD (p≤0.02 for all). Conclusion Patients with SLE with the STAT4 risk allele had a strikingly increased risk of ICVD, comparable in magnitude to that of hypertension. The results imply that a genetic predisposition is an important and previously unrecognised risk factor for ICVD in SLE, and that aPLs may be one underlying mechanism.
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| 37. |
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| 38. |
- Wahlund, Jan Erik, et al.
(författare)
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On the amount of heavy molecular ions in Titan's ionosphere
- 2009
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Ingår i: Planetary and Space Science. - : Elsevier BV. - 0032-0633 .- 1873-5088. ; 57:14-15, s. 1857-1865
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Tidskriftsartikel (refereegranskat)abstract
- We present observational evidence that the ionosphere of Titan below an altitude of 1150 km is a significant source of heavy (> 100 amu) molecular organic species. This study is based on measurements by five instruments (RPWS/LP, RPWS/E, INMS, CAPS/ELS, CAPS/IBS) onboard the Cassini spacecraft during three flybys (T17, T18, T32) of Titan. The ionospheric peaks encountered at altitudes of 950-1300 km had densities in the range 900-3000 cm(-3). Below these peaks the number densities of heavy positively charged ions reached 100-2000 cm(-3) and approached 50-70% of the total ionospheric density with an increasing trend toward lowest measured altitudes. Simultaneously measured negatively charged ion densities were in the range 50-150 cm(-3). These results imply that similar to 10(5)similar to 10(6) heavy positively charged ions/m(3)/s are continuously recombining into heavy neutrals and supply the atmosphere of Titan. The ionosphere may in this way produce 0.1-1 Mt/yr of heavy organic compounds and is therefore a sizable source for aerosol formation. We also predict that Titan's ionosphere is dominated by heavy (> 100 amu) molecular ions below 950 km.
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| 39. |
- Young, WJ, et al.
(författare)
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Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
- 2023
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1, s. 1411-
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Tidskriftsartikel (refereegranskat)abstract
- The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.
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