| 1. |
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| 2. |
- Michel, R., et al.
(författare)
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Excitation functions for the production of radionuclides by neutron-induced reactions on C, O, Mg, Al, Si, Fe, Co, Ni, Cu, Ag, Te, Pb, and U up to 180 MeV
- 2015
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Ingår i: Nuclear Instruments and Methods in Physics Research Section B. - : Elsevier BV. - 0168-583X .- 1872-9584. ; 343, s. 30-43
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Tidskriftsartikel (refereegranskat)abstract
- Irradiation experiments with well-characterized, quasi mono-energetic neutrons of energies between 32.7 MeV and 175.4 MeV were performed at UCL/Louvain-la-Neuve and TSL/Uppsala. The abundances of relatively short-lived residual radionuclides from 13 different target elements were determined by 7-spectrometry. More than 100 excitation functions of neutron-induced reactions were unfolded based on the neutron spectra and the radionuclide abundances with the aid of additional information that was provided by "guess" excitation functions calculated by the TALYS 1.0 code. The results are compared with the sparse existing data from other authors. The new excitation functions were validated by calculation of and comparison with experimental thick-target production rates. Consistency with neutron excitation functions up to 1.6 GeV, which were derived earlier by unfolding the thick-target production rates, was so demonstrated.
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| 8. |
- Gale, Gita, et al.
(författare)
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Does Crohn's Disease with Concomitant Orofacial Granulomatosis Represent a Distinctive Disease Subtype?
- 2016
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Ingår i: Inflammatory Bowel Diseases. - : Oxford University Press (OUP). - 1078-0998. ; 22:5, s. 1071-1077
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Tidskriftsartikel (refereegranskat)abstract
- Background: Although orofacial granulomatosis (OFG) may present as a separate clinical entity, it often seems in conjunction with various systemic diseases, of which Crohn's disease (CD) is one of the most common. The aim of this study was to investigate whether CD with concomitant OFG represents a distinctive disease subtype. Methods: Twenty-one patients with CD and concomitant OFG (CD+OFG group) were included in the study. As the reference group, a cohort of 39 patients with CD but without OFG (CD-R group) was used. Demographic data and clinical characteristics were recorded at the time of diagnosis. The 2 groups were compared using multivariate analyses. Results: The percentage of patients with intestinal inflammation in the upper gastrointestinal tract was significantly higher in the CD+OFG group, as compared with the CD-R group (81% versus 33%; P < 0.001). Furthermore, ileocolonic inflammation was significantly more common in the CD+OFG patients (81% versus 46%; P = 0.013). In addition, perianal disease was more frequently observed in the CD+OFG group (48% versus 18%; P = 0.033). Significantly more patients showed evidence of granulomas in the primary endoscopy in the CD+OFG group than in the CD-R group (81% versus 38%; P = 0.003). Conclusion: The data from this study suggest that the presence of CD in conjunction with OFG represents a distinctive subphenotype of CD that is characterized by extensive inflammation, perianal disease, and pronounced granuloma formation in the intestine.
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| 9. |
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| 10. |
- Gloris, M, et al.
(författare)
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Proton-induced production of residual radionuclides in lead at intermediate energies
- 2001
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Ingår i: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. - : ELSEVIER SCIENCE BV. ; 463:3, s. 593-633
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Recension (övrigt vetenskapligt/konstnärligt)abstract
- Integral excitation functions for the production of residual nuclides are basic quantities for the calculation of radioactive inventories of spallation targets in spallation neutron sources and in accelerator-driven devices for energy amplification or for
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| 11. |
- Husberg, Britt, et al.
(författare)
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Treatment with botulinum toxin in children with chronic anal fissure.
