| 1. |
- Ivarsson, Lina Birgitta, et al.
(författare)
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Treatment of Urethral Pain Syndrome (UPS) in Sweden
- 2019
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 14:11
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Urethral Pain Syndrome (UPS) in women is a recurrent urethral pain without any proven infection or other obvious pathology. There are few studies on UPS, and evidence-based treatment is lacking. The primary aim was to study what treatments are used, and to compare the treatment tradition of UPS in Sweden in 2018, with what was used in 2006.METHODS: A questionnaire on the treatment of women with UPS was sent to all public gynecology, urology, gynecologic oncology and venereology clinics, and one public general practice in each county in Sweden in 2018. Private practice clinics in gynecology responded to the survey in 2017. Comparisons were made with the same survey sent to gynecology and urology clinics in 2006.FINDINGS: Of 137 invited clinics in 2018, 99 (72.3%) responded to the survey. Seventy-seven (77.8%) of them saw women with UPS and 79.2% (61/77) of these clinics treated the patients using 19 different treatment methods. Local corticosteroids and local estrogens were the methods most used. Treatments were similar in gynecology and urology clinics in 2006 and 2018, although strong corticosteroids had increased in use in the treatment regimens of 2018. More than half of the clinics used antibiotics.INTERPRETATION: Since there is no evidence-based treatment of UPS, a wide spectrum of treatments is used, and different specialties use different treatment strategies. Despite the lack of proven infection, a large number of clinics also treated the syndrome with antibiotics. There is thus a need for well-designed randomized controlled clinical trials to find evidence-based treatments of UPS.
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| 2. |
- Sabie, Samar, et al.
(författare)
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Unmaking@CHI : Concretizing the Material and Epistemological Practices of Unmaking in HCI
- 2022
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Ingår i: CHI EA '22. - New York, NY, USA : ACM Digital Library. - 9781450391566 ; , s. 1-6
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Konferensbidrag (refereegranskat)abstract
- Design is conventionally considered to be about making and creating new things. But what about the converse of that process – unmaking that which already exists? Researchers and designers have recently started to explore the concept of “unmaking” to actively think about important design issues like reuse, repair, and unintended socio-ecological impacts. They have also observed the importance of unmaking as a ubiquitous process in the world, and its relation to making in an ongoing dialectic that continually recreates our material and technological realms. Despite the increasing attention to unmaking, it remains largely under-investigated and under-theorized in HCI. The objectives of this workshop are therefore to (a) bring together a community of researchers and practitioners who are interested in exploring or showcasing the affordances of unmaking, (b) articulate the material and epistemological scopes of unmaking within HCI, and (c) reflect on frameworks, research approaches, and technical infrastructure for unmaking in HCI that can support its wider application in the field.
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| 3. |
- Belichenko, P, et al.
(författare)
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Dendritic morphology in epileptogenic cortex from TRPE patients, revealed by intracellular Lucifer Yellow microinjection and confocal laser scanning microscopy.
- 1994
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Ingår i: Epilepsy research. - 0920-1211. ; 18:3, s. 233-47
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Tidskriftsartikel (refereegranskat)abstract
- Biopsy material was obtained from cortical epileptogenic zones (eight temporal, one occipital, one parietal and one frontal) of eleven patients aged 1.5-47 years with therapy-resistant partial epilepsy (TRPE) undergoing epilepsy surgery. Control autopsy material (two temporal, two occipital, one parietal and one frontal) was removed from six neurologically healthy cases within 6-10 hours postmortem delay. In each specimen, 100-300 pyramidal and non-pyramidal neurons were visualized by intracellular Lucifer Yellow microinjection. Single neurons were imaged using CLSM generated serial optical sections; 2-D reconstruction of each neuron was made using z-projection of serial optical images, and 3-D reconstructions and rotations were computerized. Neuronal maps from TRPE biopsies, compared to control autopsies, show markedly increased numbers of dendritic abnormalities of single pyramidal and non-pyramidal neurons in layers I, II-III, V-VII, and in the subcortical white matter. The abnormalities include: (1) increased number of non-pyramidal cells in layer I; (2) many pyramidal cells with two or three dendrites originating apically, rather than one single apical dendrite, in layers II-III; (3) atypical orientation of oblique apical and basal dendrites in pyramidal neurons of layers II-VII; (4) increased number of atypical 'dinosaur-like' and fusiform cells in layers V-VII; (5) numerous neurons in the white matter. These abnormalities may be etiological in cases with early onset, and predisposing in cases with late onset.
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| 4. |
- Bengtsson, Ylva, et al.
(författare)
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Ulriksdals slott under 350 år
- 1995
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Rapport (populärvet., debatt m.m.)abstract
- Studierna har utgått från Ulriksdals slott, uppfört av Jacob De la Gardie för 350 år sedan. Som kungligt slott har Ulriksdal genomgått ombyggnader under 1600 - och 1700-talet, men präglas idag mest av Karl XVs omfattande omdaning på 1850-talet och Gustav VI Adolfs lika genomgripande förändringar på 1920-talet.Slottet har bjudit på rika studiemöjligheter av stilideal, planlösning, interiörgestaltning, snickerikultur och stormtekniska system från hela 350-årsperioden. Genom noggranna uppmätningar och inventeringar på plats kopplade till arkivstudier har slottets komplicerade förändringshistoria kunnat analyseras,
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| 5. |
- Bishop, Kevin, et al.
(författare)
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EviWet: Evidensbaserat beslutsstöd för våtmarkers hydrologiska ekosystemtjänster
- 2024
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Vissa våtmarker kan jämna ut höga och låga vattenflöden i naturen, och därigenom mildra översvämningar och torka. Hur väl en våtmark förmår att dämpa extremflöden beror på var i naturen de ligger och vilken sorts våtmarkstyp det är. Vi vet för lite om våtmarkers hydrologiska egenskaper och betydelsen av placering i landskapet. Forskarna i EviWet har undersökt torvens vattenhållande förmåga, och därifrån skapat modeller för ekohydrologi, samt utvecklat beslutsstöd för operationell modellering. Projektet har finansierats med Formas medel för det Nationella forskningsprogrammet om klimat men administrerats av Naturvårdsverket.
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| 6. |
- Corvaisier, Matthieu, et al.
