| 1. |
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| 2. |
- Thelander, Åsa, et al.
(författare)
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IKEA's image in three countries
- 2010
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Ingår i: Consuming IKEA; different perspectives on consumer images of a global retailer. - 9789185113422 ; , s. 111-130
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Alftberg, Åsa, et al.
(författare)
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Vara av eller på? : Cochleaimplantat och ljudmiljöer
- 2016
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Ingår i: Ljud tar plats : funktionshinderperspektiv på ljudmiljöer - funktionshinderperspektiv på ljudmiljöer. - : Institute for Educational Sciences, Lund University, Sweden. - 2001-7510 .- 2001-7529. - 9789198145861 ; 11, s. 31-51
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Bokkapitel (refereegranskat)
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| 4. |
- Askman, Sandra, et al.
(författare)
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Decreased neutrophil function in newly diagnosed multiple myeloma patients is restored with lenalidomide therapy
- 2024
-
Ingår i: EUROPEAN JOURNAL OF HAEMATOLOGY. - 0902-4441 .- 1600-0609.
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Tidskriftsartikel (refereegranskat)abstract
- ObjectivesBacterial infections are common and a major cause of morbidity and mortality in multiple myeloma (MM). We have investigated the function of polymorphonuclear leukocyte (PMN), the immune system's first line of defense against bacteria, in peripheral blood (PB) and bone marrow (BM) samples from patients with newly diagnosed MM (NDMM), smoldering MM (SMM), monoclonal gammopathy of undetermined significance (MGUS) and healthy controls.MethodsPhagocytosis and oxidative burst in PMN cells from patients and healthy donors were investigated using PhagoTest and PhagoBurst assay.ResultsPMN from NDMM, SMM, and MGUS patients had reduced phagocytosis and oxidative burst ability compared with healthy controls. The dysfunction was most prominent in BM samples from MM, SMM, and MGUS patients. Importantly the reduced phagocytosis in MM patients was restored in patients on lenalidomide therapy. Consistently the ability of Escherichia coli stimulated oxidative burst in BM was reduced for the MM, SMM, and MGUS cohort in contrast to the healthy controls and the patients on lenalidomide treatment.ConclusionOur results show that MM patients have neutrophil dysfunction that could contribute to susceptibility for bacterial infections and that lenalidomide therapy was associated with restored PMN function.
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| 5. |
- Bengtsson, Anders, et al.
(författare)
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Low production of reactive oxygen species in granulocytes is associated with organ damage in systemic lupus erythematosus
- 2014
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Ingår i: Arthritis Research and Therapy. - : Springer Science and Business Media LLC. - 1478-6362 .- 1478-6354. ; 16:3
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Polymorphonuclear leukocytes (PMN) are main effector cells in the acute immune response. While the specific role of PMN in systemic lupus erythematosus (SLE) and autoimmunity is still unclear, their importance in chronic inflammation is gaining more attention. Here we investigate aspects of function, bone marrow release and activation of PMN in patients with SLE. Methods: The following PMN functions and subsets were evaluated using flow cytometry; (a) production of reactive oxygen species (ROS) after ex vivo stimulation with phorbol 12-myristate 13-acetate (PMA) or Escherichia coli (E. coli); (b) capacity to phagocytose antibody-coated necrotic cell material; (c) PMN recently released from bone marrow, defined as percentage of CD10(-)D16(low) in peripheral blood, and (d) PMN activation markers; CD11b, CD62L and C5aR. Results: SLE patients (n = 92) showed lower ROS production compared with healthy controls (n = 38) after activation ex vivo. The ROS production was not associated with corticosteroid dose or other immunotherapies. PMA induced ROS production was significantly reduced in patients with severe disease. In contrast, neither ROS levels after E. coli activation, nor the capacity to phagocytose were associated with disease severity. This suggests that decreased ROS production after PMA activation is a sign of changed PMN behaviour rather than generally impaired functions. The CD10(-)CD16(low) phenotype constitute 2% of PMN in peripheral blood of SLE patients compared with 6.4% in controls, indicating a decreased release of PMN from the bone marrow in SLE. A decreased expression of C5aR on PMN was observed in SLE patients, pointing towards in vivo activation. Conclusions: Our results indicate that PMN from SLE patients have altered function, are partly activated and are released abnormally from bone marrow. The association between low ROS formation in PMN and disease severity is consistent with findings in other autoimmune diseases and might be considered as a risk factor.
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| 6. |
- Hansson, Kristofer, et al.
(författare)
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Eget ansvar eller egen makt? : en habiliteringsparadox
- 2016
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Ingår i: Ljud tar plats : Funktionshinderperspektiv på ljudmiljöer - Funktionshinderperspektiv på ljudmiljöer. - 2001-7510 .- 2001-7529. - 9789198145861 ; 11, s. 153-153
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Bokkapitel (refereegranskat)
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| 7. |
- Hansson, Malin, 1967, et al.
(författare)
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CCL28 is increased in human Helicobacter pylori induced gastritis and mediates recruitment of gastric IgA-secreting cells.
- 2008
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Ingår i: Infection and Immunity. - 0019-9567. ; 76:7, s. 3304-11
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Tidskriftsartikel (refereegranskat)abstract
- Human Helicobacter pylori infection gives rise to an active chronic gastritis and is a major risk factor for the development of duodenal ulcer disease and gastric adenocarcinoma. The infection is accompanied by a large accumulation of immunoglobulin A (IgA)-secreting cells in the gastric mucosa, and following mucosal immunization only H. pylori-infected volunteers mounted a B-cell response in the gastric mucosa. To identify the signals for recruitment of gastric IgA-secreting cells, we investigated the gastric production of CCL28 (mucosa-associated epithelial chemokine) and CCL25 (thymus-expressed chemokine) in H. pylori-infected and uninfected individuals and the potential of gastric B-cell populations to migrate toward these chemokines. Gastric tissue from H. pylori-infected individuals contained significantly more CCL28 protein and mRNA than that from uninfected individuals, while CCL25 levels remained unchanged. Chemokine-induced migration of gastric lamina propria lymphocytes isolated from patients undergoing gastric resection was then assessed using the Transwell system. IgA-secreting cells and IgA+ memory B cells from H. pylori-infected tissues migrated toward CCL28 but not CCL25, while the corresponding cells from uninfected patients did not. Furthermore, IgG-secreting cells from H. pylori-infected patients did not migrate to CCL28 but instead to CXCL12 (SDF-1). However, chemokine receptor expression did not correlate to the migratory pattern of the different B-cell populations. These studies are the first to show increased CCL28 production during gastrointestinal infection in humans and provide an explanation for the large influx of IgA-secreting cells to the gastric mucosa in H. pylori-infected individuals.