- 2009
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Ingår i: European journal of pediatric surgery. - : Georg Thieme Verlag KG. - 0939-7248 .- 1439-359X. ; 19:5, s. 290-292
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Chronic anal fissures with painful defecation and bloodstained stools can be seen in children of all ages. Constipation may precede or appear in connection with the symptoms. Adult patients with anal fissures have been treated successfully with the injection of botulinum toxin into both the internal and external sphincter. The effect of botulinum toxin is reversible and lasts for 3-4 months. This pilot study attempted to examine whether botulinum toxin is also effective in paediatric cases of anal fissure, a treatment which not yet has been reported in the literature.MATERIAL AND METHODS: Six boys and seven girls aged 1-10 years were treated with botulinum toxin (Botox ((R))) during 2002-2005 due to chronic anal fissure. Conventional treatment with laxatives and local anaesthetics had been unsuccessful in all cases. The treatment was given to five children under 2 years of age in a dosage of 1.25 Ux2. Eight children over 2 years of age were given 2.5 Ux2. The injections were given in the external sphincter on both sides of the fissure using EMG-stimulation for guidance and were performed under light anaesthetics (Diprivan ((R))). Follow-up was conducted at 1 and 3 months after treatment.RESULTS: Within one week, 11 of the children were free from pain and blood stained stools, according to their parent's observations. One 10-year old patient initially showed some improvement but soon experienced a recurrence. After another injection with a higher dosage 2 months later, the fissure healed. One 4-year old patient did not show any signs of improvement. The laxatives, which had been withdrawn after the injection treatment, were then reinstated. At the 3 month post-treatment examination the patient was finally symptom-free with no signs of a fissure. There were no negative side-effects detected in any of the cases. Seven recurrences were noted in 6 of the patients after 3-30 months, often in connection with an episode of constipation. Repeat injections were offered and accepted by four of these patients, once more producing good immediate results.CONCLUSION: Treatment with botulinum toxin in the external sphincter produces a quick and effective alleviation of pain with healing of chronic anal fissures in children. The treatment is not considered to carry any risks but requires light anaesthesia. Recurrences are common after the pharmacological effect has receded but can be cured with an additional injection.
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| 12. |
- Issa, Shams A. M., et al.
(författare)
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Proton-induced production of residual radionuclides in Re-nat up to 2590 MeV
- 2013
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Ingår i: Nuclear Instruments and Methods in Physics Research Section B. - : Elsevier BV. - 0168-583X .- 1872-9584. ; 298, s. 19-32
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Tidskriftsartikel (refereegranskat)abstract
- The excitation functions for residual nuclide production by proton reactions on rhenium was investigated using activated targets from irradiation experiments at the cyclotron of the Svedberg Laboratory at Uppsala up to 180 MeV and the higher energies were used at the Laboratoire Saturne at Saclay. The measured experimental results were compared with previous published and theoretical models calculations by the codes TALYS, INCL4 + ABLA and Bertini/Dresner. A total of 5252 cross-section was determined covering 54 residual nuclides in the energy range from 78.2 to 2590 MeV.
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| 13. |
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| 14. |
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| 15. |
- Katritsis, Demosthenes G, et al.
(författare)
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Executive Summary : European Heart Rhythm Association Consensus Document on the Management of Supraventricular Arrhythmias
- 2016
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Ingår i: Arrhythmia & electrophysiology review. - 2050-3369. ; 5:3, s. 210-224
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Tidskriftsartikel (refereegranskat)abstract
- This paper is an executive summary of the full European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, published in Europace. It summarises developments in the field and provides recommendations for patient management, with particular emphasis on new advances since the previous European Society of Cardiology guidelines. The EHRA consensus document is available to read in full at http://europace.oxfordjournals.org.
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| 16. |
- Laycock Pedersen, Rebecca, et al.
(författare)
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Distinguishing transdisciplinary (and) action research in sustainability science : a comparative systematic-narrative hybrid literature review
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- There are many socially engaged research modes in sustainability science. The main ones are action research and transdisciplinary research. There is also transdisciplinary action research, a field that seems to combine the two. This paper aims to provide a better understanding of the differences between these research modes in the context of sustainability science to help potential users to determine appropriate research mode(s) to fulfil their purposes. To do so, we asked three research questions: (i) What are the aims of these research modes? (ii) What are some methods used to fulfil the aims of these research modes? (iii) In what empirical domain are the different approaches being used today? Using a comparative systematic-narrative hybrid literature review and bibliometric studies the paper attempts to fulfil the set aim. In total, we analysed 1487 articles in-depth, of which 633 utilised the action research mode, 787 used transdisciplinary research, and 67 used transdisciplinary action research. There are a lot of similarities between the research modes, e.g. they all use traditional qualitative social science research methods, engage the same types of stakeholders, and address the same sustainability issues. But the differences relate to the aims of the research modes. Researchers employing action research seem to be more intent on achieving action in the practice domain and knowledge from that action for both practitioners and researchers (action-for-knowledge). In contrast, researchers employing transdisciplinary research rather seem to be more intent on producing new, relevant and shared knowledge for an action that is later undertaken in the practice domain (knowledge-for-action). Although this might be a premature conclusion, researchers employing transdisciplinary action research seem to be more intent on achieving action based on integrative knowledge (integrative knowledge-for-action). Finally, some advice regarding the choice of research mode for a particular purpose is presented.
