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3. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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4. |
- Danilovich, T., et al.
(författare)
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ATOMIUM: halide molecules around the S-type AGB star W Aquilae
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 655
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Tidskriftsartikel (refereegranskat)abstract
- Context. S-type asymptotic giant branch (AGB) stars are thought to be intermediates in the evolution of oxygen- to carbon-rich AGB stars. The chemical compositions of their circumstellar envelopes are also intermediate but have not been studied in as much detail as their carbon- and oxygen-rich counterparts. W Aql is a nearby S-type star, with well-known circumstellar parameters, making it an ideal object for in-depth study of less common molecules. Aims. We aim to determine the abundances of AlCl and AlF from rotational lines, which have been observed for the first time towards an S-type AGB star. In combination with models based on PACS observations, we aim to update our chemical kinetics network based on these results. Methods. We analyse ALMA observations towards W Aql of AlCl in the ground and first two vibrationally excited states and AlF in the ground vibrational state. Using radiative transfer models, we determine the abundances and spatial abundance distributions of (AlCl)-Cl-35, (AlCl)-Cl-37, and AlF. We also model HCl and HF emission and compare these models to PACS spectra to constrain the abundances of these species. Results. AlCl is found in clumps very close to the star, with emission confined within 0 ''.1 of the star. AlF emission is more extended, with faint emission extending 0 ''.2 to 0 ''.6 from the continuum peak. We find peak abundances, relative to H-2, of 1.7 x 10(-7) for (AlCl)-Cl-35, 7 x 10(-8) for (AlCl)-Cl-37, and 1 x 10(-7) for AlF. From the PACS spectra, we find abundances of 9.7 x 10(-8) and <= 10(-8), relative to H-2, for HCl and HF, respectively. Conclusions. The AlF abundance exceeds the solar F abundance, indicating that fluorine synthesised in the AGB star has already been dredged up to the surface of the star and ejected into the circumstellar envelope. From our analysis of chemical reactions in the wind, we conclude that AlF may participate in the dust formation process, but we cannot fully explain the rapid depletion of AlCl seen in the wind.
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5. |
- Baudry, A., et al.
(författare)
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ATOMIUM: Probing the inner wind of evolved O-rich stars with new, highly excited H2O and OH lines
- 2023
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Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 674
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Tidskriftsartikel (refereegranskat)abstract
- Context. Water (H2O) and the hydroxyl radical (OH) are major constituents of the envelope of O-rich late-type stars. Transitions involving energy levels that are rotationally or vibrationally highly excited (energies & GSIM;4000 K) have been observed in both H2O and OH. These and more recently discovered transitions can now be observed at a high sensitivity and angular resolution in the inner wind close to the stellar photosphere with the Atacama Large Millimeter/submillimeter Array (ALMA). Aims. Our goals are: (1) to identify and map the emission and absorption of H2O in several vibrational states, and of OH in Lambda-doubling transitions with similar excitation energies; and (2) to determine the physical conditions and kinematics in gas layers close to the extended atmosphere in a sample of asymptotic giant branch stars (AGBs) and red supergiants (RSGs). Methods. Spectra and maps of H2O and OH lines observed in a 27 GHz aggregated bandwidth and with an angular resolution of similar to 0."02-1."0 were obtained at two epochs with the main ALMA array. Additional observations with the Atacama Compact Array (ACA) were used to check for time variability of water transitions. Radiative transfer models of H2O were revisited to characterize masing conditions. Up-to-date chemical models were used for comparison with the observed OH/H2O abundance ratio. Results. Ten rotational transitions of H2O with excitation energies similar to 4000-9000 K were observed in vibrational states up to (& upsilon;(1),& upsilon;(2),& upsilon;(3)) = (0,1,1). All but one are new detections in space, and from these we have derived accurate rest frequencies. Hyperfine split Lambda-doubling transitions in & upsilon; = 0, J = 27/2 and 29/2 levels of the (2)& pi;(3/2) state, as well as J = 33/2 and 35/2 of the (2)& pi;(1/2) state of OH with excitation energies of similar to 4780-8900 K were also observed. Four of these transitions are new detections in space. Combining our measurements with earlier observations of OH, the & upsilon; = 0 and & upsilon; = 1 Lambda-doubling frequencies have been improved. Our H2O maps show compact emission toward the central star and extensions up to twelve stellar radii or more. The 268.149 GHz emission line of water in the & upsilon;(2) = 2 state is time variable, tends to be masing with dominant radiative pumping, and is widely excited in AGBs and RSGs. The widespread but weaker 262.898 GHz water line in the & upsilon;(2) = 1 state also shows signs of maser emission. The OH emission is weak and quasithermally excited. Emission and absorption features of H2O and OH reveal an infall of matter and complex kinematics influenced by binarity. From the OH and H2O column densities derived with nonmasing transitions in a few sources, we obtain OH/H2O abundance ratios of similar to(0.7-2.8) x 10(-2).