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| 8. |
- Hellmark, Thomas, et al.
(författare)
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Eosinophils in anti-neutrophil cytoplasmic antibody associated vasculitis
- 2019
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Ingår i: BMC Rheumatology. - : Springer Science and Business Media LLC. - 2520-1026. ; 3:9
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Tidskriftsartikel (refereegranskat)abstract
- Background: Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) are characterized by autoimmune small vessel inflammation. Eosinophils are multifunctional cells with both pro-inflammatory and immunoregulatory properties. Tissue activated eosinophils secrete cyto- and chemokines and form extracellular traps (EETs), they release free granules and produce reactive oxygen species. The role of eosinophils is well established in eosinophilic granulomatosis with polyangiitis (EGPA) but very little is known about their role in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).Methods: The expression of surface markers CD11c, CD11b, CD16, CD35, CD62L, CD64, CD88, Siglec-8 and CD193 and reactive oxygen species production by peripheral blood eosinophils were studied using flow cytometry. Fluorescence microscopy was used to visualize the release of eosinophil extracellular DNA traps (EETs). 98 GPA and MPA patients and 121 healthy controls were included in the study.Results: Both GPA and MPA patients had decreased frequency of eosinophils in peripheral blood compared with healthy controls (p < 0.0001), which could not solely be explained by corticosteroid treatment. The patient's eosinophils showed increased surface expression of the Fc receptors CD16 (p < 0.0001) and CD64 (p = 0.0035) as well as CCR3 (CD193) (p = 0.0022). Decreased expression was found of the complement receptors CD35 (p = 0.0022), CD88 (p < 0,0001) as well as CD11c (p < 0,0001), CD11b (p = 0.0061) and Siglec-8 (p = 0,0015). Moreover, GPA and MPA eosinophils, showed decreased capacity to produce ROS (p < 0.0001). ANCA stimulation of eosinophils from GPA and MPA patients after C5a priming enhanced EETosis (p = 0,0088).Conclusions: The percentage of eosinophils were decreased in peripheral blood in GPA and MPA patients and showed altered surface marker expression and function. The enhanced EETosis after ANCA stimulation, suggests that eosinophil can contribute to the autoantibody driven inflammatory process.
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| 9. |
- Jansen, Willemijn J, et al.
(författare)
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Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.
- 2022
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Ingår i: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 79:3, s. 228-243
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Tidskriftsartikel (refereegranskat)abstract
- One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design.To estimate the prevalence of amyloid abnormality in persons with normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia and to examine the potential implications of cutoff methods, biomarker modality (CSF or PET), age, sex, APOE genotype, educational level, geographical region, and dementia severity for these estimates.This cross-sectional, individual-participant pooled study included participants from 85 Amyloid Biomarker Study cohorts. Data collection was performed from January 1, 2013, to December 31, 2020. Participants had normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia. Normal cognition and subjective cognitive decline were defined by normal scores on cognitive tests, with the presence of cognitive complaints defining subjective cognitive decline. Mild cognitive impairment and clinical AD dementia were diagnosed according to published criteria.Alzheimer disease biomarkers detected on PET or in CSF.Amyloid measurements were dichotomized as normal or abnormal using cohort-provided cutoffs for CSF or PET or by visual reading for PET. Adjusted data-driven cutoffs for abnormal amyloid were calculated using gaussian mixture modeling. Prevalence of amyloid abnormality was estimated according to age, sex, cognitive status, biomarker modality, APOE carrier status, educational level, geographical location, and dementia severity using generalized estimating equations.Among the 19097 participants (mean [SD] age, 69.1 [9.8] years; 10148 women [53.1%]) included, 10139 (53.1%) underwent an amyloid PET scan and 8958 (46.9%) had an amyloid CSF measurement. Using cohort-provided cutoffs, amyloid abnormality prevalences were similar to 2015 estimates for individuals without dementia and were similar across PET- and CSF-based estimates (24%; 95% CI, 21%-28%) in participants with normal cognition, 27% (95% CI, 21%-33%) in participants with subjective cognitive decline, and 51% (95% CI, 46%-56%) in participants with mild cognitive impairment, whereas for clinical AD dementia the estimates were higher for PET than CSF (87% vs 79%; mean difference, 8%; 95% CI, 0%-16%; P=.04). Gaussian mixture modeling-based cutoffs for amyloid measures on PET scans were similar to cohort-provided cutoffs and were not adjusted. Adjusted CSF cutoffs resulted in a 10% higher amyloid abnormality prevalence than PET-based estimates in persons with normal cognition (mean difference, 9%; 95% CI, 3%-15%; P=.004), subjective cognitive decline (9%; 95% CI, 3%-15%; P=.005), and mild cognitive impairment (10%; 95% CI, 3%-17%; P=.004), whereas the estimates were comparable in persons with clinical AD dementia (mean difference, 4%; 95% CI, -2% to 9%; P=.18).This study found that CSF-based estimates using adjusted data-driven cutoffs were up to 10% higher than PET-based estimates in people without dementia, whereas the results were similar among people with dementia. This finding suggests that preclinical and prodromal AD may be more prevalent than previously estimated, which has important implications for clinical trial recruitment strategies and health care planning policies.
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| 10. |
- Johansson, Åsa Cm, et al.