(författare)
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The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells
- 2021
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Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 4:1, s. 767-
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Tidskriftsartikel (refereegranskat)abstract
- Changes in the location of γ-tubulin ensure cell survival and preserve genome integrity. We investigated whether the nuclear accumulation of γ-tubulin facilitates the transport of proliferating cell nuclear antigen (PCNA) between the cytosolic and the nuclear compartment in mammalian cells. We found that the γ-tubulin meshwork assists in the recruitment of PCNA to chromatin. Also, decreased levels of γ-tubulin reduce the nuclear pool of PCNA. In addition, the γ-tubulin C terminus encodes a PCNA-interacting peptide (PIP) motif, and a γ-tubulin–PIP-mutant affects the nuclear accumulation of PCNA. In a cell-free system, PCNA and γ-tubulin formed a complex. In tumors, there is a significant positive correlation between TUBG1 and PCNA expression. Thus, we report a novel mechanism that constitutes the basis for tumor growth by which the γ-tubulin meshwork maintains indefinite proliferation by acting as an opportune scaffold for the transport of PCNA from the cytosol to the chromatin.
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| 7. |
- Forlano, Laura, et al.
(författare)
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Mending and Growing in Feminist Speculative Fabulations : Design’s Unfaithful Daughters
- 2016
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Ingår i: DRS2016 Conversations. - London : University of Brighton; DesignResearchSociety; Imperial College London, Royal College of Art, PHDBYDESIGN.
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Konferensbidrag (populärvet., debatt m.m.)abstract
- This conversation seeks to consider design research practices around critical and speculative design which have been criticised for their lack of public engagement and awareness of their political and normative positions. In particular, we are interested in the ways in which feminist speculative fabulation offer alternative approaches through attention to core feminist arguments around corporeality, materiality, embodiment, affectivity and experientiality. Our conversation will imagine new ways of practicing design by examining relationships between speculative futures and reimaginings of the past; the role of a feminist perspective in problem-making and questioning; speculative design and fabulation as participatory practice; the role of practices around mending, growing, maintaining and repairing; and, the posthuman design and the anthropocene.
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| 8. |
- Fredholm, Hanna, et al.
(författare)
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Long-term outcome in young women with breast cancer : a population-based study
- 2016
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Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 0167-6806 .- 1573-7217. ; 160:1, s. 131-143
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Tidskriftsartikel (refereegranskat)abstract
- Whether young age at diagnosis of breast cancer is an independent risk factor for death remains controversial, and the question whether young age should be considered in treatment decisions is still to be answered. From a population-based cohort of 22,017 women with breast cancer, all women < 35 years (n = 471) were compared to a random sample of 700 women aged 35-69 years from the same cohort. Information on patient and tumor characteristics, treatment, and follow-up was collected from the medical records. Tissue microarrays were produced for analysis of classical biomarkers. Breast cancer-specific survival (BCSS), distant disease-free survival (DDFS), and locoregional recurrence-free survival (LRFS) by age were compared using women 50-69 years as reference. At 10 years follow-up, women < 35 years and 35-39 years had a worse BCSS [age < 35 years 69 % (HR 2.75, 95 % CI 1.93-3.94), age 35-39 years 76 % (HR 2.33, 95 % CI 1.54-3.52), age 40-49 years 84 % (HR 1.53, 95 % CI 0.97-2.39), and age 50-69 years 89 % (reference)]. The worse BCSS was statistically significant in stages I-IIa and Luminal B tumors. At multivariate analysis age < 35 years and 35-39 years confined a risk in LRFS (HR 2.13, 95 % CI 1.21-3.76 and HR 1.97, 95 % CI 1.06-3.68) but not in DDFS and BCSS. In the subgroup of women < 40 years with luminal tumors stage I-IIa, low age remained an independent risk factor also in DDFS (HR 1.87, 95 % CI 1.03-3.44). Young women have a high risk of systemic disease even when diagnosed in an early stage. The excess risk of relapse is most pronounced in Luminal B tumors, where low age is an independent prognostic factor of DDFS and LRFS.
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| 9. |
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| 10. |
- Frändberg, Lotta, 1964, et al.
(författare)
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Aspects of Corporeal, Virtual and Media Mobility Development in Sweden
- 2008
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Ingår i: Cosmobilities workshop: The future of Cosmobilities Network, 12-14 march 2008, Holbaek, Denmark.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Diverse forms of spatial mobility are significant features of current social life. The rapid and converging development of space-transcending technologies (high-speed transportation and information and communication technologies) and still increasing virtual access to other places through media representation (e.g. news and popular culture) are thoroughly affecting people’s use of space and place. Decreased friction of distance, extended social networks and everyday activity patterns are major indicators of this. Gradually, spatial mobility is becoming institutionalised and expected, turning high levels of travel and communication from a choice to more of a necessity. Our projects aim to explore the development of various forms of spatial mobility and human interaction, be they physical, virtual, or media related. Their intricate interrelations in terms of complements, substitutes, displacements, and modifications − and the intersections between these − are a particular focus.
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| 11. |
- Frändberg, Lotta, 1964, et al.
(författare)
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Integrated Mobility Research
- 2004
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Ingår i: Poster at the International Geographical Union’s congress, Glasgow 15-20 August 2004.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 12. |
- Granberg, Hjalmar, et al.
(författare)
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It’s a bird! It’s a plane! It’s a super multimaterial!
- 2015
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Ingår i: Paper Conference and Trade Show (PaperCon 2015). - : TAPPI Press. - 9781510818873 ; , s. 492-504
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Konferensbidrag (refereegranskat)abstract
- Matching market demands and technological solutions is not always straightforward. In this article, we report on one material, a cellulose-PLA multimaterial, which was made on a full-scale pilot paper machine and adapted to five different market applications having specialized and often conflicting demands. The material can be injection molded, 3D-printed, hot pressed, treated as a textile, used in a laminate, or converted as a paper board, giving it a wide range of possible properties depending on how it is processed.The five application areas presented here were identified as gaps in the marketplace where seemingly conflicting needs were desired: opacity and transparency; compact for transport but having an expanded size during use; stiffness and flexibility; strength and light-weight; and durability and degradability. These properties are exemplified in a number of material and product demonstrators, illustrating how tailored solutions can give products with distinctly different personalities. The material can be made flexible and given movement as graceful as the wing of a bird or be processed to be strong and light-weight enough to be used in vehicles like airplanes. By having one material that is produced on a large scale, but then processed according to specific market demands and expectations, the gap between needing scale and needing scope is bridged.