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6. |
- Montargès, M., et al.
(författare)
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The VLT/SPHERE view of the A TOMIUM cool evolved star sample: I. Overview: Sample characterization through polarization analysis
- 2023
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 671
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Tidskriftsartikel (refereegranskat)abstract
- Context. Low- and intermediate-mass asymptotic giant stars and massive red supergiant stars are important contributors to the chemical enrichment of the Universe. They are among the most efficient dust factories of the Galaxy, harboring chemically rich circumstellar environments. Yet, the processes that lead to dust formation or the large-scale shaping of the mass loss still escape attempts at modeling. Aims. Through the ATOMIUM project, we aim to present a consistent view of a sample of 17 nearby cool evolved stars. Our goals are to unveil the dust-nucleation sites and morphologies of the circumstellar envelope of such stars and to probe ambient environments with various conditions. This will further enhance our understanding of the roles of stellar convection and pulsations, and that of companions in shaping the dusty circumstellar medium. Methods. Here we present and analyze VLT/SPHERE-ZIMPOL polarimetric maps obtained in the visible (645- 820 nm) of 14 out of the 17 ATOMIUM sources. They were obtained contemporaneously with the ALMA high spatial resolution data. To help interpret the polarized signal, we produced synthetic maps of light scattering by dust, through 3D radiative transfer simulations with the RADMC3D code. Results. The degree of linear polarization (DoLP) observed by ZIMPOL spreads across several optical filters. We infer that it primarily probes dust located just outside of the point spread function of the central source, and in or near the plane of the sky. The polarized signal is mainly produced by structures with a total optical depth close to unity in the line of sight, and it represents only a fraction of the total circumstellar dust. The maximum DoLP ranges from 0.03- 0.38 depending on the source, fractions that can be reproduced by our 3D pilot models for grains composed of olivine, melilite, corundum, enstatite, or forsterite. The spatial structure of the DoLP shows a diverse set of shapes, including clumps, arcs, and full envelopes. Only for three sources do we note a correlation between the ALMA CO ν = 0, J = 2-1 and SiO ν = 0, J = 5-4 lines, which trace the gas density, and the DoLP, which traces the dust. Conclusions. The clumpiness of the DoLP and the lack of a consistent correlation between the gas and the dust location show that, in the inner environment, dust formation occurs at very specific sites. This has potential consequences for the derived mass-loss rates and dust-to-gas ratio in the inner region of the circumstellar environment. Except for π1 Gru and perhaps GY Aql, we do not detect interactions between the circumstellar wind and the hypothesized companions that shape the wind at larger scales. This suggests that the orbits of any other companions are tilted out of the plane of the sky.
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7. |
- Wallström, Sofia, 1988, et al.