(författare)
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Impaired phagocytosis and reactive oxygen species production in phagocytes is associated with systemic vasculitis
- 2016
-
Ingår i: Arthritis Research & Therapy. - : Springer Science and Business Media LLC. - 1478-6354 .- 1478-6362. ; 18
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) is a group of autoimmune diseases, characterized by small vessel inflammation. Phagocytes such as neutrophils and monocytes are the main effector cells found around the inflamed vessel wall. Therefore, we wanted to investigate aspects of function and activation of these cells in patients with AAV.METHODS: Flow cytometry was used to evaluate: the expression of activation markers (CD11c, CD62L, CD177 and C5aR); the number of recently released neutrophils from bone marrow, defined as CD10(-)D16(low) cells in peripheral blood; and the capacity of peripheral blood monocytes and polymorphonuclear leukocytes (PMN) to produce reactive oxygen species and to phagocytose opsonized bacteria.RESULTS: AAV patients (n = 104) showed an increase of CD10(-)CD16(low) neutrophils and total PMN in peripheral blood, suggesting a combination of increased bone marrow release and prolonged survival. An increased percentage of AAV PMN expressed CD177 but no other signs of activation were seen. A decreased production of reactive oxygen species was observed in AAV phagocytes, which was associated with disease activity. Moreover, granulocytes from patients with microscopic polyangiitis showed lower oxidative burst capacity compared to patients with granulomatosis with polyangiitis or eosinophilic granulomatosis with polyangiitis. In addition, decreased phagocytosis capacity was seen in PMN and monocytes.CONCLUSION: Our results indicate that phagocytes from AAV patients have impaired function, are easily mobilized from bone marrow but are not particularly activated. The association between low reactive oxygen species formation in PMN and disease severity is consistent with findings in other autoimmune diseases and might be considered as a risk factor.
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| 11. |
- Kindlund, Bert, 1969, et al.
(författare)
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FOXP3-expressing CD4(+) T-cell numbers increase in areas of duodenal gastric metaplasia and are associated to CD4(+) T-cell aggregates in the duodenum of Helicobacter pylori-infected duodenal ulcer patients.
- 2009
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Ingår i: Helicobacter. - : Wiley. - 1523-5378 .- 1083-4389. ; 14:3, s. 192-201
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: We have previously demonstrated that Helicobacter pylori infection is associated with an increased number of CD4(+)CD25(high) regulatory T cells in the gastric and duodenal mucosa. In this study, we determined the number and localization of CD4(+) cells expressing the regulatory T-cell-specific transcription factor FOXP3 in the antrum and duodenum of duodenal ulcer patients, asymptomatic carriers, and uninfected individuals. We also determined gene expression levels of FOXP3 as well as anti- and proinflammatory cytokines before and after H. pylori eradication. METHODS: Cellular FOXP3 expression was studied by immunofluorescence and flow cytometry, and transcription levels of FOXP3, interleukin (IL)-10, transforming growth factor-beta, CD4, and interferon-gamma were analyzed by real-time reverse transcription-polymerase chain reaction. RESULTS: We found an increased (6-fold) frequency of CD4(+)FOXP3(+) T cells in H. pylori-infected gastric mucosa; interestingly 26% of these cells did not co-express CD25. The increase of FOXP3-expressing T cells in the antrum of infected individuals was dependent on the presence of H. pylori, since eradication therapy resulted in 4-fold lower levels of FOXP3 and IL-10 mRNA in the antrum. Furthermore, higher numbers of CD4(+)FOXP3(+) T cells were found in areas of duodenal gastric metaplasia in the duodenum of duodenal ulcer patients compared to duodenal gastric metaplasia of asymptomatic individuals and healthy mucosa in both patient groups. In duodenal ulcer patients, the CD4(+)FOXP3(+) T cells were more highly associated to aggregates in the duodenal mucosa. CONCLUSION: The numbers of CD4(+)FOXP3(+) T cells are increased and localized in CD4(+) T-cell aggregates in areas of duodenal gastric metaplasia in duodenal ulcer patients.
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| 12. |
- Klaric, Lucija, et al.
(författare)
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Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19.
- 2021
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Ingår i: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory. ; , s. 1-28
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Severe COVID-19 is characterised by immunopathology and epithelial injury. Proteomic studies have identified circulating proteins that are biomarkers of severe COVID-19, but cannot distinguish correlation from causation. To address this, we performed Mendelian randomisation (MR) to identify proteins that mediate severe COVID-19. Using protein quantitative trait loci (pQTL) data from the SCALLOP consortium, involving meta-analysis of up to 26,494 individuals, and COVID-19 genome-wide association data from the Host Genetics Initiative, we performed MR for 157 COVID-19 severity protein biomarkers. We identified significant MR results for five proteins: FAS, TNFRSF10A, CCL2, EPHB4 and LGALS9. Further evaluation of these candidates using sensitivity analyses and colocalization testing provided strong evidence to implicate the apoptosis-associated cytokine receptor FAS as a causal mediator of severe COVID-19. This effect was specific to severe disease. Using RNA-seq data from 4,778 individuals, we demonstrate that the pQTL at the FAS locus results from genetically influenced alternate splicing causing skipping of exon 6. We show that the risk allele for very severe COVID-19 increases the proportion of transcripts lacking exon 6, and thereby increases soluble FAS. Soluble FAS acts as a decoy receptor for FAS-ligand, inhibiting apoptosis induced through membrane-bound FAS. In summary, we demonstrate a novel genetic mechanism that contributes to risk of severe of COVID-19, highlighting a pathway that may be a promising therapeutic target.
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| 13. |
- Petersson, Julia, et al.
(författare)
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Bone Marrow Neutrophils of Multiple Myeloma Patients Exhibit Myeloid-Derived Suppressor Cell Activity
- 2021
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Ingår i: Journal of Immunology Research. - : Hindawi Limited. - 2314-8861 .- 2314-7156. ; 2021
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Tidskriftsartikel (refereegranskat)abstract
- Activated normal density granulocytes (NDGs) can suppress T-cell responses in a similar way as myeloid-derived suppressor cells (MDSCs). In this study, we tested the hypothesis that NDGs from blood and bone marrow of multiple myeloma (MM) patients have the ability to suppress T-cells, as MDSC. MM is an incurable plasma cell malignancy of the bone marrow. Like most malignancies, myeloma cells alter its microenvironment to promote tumor growth, including inhibition of the immune system. We found that MM NDG from the bone marrow suppressed proliferation of T-cells, in contrast to healthy donors. The inhibitory effect could not be explained by changed levels of mature or immature NDG in the bone marrow. Moreover, NDG isolated from the blood of both myeloma patients and healthy individuals could inhibit T-cell proliferation and IFN-gamma production. On the contrary to previous studies, blood NDGs did not have to be preactivated to mediate suppressive effects. Instead, they became activated during coculture, indicating that contact with activated T-cells is important for their ability to regulate T-cells. The inhibitory effect was dependent on the production of reactive oxygen species and could be reverted by the addition of its inhibitor, catalase. Our findings suggest that blood NDGs from MM patients are suppressive, but no more than NDGs from healthy donors. However, only bone marrow NDG from MM patients exhibited MDSC function. This MDSC-like suppression mediated by bone marrow NDG could be important for the growth of malignant plasma cells in MM patients.
