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| 2. |
- Bousquet, J, et al.
(författare)
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Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
- 2020
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Ingår i: Clinical and translational allergy. - : Wiley. - 2045-7022. ; 10:1, s. 58-
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Tidskriftsartikel (refereegranskat)abstract
- There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
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- Bosnic-Anticevich, S, et al.
(författare)
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ARIA pharmacy 2018 "Allergic rhinitis care pathways for community pharmacy"
- 2019
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 74:7, s. 1219-1236
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Forskningsöversikt (refereegranskat)abstract
- Pharmacists are trusted health professionals. Many patients use over-the-counter (OTC) medications and are seen by pharmacists who are the initial point of contact of allergic rhinitis management in most countries. The role of pharmacists in integrated care pathways (ICPs) for allergic diseases is important. This paper builds on existing studies and provides tools intended to help pharmacists provide optimal advice/interventions/strategies to patients with rhinitis. The ARIA-pharmacy ICP includes a diagnostic questionnaire specifically focusing attention on key symptoms and markers of the disease, a systematic Diagnosis Guide (including differential diagnoses) and a simple flowchart with proposed treatment for rhinitis and asthma multimorbidity. Key prompts for referral within the ICP are included. The use of technology is critical to enhance the management of AR. However, the ARIA-pharmacy ICP should be adapted to local health care environments/situations as regional (national) differences exist in pharmacy care.
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| 9. |
- Bousquet, Jean, et al.
(författare)
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ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice
- 2021
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 76:1, s. 168-190
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Forskningsöversikt (refereegranskat)abstract
- Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
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| 10. |
- Ivanov, Alexander V., et al.
(författare)
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Bis(diethyldithiocarbamato)pyridinezinc(II) and -copper(II) clathrates M(Edtc)2Py·nL (L = CH2Cl2 and CHCl3; n = 1 and 0.5) : Molecular and crystal structures and EPR and high-resolution solid-state (13C, 15N) NMR spectra
- 1999
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Ingår i: Russian journal of coordination chemistry. - 1070-3284 .- 1608-3318. ; 25:8, s. 543-555
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Tidskriftsartikel (refereegranskat)abstract
- X-ray diffraction analysis, EPR, and high-resolution solid-state (13C, 15N) NMR spectroscopy were used to examine structural organization and spectral properties of six bis(diethyldithiocarbamato)pyridine-zinc(II) and copper(II) solvates with dichloromethane and chloroform, M(Edtc)2Py·nL (n = 1 and 0.5). Typical of the clathrate-type structures, the compounds are penetrated by the ordered molecular channels filled with chemically nonbonded chlorohydrocarbon molecules. At the molecular level, the geometry of coordination polyhedra of complexing atoms is intermediate between trigonal bipyramidal and square pyramidal (the contribution of the square-pyramidal component is quantitatively estimated for the zinc clathrate). Accordingly, the ground state of the unpaired electron in the copper(II) compounds is a combination of the dx2-y2 and dz2 orbitals. It is shown that the nonequivalence of the Edtc- ligands in zinc(II) clathrates manifests itself both magnetically and structurally. The chlorine atoms of the solvate dichloromethane molecules, unlike chloroform molecules, are disordered over the two structural positions with different multiplicities. The 13C and 15N NMR signals are assigned to the atomic positions in the resolved molecular structures
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| 11. |
- Ivanov, Alexander V., et al.
(författare)
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Bis(diethyldithiocarbamato)pyridinezinc(II) and copper(II) clathrates with pyridine: Molecular structure and EPR and high-resolution solid-state (13C, 15N) NMR spectra
- 1998
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Ingår i: Russian journal of coordination chemistry. - 1070-3284 .- 1608-3318. ; 24:9, s. 645-654
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Tidskriftsartikel (refereegranskat)abstract
- EPR, high-resolution solid-state (13C, 15N) NMR, and X-ray diffraction methods were used to study bis(diethyldithiocarbamato)pyridinezinc(II) and copper(II) clathrates with pyridine, M(EdIc)2Py · Py. The structural functionalities of the Py molecules in these clathrates were found to be different: one of them is coordinated to the complexing atom, while the other (solvate) is hydrogen-bonded to the sulfur atom of one of the ligands. The heterocycle of the uncoordinated Py molecule was found to be geometrically distorted. The structures of the copper and zinc coordination polyhedra are close to trigonal-bipyramidal: two sulfur atoms and the nitrogen atom of pyridine form the equatorial plane; another two sulfur atoms occupy axial positions at larger distances. EPR spectra of the magnetically diluted copper(II) clathrate exhibit well-resolved SHFS from the nitrogen atom of Py, owing to the contribution of the dz2 orbital to the ground-state wave function of the unpaired electron. The NMR data suggest that the nitrogen atoms of the Edtc- ligands are magnetically inequivalent and that the 15N chemical shift of the uncoordinated Py molecule changes in an unusual fashion. Signal assignment was carried out for the experimental 13C and 15N NMR spectra
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| 12. |
- Ivanov, Alexander V., et al.