(författare)
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ATOMIUM: Molecular inventory of 17 oxygen-rich evolved stars observed with ALMA
- 2024
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 681
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Tidskriftsartikel (refereegranskat)abstract
- Context. The dusty winds of cool evolved stars are a major contributor of the newly synthesised material enriching the Galaxy and future generations of stars. However, the details of the physics and chemistry behind dust formation and wind launching have yet to be pinpointed. Recent spatially resolved observations show the importance of gaining a more comprehensive view of the circumstellar chemistry, but a comparative study of the intricate interplay between chemistry and physics is still difficult because observational details such as frequencies and angular resolutions are rarely comparable. Aims. Aiming to overcome these deficiencies, ATOMIUM is an ALMA Large Programme to study the physics and chemistry of the circumstellar envelopes of a diverse set of oxygen-rich evolved stars under homogeneous observing conditions at three angular resolutions between ∼0.02′1.4′. Here we summarize the molecular inventory of these sources, and the correlations between stellar parameters and molecular content. Methods. Seventeen oxygen-rich or S-Type asymptotic giant branch (AGB) and red supergiant (RSG) stars have been observed in several tunings with ALMA Band 6, targeting a range of molecules to probe the circumstellar envelope and especially the chemistry of dust formation close to the star. We systematically assigned the molecular carriers of the spectral lines and measured their spectroscopic parameters and the angular extent of the emission of each line from integrated intensity maps. Results. Across the ATOMIUM sample, we detect 291 transitions of 24 different molecules and their isotopologues. This includes several first detections in oxygen-rich AGB/RSG stars: PO v = 1, SO2 v1 = 1 and v2 = 2, and several high energy H2O transitions. We also find several first detections in S-Type AGB stars: vibrationally excited HCN v2 = 2,3 and SiS v = 4,5,6, as well as first detections of the molecules SiC, AlCl, and AlF in W Aql. Overall, we find strong correlations between the following molecular pairs: CS and SiS, CS and AlF, NaCl and KCl, AlO and SO, SO2 and SO, and SO2 and H2O; meaning both molecules tend to have more detected emission lines in the same sources. The measured isotopic ratios of Si and S are found to be consistent with previous measurements, except for an anomalously high 29Si/30Si ratio of 4 ± 1 in the RSG VX Sgr. Conclusions. This paper presents the overall molecular inventory and an initial analysis of the large ATOMIUM dataset, laying the groundwork for future work deriving molecular abundances and abundance profiles using radiative transfer modeling which will provide more rigorous tests for chemical models.
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8. |
- Gottlieb, C. A., et al.
(författare)
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ATOMIUM: ALMA tracing the origins of molecules in dust forming oxygen rich M-type stars: Motivation, sample, calibration, and initial results
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 660
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Tidskriftsartikel (refereegranskat)abstract
- This overview paper presents atomium, a Large Programme in Cycle 6 with the Atacama Large Millimeter/submillimeter Array (ALMA). The goal of atomium is to understand the dynamics and the gas phase and dust formation chemistry in the winds of evolved asymptotic giant branch (AGB) and red supergiant (RSG) stars. A more general aim is to identify chemical processes applicable to other astrophysical environments. Seventeen oxygen-rich AGB and RSG stars spanning a range in (circum)stellar parameters and evolutionary phases were observed in a homogeneous observing strategy allowing for an unambiguous comparison. Data were obtained between 213.83 and 269.71 GHz at high (0.025-0.050), medium (0.13-0.24), and low (~1) angular resolution. The sensitivity per ~1.3 km s-1 channel was 1.5-5 mJy beam-1, and the line-free channels were used to image the millimetre wave continuum. Our primary molecules for studying the gas dynamics and dust formation are CO, SiO, AlO, AlOH, TiO, TiO2, and HCN; secondary molecules include SO, SO2, SiS, CS, H2O, and NaCl. The scientific motivation, survey design, sample properties, data reduction, and an overview of the data products are described. In addition, we highlight one scientific result - the wind kinematics of the atomium sources. Our analysis suggests that the atomium sources often have a slow wind acceleration, and a fraction of the gas reaches a velocity which can be up to a factor of two times larger than previously reported terminal velocities assuming isotropic expansion. Moreover, the wind kinematic profiles establish that the radial velocity described by the momentum equation for a spherical wind structure cannot capture the complexity of the velocity field. In fifteen sources, some molecular transitions other than 12CO v = 0 J = 2 - 1 reach a higher outflow velocity, with a spatial emission zone that is often greater than 30 stellar radii, but much less than the extent of CO. We propose that a binary interaction with a (sub)stellar companion may (partly) explain the non-monotonic behaviour of the projected velocity field. The atomium data hence provide a crucial benchmark for the wind dynamics of evolved stars in single and binary star models.
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9. |
- Decin, L., et al.
(författare)
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(Sub)stellar companions shape the winds of evolved stars
- 2020
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 369:6509, s. 1497-1500
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Tidskriftsartikel (refereegranskat)abstract
- Binary interactions dominate the evolution of massive stars, but their role is less clear for low- and intermediate-mass stars. The evolution of a spherical wind from an asymptotic giant branch (AGB) star into a nonspherical planetary nebula (PN) could be due to binary interactions. We observed a sample of AGB stars with the Atacama Large Millimeter/submillimeter Array (ALMA) and found that their winds exhibit distinct nonspherical geometries with morphological similarities to planetary nebulae (PNe). We infer that the same physics shapes both AGB winds and PNe; additionally, the morphology and AGB mass-loss rate are correlated. These characteristics can be explained by binary interaction. We propose an evolutionary scenario for AGB morphologies that is consistent with observed phenomena in AGB stars and PNe.