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| 14. |
- TEDDY study group, The, et al.
(författare)
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The environmental determinants of diabetes in the young (TEDDY) study: Study design
- 2007
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Ingår i: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X .- 1399-5448. ; 8:5, s. 286-298
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Tidskriftsartikel (refereegranskat)abstract
- The primary objective of this multicenter, multinational, epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of autoimmunity and type 1 diabetes mellitus (T1DM). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression or with protection from the development of T1DM will also be identified. The Environmental Determinants of Diabetes in the Young (TEDDY) is an observational cohort study in which newborns who are younger than 4 months and have high-risk human leukocyte antigen alleles in the general population or are first-degree relatives (FDRs) of patients affected with T1DM will be enrolled. Six clinical centers in the USA and Europe will screen 361 588 newborns, of which it is anticipated that 17 804 will be eligible for enrollment with just over 7800 followed. Recruitment will occur over 5 yr, with children being followed to the age of 15 yr. Identification of such factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay, or reverse T1DM.
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| 15. |
- Thelander, Åsa, et al.
(författare)
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Newspapers - image formation agents for retailers?
- 2009
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Ingår i: Medien im Marketing; Optionen der Unternehmenskommunikation. - 9783834907356 ; , s. 429-451
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this study is to analyse the role of newspapers as an image formation agent for retailers. The role of the media has been emphasised in theories about image formation but there are few empirical studies of the role of newspapers. This is an explorative study of how IKEA is represented in British and Swedish newspapers. The study is based on a quantitative content analysis of 153 news articles. The analysis shows differences in reporting between Sweden and Britain and that the store, the unique feature of a retailer, does not feature in the strategic public relation work.
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| 16. |
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| 17. |
- Westerlund, Julia, et al.
(författare)
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Suppression of T-Cell Proliferation by Normal Density Granulocytes Led to CD183 Downregulation and Cytokine Inhibition in T-Cells
- 2022
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Ingår i: Journal of Immunology Research. - : Hindawi Limited. - 2314-7156 .- 2314-8861. ; 2022
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Tidskriftsartikel (refereegranskat)abstract
- Normal density granulocytes (NDGs) can suppress T-cell responses in a similar way as myeloid-derived suppressor cells (MDSCs). In this study, we tested the hypothesis that NDGs from healthy donors preferentially inhibit T helper 1 (Th1) cells and investigated the myeloid-derived suppressive effect in different T-cell populations. We found that NDG-induced suppression of T-cell proliferation was contact dependent, mediated by integrin CD11b, and dependent on NDG-production of reactive oxygen species (ROS). The suppression was rapid and occurred within the first few hours of coculture. The suppression did not influence the CD8 +/CD4 + ratio indicating an equal sensitivity in these populations. We further analyzed the CD4 + T helper subsets and found that NDGs induced a loss of Th1 surface marker, CD183, that was unrelated to ligand-binding to CD183. In addition, we analyzed the Th1, Th2, and Th17 cytokine production and found that all cytokine groups were suppressed when T-cells were incubated with NDGs. We therefore concluded that NDGs do not preferentially suppress Th1-cells. Instead, NDGs generally suppress Th cells and cytotoxic T-cells but specifically downregulate the Th1 marker CD183.
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| 18. |
- Wichert, Stina, et al.
(författare)
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Bone marrow eosinophils in plasma cell disorders
- 2018
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Ingår i: Experimental Hematology. - : Elsevier BV. - 0301-472X. ; 66, s. 5-31
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Tidskriftsartikel (refereegranskat)abstract
- In experimental studies, eosinophils have been shown to promote the survival, proliferation, and retention of plasma cells in the bone marrow (BM). The clinical significance of eosinophils in plasma cell disorders (PCDs) in humans is largely unknown. This study focuses on the frequency and phenotype of eosinophils in the BM and peripheral blood (PB) in patients with untreated PCD compared with healthy controls. The number of eosinophils per se did not correlate with the number of BM plasma cells or disease stage. The expression of chemokine receptor 4, which is important in the homing capacity to bone marrow stromal cells, was significantly higher in patient eosinophils and increased with disease stage. BM eosinophils from patients, especially from those with manifest disease, were more activated. Another finding in this study was that eosinophils in PB and BM from both patients and healthy controls expressed CD80 (B7-1). We discuss probable immunomodulatory consequences of surface expression of CD80 by eosinophils in conditions with marked T-cell exhaustion (e.g., multiple myeloma). Finally, we found that patients treated with corticosteroids had low levels of circulating eosinophils but preserved levels of eosinophils in the BM.
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| 19. |
- Wichert, Stina, et al.
(författare)
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Phagocyte Function Decreases after High-Dose Treatment with Melphalan and Autologous Stem Cell Transplantation in Patients with Multiple Myeloma.
- 2016
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Ingår i: Experimental Hematology. - : Elsevier BV. - 1873-2399 .- 0301-472X. ; 44:5, s. 342-351
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Tidskriftsartikel (refereegranskat)abstract
- High-dose melphalan with autologous hematopoietic stem cell transplantation (ASCT) is standard of care for younger newly diagnosed multiple myeloma patients, with the aim of achieving as deep and complete response as possible after various combinations of induction therapy. However, it is frequently associated with infectious complications. This study investigated the effects of high-dose treatment with autologous stem cell support on patients' innate immunity, with a focus on subpopulations and functioning of recently released polymorphonuclear leukocytes (PMNs) and monocytes in peripheral blood. Flow cytometry-based analysis was used to measure the degree of PMN maturation and activation, before and after ASCT and compared to healthy controls. After high-dose treatment and ASCT, a smaller proportion of patients' PMNs had capacity for oxidative burst. Moreover, patients' PMNs, both before and after ASCT, showed reduced capacity for phagocytosis. Eosinophils, which recently have been suggested to play a role in promoting malignant plasma cell proliferation, were markedly reduced after ASCT, with slow regeneration. HLA-DR expression by monocytes was significantly depressed after ASCT, a characteristic often attributed to monocytic myeloid-derived suppressor cells. Our results suggest that several aspects of phagocytic functions are impaired for at least 20 days after ASCT.