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| 17. |
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| 19. |
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| 20. |
- Malmborg, J., et al.
(författare)
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Effects of modeling strategies for a slab track on predicted ground vibrations
- 2020
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Ingår i: Soil Dynamics and Earthquake Engineering. - : Elsevier BV. - 0267-7261. ; 136
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Tidskriftsartikel (refereegranskat)abstract
- In the paper, the effect of modeling strategies regarding the dynamic behavior of a railway slab track on a layered half-space is studied. The track is modeled with various degrees of accuracy through the use of either beam theory, shell finite elements or solid finite elements. The underlying soil response is included through a dynamic stiffness, obtained via the Green's function for a horizontally layered visco-elastic half-space in the frequency–wavenumber domain. The effect of different assumptions regarding the track cross-section behavior and the track–soil interface conditions on the resulting free-field vibrations are studied for a harmonic load moving along the track. First, only the out-of-plane displacements of the slab–soil interface are coupled, i.e. only the vertical contact pressure is accounted for. Secondly, the effect of coupling the slab–soil in-plane displacements on the free-field vibrations is studied. It is found that the in-plane slab–soil coupling significantly affects the vertical vibration in the free-field. It is also found that a beam model of the track yields accurate response levels compared to a solid continuum model in the case of a thick slab, whereas considerable differences are obtained for a thin slab.
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| 21. |
- Malmborg, J., et al.
(författare)
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Evaluating the effect of vibration isolation mats on train-induced ground vibrations
- 2019. - 1
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Ingår i: Advances in Engineering Materials, Structures and Systems : Innovations, Mechanics and Applications - Proceedings of the 7th International Conference on Structural Engineering, Mechanics and Computation, 2019 - Innovations, Mechanics and Applications - Proceedings of the 7th International Conference on Structural Engineering, Mechanics and Computation, 2019. - : CRC Press. - 9781138386969 - 9780429426506 ; , s. 85-90
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Konferensbidrag (refereegranskat)abstract
- In the present paper, the effectiveness of a vibration isolation mat for a railway slab track system is studied using a finite element model of the railway track. The finite elements are formulated in a moving frame of reference following the moving load at a particular speed. The rails are modeled using Bernoulli beams, whereas the track slab and an underlying supporting plate are modeled using Kirchhoff plate elements. The vibration isolation mat is modeled as a continuous visco-elastic layer between the track slab and the supporting plate. The response of the underlying soil is represented through a dynamic stiffness matrix, obtained via the Green’s function for a horizontally layered visco-elastic strata in a moving frame of reference in the frequency– wavenumber domain. The model accounts for the quasi-static excitation caused by the static axle loads of a vehicle, as well as the dynamic excitation caused by the vehicle running over an uneven rail. The free-field response and the insertion loss obtained with the vibration isolation mat is first evaluated for a harmonic load moving along the track. Band-averaged vibration levels and the insertion loss for a fixed point next to the track are then calculated for a train cart, represented by a 10 degree-of-freedom multi-body system, running at different speeds.
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| 22. |
- Malmborg, J., et al.
(författare)
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Modeling train-induced ground-borne vibrations using FEM in a moving frame of reference
- 2019
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Ingår i: COMPDYN 2019 - 7th International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering, Proceedings. - Athens : Institute of Structural Analysis and Antiseismic Research School of Civil Engineering National Technical University of Athens (NTUA) Greece. - 2623-3347. - 9786188284456 ; 3, s. 5899-5912
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Konferensbidrag (refereegranskat)abstract
- To predict ground-borne vibration levels caused by railway traffic, models for estimating the load from the vibration source, as well as the vibration transmission through the ground, are needed. In the present paper, a finite element formulation in a frame of reference following the moving load, is used for modeling a railway slab track. The response of the underlying soil is represented through a dynamic stiffness matrix, obtained via the Green’s function for a horizontally layered visco-elastic half-space in a moving frame of reference in the frequency–wavenumber domain. The track can be modeled as continuously connected beams, but the use of plate elements allows for more general stress and displacement distributions in the transverse direction of the slab to be resolved. Here, the free-field response due to a harmonic load moving along a slab track, is evaluated and compared using different modeling strategies for the slab.