(författare)
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Rotation isomers of bis(diethyldithiocarbamato)zinc(II) adduct with pyridine, Zn(EDtc)(2)center dot Py: ESR, C-13 and N-15 CP/MAS NMR and single-crystal X-ray diffraction studies
- 1999
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Ingår i: Polyhedron. - 0277-5387 .- 1873-3719. ; 18:15, s. 2069-2078
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Tidskriftsartikel (refereegranskat)abstract
- The adduct of bis(diethyldithiocarbamato)zinc(II) with pyridine, Zn(EDtc)2·Py, was prepared and studied by means of ESR (63Cu2+ and 65Cu2+ were used as spin labels), solid-state natural abundance 13C and 15N CP/MAS NMR spectroscopy and single-crystal X-ray diffraction data analysis. Two rotation isomers of the adduct were unambiguously determined by these three independent methods. It was found that these two isomers have different orientations of the pyridine ring about the N(Py)-Zn axis. The acute angles of the plane of the pyridine molecules relative to the most weak Zn-S bond are equal to 45.6 and 52.7° in the different isomers. Adduct molecules adopt a geometry which is intermediate between the square pyramidal (C4v) and the trigonal bipyramidal (D3h). All ESR and NMR resonances of Zn(EDtc)2·Py were assigned
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| 15. |
- Ma, G. B., et al.
(författare)
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Structure of the dimethyl sulfoxide solvated thallium(III) ion in solution and in the solid state
- 2001
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Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 0020-1669 .- 1520-510X. ; 40:25, s. 6432-6438
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Tidskriftsartikel (refereegranskat)abstract
- The structure and vibrational spectra of the dimethyl sulfoxide solvated thallium(III) ion have been studied in a dimethyl sulfoxide solution and in the solid state. X-ray crystallography shows a trigonal unit cell, space group R (3) over bar (No. 148), for the [TI(dmso)(6)](ClO4)(3) Compound with Z = 3, a = b = 11.9764(13) [11.8995(9)] Angstrom, c = 20.802(2) [20.467(2)] Angstrom, and V = 2584.0(5) [2509.9(4)] Angstrom (3) at 295 [150] K. The crystal structure comprises a highly symmetric hexakis(dimethyl sulfoxide)thallium(III) ion, with thallium in a 3 symmetry site and a TI-O bond distance of 2.224(3) Angstrom at 295 K. The octahedral TlO6 kernel is compressed along the threefold axis with an O-Tl-O bond angle of 96.20(11)degrees. The Tl-O-S bond angle of 120.7(2)degrees corresponds to a Tl . . .S distance of 3.292(2) Angstrom. One perchlorate ion centered on the (3) over bar axis was described by a statistically disordered model. A low-temperature EXAFS study (10 K) resulted in the TI-O and Tl . . .S distances of 2.221(4) and 3.282(6) Angstrom, respectively, consistent with a Tl-O-S bond angle of 120(1)degrees. The low Debye-Waller factors confirm a regular coordination without the disorder of the dimethyl sulfoxide ligands, which would have resulted from the alternative choice of space group R3 for the crystal structure. Raman and infrared spectra have been recorded and assigned, with the bands at 435 and 447 cm(-1) corresponding to the vibrational frequency of the symmetric and asymmetric TI-O stretching modes, respectively. EXAFS data of a 0.5 mol dm(-3) thallium(III) trifluoromethanesulfonate in a dimethyl sulfoxide solution were consistent with that of a hexasolvated ion with mean Tl-O and Tl . . .S distances of 2.22(1) and 3.33(2) Angstrom, respectively, which correspond to a mean Tl-O-S bond angle of 124(2)degrees. The anomalously large disorder parameter for the TI-O distances is consistent with a weal, pseudo-Jahn-Teller effect. The Tl-205, C-13, and H-1 NMR spectra of the complex in solution show single signals at 1886, 39.5, and 2.3 ppm, respectively.
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