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| 20. |
- Ackum, Susanne, et al.
(författare)
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Vi tar fram en handfast plan för en omstart av Sverige
- 2020
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Ingår i: Dagens Nyheter. - 1101-2447. ; :27 april
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Det är /.../ fullt möjligt att tänka strategiskt och systematiskt även i brinnande kris. Omstartskommissionen hoppas kunna bidra till fokus, analys och konkreta policyförslag för att stödja Sveriges långsiktiga inriktning. Vi kommer att under våren och sommaren anordna seminarier och hearings om vårt arbete, delrapporter ska läggas fram – och när budgetarbetet börjar och Riksdagen öppnar, vill vi kunna bidra med en rejäl och handfast plan för hur vi omstartar Sverige.
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| 21. |
- Aghaee, Naghmeh, et al.
(författare)
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Interaction Gaps in PhD Education and ICT as a Way Forward: Results from a Study in Sweden
- 2016
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Ingår i: International Review of Research in Open and Distance Learning. - : Athabasca University Press. - 1492-3831. ; 17:3, s. 360-383
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Tidskriftsartikel (refereegranskat)abstract
- Many research studies have highlighted the low completion rate and slow progress in PhD education. Universities strive to improve throughput and quality in their PhD education programs. In this study, the perceived problems of PhD education are investigated from PhD students' points of view, and how an Information and Communication Technology Support System (ICTSS) may alleviate these problems. Data were collected through an online open questionnaire sent to the PhD students at the Department of (the institution's name has been removed during the double-blind review) with a 59% response rate. The results revealed a number of problems in the PhD education and highlighted how online technology can support PhD education and facilitate interaction and communication, affect the PhD students' satisfaction, and have positive impacts on PhD students' stress. A system was prototyped, in order to facilitate different types of online interaction through accessing a set of online and structured resources and specific communication channels. Although the number of informants was not large, the result of the study provided some rudimentary ideas that refer to interaction problems and how an online ICTSS may facilitate PhD education by providing distance and collaborative learning, and PhD students' self-managed communication.
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| 22. |
- Ahlberg, Erik, et al.
(författare)
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"Vi klimatforskare stödjer Greta och skolungdomarna"
- 2019
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Ingår i: Dagens nyheter (DN debatt). - 1101-2447.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- DN DEBATT 15/3. Sedan industrialiseringens början har vi använt omkring fyra femtedelar av den mängd fossilt kol som får förbrännas för att vi ska klara Parisavtalet. Vi har bara en femtedel kvar och det är bråttom att kraftigt reducera utsläppen. Det har Greta Thunberg och de strejkande ungdomarna förstått. Därför stödjer vi deras krav, skriver 270 klimatforskare.
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| 23. |
- Alftberg, Åsa, et al.
(författare)
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Fenomenologins möjligheter i etnologin: Rapport från en nationell workshop.
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Fredag den 17 december 2010 genomfördes en nationell workshop kring fenomenologins vara i etnologin vid Institutionen för kulturvetenskaper, Lunds universitet. Denna rapport är ett resultat från workshopen och skall ses som ett försök att intensifiera den diskussion som var på workshopen. Etnologin har tagit inspiration från fenomenologin och i denna filosofi har ämnet funnit teorier och metodologier för att utveckla kulturanalysen. Ibland har inspirationen kommit från de fenomenologiska klassikerna - Martin Heidegger, Maurice Merleau-Ponty, Simone de Beauvoir – andra gånger har inspirationen varit antropologer och sociologer som har varit starkt färgade av fenomenologin. Idag vågar vi påstå att det finns en så stor etnologisk diskussion och användning av denna filosofi att vi kan prata om en etnologisk tolkning av fenomenologi.
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| 24. |
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| 25. |
- Alftberg, Åsa, et al.
(författare)
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Introduction : Self-care Translated into Practice
- 2012
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Ingår i: Culture Unbound. - : Linköping University Electronic Press. - 2000-1525. ; 4:3, s. 415-424
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The overall expectation placed upon individuals to take responsibility for their own life, has in cultural studies been described in terms of neo-liberalism and defined as an internationally prevailing ideological paradigm (Dean 1999; Smart 2003; Gilbert 2008). In this thematic section of Culture Unbound there are many examples of how, if and when these ideas affect people’s everyday life. The discussions revolve around living with long-term sickness, the organization of healthcare, and questions concerning well-being. This is a special issue that analyses how cultural ideas about self-care and self-care management take practical form, looking for those social practices that are uncertain and ambiguous (Reckwitz 2002). In this introduction, we as theme-editors present the predominant themes that are discussed in more depth in the individual articles. In view of how personal strategies for living and life planning are open to continual revision and how those strategies increasingly emphasize the relationship between identity and the biological (Kaufman 2010), we seek to explore how this is translated into practice. Self-care and its technologies take place in everyday life, and will be examined using an ethnographic approach.
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| 26. |
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| 27. |
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| 28. |
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| 29. |
- Alftberg, Åsa, et al.
(författare)
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Vinsten med att ta ansvar för hälsa
- 2019
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Ingår i: Health Management: vinst, värde och kvalitet i hälso- och sjukvård. - : Sanoma Utbildning. - 9789152356067 ; , s. 133-150
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Bokkapitel (refereegranskat)
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| 30. |
- Andersson Broms, Åsa, et al.
(författare)
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After Work
- 2019
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Annan publikation (populärvet., debatt m.m.)abstract
- Economic stress under wage earning has been abolished. Machines and AI have taken over dirty, heavy and tedious work. Money and social injustice are banned. All the technological resources of humanity can be used to reset the global economy to harmonize with ecology. Free citizens can spend their time in leisure practicing, music, art, and poetry. Visions of the future are already here.But is it a utopia that we are seeing materializing around us or a dystopia? What will happen to people when nobody wants their labor? Does there already exist a firm border between those who have a job, with all that it entails of social and economic benefits, and the people that are on the other side of the fence- the people that have to sell their work by the hour, and who in practice are modern slaves under apps and SMS. Is everything for sale? Can you sell voluntary labour?During this exhibition, these issues are further developed through artworks by Work-a-work.