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| 23. |
- Malmborg, J., et al.
(författare)
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Numerical investigation of railway subgrade stiffening : Critical speed and free-field vibrations
- 2022
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Ingår i: Transportation Geotechnics. - : Elsevier BV. - 2214-3912. ; 34
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Tidskriftsartikel (refereegranskat)abstract
- For a train speed close to the speed of elastic waves in the soil, often referred to as “critical speed”, largely elevated vibration responses occur. This can be a practical problem for soft soil sites, where the phenomenon may cause excessive vibrations in the track and also at distances far from the track. To ensure the running safety of the train, the long-term quality of the track and to reduce the vibrations in the surroundings, such effects must be avoided. An effective counter-measure is to increase the stiffness of the soil underneath the track, thereby increasing the critical velocity. In this paper, a 2.5D finite element model is used for studying the critical velocity phenomenon and its mitigation through soil stiffening, for a ballasted track on a layered half-space with very soft soil. Soil improvement under the track, in the shape of a solid block or as various number of panels, with varying depth and stiffness is considered. The effect of the soil improvement is evaluated both in terms of the maximum rail and free-field displacements. It is shown that a shallow soil stiffening increases the critical velocity and reduces the rail and free-field response for load speeds near the shear wave velocity of the soft top soil layer. It is also demonstrated that a deep soil stiffening, by use of panels along the track direction, increases the critical velocity further, and may also be efficient in reducing the response for load speeds near the shear wave speed of the underlying half-space.
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| 24. |
- Malmborg, J., et al.
(författare)
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Numerical study on train-induced vibrations : A comparison of timber and concrete buildings
- 2024
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Ingår i: Structures. - 2352-0124. ; 62
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Tidskriftsartikel (refereegranskat)abstract
- This paper deals with the prediction of train-induced building vibrations by using a numerical framework. The framework is based on a sub-structure approach, where a sequence of different models are used. The free-field ground vibrations and the track receptance are calculated using 2.5D technique where the railway track is represented by finite elements that couple to a dynamic stiffness of the underlying soil, which in turn is obtained from the Green's function of a horizontally layered half-space using a layer transfer matrix approach. A planar multi-body model of the train, coupled to the track receptance, is used for calculating the train–track interaction forces as the train runs over an uneven rail. Finally, the building response to the incident wavefield is calculated using a 3D finite element model, accounting for the soil dynamic stiffness. The framework is used to evaluate the vibrations in two buildings with identical layout, one lightweight wooden building and one heavyweight concrete building, due to a passenger train passing by at two different speeds. It was found that the difference in response between the two buildings were small. Compared to the incident wavefield, an amplification of the response inside the building was found in frequency bands around the fundamental natural frequencies of the slabs; however for higher frequencies and in terms of the 1 s running RMS velocity the building response was reduced. Further, it was found that accounting for soil-structure-interaction, as opposed to simply enforcing the free-field displacements at the building foundations, significantly reduced the building response in terms of 1 s RMS velocity.
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| 27. |
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| 29. |
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| 30. |
- Malmquist, Marianne, 1961, et al.
(författare)
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Frequent Occurrence of Perianal Disease and Granuloma Formation in Patients with Crohn's Disease and Coexistent Orofacial Granulomatosis
- 2023
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Ingår i: Digestive Diseases and Sciences. - : Springer Science and Business Media LLC. - 0163-2116 .- 1573-2568. ; 68:7, s. 3129-3138
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundOrofacial granulomatosis (OFG) is an inflammatory disorder of the perioral region and oral cavity. Crohn's disease (CD) in conjunction with OFG (CD-OFG), has been suggested to constitute a phenotype of CD with distinct features at diagnosis.AimsThe aim of this project was to investigate whether the distinct phenotypic features of CD-OFG persist in the years following the initial diagnosis of CD.MethodsClinical data were extracted from medical records covering the first 5 years post-diagnosis for a cohort of patients with CD-OFG, and were compared to those of references with CD without OFG.ResultsThe clinical characteristics of our cohort of patients with CD-OFG (N = 25) were evaluated in comparison to references with CD without OFG (ratio 1:2). Five years post-diagnosis, more patients with CD-OFG had a phenotype with perianal disease (cumulative incidence: 16/25, 64% vs 13/50, 26%, P = 0.002) and intestinal granulomas (cumulative incidence: 22/25, 88% vs 24/50, 48%, P = 0.0009) than patients in the CD reference group. The patients with CD-OFG were also more likely to have undergone perianal surgery (12/25, 48% vs 4/50, 8%, P = 0.0002). At the end of the observation period, more of the patients with CD-OFG were receiving combination therapy, i.e., immunomodulators and tumor necrosis factor antagonists, than those in the CD reference group (9/25, 36% vs 5/50, 10%, P = 0.01).ConclusionThe results support the notion that CD in conjunction with OFG represents a specific phenotype of CD that is characterized by frequent perianal disease, pronounced intestinal granuloma formation and a need for extensive therapy.