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| 13. |
- Gyimóthy, Szilvia, et al.
(författare)
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Popcultural tourism: A research manifesto
- 2013
-
Ingår i: Celebrating and enhancing the tourism knowledge-based platform: A tribute to Jafar Jafari, Palma de Mallorca October 23-25 2013.
-
Konferensbidrag (refereegranskat)
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| 14. |
- Gyimóthy, Szilvia, et al.
(författare)
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Popculture tourism : A research manifesto
- 2015
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Ingår i: Tourism Research Frontiers. - Bingley : Emerald Group Publishing Limited. - 9781783509935 - 9781783509942 ; 20, s. 13-26
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Bokkapitel (refereegranskat)abstract
- Tourism in the wake of films, literature, and music is gaining interest among academics and practitioners alike. Despite the significance of converging tourism and media production and popcultural consumption, theorizing in this field is weak. This chapter explores complex relationships among popcultural phenomena, destination image creation, and tourism consumption. By taking a broader social science approach, it revisits and connects research themes, such as symbolic consumption, negotiated representations, fans and fandom, technology mediation, and media convergence. The chapter concludes with an integrative model, or "popcultural placemaking loop," which is qualified through six propositions. Copyright © 2015 by Emerald Group Publishing Limited.
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| 15. |
- Hansen, Kristina, et al.
(författare)
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Age at smoking initiation and self-rated health among second grade high school boys and girls in Scania, Sweden, a cross-sectional study.
- 2015
-
Ingår i: BMC Public Health. - : Springer Science and Business Media LLC. - 1471-2458. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- Smoking is usually initiated early in life and most adult regular smokers have started smoking before 18 years of age. A younger age at smoking initiation is associated with risk taking behaviours and worse health outcomes regarding psychological and somatic conditions, suggested to be caused by exposure during critical developmental periods. The present study aims to investigate self-rated health among second grade high school boys and girls related to age at smoking initiation (<14 years of age and ≥ 14 years of age) among current and former smokers, compared to never smokers.
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| 16. |
- Hansen, Kristina, et al.
(författare)
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Early exposure to secondhand tobacco smoke and the development of allergic diseases in 4 year old children in Malmo, Sweden
- 2010
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Ingår i: BMC Pediatrics. - : Springer Science and Business Media LLC. - 1471-2431. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Background: Earlier studies have shown an association between secondhand tobacco smoke and allergy development in children. Furthermore, there is an increased risk of developing an allergy if the parents have an allergy. However, there are only few studies investigating the potential synergistic effect of secondhand tobacco smoke and allergic heredity on the development of an allergy. Methods: The study was population-based cross-sectional with retrospective information on presence of secondhand tobacco smoke during early life. The study population consisted of children who visited the Child Health Care (CHC) centres in Malmo for their 4-year health checkup during 2006-2008 and whose parents answered a self-administered questionnaire (n = 4,278 children). The questionnaire was distributed to parents of children registered with the CHC and invited for the 4-year checkup during the study period. Results: There was a two to four times increased odds of the child having an allergy or having sought medical care due to allergic symptoms if at least one parent had an allergy, while there were rather small increased odds related to presence of secondhand smoke during the child's first month in life or at the age of 8 months. However, children with heredity for allergies and with presence of secondhand tobacco smoke during their first year in life had highly increased odds of developing an allergy and having sought medical care due to allergic symptoms at 4 years of age. Thus, there was a synergistic effect enhancing the independent effects of heredity and exposure to secondhand tobacco smoke on allergy development. Conclusions: Children with a family history of allergies and early exposure to secondhand tobacco smoke is a risk group that prevention and intervention should pay extra attention to. The tobacco smoke effect on children is an essential and urgent question considering it not being self chosen, possibly giving life lasting negative health effects and being possible to reduce.
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| 17. |
- Hedström, Ragnar, 1952-, et al.
(författare)
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Innovationsupphandling och implementering av komplexa signalsystem : arbetsprocesser och verktyg
- 2016
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Projektets syfte är att identifiera problem och behov som möjliggör att en beställarorganisation uppnår målen för funktionalitet, tid och budget för innovationsupphandling av signalsystem. En litteraturgenomgång och att antal workshops med efterföljande strukturerad analys har genomförts. Spårburen trafik har någon form av styrsystem och säkerhetskoncept där signalsystemet utgör en väsentlig del av säkerheten. Ur ett systemperspektiv är signalsystem en komplex och tekniskt avancerad infrastruktur som behöver behandlas tvärvetenskapligt. Varje delsystem och varje objekt i trafikstyrningssystemet är vanligtvis inte komplicerat i sig självt. Kombinationen av många delsystem och integrationen med övrig infrastruktur skapar en komplex struktur och blir en abstrakt, icke visuell skapelse. För att hantera komplexiteten och närma sig ett hanterbart sätt att identifiera vilka behov som finns för en effektiv och innovativ utveckling av signalsystem gjordes en analys av signalsystem ur ett processperspektiv. Behoven analyserades sedan ur två teoretiska perspektiv – Integrerad Produktutveckling (IPU) och Systems Engineering (SE) som båda innehåller beskrivningar av hur olika aktörer vid produktutveckling bör involveras med avseende på roller och ansvar. Analyserna och resultatet från workshopen identifierade ett antal problemområden som behöver hanteras för att utveckling av signalsystem ska kunna genomföras på ett bättre sätt i framtiden. Flera problemområden finns identifierade i teoretiska beskrivningar för i IPU och SE men de behöver anpassas till beställarorganisationer.
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| 18. |
- Hillgren, Per-Anders, et al.