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10. |
- Planquart, L., et al.
(författare)
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An impressionist view of V Hydrae: When MATISSE paints asymmetric giant blobs
- 2024
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 687
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Tidskriftsartikel (refereegranskat)abstract
- Context . Asymptotic giant branch (AGB) stars enrich the interstellar medium through their mass loss. The mechanism(s) shaping the circumstellar environment of mass-losing stars is not clearly understood so far. Aims. Our purpose is to study the effect of binary companions located within the first 10 stellar radii from the primary AGB star. In this work, we target the mass-losing carbon star V Hydrae (V Hya) and search for signatures of its companion in the dust-forming region of the atmosphere. Methods . The star was observed in the L and N bands with the VLTI/MATISSE instrument at low spectral resolution. We reconstructed images of the photosphere and surroundings of V Hya using the two bands and compared our interferometric observables with VLTI/MIDI and VISIR archival data. To constrain the dust properties, we used the 1D radiative transfer code DUSTY to model the spectral energy distribution. Results . The star is dominated by dust emission in the L- and N-bands. The MATISSE reconstructed images show asymmetric and elongated structures in both infrared bands. In the L band, we detected an elongated shape of approximately 15 mas that likely is of photospheric origin. In the N band, we found a 20 mas extension northeast from the star and perpendicular to the L-band elongated axis. The position angle and the size of the N-band extension match the prediction of the companion position at the MATISSE epoch. By comparing MATISSE N-band with MIDI data, we deduce that the elongation axis in the N-band has rotated since the previous interferometric measurements 13 yr ago, supporting the idea that the particle enhancement is related to the dusty clump moving along with the companion. The VISIR image confirms the presence of a large-scale dusty circumstellar envelope surrounding V Hya. Conclusions . The MATISSE images unveil the presence of a dust enhancement at the position of the companion. This opens new doors for further analyses of the binary interaction with an AGB component.
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11. |
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12. |
- Vlemmings, Wouter, 1974, et al.
(författare)
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Magnetically aligned dust and SiO maser polarisation in the envelope of the red supergiant VY Canis Majoris
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 603, s. A92-
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Tidskriftsartikel (refereegranskat)abstract
- Aims. Polarisation observations of circumstellar dust and molecular (thermal and maser) lines provide unique information about dust properties and magnetic fields in circumstellar envelopes of evolved stars. Methods. We use Atacama Large Millimeter/submillimeter Array (ALMA) Band 5 science verification observations of the red supergiant VY CMa to study the polarisation of SiO thermal /maser lines and dust continuum at similar to 1.7 mm wavelength. We analyse both linear and circular polarisation and derive the magnetic field strength and structure, assuming the polarisation of the lines originates from the Zeeman effect, and that of the dust originates from aligned dust grains. We also discuss other effects that could give rise to the observed polarisation. Results. We detect, for the first time, significant polarisation (similar to 3%) of the circumstellar dust emission at millimeter wavelengths. The polarisation is uniform with an electric vector position angle of similar to 8 degrees. Varying levels of linear polarisation are detected for the J = 4-3 (SiO)-Si-28 nu = 0; 1; 2; and (SiO)-Si-29 nu = 0; 1 lines, with the strongest polarisation fraction of similar to 30% found for the (SiO)-Si-29 nu = 1 maser. The linear polarisation vectors rotate with velocity, consistent with earlier observations. We also find significant (up to similar to 1%) circular polarisation in several lines, consistent with previous measurements. We conclude that the detection is robust against calibration and regular instrumental errors, although we cannot yet fully rule out non-standard instrumental effects. Conclusions. Emission from magnetically aligned grains is the most likely origin of the observed continuum polarisation. This implies that the dust is embedded in a magnetic field >13 mG. The maser line polarisation traces the magnetic field structure. The magnetic field in the gas and dust is consistent with an approximately toroidal field configuration, but only higher angular resolution observations will be able to reveal more detailed field structure. If the circular polarisation is due to Zeeman splitting, it indicates a magnetic field strength of similar to 1-3 Gauss, consistent with previous maser observations.
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13. |
- Cernicharo, J., et al.