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| 31. |
- Michel, R, et al.
(författare)
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Cross sections for the production of residual nuclides by low- and medium-energy protons from the target elements C, N, O, Mg, Al, Si, Ca, Ti, V, Mn, Fe, Co, Ni, Cu, Sr, Y, Zr, Nb, Ba and Au
- 1997
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Ingår i: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS. - : ELSEVIER SCIENCE BV. ; 129:2, s. 153-193
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Recension (övrigt vetenskapligt/konstnärligt)abstract
- Cross sections for residual nuclide production by p-induced reactions were measured from thresholds up to 2.6 GeV using accelerators at CERN/Geneve, IPN/Orsay, KFA/Julich, LANL/Los Alamos, LNS/Saclay, PSI/Villigen, TSL/Uppsala, LUC/Louvain La Neuve. The t
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| 32. |
- Mouratidou, N., et al.
(författare)
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Identification of Childhood-Onset Inflammatory Bowel Disease in Swedish Healthcare Registers: A Validation Study
- 2022
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Ingår i: CLINICAL EPIDEMIOLOGY. - 1179-1349. ; 14, s. 591-600
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The Swedish National Patient Register (NPR) is often used in observational studies of childhood-onset inflammatory bowel disease (IBD) (<18 years of age) and its subtypes, but the validity of previously used register-based algorithms for capturing childhood-onset IBD has never been examined. Methods: We identified a random sample of 233 individuals with at least two first ever diagnostic listings of IBD in the NPR between 2002 and 2014. We calculated the test characteristics for different register-based definitions of IBD and its subtypes using the Copenhagen criteria and the revised Porto criteria as gold standard, both based on medical chart review. We made assumptions of the occurrence of undiagnosed IBD in the general child population based on available literature. Results: Out of 233 individuals with at least two diagnostic listings of IBD, 216 had true IBD, resulting in a positive predictive value (PPV) = 93% (95% confidence interval (CI) 89-96), sensitivity = 88% (95% CI 83-92), specificity = 100% (95% CI 100-100), and negative predictive value (NPV) = 100% (95% CI 100-100). The PPV for the NPR-based definitions of IBD subtypes at time of first IBD diagnosis and at end of follow-up were 78% (95% CI 69-86) and 88% (95% CI 80-94), respectively, for Crohn's disease and 74% (95% CI 63-83) and 71% (95% CI 60-80), respectively, for ulcerative colitis. Conclusion: The validity of register-based definitions of childhood-onset IBD in the Swedish NPR is high and can be used to identify patients in observational research.
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| 35. |
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| 36. |
- Strachan, P.A., et al.
(författare)
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The evolving UK wind energy industry : Critical policy and management aspects of the emerging research agenda
- 2006
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Ingår i: European Environment. - : Wiley. - 0961-0405 .- 1099-0976. ; 16:1
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Tidskriftsartikel (refereegranskat)abstract
- In recent years, renewable energy - and in particular wind power - has come to the fore of both international and UK national environmental policy debates. In addition to helping to meet its Kyoto obligations, the British Government has indicated its desire For a much larger slice of the international wind energy market, and has consequently developed a national strategy to stimulate a more vibrant UK wind energy industry. With this in mind, the British Government's Climate Change Programme (DETR, 2000) and more recent Energy White Paper (DTI, 2003) outline the UK energy strategy for the coming two decades, with wind power featuring as a core component. This article critically considers the prospects for the development of a wind energy industry in the UK and introduces five strategic opportunities and five strategic barriers in this evolving segment of the energy market. The article concludes with recommendations to enhance public acceptance of wind energy and four important areas for future research are outlined. Copyright © 2006 John Wiley & Sons, Ltd and ERP Environment.
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| 39. |
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| 40. |
- Tjernberg, A. R., et al.