(författare)
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Glossary: Collaborative Future-Making
- 2020
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Collaborative Future-Making is a research platform at the Faculty of Culture and Society at Malmö University that is concerned with how to envision, elaborate and prototype multiple, inclusive, and sustainable futures. The platform gathers around 20 researchers that share a methodological interest in how critical perspectives from the humanities and social sciences can be combined with the constructive and collaborative aspects of making and prototyping in design research.The research centers around two major themes:Critical imagination, which focuses on how basic assumptions, norms and structures can be challenged to widen the perspectives on what can constitute socially, culturally, ecologically and economically sustainable and resilient futures.Collaborative engagements, which focuses on how we can set up more inclusive collaborations to prototype and discuss alternative futures, engaging not only professionals and policy makers but also citizens and civil society.During 2019 the research group set out to make a shared glossary for collaborative future-making. The glossary is multiple in purpose and exists in several versions. Hopefully there will be more to come. At first, the making and articulation of the glossary was used within the research group as an exercise to share concepts that we found central to collaborative future-making, coming from different disciplines. This published version of the glossary was assembled to be used during a workshop called Imagining Collaborative Future-Making, which gathered a group of international researchers from different disciplines.The collection of concepts reflects the heterogeneous and diverse character of the research group and a strong belief in that plurality regarding ontologies and epistemologies will be crucial to be able to handle the multiple uncertainties and complex challenges we have to face in the future. Some of the concepts are already well established within different research communities, but gain a specific meaning in relation to the research area. Others are more preliminary attempts to advance our understanding or probe into new potential practices within collaborative future-making. In that sense the concepts in the glossary are well situated and grounded in past and ongoing research within this research group, at the same time as they are meant to suggest, propose and point towards practices and approaches yet to come.The concepts in this glossary are not only meant to be descriptive but also performative. In that sense, assembling and circulating this glossary is part of collaborative future-making. As pointed out by Michelle Westerlaken in her articulation of “Doing Concepts” (see page 15), “...without proposing, critiquing, or working towards a common or uncommon understanding of certain concepts, it becomes impossible to ‘make futures’ in any deliberate fashion.”
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| 19. |
- Holmstedt, Janna, 1972-
(författare)
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Are you ready for a wet live-in? : explorations into listening
- 2017
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- Listen. If I ask you to listen, what is it that I ask of you—that you will understand, or perhaps obey? Or is it some sort of readiness that is requested? What occurs with a body in the act of listening? How do sound and voice structure audio-visual-spatial relations in concrete situations?This doctoral thesis in fine arts consists of six artworks and an essay that documents the research process, or rather, acts as a travelogue as it stages and narrates a series of journeys into a predominantly sonic ecology. One entry into this field is offered by the animal “voice” and attempts to teach animals to speak human language. The first journey concerns a specific case where humanoid sounds were found to emanate from an unlikely source—the blowhole of a dolphin. Another point of entry is offered by the acousmatic voice, a voice split from its body, and more specifically, my encounter with the disembodied voice of Steve Buscemi in a prison in Philadelphia. This listening experience triggered a fascination with, and an inquiry into, the voices that exist alongside us, the parasitic relation that audio technology makes possible, and the way an accompanying voice changes one’s perceptions and even one’s behavior. In the case of both the animal and the acousmatic, the seemingly trivial act of attending to a voice quickly opens up a complex space of embodied entanglements with the potential to challenge much of what we take for granted. At the heart of my inquiry is a series of artworks made between 2012 and 2016, which constitute a third journey: the performance Limit-Cruisers (#1 Sphere), the praxis session Limit-Cruisers (#2 Crowd), the installations Therapy in Junkspace, Fluorescent You, and “Then, ere the bark above their shoulders grew,” and the lecture performance Articulations from the Orifice (The Dry and the Wet).The relationship between what is seen and heard is being explored and renegotiated in the arts and beyond. We are increasingly addressed by prerecorded and synthetic voices in both public and private spaces. Simultaneously, our notions of human communication are challenged and complicated by recent research in animal communication. My work attempts to address the shifts and complexities embodied in these developments. The three journeys are deeply entwined with theoretical inquiries into human-animal relationships, technology, and the philosophy of sound. In the essay, I consider as well how other artistic practices are exploring this same complex space. What I put forward is a materialist and concrete approach to listening understood as a situated practice. Listening is both a form of co-habitation and an ecology. In and through listening, I claim, one could be said to perform in concert with the things heard while at the same time being changed by them.
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| 20. |
- Horn, Djanda, et al.
(författare)
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Managing a stressful work environment through improved teamwork - a qualitative content analysis of nurses working environment within emergency care
- 2018
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Ingår i: International Archives of Nursing and Health Care. - 2469-5823. ; 4:4
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Tidskriftsartikel (refereegranskat)abstract
- Aim: The aim of this study was to describe nurses’ experiences of their working environment in emergency departments at a general hospital in Manila, Philippines. Background: The working environment within emergency care is complex and unpredictable and may influence patient safety. Nurses are challenged by increased patient flow, staff shortages and heavy workload. Methods: This study used a qualitative content analysis with an inductive approach based on semi-structured interviews with nine nurses at emergency departments. Results: One category, improved teamwork toward a healthy working environment, which included two subcategories, barriers to providing a high quality of care and managing a stressful work environment, describe nurses’ experiences with their work environment at emergency departments in the Philippines. Conclusion: Workload manifests through a high patient ratio and patient safety-affected prioritizations of patients, which is why basic nursing is limited. Therefore, improved teamwork built upon person-centered care is needed to increase the high quality of care as well as a healthy working environment.
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| 21. |
- Hörnberg, Kristina, 1964-, et al.
(författare)
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Body function in patients with early rheumatoid arthritis : a 2-year prospective study
- 2007
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Ingår i: Advances in Physiotherapy. - : Taylor & Francis. - 1403-8196 .- 1651-1948. ; 9:4, s. 144-150
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this prospective study was to analyse joint and muscle function and aerobic capacity over 2 years in a group of patients with early rheumatoid arthritis (RA; i.e. symptomatic for <12 months) in relation to age, pain and disease activity. Sixty-six patients with early RA were followed for 24 months. Joint and muscle function was measured using Signals of Functional Impairment (SOFI) index and aerobic capacity with sub-maximal test on ergometer bicycle. Pain was estimated on Visual Analogue Scale (VAS) and disease activity using 28-joint count Disease Activity Score (DAS 28). Joint and muscle function was impaired in almost all patients at inclusion and after 24 months. Male patients were more affected compared with females and the significant correlation with pain and DAS 28 decreased over time. Aerobic capacity was maintained and not influenced by sex, age or pain but related significantly to disease activity. The majority of the patients with early RA had impairments of the joint and muscle function over 24 months, even though disease activity decreased significantly. There is a need for regular evaluations of physical functions besides disease activity to prevent continuous development of functional losses.
