| 1. |
- Blaschikoff, Ludmilla, et al.
(author)
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A multidisciplinary study of Iberian Chalcolithic dogs
- 2022
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In: Journal of Archaeological Science. - : Elsevier BV. - 2352-409X .- 2352-4103. ; 42
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Journal article (peer-reviewed)abstract
- Domesticated dogs have been present in the Iberian Peninsula long before other domesticated species, back to the late Palaeolithic period. Their origin is still uncertain, but dogs were already well established during the Chalcolithic period (ca. 5000-4000 BP). This study employed a multidisciplinary approach comprising osteometric, radiographic and palaeogenomic analyses to characterize Chalcolithic Iberian Canis remains. Two Chalcolithic archaeological sites - Leceia, Oeiras, in Portugal, and El Caset ' on de la Era, Villalba de los Alcores, Valladolid, in Spain - were the main focus of this study. Osteometric and odontometric data from eleven other sites in Iberia were also included. Osteometric results show signs of phenotypic variability, likely the result of human-driven selective pressure. Dental radiographic and dental wear analyses allowed age at death estimation for four individuals (two juvenile and two adults). Three Chalcolithic Iberian dogs had their mitogenomes resequenced and the mitochondrial DNA analysis allowed to assign each individual to two of the major known haplogroups - A and C. Molecular sex infered by the chromosomeX/chromosome1 coverage ratio allowed to identify one female and two males. This study unveils some aspects of the Iberian Chalcolithic dogs: these dogs already exhibited various morphotypes whose profiles might be associated to the performance of certain tasks, as well as mitogenomes of two distinct lineages that help tracking the evolutionary paths of Iberian dogs.
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| 2. |
- Kehoe, Laura, et al.
(author)
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Make EU trade with Brazil sustainable
- 2019
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Journal article (other academic/artistic)
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| 3. |
- Kifokeris, Dimosthenis, 1988, et al.
(author)
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Bridge quality appraisal methodology: application in a reinforced concrete overpass roadway bridge
- 2018
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In: Journal of Infrastructure Systems. - 1076-0342. ; 24:4
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Journal article (peer-reviewed)abstract
- Bridge quality control plans and asset management systems are often integrated in collective frameworks used by authorities nationally and internationally. Similarities among these frameworks include the utilization of performance indicators for quality appraisal. However, there are discrepancies in the ways such frameworks are researched, developed, and applied. Additionally, there are problematic aspects even in their common characteristics, like the relative absence of correlation between observed performance indicator values and benchmarked ones, and the deliverables’ disparity due to the diversity of the quantified indicator variables. For the alleviation of such problematic aspects, this paper presents a bridge quality appraisal methodological and computational framework. It builds on (1) the adaptation of the sustainable building methodology and its combination with expert input solicitation methods and the research findings of the European Cooperation in Science & Technology (COST) Action TU1406, and (2) a multi-input adaptation of the analytical hierarchy process. The methodology is presented in terms of its general procedural steps and calculating requirements, and then it is tailored to reinforced concrete overpass roadway bridges. The methodology’s application in a real case study concludes the presented research.
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| 4. |
- Kifokeris, Dimosthenis, 1988, et al.
(author)
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Bridge quality appraisal methodology: application in the Strimonas Bridge. Case study.
- 2018
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In: Baltic Journal of Road and Bridge Engineering. - : Riga Technical University. - 1822-4288 .- 1822-427X. ; 13:3, s. 331-343
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Journal article (peer-reviewed)abstract
- In the current utilization of Performance Indicators for bridge Quality Control, there is no correlation between observed and benchmarked Performance Indicator values, and an ambiguity of deliverables due to the diverse nature of Performance Indicators. For the alleviation of those above, this paper presents a methodology that appraises the quality of bridges. This methodology builds on the adaptation of the Sustainable Building Method and its combination with expert input solicitation methods and the research findings of COST Action TU1406. In addition, it features an adaptation of the Analytical Hierarchy Process. The methodology is presented regarding its general procedural steps and calculating requirements, and then it is tailored to the case study of Strimonas Bridge in Greece.
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| 5. |
- Pocas, Juliana, et al.
(author)
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Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival
- 2023
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences (PNAS). - 0027-8424 .- 1091-6490. ; 120:20
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Journal article (peer-reviewed)abstract
- Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a transmembrane pro-teoglycan, is highly expressed in intestinal subtype gastric tumors and that this sig -nature associates with patient poor survival. Further, we mechanistically demonstrate that SDC4 is a master regulator of gastric cancer cell motility and invasion. We also find that SDC4 decorated with heparan sulfate is efficiently sorted in extracellular vesicles (EVs). Interestingly, SDC4 in EVs regulates gastric cancer cell-derived EV organ distribution, uptake, and functional effects in recipient cells. Specifically, we show that SDC4 knockout disrupts the tropism of EVs for the common gastric cancer metastatic sites. Our findings set the basis for the molecular implications of SDC4 expression in gastric cancer cells and provide broader perspectives on the development of therapeutic strategies targeting the glycan-EV axis to limit tumor progression.
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| 6. |
- Proletov, Ian, et al.
(author)
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Primary and secondary glomerulonephritides 1.
- 2014
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In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - : Oxford University Press (OUP). - 1460-2385. ; 29 Suppl 3:May, s. 186-200
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Journal article (peer-reviewed)
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