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| 31. |
- Andersson Broms, Åsa, et al.
(författare)
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Artist Salary Now!
- 2018
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Annan publikation (populärvet., debatt m.m.)abstract
- Should we spend our time filling out forms or making art? was the rhetorical question that acted as a starting point for “Konsnärslön nu!”, an event at Gallery Tegen2 in Stockholm in September 2018. Over a period of a month, a group of artists performed a think tank and a campaign headquarters as a means to provoke discussion. The exhibition also provided space for a series of semi-public talks where the question of a possible basic income for artists was further developed during the exhibition. The talks engaged activists from the universal basic income movement, politicians, researchers, and artists. In this report we describe the ideas behind the project and the discussions that evolved in the talks and interviews with artists. As a result of the project we propose an artist salary as a pilot for a future basic income, a salary that eventually will be for everyone (not only artists). A salary to allow for time to take care of our commons and existential issues. A modest salary based on the modest needs of artists. Unlike a universal basic income, it is intended for a specific purpose, our shared society. And, since we claim that society is an art, it is up to each one of us to define what society is.
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| 32. |
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| 33. |
- Andersson, Jenny, et al.
(författare)
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Decision‐Making in Seeking Emergency Care for Stroke Symptoms
- 2022
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Ingår i: Stroke: Vascular and Interventional Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 2694-5746. ; 2:6
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundPrevious studies have shown that rapid treatment for stroke, especially ischemic stroke, reduces mortality and disability. The focus has mainly been on reducing time from arrival at hospital to start of treatment. However, the main reason for delay is often time from symptom onset to arrival at hospital. This study therefore aimed to explore decision‐making processes after the onset of stroke symptoms in patients experiencing a first‐time stroke.MethodsWe included 36 patients aged 18 and older, all of whom were hospitalized with a first‐time stroke between October 2018 and April 2020. All patients were interviewed once within 4 weeks of symptom onset and before hospital discharge. Eligible patients were identified retrospectively through a targeted review of medical records. The data were collected and analyzed according to the grounded theory methodology.ResultsIn total, 43 potential patients were identified and asked to participate. Overall, 36 patients were included in the study: 17 women (median age 77.0 years, interquartile range 17.5) and 19 men (median age 65.7 years, interquartile range 17.2). All interviewees felt fear, and this affected their decision to seek emergency care. The decision‐making processes were described by the core category of “Acting on fear.” The reason for feeling frightened determined the actions taken. The reasons were sorted into 3 main categories: (1) “seeking care”–recognized stroke symptoms and acted immediately; (2) “pending and reluctance”–suspected stroke but awaited to seek care; and (3) “seeking an explanation”–confused by symptoms.ConclusionWe found that decision‐making when experiencing stroke symptoms was complex. All patients felt fear, which determined their actions. Some patients knew about stroke symptoms and acted immediately. Others suspected stroke but still chose to wait, whereas others were confused and tried to find answers. These results could contribute to form future awareness campaigns.
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| 34. |
- Andersson, Jenny, et al.
(författare)
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Symptoms at stroke onset as described by patients: a qualitative study
- 2024
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Ingår i: BMC Neurology. - : Springer Nature. - 1471-2377. ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Stroke is a common and severe disease that requires prompt care. Symptom expressions as one-sidedweakness and speech difficulties are common and included in public stroke campaigns. For some patients stroke canpresent with subtle and less common symptoms, difficult to interpret. The symptom severity assessed by the NationalInstitutes of Health Stroke Scale has decreased, and symptoms at onset may have changed. Therefore, we aimed toinvestigate how patients describe their symptoms at the onset of a first-time stroke.Methods:The study used a qualitative descriptive design and conventional content analysis. Data were collectedthrough recorded interviews with 27 patients aged 18 years and older hospitalised with a first-time stroke betweenOctober 2018 and April 2020. Data were analysed on a manifest level.Results: Symptoms at stroke onset were presented in two themes: Altered Reality and Discomfort and Changed BodyFunctions and described in five categories. Various types of symptoms were found. All symptoms were perceivedas sudden, persistent, and never experienced before and this appear as a “red thread” in the result. Regardless ofsymptom expressions, no specific symptom was described as more severe than another.Conclusions: Stroke symptoms were described with a variety of expressions. Many described complex symptomsnot typical of stroke, which can make it difficult to recognise the symptoms as a stroke and delay medical care. Publicstroke campaigns should emphasize the importance of seeking medical care at the slightest suspicion of stroke andcould be designed to help achieve this.
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| 35. |
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| 36. |
- Arehag, Marie, 1952, et al.
(författare)
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Outcomes-focused evaluation of engineering programs - Inhibitor or stimulant for improvement?
- 2013
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Ingår i: Proceedings of the 9th International CDIO Conference, Cambridge, USA.
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Konferensbidrag (refereegranskat)abstract
- In Sweden, a new model for quality evaluation of higher education is being introduced. It is internationally unique. A very strong emphasis on assessing the quality of an entire education through its outcomes, defined by samples of final degree reports, is perhaps the most original feature of the model. This is claimed to enable a direct assessment of quality rather than the indirect assessment used in conventional models. The model has, however, been intensively debated during its development and first years of use. The aims of this paper are first to evaluate in what ways and to what extent the Swedish national model for evaluation of higher education contributes to the quality improvement of the evaluated programs, and second to describe and evaluate an approach for organizing the project to prepare the evaluation documentation for a large-scale education evaluation. The paper concludes that on an overall and averaged level, the project participants estimated that the model will contribute to positive effects. Specific areas are identified including ethics and focus of final degree reports. However, there is a strong variance in the data: There is a substantial fraction of participants who have not identified any improvements or weak spots, and who do not think that the evaluation preparation will positively affect education quality development. Chalmers University of Technology chose to approach the evaluation with a centrally managed project. The setup gave possibilities for rationalization through common training, supporting materials, a common document database and for information sharing across departmental boundaries. Nevertheless, the project was very time-consuming with an average of 540 hours spent for each program/degree.