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| 22. |
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| 23. |
- Johnell, Kristina, et al.
(författare)
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Anxiolytic-hypnotic drug use associated with trust, social participation, and the miniaturization of community: A multilevel analysis
- 2006
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Ingår i: Social Science and Medicine. - : Elsevier BV. - 1873-5347 .- 0277-9536. ; 62:5, s. 1205-1214
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Tidskriftsartikel (refereegranskat)abstract
- The concept of social capital has gained wide interest in public health research in recent years. However, we suggest a concept that was introduced and developed by Fukuyama, named "miniaturization of community".. as an alternative to that of social capital. The concept of miniaturization of community emphasizes that a high level of social participation can be accompanied by a low level of trust, both at the individual and at the community level, which may in turn result in social disorder and lack of social cohesion. When society becomes more disordered, people may tend to feel more insecure and anxious. Use of anxiolytic-hypnotic drugs (AHDs) could under such circumstances be a coping strategy. In this study, we first wanted to investigate whether the contextual component of the miniaturization of community concept (i.e. area high social participation and low trust) is associated with individual AHD use, over and above individual characteristics. Secondly, we aimed to study whether people living in the same municipality share a similar probability of AHD use, after adjusting for individual characteristics, and if so, how large this contextual phenomenon is. We used data on 20,319 women and 17,850 men aged 18-79 years from 58 municipalities in six regions in central Sweden, who participated in the Life & Health year 2000 postal survey. We applied multilevel logistic regression analysis with individuals at the first level and areas at the second level. Our results suggest that living in an area with a high level of miniaturization of community seems to be associated with individual AHD use, beyond people's individual characteristics including their own level of social participation and trust. The concept of miniaturization of community may be an extension of the classic concept of social capital and may increase our understanding of contextual effects on health. (c) 2005 Elsevier Ltd. All rights reserved.
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| 24. |
- Johnell, Kristina, et al.
(författare)
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Individual characteristics, area social participation, and primary non-concordance with medication: a multilevel analysis
- 2006
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Ingår i: BMC Public Health. - : Springer Science and Business Media LLC. - 1471-2458. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Background: Non-concordance with medication remains a major public health problem that imposes a considerable financial burden on the health care system, and there is still a need for studies on correlates of non-concordance. Our first aim is to analyse whether any of the individual characteristics age, educational level, financial strain, self-rated health, social participation, and trust in the health care system are associated with primary non-concordance with medication. Our second aim is to investigate whether people living in the same area have similar probability of primary non-concordance with medication, that relates to area social participation. Methods: We analysed cross sectional data from 9 070 women and 6 795 men aged 18 to 79 years, living in 78 areas in central Sweden, who participated in the Life & Health year 2000 survey, with multilevel logistic regression (individuals at the first level and areas at the second level). Results: Younger age, financial strain, low self-rated health, and low trust in the health care system were associated with primary non-concordance with medication. However, area social participation was not related to primary non-concordance, and the variation in primary non-concordance between the areas was small. Conclusion: Our results indicate that people in central Sweden with younger age, financial difficulties, low self-rated health, and low trust in the health care system may have a higher probability of primary non-concordance with medication. However, the area of residence - as defined by administrative boundaries - seems to play a minor role for primary non-concordance.
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| 25. |
- Johnsen, Andreas
(författare)
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Architecture-Based Verification of Dependable Embedded Systems
- 2013
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Quality assurance of dependable embedded systems is becoming increasingly difficult, as developers are required to build more complex systems on tighter budgets. As systems become more complex, system architects must make increasingly complex architecture design decisions. The process of making the architecture design decisions of an intended system is the very first, and the most significant, step of ensuring that the developed system will meet its requirements, including requirements on its ability to tolerate faults. Since the decisions play a key role in the design of a dependable embedded system, they have a comprehensive effect on the development process and the largest impact on the developed system. Any faulty architecture design decision will, consequently, propagate throughout the development process, and is likely to lead to a system not meeting the requirements, an unacceptable level of dependability and costly corrections.Architecture design decisions are in turn critical with respect to quality and dependability of a system, and the cost of the development process. It is therefore crucial to prevent faulty architecture design decisions and, as early as practicable, detect and remove faulty decisions that have not successfully been prevented. The use of Architecture Description Languages (ADLs) helps developers to cope with the increasing complexity by formal and standardized means of communication and understanding. Furthermore, the availability of a formal description enables automated and formal analysis of the architecture design.The contribution of this licentiate thesis is an architecture quality assurance framework for safety-critical, performance-critical and mission-critical embedded systems specified by the Architecture Analysis and Design Language (AADL). The framework is developed through the adaption of formal methods, in particular traditional model checking and model-based testing techniques, to AADL, by defining formal verification criteria for AADL, and a formal AADL-semantics. Model checking of AADL models provides evidence of the completeness, consistency and correctness of the model, and allows for automated avoidance of faulty architecture design decisions, costly corrections and threats to quality and dependability. In addition, the framework can automatically generate test suites from AADL models to test a developed system with respect to the architecture design decisions. A successful test suite execution provides evidence that the architecture design has been implemented correctly. Methods for selective regression verification are included in the framework to cost-efficiently re-verify a modified architecture design, such as after a correction of a faulty design decision.
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| 26. |
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| 27. |
- Jönsson, Li, et al.
(författare)
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Grief and Hope in Transition : An orienteering guide
- 2023
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Bok (populärvet., debatt m.m.)abstract
- In the project Grief and Hope in Transition, our approach to transition has been one of reorientation, a departure from the belief in new technologies as the solution to all kinds of problems, an attempt at deviation from modernity’s familiar territories and road maps. Together with people living in different rural areas in Sweden’s southern most landscape Scania, we formed a study group in future orienteering.This book is an outcome of the collaborative work done to explore how to transition into becoming fossil-free and how to let go of optimism that places agency elsewhere (such as in others' roadmaps and tech-fixes). It describes how we through designerly ways have addressed the challenge of how to restore a sense of attachments and commitment to the unfolding of the future.