(författare)
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A high-resolution line survey of IRC+10216 with Herschel/HIFI First results: Detection of warm silicon dicarbide (SiC2)
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 521:1, s. Article Number: L8-
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Tidskriftsartikel (refereegranskat)abstract
- We present the first results of a high-spectral-resolution survey of the carbon-rich evolved star IRC+10216 that was carried out with the HIFI spectrometer onboard Herschel. This survey covers all HIFI bands, with a spectral range from 488 to 1901 GHz. In this letter we focus on the band-1b spectrum, in a spectral range 554.5-636.5 GHz, where we identified 130 spectral features with intensities above 0.03 K and a signal-to-noise ratio >5. Detected lines arise from HCN, SiO, SiS, CS, CO, metal-bearing species and, surprisingly, silicon dicarbide (SiC2). We identified 55 SiC2 transitions involving energy levels between 300 and 900 K. By analysing these rotational lines, we conclude that SiC2 is produced in the inner dust formation zone, with an abundance of similar to 2 x 10(-7) relative to molecular hydrogen. These SiC2 lines have been observed for the first time in space and have been used to derive an SiC2 rotational temperature of similar to 204 K and a source-averaged column density of similar to 6.4 x 10(15) cm(-2). Furthermore, the high quality of the HIFI data set was used to improve the spectroscopic rotational constants of SiC2.
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14. |
- Decin, L., et al.
(författare)
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Study of the aluminium content in AGB winds using ALMA Indications for the presence of gas-phase (Al2O3)n clusters
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 608, s. A55-
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Tidskriftsartikel (refereegranskat)abstract
- Context. The condensation of inorganic dust grains in the winds of evolved stars is poorly understood. As of today, it is not yet known which molecular clusters form the first dust grains in oxygen-rich (C/O 34) can be the potential agents of the broad 11 mu m feature in the SED and in the interferometric data and we propose potential formation mechanisms for these large clusters.
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15. |
- Khouri, Theo, 1985, et al.
(författare)
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Imaging the dust and the gas around Mira using ALMA and SPHERE/ZIMPOL
- 2018
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Ingår i: Proceedings of the International Astronomical Union. - 1743-9213 .- 1743-9221. ; 14:S343, s. 31-35
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Konferensbidrag (refereegranskat)abstract
- The mass-loss mechanism of asymptotic giant branch stars has long been thought to rely on two processes: Stellar pulsations and dust formation. The details of the mass-loss mechanism have remained elusive, however, because of the overall complexity of the dust formation process in the very dynamical pulsation-enhanced atmosphere. Recently, our understanding of AGB stars and the associated mass loss has evolved significantly, thanks both to new instruments which allow sensitive and high-angular-resolution observations and the development of models for the convective AGB envelopes and the dust formation process. ALMA and SPHERE/ZIMPOL on the VLT have been very important instruments in driving this advance in the last few years by providing high-angular resolution images in the sub-mm and visible wavelengths, respectively. I will present observations obtained using these instruments at the same epoch (2.5 weeks apart) of the AGB star Mira that resolve even the stellar disk. The ALMA data reveals the distribution and dynamics of the gas around the star, while the polarised light imaged using SPHERE shows the distribution of the dust grains expected to drive the outflows. Moreover, the observations show a central source surrounded by asymmetric distributions of gas and dust, with complementary structures seen in the two components. We model the observed CO v = 1, J = 3-2 line to determine the density, temperature and velocity of gas close to the star. This model is then used to estimate the abundance of AlO. Our results show that only a very small fraction of aluminium (‰20.1%) is locked in AlO molecules. We also calculate models to fit the observed polarised light based on the gas densities we find. The low level of visible-light polarisation detected using ZIMPOL implies that, at the time of the observations, aluminium atoms are either not efficiently depleted into dust or the aluminium-oxide grains are relatively small (‰20.02μm).
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16. |
- Khouri, Theo, 1985, et al.
(författare)
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Observational identification of a sample of likely recent common-envelope events
- 2022
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Ingår i: Nature Astronomy. - : Springer Science and Business Media LLC. - 2397-3366. ; 6:2, s. 275-286
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Tidskriftsartikel (refereegranskat)abstract
- One of the most poorly understood stellar evolutionary paths is that of binary systems undergoing common-envelope evolution, when the envelope of a giant star engulfs the orbit of a companion. The interaction that ensues leads to a great variety of astrophysical systems and associated phenomena, but happens over a very short timescale. Unfortunately, direct empirical studies of this momentous and complex phase are difficult at present because few objects experiencing, or having just experienced, common-envelope evolution are known. Here we present Atacama Large Millimeter/submillimeter Array observations of minor CO isotopologues towards a sample of sources known as water fountains, which reveal that almost all of them recently lost a substantial fraction of their initial mass over a timescale of less than a few tens to a few hundreds of years. The only known mechanism able to explain such rapid mass ejection, corresponding to a large fraction of the stellar mass, is the common-envelope evolution. A stellar population analysis shows that the number of water-fountain sources in the Milky Way is comparable to the expected number of common-envelope events that involve low-mass evolved stars. Thus, the known sample of water-fountain sources accounts for a large fraction of the systems undergoing a common-envelope phase in our Galaxy. As one of the distinguishing characteristics of water-fountain sources is their fast bipolar outflow, we conclude that outflows and jets play an important role right before, during or immediately after the common-envelope phase.