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| 37. |
- Aretun, Åsa, et al.
(författare)
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Ekonomiska styrmedel för en hållbar personbilstrafik : konsekvenser för tillgänglighet: en kunskapsöversikt
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med denna rapport är att presentera en översikt av befintliga styrmedel i Norge och Sverige som avser att ge ekonomiska incitament för individer att förändra sin bilanvändning i hållbar riktning. Syftet är vidare att ge en kunskapsöversikt kring hur dessa styrmedel har behandlats i internationell tillgänglighetsforskning där frågor kring jämlikhet och fördelning av tillgänglighet mellan individer och grupper i samhället fokuseras. Rapporten inleds med en översikt av befintliga styrmedel som syftar till hållbar personbilstrafik i Norge och Sverige. Rapporten fortsätter med en introduktion av internationell tillgänglighetsforskning; hur tillgänglighet, jämlikhet och fördelning konceptualiseras och utforskas inom denna forskning och forskningens centrala resultat. Därefter redogörs för hur ekonomiska styrmedel som syftar till hållbar personbilstrafik behandlas i tillgänglighetslitteraturen samt vilka behov av vidare forskning som identifieras i denna litteratur. Rapporten avslutas med att presentera ett antal områden av relevans för fortsatt forskning i Sverige och Norge. I rapporten visas att ekonomiska styrmedel riktade mot personbilstrafik för att åstadkomma hållbara transporter har uppmärksammats alltmer i internationell tillgänglighetsforskning under senare år. I tillgänglighetslitteraturen behandlas och diskuteras dessa ekonomiska styrmedel utifrån forskningsresultat inom fältet kring ojämlika strukturella förhållanden när det gäller medborgares tillgång till transporter och dess sociala konsekvenser. Genomgående bedöms de ekonomiska styrmedlen leda till att transportrelaterad social ojämlikhet och utsatthet ökar. Styrmedlen förväntas försämra tillgängligheten för de medborgare som har svårt att bära ökade transportkostnader, men som samtidigt måste använda bil för att få tillgång till nödvändiga samhällsfunktioner såsom exempelvis arbete, baskonsumtion, utbildning, hälso- och sjukvård. I grunden hänger denna problematik samman med en bilanpassad samhällsbyggnad avseende lokaliseringsmönster och transportinfrastruktur som försvårar för människor att skapa tillgänglighet med andra transportmedel: gång-, cykel- och kollektivtrafik. De ekonomiska styrmedlen avvisas inte som sådana i litteraturen. Däremot riktas kritik mot att införandet av dessa inte åtföljs av förändrade lokaliseringsmönster samt satsningar på alternativ transportinfrastruktur som minskar medborgares bilberoende och som därmed skulle mildra negativa jämlikhets- och fördelningseffekter.
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| 38. |
- Aretun, Åsa, et al.
(författare)
-
Ekonomiska styrmedel för en hållbar personbilstrafik – konsekvenser för tillgänglighet : En kunskapsöversikt
- 2012
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med denna rapport är att presentera en översikt av befintliga styrmedel i Norge och Sverige som avser att ge ekonomiska incitament för individer att förändra sin bilanvändning i hållbar riktning. Syftet är vidare att ge en kunskapsöversikt kring hur dessa styrmedel har behandlats i internationell tillgänglighetsforskning där frågor kring jämlikhet och fördelning av tillgänglighet mellan individer och grupper i samhället fokuseras. Rapporten inleds med en översikt av befintliga styrmedel som syftar till hållbar personbilstrafik i Norge och Sverige. Rapporten fortsätter med en introduktion av internationell tillgänglighetsforskning; hur tillgänglighet, jämlikhet och fördelning konceptualiseras och utforskas inom denna forskning och forskningens centrala resultat. Därefter redogörs för hur ekonomiska styrmedel som syftar till hållbar personbilstrafik behandlas i tillgänglighetslitteraturen samt vilka behov av vidare forskning som identifieras i denna litteratur. Rapporten avslutas med att presentera ett antal områden av relevans för fortsatt forskning i Sverige och Norge. I rapporten visas att ekonomiska styrmedel riktade mot personbilstrafik för att åstadkomma hållbara transporter har uppmärksammats alltmer i internationell tillgänglighetsforskning under senare år. I tillgänglighetslitteraturen behandlas och diskuteras dessa ekonomiska styrmedel utifrån forskningsresultat inom fältet kring ojämlika strukturella förhållanden när det gäller medborgares tillgång till transporter och dess sociala konsekvenser. Genomgående bedöms de ekonomiska styrmedlen leda till att transportrelaterad social ojämlikhet och utsatthet ökar. Styrmedlen förväntas försämra tillgängligheten för de medborgare som har svårt att bära ökade transportkostnader, men som samtidigt måste använda bil för att få tillgång till nödvändiga samhällsfunktioner såsom exempelvis arbete, baskonsumtion, utbildning, hälso- och sjukvård. I grunden hänger denna problematik samman med en bilanpassad samhällsbyggnad avseende lokaliseringsmönster och transportinfrastruktur som försvårar för människor att skapa tillgänglighet med andra transportmedel: gång-, cykel- och kollektivtrafik. De ekonomiska styrmedlen avvisas inte som sådana i litteraturen. Däremot riktas kritik mot att införandet av dessa inte åtföljs av förändrade lokaliseringsmönster samt satsningar på alternativ transportinfrastruktur som minskar medborgares bilberoende och som därmed skulle mildra negativa jämlikhets- och fördelningseffekter. I tillgänglighetslitteraturen poängteras att kunskapen generellt är bristfällig kring bilberoende respektive hur tillgängligheten med alternativa transportslag ser ut i samhället; hur tillgänglighet fördelar sig mellan individer och grupper med olika transportförutsättningar och transportbehov i samspel med lokaliseringsmönster och transportinfrastruktur. Bristen på kunskap förklaras med att tillgänglighet kräver analys av empiriska faktorer som traditionellt har ansetts ligga utanför transportområdet. I mycket transportforskning fokuseras resande och rörlighet som sådant. Denna fokusering präglar även 6 VTI notat 33-2012 FoU om ekonomiska styrmedel, vilket således medför att jämlikhets- och fördelningseffekter avseende rörlighet utreds. Tillgänglighet kräver studium av hur människors transportbehov och transportvillkor är sammanlänkade med hur samhällslivet är organiserat i tid och rum. För att utreda jämlikhets- och fördelningseffekter av ekonomiska styrmedel avseende tillgänglighet måste modeller och metoder som kan hantera sociospatiala förhållanden appliceras, där hänvisning görs till utvecklingsarbetet inom tillgänglighetsforskningen kring Social Impact Assessments och Accessibility Planning. Det är angeläget att i kommande FoU testa och utveckla den här typen av modeller, anpassade till geografiska förhållanden i Sverige och Norge. Det är vidare viktigt att studera hur miljömål och tillgänglighetsmål och eventuella målkonflikter hanteras i den politiskt-administrativa processen som föranleder ekonomiska styrmedel riktade mot personbilstrafiken. Det är också angeläget att studera hur en bättre samverkan kan ske mellan olika transportpolitiska verktyg för att uppnå mål om hållbara transporter såsom styrmedel, regleringar, transportplanering och fysisk planering. För denna FoU kan ett komparativt perspektiv mellan Norge och Sverige vara värdefullt.