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| 28. |
- Jönsson, Li, et al.
(författare)
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How Can We Come to Care in and Through Design?
- 2019
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Ingår i: Nordes 2019: Who Cares?. - Eespo : Nordic Design Research. ; , s. 1-8, s. 1-8
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Konferensbidrag (refereegranskat)abstract
- On a generic level, caring can be described as "everything that we do to maintain, continue, and repair our 'world' so that we can live in it as well as possible" (Fisher and Tronto, 1990). This paper asks how we as design researchers in Scandinavia come to care, for our world and more specifically for the local NORDES community. We do this by describing how we have maintained, continued and added (as a practice of repair) in relation to the most recent NORDES summer school (2018). The summer school invited students to work with tensions between despair, in a site marked and haunted (Tsing et al., 2017) by the aftermath of industrial design practices and hope, by making time for soil (Puig de la Bellacasa, 2017) in a community-supported agricultural scheme. The paper invites you to share some cruxes and insights that emerged, and to imagine teaching with care as a collective process that attempts to bring things together, not as oppositions, but as generative and productive relations.
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| 29. |
- Jönsson, Li, et al.
(författare)
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Narrating ecological grief and hope through reproduction and translations
- 2022
-
Ingår i: DRS2022. - Bilbao : Design Research Society. - 9781912294572 ; , s. 68-68
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Konferensbidrag (refereegranskat)abstract
- The Swedish government has decided that Sweden will become carbon neutral by 2045. What are the implications for us as citizens in such a transition? What formats allow us to favour careful transformation over progress through radical innovation? In this paper, we attempt to understand grief and hope in the context of this transition. We describe a designerly format of re-production and translation aimed at collectively working through potential future changes, uncertainties and loss. Influenced by plaster moulding techniques used at a closed-down pottery, we invite participants to reproduce and translate original animal and plant motifs into present circumstances. These practical hands-on engagements allow us to notice and articulate change in relation to the past and orient ourselves towards uncertain futures. Hope can be found in the ruins of industries, in locally produced alternative energies and in small-scale attempts to undo biodiversity loss.
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| 30. |
- Jönsson, Li, et al.
(författare)
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The thickening of futures
- 2021
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Ingår i: Futures. - : Elsevier. - 0016-3287 .- 1873-6378. ; 134:December
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Tidskriftsartikel (refereegranskat)abstract
- This paper engages with biodiversity loss. In particular, it focuses on observations and scientific facts: the decline of pollinators and what that entails for the co-living of humans and more-than-humans. This kind of work often reaches the publics as thin stories of limited futures.The article explores how to situate the issue of out-of-sync plant–pollinator relationships into thick, ongoing presents rather than as a distant future that is out of one’s own hands. This is done through a collaborative design project that experiments with various formats for staging more material, embodied and experiential ways to sensitise and invite humans to experience the issue of pollination. We therefore explore and give an account of how we have situated the issues in a thick, ongoing present as an anticipatory practice. We thus suggest a practice that becomes both sticky and sweaty; in addition, the practice moves some pollination facts into not only matters of concern but also matters of care.In doing so, we forward the role that design researchers can play in environmental and collaborative anticipation by engaging with emerging approaches to both biodiversity loss and collaborative future-making that are simultaneously conflicting and harsh as well as hopeful.
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| 31. |
- Kimbung, Siker, et al.
(författare)
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Contrasting breast cancer molecular subtypes across serial tumor progression stages: biological and prognostic implications.
- 2015
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 6:32, s. 33306-18
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Tidskriftsartikel (refereegranskat)abstract
- The relevance of the intrinsic subtypes for clinical management of metastatic breast cancer is not comprehensively established. We aimed to evaluate the prevalence and prognostic significance of drifts in tumor molecular subtypes during breast cancer progression. A well-annotated cohort of 304 women with advanced breast cancer was studied. Tissue microarrays of primary tumors and synchronous lymph node metastases were constructed. Conventional biomarkers were centrally assessed and molecular subtypes were assigned following the 2013 St Gallen guidelines. Fine-needle aspirates of asynchronous metastases were transcriptionally profiled and subtyped using PAM50. Discordant expression of individual biomarkers and molecular subtypes was observed during tumor progression. Primary luminal-like tumors were relatively unstable, frequently adopting a more aggressive subtype in the metastases. Notably, loss of ER expression and a luminal to non-luminal subtype conversion was associated with an inferior post-recurrence survival. In addition, ER and molecular subtype assessed at all tumor progression stages were independent prognostic factors for post-recurrence breast cancer mortality in multivariable analyses. Our results demonstrate that drifts in tumor molecular subtypes may occur during tumor progression, conferring adverse consequences on outcome following breast cancer relapse.
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| 32. |
- Klett, Matilda, et al.
(författare)
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Non-uniform aging of cycled commercial LiFePO4//graphite cylindrical cells revealed by post-mortem analysis
- 2014
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Ingår i: Journal of Power Sources. - : Elsevier BV. - 0378-7753 .- 1873-2755. ; 257, s. 126-137
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Tidskriftsartikel (refereegranskat)abstract
- Aging of power-optimized commercial 2.3 Ah cylindrical LiFePO4//graphite cells to be used in hybrid electric vehicle is investigated and compared for three different aging procedures; (i) using a simulated hybrid electric vehicle cycle within a narrow SOC-range, (ii) using a constant-current cycle over a 100% SOC-range, and (iii) stored during three years at 22 degrees C. Postmortem analysis of the cells is performed after full-cell electrochemical characterization and discharge. EIS and capacity measurements are made on different parts of the disassembled cells. Material characterization includes SEM, EDX, HAXPES/XPS and XRD. The most remarkable result is that both cycled cells displayed highly uneven aging primarily of the graphite electrodes, showing large differences between the central parts of the jellyroll compared to the outer parts. The aging variations are identified as differences in capacity and impedance of the graphite electrode, associated with different SEI characteristics. Loss of cyclable lithium is mirrored by a varying degree of lithiation in the positive electrode and electrode slippage. The spatial variation in negative electrode degradation and utilization observed is most likely connected to gradients in temperature and pressure, that can give rise to current density and potential distributions within the jellyroll during cycling. (C) 2014 Elsevier B.V. All rights reserved.