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17. |
- Melloni, Chiara, et al.
(författare)
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Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer : Insights from the ARISTOTLE Trial.
- 2017
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Ingår i: American Journal of Medicine. - : Elsevier BV. - 0002-9343 .- 1555-7162. ; 130:12, s. 1440-1448.e1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Cancer is associated with a prothrombotic state and increases the risk of thrombotic events in patients with atrial fibrillation. We described the clinical characteristics and outcomes and assessed the safety and efficacy of apixaban versus warfarin in patients with atrial fibrillation and cancer in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.METHODS: The association between cancer and clinical outcomes was assessed using Cox regression models. At baseline, 1236 patients (6.8%) had a history of cancer; 12.7% had active cancer, and 87.3% had remote cancer.RESULTS: There were no significant associations between history of cancer and stroke/systemic embolism, major bleeding, or death. The effect of apixaban versus warfarin for the prevention of stroke/systemic embolism was consistent among patients with a history of cancer (event/100 patient-years = 1.4 vs 1.2; hazard ratio [HR], 1.09; 95% confidence interval [CI], 0.53-2.26) and no cancer (1.3 vs 1.6; HR, 0.77; 95% CI, 0.64-0.93) (P interaction = .37). The safety and efficacy of apixaban versus warfarin were preserved among patients with and without active cancer. Apixaban was associated with a greater benefit for the composite of stroke/systemic embolism, myocardial infarction, and death in active cancer (HR, 0.30; 95% CI, 0.11-0.83) versus without cancer (HR, 0.86; 95% CI, 0.78-0.95), but not in remote cancer (HR, 1.46; 95% CI, 1.01-2.10) (interaction P = .0028).CONCLUSIONS: Cancer was not associated with a higher risk of stroke. The superior efficacy and safety of apixaban versus warfarin were consistent in patients with and without cancer. Our positive findings regarding apixaban use in patients with atrial fibrillation and cancer are exploratory and promising, but warrant further evaluation.
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18. |
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19. |
- O Gorman, Eamon, 1984, et al.
(författare)
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ALMA Observations of Anisotropic Dust Mass Loss around VY CMa
- 2015
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Ingår i: 4th ALMA Science Conference on Revolution in Astronomy with ALMA: The Third Year, Tokyo, Japan, 8-11 December. - 9781583818831 ; 499, s. 335-336
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Konferensbidrag (refereegranskat)abstract
- We present high resolution ALMA Science Verification data of the continuum emission around the highly evolved oxygen-rich red supergiant VY CMa. These data enable us to study the dust in its inner circumstellar environment at a spatial resolution of 129 mas at 321 GHz and 59 mas at 658 GHz, thus allowing us to trace dust on spatial scales down to 11 R-star (71 AU). Two prominent dust components are detected and resolved. We find that at least 17% of the dust mass around VY CMa is located in clumps ejected within a more quiescent roughly spherical stellar wind, with a quiescent dust mass loss rate of 5 x 10(-6) M-circle dot yr(-1). The anisotropic morphology of the dust indicates a continuous, directed mass loss over a few decades, suggesting that this mass loss cannot be driven by large convection cells alone.
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20. |
- O Gorman, Eamon, 1984, et al.