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| 39. |
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| 40. |
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| 41. |
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| 42. |
- Blomkvist, Marita, et al.
(författare)
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Gendered structures in academic entrepreneurship and innovation – A development towards world-class standard in educational programmes in Sweden
- 2010
-
Ingår i: VIII Triple Helix International Conference on University, Industry and Government Linkages. ; , s. 35-35
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Konferensbidrag (refereegranskat)abstract
- An integration of activities such as incubators, technology transfer, student and alumni organisations etc related to entrepreneurship education is seen as promoting economic development and innovativeness in many parts of the world. This way of creating systems for entrepreneurship development has also recently been focused in Sweden. As a result of Swedish Government's ambition to stimulate growth economy, university entrepreneurship education program spring up all over the country in order to promote students' entrepreneurship.From previous research we know that the infrastructure has an impact for entrepreneurship (Delatte & Baytos, 1993; Hannon, 2003; Rosa & Dawson, 2006, Xu, 2010). The structure relates to the number of individuals in the management structure and the role the individual has in the management structure such as member of the board or manager. It also refers to characteristics of the individuals involved in the management such as diversity, gender, age, education competence and previous experience (Rosa & Dawson, 2006). Further, it has been shown that managers are important since a lack of role models have been shown to have an impact for both female entrepreneurs and female managers in decisions of starting and/or managing a business (Crampton & Mishra, 1999; Mattis, 2004). However, public and private initiatives aimed to support business development usually are following a gender blind norm both in the way it is presented, for example regarding language and psychological accessibility, and considering the fields pointed out. Research shows that women don't feel themselves addressed by these initiatives or that it concerns them (NUTEK, 2001; NUTEK, R 2007:34).Swedish Government recently challenged to higher education institutions to apply for finance to a development towards world- class standard in educational programmes in entrepreneurship and innovation (Prop. 2008/2009:1/16). The invitation was directed to higher education institutions that already run advanced studies in entrepreneurship and innovation and that also have a strong connection to research in the same area. Swedish National Agency for Higher Education was commissioned by the Government to examine the applications and invited a panel of international academic experts to asses the applications. Eleven applications were submitted from higher education institutions in the field of entrepreneurship and innovation. Four of the eleven institutions which applied where recommended by the panel of experts and these institutions were further ranked and recommended by Swedish National Agency for Higher Education to the University Chancellor. Two of these institutions were finally selected to be financed by the Swedish Government.This paper focuses on these eleven applications and the review process. The aim of the paper is to analyze and illustrate in what way the applications as well as the review process is gendered for example in terms of discourse and symbols in relation to educational setting, organizational structure, infrastructure, education management, education team assigned and branches of industry (Acker, 1992; Bruni, Gherardi & Poggio, 2005; Gunnarsson, Westberg, Andersson & Balkmar, 2007). We expect to find how gender is mirrored in these highly ranked applications and what impact the presence or absence of a gender focus will have for entrepreneurship and innovation education.
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| 43. |
- Boije, Robert, et al.
(författare)
-
Fastighetsskatten
- 2004
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Ingår i: Ekonomisk Debatt. - 0345-2646. ; 32:3, s. 45-56
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 44. |
- Braunerhjelm, Pontus, 1953-, et al.
(författare)
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Så startar Sverige om
- 2020
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Annan publikation (populärvet., debatt m.m.)
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| 45. |
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| 46. |
- Brokelind, Cécile, et al.
(författare)
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COVID-19 Nordic Responses
- 2020
-
Ingår i: Intertax. - 1875-8347. ; 48:8 & 9, s. 754-760
-
Tidskriftsartikel (refereegranskat)abstract
- The Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) have adopted various tax policy measures in order to confront the current economic crisis caused by the downscale of their domestic economies. Despite their common characteristics (size, economic situation, institutional settings), the Nordic countries have adopted different strategies to limit the detrimental effects of the crisis, which this contribution describes and explains. Furthermore, this article compares the short term tax measures adopted in March and April 2020 in these countries and also analyses options for needed reforms to cope with future crises.
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| 47. |
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| 48. |
- Brokelind, Cécile, et al.
(författare)
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Tax Incentives, Tax Expenditures Theories in R&D: The Case of Sweden
- 2014
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Ingår i: World Tax Journal. - 1878-4917. ; 6:2, s. 168-200
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Tidskriftsartikel (refereegranskat)abstract
- This article investigates whether public funds should support R&D and if so, how such support should be designed in order to be efficient and to comply with the legal requirements stated in EU law and in domestic budget law. The article puts the emphasis on tax expenditure and, in particular, on tax incentives. The findings show that Member States should only subsidize projects where the social benefit exceeds the private benefit. However, in reality, such selection proves impossible, and even if it was possible, EU State aid law could prohibit it.
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| 49. |
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| 50. |
- Brundin, Patrik, et al.
(författare)
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Graft survival
- 1999
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Ingår i: Journal of Neurosurgery. - 0022-3085. ; 90:4, s. 804-805
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Tidskriftsartikel (refereegranskat)
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