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| 33. |
- Lagerstedt, Kristina, 1976, et al.
(författare)
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Tumor Genome Wide DNA Alterations Assessed by Array CGH in Patients with Poor and Excellent Survival Following Operation for Colorectal Cancer.
- 2007
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Ingår i: Cancer informatics. - 1176-9351. ; 3, s. 341-55
-
Tidskriftsartikel (refereegranskat)abstract
- Genome wide DNA alterations were evaluated by array CGH in addition to RNA expression profiling in colorectal cancer from patients with excellent and poor survival following primary operations.DNA was used for CGH in BAC and cDNA arrays. Global RNA expression was determined by 44K arrays. DNA and RNA from tumor and normal colon were used from cancer patients grouped according to death, survival or Dukes A, B, C and D tumor stage. Confirmed DNA alterations in all Dukes A - D were judged relevant for carcinogenesis, while changes in Dukes C and D only were regarded relevant for tumor progression.Copy number gain was more common than loss in tumor tissue (p < 0.01). Major tumor DNA alterations occurred in chromosome 8, 13, 18 and 20, where short survival included gain in 8q and loss in 8p. Copy number gains related to tumor progression were most common on chromosome 7, 8, 19, 20, while corresponding major losses appeared in chromosome 8. Losses at chromosome 18 occurred in all Dukes stages. Normal colon tissue from cancer patients displayed gains in chromosome 19 and 20. Mathematical Vector analysis implied a number of BAC-clones in tumor DNA with genes of potential importance for death or survival.The genomic variation in colorectal cancer cells is tremendous and emphasizes that BAC array CGH is presently more powerful than available statistical models to discriminate DNA sequence information related to outcome. Present results suggest that a majority of DNA alterations observed in colorectal cancer are secondary to tumor progression. Therefore, it would require an immense work to distinguish primary from secondary DNA alterations behind colorectal cancer.
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| 34. |
- Larson, Mia, 1965, et al.
(författare)
-
Hållbart turismföretagande i kustsamhällen
- 2013
-
Ingår i: Framtidskuster. Hållbar utveckling i kustsamhällen. - Göteborg : Makadam Förlag. - 9789170611308 ; , s. 173-196
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 35. |
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| 36. |
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| 37. |
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| 38. |
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| 39. |
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| 40. |
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| 41. |
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| 42. |
- Larsson, Anders, 1961, et al.
(författare)
-
Bridging the knowledge gap between the old and the new : regional marine experience production in Orust, Västra Götaland, Sweden
- 2014
-
Ingår i: European Planning Studies. - : Informa UK Limited. - 0965-4313 .- 1469-5944. ; 22:8, s. 1551-1568
-
Tidskriftsartikel (refereegranskat)abstract
- Today many regions in the industrialized world have to deal with a transformation from traditional industry such as agriculture or manufacturing to service-oriented production such as tourism. Nevertheless, few studies highlight the possibilities and limitations of inter-sectoral knowledge sharing among stakeholders representing these sectors and hence there seem to be missed opportunities for mutual collaboration in the era of experience production. Using an evolutionary perspective, this article aims to analyse how the leisure boat manufacturing and the tourism sectors in the municipality of Orust on the Swedish west coast, combine knowledge from these two sectors as a way to spur innovation in experience production. The article shows how there are a number of limitations to sectoral knowledge interaction. Some of them can be linked to the conservative nature of the traditional industry, and to the immature nature of the tourism sector, others to the role of policy. However, at the same time as there being a number of obstacles for collaboration, the article reveals some interesting possibilities to form inter-sectoral knowledge sharing.
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| 43. |
- Larsson, Anders, 1961, et al.
(författare)
-
Bridging the Knowledge-gap Between the Old and the New: Regional Marine Experience Production in Orust, Västra Götaland, Sweden
- 2015
-
Ingår i: Innovation and Tourism Destination Development. - London : Routledge. - 9781138922464
-
Bokkapitel (refereegranskat)abstract
- Today many regions in the industrialized world have to deal with a transformation from traditional industry such as agriculture or manufacturing to service-oriented production such as tourism. Nevertheless, few studies highlight the possibilities and limitations of inter-sectoral knowledge sharing among stakeholders representing these sectors and hence there seem to be missed opportunities for mutual collaboration in the era of experience production. Using an evolutionary perspective, this article aims to analyse how the leisure boat manufacturing and the tourism sectors in the municipality of Orust on the Swedish west coast, combine knowledge from these two sectors as a way to spur innovation in experience production. The article shows how there are a number of limitations to sectoral knowledge interaction. Some of them can be linked to the conservative nature of the traditional industry, and to the immature nature of the tourism sector, others to the role of policy. However, at the same time as there being a number of obstacles for collaboration, the article reveals some interesting possibilities to form inter-sectoral knowledge sharing.
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| 44. |
- Latva-Somppi, Riikka, et al.
(författare)
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Entangled Materialities : Caring for soil communities at glass industry sites
- 2021
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Ingår i: FORMakademisk. - Oslo : Universitetsbiblioteket OsloMet. - 1890-9515. ; 14:2, s. 1-14
-
Tidskriftsartikel (refereegranskat)abstract
- This paper discusses craft and design practices through their impact on the environment. We consider how to act concerning the consequences of the craft and design industry. Also, we reflect on the agency of our field of practice in changing how we perceive the environment. We present three case studies of the European glass industry sites in Sweden, Italy and Finland, where we study contamination of the soil with participatory, speculative and craft methods. Through these cases, we reflect on our role in soil communities and ask how we may act in them with responsibility, hope and care. We conclude by proposing to act locally, to share our practices and make them visible, expanding our situated, personal skills and knowledge towards the political.
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| 45. |
- Laurien, Thomas, 1967, et al.