(författare)
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ALMA observations of anisotropic dust mass loss in the inner circumstellar environment of the red supergiant VY Canis Majoris
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 573, s. Article no. L1-
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Tidskriftsartikel (refereegranskat)abstract
- The processes leading to dust formation and the subsequent role it plays in driving mass loss in cool evolved stars is an area of intense study. Here we present high resolution ALMA Science Verification data of the continuum emission around the highly evolved oxygen-rich red supergiant VY CMa. These data enable us to study the dust in its inner circumstellar environment at a spatial resolution of 129 mas at 321 GHz and 59 mas at 658 GHz, thus allowing us to trace dust on spatial scales down to 11 R-star (71 AU). Two prominent dust components are detected and resolved. The brightest dust component. C, is located 334 mas (61 R-star) southeast of the star and has a dust mass of at least 2.5 x 10(-4) M-circle dot. It has a dust emissivity spectral index of beta = -0.1 at its peak, implying that it is optically thick at these frequencies with a cool core of T-d less than or similar to 100 K. Interestingly, not a single molecule in the ALMA data has emission close to the peak of this massive dust clump. The other main dust component. VY, is located at the position of the star and contains a total dust mass of 4.0 x 10(-)5 M-circle dot. It also contains a weaker dust feature extending over 60 R-star to the north with the total component having a typical dust emissivity spectral index of beta = 0.7. We find that at least 17% of the dust mass around VY CMa is located in clumps ejected within a more quiescent roughly spherical stellar wind, with a quiescent dust mass loss rate of 5 x 10(-6) M-circle dot yr(-1). The anisotropic morphology of the dust indicates a continuous, directed mass loss over a few decades, suggesting that this mass loss cannot be driven by large convection cells alone.
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21. |
- Olofsson, Henrik, 1972, et al.
(författare)
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CO line observations of OH/IR stars in the inner Galactic Bulge: Characteristics of stars at the tip of the AGB
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 665
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Tidskriftsartikel (refereegranskat)abstract
- Context. OH/IR stars are examples of late stellar evolution on the asymptotic giant branch (AGB), and they are, as such, important objects to study. They are also excellent probes of stellar populations, in particular in regions of high interstellar extinction such as the central regions of our Galaxy. Aims. Our goal is to characterise the stellar and circumstellar properties of high-mass-loss-rate OH/IR stars in the inner Galactic Bulge using the Atacama Large Millimeter/submillimeter Interferometer (ALMA). Methods. Rotational lines of (CO)-C-12 and (CO)-C-13, as well as a millimetre-wave continuum, have been observed for a sample of 22 OH/IR stars in directions within 2 degrees of the Galactic Centre. Photometry data (approximate to 1-30 mu m) have been gathered from the literature to construct spectral energy distributions (SEDs) and to determine pulsational variability. Radiative transfer models have been used to interpret the line and photometry data. Results. All stars in the sample were detected in at least one CO line, and eight objects were detected in 324 GHz continuum. Based on luminosity criteria, the sample is divided into 17 objects that most likely lie within the inner Galactic Bulge, and five objects that are most likely foreground objects. The median luminosity of the inner-Galactic-Bulge sub-sample, 5600 L-circle dot, corresponds to an initial mass in the range 1.2-1.6 M-circle dot, indicating that these inner-Galactic-Bulge OH/IR stars descend from solar-type stars. The objects in this sub-sample are further divided into two classes based on their SED characteristics: Eleven objects have SEDs that are well matched by models invoking dust envelopes extending from a few stellar radii and outwards, while six objects are better modelled as having detached dust envelopes with inner radii in the range 200-600 au and warmer central stars. The former objects have periodic variability, while the latter objects are predominantly non-periodic. The median gas-mass-loss rate, gas terminal expansion velocity, gas-to-dust mass ratio, and circumstellar (CO)-C-12/(CO)-C-13 abundance ratio have been estimated to be 2 x 10(-5) M-circle dot yr(-1), 18 km s(-1), 200 (excluding the sources with detached dust envelopes, which show markedly lower gas-to-dust ratios), and 5, respectively, for the inner-Galactic-Bulge sub-sample. All line brightness distributions are resolved at an angular scale of approximate to 0 ''.15, but only two objects show a structure in their circumstellar envelopes at our resolution and sensitivity. In both cases, this structure takes the form of a cavity and a bipolar morphology. Conclusions. The inner-Galactic-Bulge sub-sample consists of high mass-loss-rate stars that descend from solar-type progenitors and that lie near the tip of the AGB. Some of the sample stars may have recently ceased mass loss and, hence, have begun to evolve beyond the AGB, as evidenced by a change in circumstellar characteristics and indications of warmer central stars. The inferred very low stellar C-12/C-13 isotope ratios are indicative of CNO-cycle nuclear processing, and they are most likely established at the surfaces of the stars during the first dredge-up on the red giant branch since these stars are not expected to experience hot-bottom burning. The inner-Galactic-Bulge OH/IR stars studied here constitute an excellent sample of equidistant objects for the purpose of understanding the evolution of the mass-loss-rate characteristics at the tip of the AGB.