(författare)
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Coronavirus disease 2019 and gastrointestinal disorders in children
- 2023
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Ingår i: Therapeutic Advances in Gastroenterology. - 1756-283X. ; 16
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Tidskriftsartikel (refereegranskat)abstract
- During the past 3 years, the coronavirus disease 2019 (COVID-19) pandemic has had a great impact on people all over the world. However, it has become evident that disease manifestations and severity differ across age groups. Most children have a milder disease course than adults but possibly more pronounced gastrointestinal (GI) symptoms. Given the child's developing immune system, the impact of COVID-19 on disease development may differ compared to adults. This study reviews the potential bi-directional relationship between COVID-19 and GI diseases in children, focusing on common pediatric conditions such as functional GI disorders (FGID), celiac disease (CeD), and inflammatory bowel disease (IBD). Children with GI diseases, in general, and CeD and IBD, in particular, do not seem to have an increased risk of severe COVID-19, including risks of hospitalization, critical care need, and death. While infections are considered candidate environmental factors in both CeD and IBD pathogenesis, and specific infectious agents are known triggers for FGID, there is still not sufficient evidence to implicate COVID-19 in the development of either of these diseases. However, given the scarcity of data and the possible latency period between environmental triggers and disease development, future investigations in this field are warranted.
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| 41. |
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| 42. |
- Varnäs, K., et al.
(författare)
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Integrated strategy for use of positron emission tomography in nonhuman primates to confirm multitarget occupancy of novel psychotropic drugs : An example with AZD3676
- 2016
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Ingår i: Journal of Pharmacology and Experimental Therapeutics. - : American Society for Pharmacology and Experimental Therapy. - 0022-3565 .- 1521-0103. ; 358:3, s. 464-471
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Tidskriftsartikel (refereegranskat)abstract
- Positron emission tomography (PET) is widely applied in central nervous system (CNS) drug development for assessment of target engagement in vivo. As the majority of PET investigations have addressed drug interaction at a single binding site, findings of multitarget engagement have been less frequently reported and have often been inconsistent with results obtained in vitro. AZD3676 [N,N-dimethyl-7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl) benzofuran-2-carboxamide] is a novel combined serotonin (5- hydroxytryptamine) 5-HT1A and 5-HT1B receptor antagonist that was developed for the treatment of cognitive impairment in Alzheimer's disease. Here, we evaluated the properties of AZD3676 as a CNS drug by combining in vitro and ex vivo radioligand binding techniques, behavioral pharmacology in rodents, and PET imaging in nonhuman primates. Target engagement in the nonhuman primate brain was assessed in PET studies by determination of drug-induced occupancy using receptorselective radioligands. AZD3676 showed preclinical properties consistent with CNS drug potential, including nanomolar receptor affinity and efficacy in rodent models of learning and memory. In PET studies of the monkey brain, AZD3676 inhibited radioligand binding in a dose-dependent manner with similar affinity at both receptors. The equally high affinity at 5-HT1A and 5-HT1B receptors as determined in vivo was not predicted from corresponding estimates obtained in vitro, suggestingmore than 10-fold selectivity for 5-HT1A versus 5-HT1B receptors. These findings support the further integrated use of PET for confirmation of multitarget occupancy of CNS drugs. Importantly, earlier introduction of PET studies in nonhuman primates may reduce future development costs and the requirement for animal experiments in preclinical CNS drug development programs.
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| 43. |
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| 44. |
- von Malmborg, Fredrik, et al.
(författare)
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Climate policy, ecological modernization and the UK emission trading scheme
- 2005
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Ingår i: European Environment. - : Wiley. - 0961-0405 .- 1099-0976. ; 15:3, s. 143-160
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Tidskriftsartikel (refereegranskat)abstract
- Since the election of the Labour government in 1997, leading to a flurry of policy documents utilizing ecological modernization language, the UK has seen a steady growth in the use of new environmental policy instruments, with the British government having launched in 2002 the world's first national economy-wide emission trading scheme for greenhouse gases. Among other things, the UK Emissions Trading Scheme aims at stimulating a transition of the UK towards a low-carbon economy. Reporting findings of a recent survey of those 31 organizations participating directly in the scheme, this article critically examines the effectiveness of the scheme as an instrument in climate policy and ecological modernization. The study reveals a number of issues that appear to have been 'glossed over' by recent Government reports, and questions whether the UK ETS and climate policy in practice are vehicles for ecological modernization. Copyright © 2005 John Wiley & Sons, Ltd and ERP Environment.
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