(författare)
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An Emerging Posthumanist Design Landscape
- 2022
-
Ingår i: Palgrave Handbook of Critical Posthumanism. - Cham : Palgrave Macmillan. - 9783030426811 - 9783030426811 - 9783031049576 - 9783031049583
-
Bokkapitel (refereegranskat)abstract
- A designer is somebody who points, who designates, and gives directions. Design thereby has a direction into the future. What directions are designers pointing out if design is coupled with posthumanism? Posthumanism has come into being in a landscape of both ideas and design. That which has previously been designed and produced is coming back and it can help us point out harmful inequalities if we sharpen our observational tools and concepts.“An Emerging Posthumanist Design Landscape” is an overflowing designated area for examples and thinking on compositions of design and critical posthumanism. It is a landscape in the making, yet scarred by previous design cultures and histories. As design researchers operating out of Scandinavian academia, we invite readers/travelers to meander through an emerging hybrid landscape and to make a few selected stops at the sites of our own recent design interventions. We articulate concepts, frictions, and opportunities sprouted in a sprawling and increasingly populated landscape of design and posthumanism. Posthumanist thinking questions and recharges fundamental design concepts and methods/approaches, e.g.: Who are the actors of posthumanist design? Where does it take place? What do we design? What materials do we use? How do we work? When does design take place? Why are compositions of design and critical posthumanism important undertakings? The responses to these questions sketch trajectories for further travels and the co-creation of an emerging posthumanist design landscape.
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| 46. |
- Light, Ann, et al.
(författare)
-
Designing transformative futures
- 2022
-
Konferensbidrag (refereegranskat)abstract
- What makes the design of futures sufficiently transformative? Worldwide, people are aware of the need to change and keep changing to address eco-social challenges and their fall-out in an age of crises and transitions in climate, biodiversity, and health. Calls for climate justice and the development of eco-social sensibilities speak to the need for dynamic and provisional engagements. Such concerns raise age-old issues of inequality and colonialist destruction. Our designs carry the imprint of this current politics, wittingly or unwittingly, into worlds to come. This conversa- tion asked how might we respond fluidly to coming uncertainties, questioning our own practices to sow the seeds of more radical transformation, while recognizing the structural forces that can limit or temper opportunities for design activism. It was or- ganized in three quadrant exercises, which we also reflect upon.
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| 47. |
- Lindström, Annika, et al.
(författare)
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Få ett gott djuröga med hjälp av eyetracking : en pilotstudie
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Can eyetracking as a tool be used to educate new staff at a farm?This pilot project evaluates the potential of eyetracking as a tool for training new staff on a farm in practical knowledge about animal welfare.A basic prerequisite for economically profitable animal production is healthy animals with good growth. Detecting animals in need of extra care during rounds is a challenge when there are many animals that need to be checked in a short time. The experience of the staff is an important component, but access to qualified staff is a scarce commodity. The experience of the skilled staff is rarely written down but constitutes a tacit knowledge that is very sensitive to whether staff quit or fall ill. Hiring foreign labor is becoming more common, in which case the potential to take part in the workforce's overall competence will determine how well the new workers will succeed in their tasks.By using technical tools such as eyetracking, you can record what a person is looking at in a certain environment. With this technology one could easily show and educate, e.g. staff, new employees, and students, what it is an experienced caretaker looks at when minding the animals. The technology makes it possible to visualize what an experienced caretaker is observing. In that way eyetracking has the potential to improve the working environment by streamlining the work of training new staff and getting everyone in the work team (experienced or not) to perform the tasks at the same high level as the most experienced.
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| 48. |
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| 49. |
- Lindström, Cecilia, et al.
(författare)
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Effects of Pediococcus parvulus 2.6 and its exopolysaccharide on plasma cholesterol levels and inflammatory markers in mice
- 2012
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Ingår i: AMB Express. - : Springer Science and Business Media LLC. - 2191-0855. ; 2:66
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Tidskriftsartikel (refereegranskat)abstract
- Intake of dietary fibres may reduce the prevalence of physiological risk factors of the metabolic syndrome, such as high plasma lipid levels and low-grade inflammatory state. Dietary fibres are usually of plant origin however microbial exopolysaccharides (EPSs) have analogue structures that could potentially exert similar physiological effects. Pediococcus parvulus 2.6 (Pd 2.6) excretes a ropy EPS and has previously shown probiotic potential. The aim of this work was to evaluate physiological effects of Pd 2.6 and its EPS in vivo. The live Pd 2.6 (both the ropy and non-ropy isogenic variant) and its purified EPS were fed to hypercholesterolemic LDL-receptor deficient mice for 6 weeks to investigate their effects on cholesterol levels and the inflammatory tone of the animals. Both variants of Pd 2.6 survived passage through the mouse gut fulfilling an important criterion of probiotics. The ability to produce EPS was conferring an advantage to survival (faecal recovery of 3.7 (1.9-8.7) vs. 0.21 (0.14-0.34) *108 CFU, P < 0.001, median and 25th and 75th percentiles). The ropy Pd 2.6 decreased the levels of soluble vascular cell adhesion molecule-1 compared to the EPS alone (591 ± 14 vs. 646 ± 13 ng/ml, P < 0.05). An increase in liver weight in mice fed the purified EPS was observed, but with no change in liver lipids. No changes in blood lipids were detected in any group. Further the EPS induced growth of the caecal tissue and increased the amount of caecal content showing bulking properties like that of a dietary fibre.
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| 50. |
- Lindström, Cecilia, et al.
(författare)
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Evaluation of commercial microbial hydrocolloids concerning their effects on plasma lipids and caecal formation of SCFA in mice
- 2012
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Ingår i: Food Hydrocolloids. - : Elsevier BV. - 0268-005X. ; 28:2, s. 367-372
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Tidskriftsartikel (refereegranskat)abstract
- Exopolysaccharides (EPS) are excreted by microorganisms into the surrounding environment and have been shown to have various physiological effects and are commonly used as food additives due to their rheological properties. Four commercially available microbial EPS with different polymeric structures and composition were tested in LDL receptor knock-out mice to investigate their effect on blood cholesterol, lipoproteins and caecal formation of SCFA. After four weeks on a Western diet supplemented with 4% EPS there were significant increases in caecal content and caecal tissue weight for the EPS groups compared to the control. The total pool of caecal short chain fatty acids was increased when mice were fed scleroglucan, xanthan and dextran. There were no differences in plasma cholesterol levels on the experimental diets compared to the control. Plasma triglycerides did not differ between groups. The results indicate that EPS supplementation to a Western diet may help in maintaining a healthy intestinal environment. (C) 2012 Elsevier Ltd. All rights reserved.
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