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22. |
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23. |
- Ramstedt, Sofia, et al.
(författare)
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CO envelope of the symbiotic star R Aquarii seen by ALMA
- 2018
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 616
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Tidskriftsartikel (refereegranskat)abstract
- The symbiotic star R Aqr is part of a small sample of binary AGB stars observed with the Atacama Large Millimeter/submillimeter Array (ALMA). The sample stars are: R Aqr, Mira, W Aql, and π1Gru. The sample covers a range in binary separation and wind properties, where R Aqr is the source with the smallest separation. The R Aqr binary pair consists of an M-type AGB star and a white dwarf at a separation of 45 mas, equivalent to about 10 AU at 218 pc. The aim of the ALMA study is to investigate the dependence of the wind shaping on the binary separation and to provide constraints for hydrodynamical binary interaction models. R Aqr is particularly interesting as the source with the smallest separation and a complex circumstellar environment that is strongly affected by the interaction between the two stars and by the high-energy radiation resulting from this interaction and from the hot white dwarf companion. The CO(J = 3 →2) line emission has been observed with ALMA at ∼0.5′′ spatial resolution. The CO envelope around the binary pair is marginally resolved, showing what appears to be a rather complex distribution. The outer radius of the CO emitting region is estimated from the data and found to be about a factor of 10 larger than previously thought. This implies an average mass-loss rate during the past ∼100 yr of 2×10-7M∗yr-1, a factor of 45 less than previous estimates. The channel maps are presented and the molecular gas distribution is discussed and set into the context of what was previously known about the system from multiwavelength observations. Additional molecular line emission detected within the bandwidth covered by the ALMA observations is also presented. Because of the limited extent of the emission, firm conclusions about the dynamical evolution of the system will have to wait for higher spatial resolution observations. However, the data presented here support the assumption that the mass-loss rate from the Mira star strongly varies and is focused on the orbital plane.
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24. |
- Saberi, M., et al.
(författare)
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First detection of AlF line emission towards M-type AGB stars
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 663
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Tidskriftsartikel (refereegranskat)abstract
- The nucleosynthesis production of fluorine (F) is still a matter of debate. Asymptotic giant branch (AGB) stars are one of the main candidates for F production. However, their contribution to the total F budget is not fully known due to the lack of observations. In this paper, we report the detection of aluminium monofluoride (AlF) line emission, one of the two main carriers of F in the gas-phase in the outflow of evolved stars, towards five nearby oxygen-rich (M-type) AGB stars. We studied the Atacama large millimetre/sub-millimetre array (ALMA) observations of AlF (v = 0, J = 4-3, 9-8, 10-9, and 15-14) and (v = 1, J = 7-6) line emission towards o Ceti, and (v = 0, J = 7-6 and 15-14) lines towards R Leo. We also report a tentative detection of AlF (v = 0, J = 7-6) line in IK Tau, (v = 0, J = 15-14) line towards R Dor, and (v = 0, J = 7-6 and J = 15-14) lines in W Hya. From spatially resolved observations, we estimated the AlF emitting region with a radius ∼11R∗ for o Ceti and ∼9R∗ for R Leo. From population diagram analysis, we report the AlF column densities of ∼5.8 × 1015 cm-2 and ∼3 × 1015 cm-2 for o Ceti and R Leo, respectively, within these regions. For o Ceti, we used the C18O (v = 0, J = 3-2) observations to estimate the H2 column density of the emitting region. We found a fractional abundance of fAIF/H2 ∼ (2.5 ± 1.7) × 10-8. This gives a lower limit on the F budget in o Ceti and is compatible with the solar F budget fF/H2 = (5 ± 2) × 10-8. For R Leo, a fractional abundance fAIF/H2 = (1.2 ± 0.5) × 10-8 is estimated. For other sources, we cannot precisely determine the emitting region based on the available data. Assuming an emitting region with a radius of ∼11R∗ and the rotational temperatures derived for o Ceti and R Leo, we crudely approximated the AlF column density to be ∼(1.2-1.5) × 1015 cm-2 in W Hya, ∼(2.5-3.0) × 1014 cm-2 in R Dor, and ∼(0.6-1.0) × 1016 cm-2 in IK Tau. These result in fractional abundances within a range of fAIF/H2 ∼ (0.1 - 4) × 10-8 in W Hya, R Dor, and IK Tau.
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