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Sökning: WFRF:(Nicholas Kimberly)

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1.
  • Dudding, Tom, et al. (författare)
  • Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci
  • 2019
  • Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 10, s. 1-12
  • Tidskriftsartikel (refereegranskat)abstract
    • Mouth ulcers are the most common ulcerative condition and encompass several clinical diagnoses, including recurrent aphthous stomatitis (RAS). Despite previous evidence for heritability, it is not clear which specific genetic loci are implicated in RAS. In this genome-wide association study (n = 461,106) heritability is estimated at 8.2% (95% CI: 6.4%, 9.9%). This study finds 97 variants which alter the odds of developing non-specific mouth ulcers and replicate these in an independent cohort (n = 355,744) (lead variant after meta-analysis: rs76830965, near IL12A, OR 0.72 (95% CI: 0.71, 0.73); P = 4.4e-483). Additional effect estimates from three independent cohorts with more specific phenotyping and specific study characteristics support many of these findings. In silico functional analyses provide evidence for a role of T cell regulation in the aetiology of mouth ulcers. These results provide novel insight into the pathogenesis of a common, important condition.
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3.
  • Vos, Theo, et al. (författare)
  • Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
  • 2015
  • Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 386:9995, s. 743-800
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2.4 billion and 1.6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537.6 million in 1990 to 764.8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114.87 per 1000 people to 110.31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21.1% in 1990 to 31.2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
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4.
  • Abazajian, Kevork, et al. (författare)
  • CMB-S4 : Forecasting Constraints on Primordial Gravitational Waves
  • 2022
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 926:1
  • Tidskriftsartikel (refereegranskat)abstract
    • CMB-S4—the next-generation ground-based cosmic microwave background (CMB) experiment—is set to significantly advance the sensitivity of CMB measurements and enhance our understanding of the origin and evolution of the universe. Among the science cases pursued with CMB-S4, the quest for detecting primordial gravitational waves is a central driver of the experimental design. This work details the development of a forecasting framework that includes a power-spectrum-based semianalytic projection tool, targeted explicitly toward optimizing constraints on the tensor-to-scalar ratio, r, in the presence of Galactic foregrounds and gravitational lensing of the CMB. This framework is unique in its direct use of information from the achieved performance of current Stage 2–3 CMB experiments to robustly forecast the science reach of upcoming CMB-polarization endeavors. The methodology allows for rapid iteration over experimental configurations and offers a flexible way to optimize the design of future experiments, given a desired scientific goal. To form a closed-loop process, we couple this semianalytic tool with map-based validation studies, which allow for the injection of additional complexity and verification of our forecasts with several independent analysis methods. We document multiple rounds of forecasts for CMB-S4 using this process and the resulting establishment of the current reference design of the primordial gravitational-wave component of the Stage-4 experiment, optimized to achieve our science goals of detecting primordial gravitational waves for r > 0.003 at greater than 5σ, or in the absence of a detection, of reaching an upper limit of r < 0.001 at 95% CL.
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5.
  • Ebersole, Charles R., et al. (författare)
  • Many Labs 5: Testing Pre-Data-Collection Peer Review as an Intervention to Increase Replicability
  • 2020
  • Ingår i: Advances in Methods and Practices in Psychological Science. - : Sage. - 2515-2467 .- 2515-2459. ; 3:3, s. 309-331
  • Tidskriftsartikel (refereegranskat)abstract
    • Replication studies in psychological science sometimes fail to reproduce prior findings. If these studies use methods that are unfaithful to the original study or ineffective in eliciting the phenomenon of interest, then a failure to replicate may be a failure of the protocol rather than a challenge to the original finding. Formal pre-data-collection peer review by experts may address shortcomings and increase replicability rates. We selected 10 replication studies from the Reproducibility Project: Psychology (RP:P; Open Science Collaboration, 2015) for which the original authors had expressed concerns about the replication designs before data collection; only one of these studies had yielded a statistically significant effect (p < .05). Commenters suggested that lack of adherence to expert review and low-powered tests were the reasons that most of these RP:P studies failed to replicate the original effects. We revised the replication protocols and received formal peer review prior to conducting new replication studies. We administered the RP:P and revised protocols in multiple laboratories (median number of laboratories per original study = 6.5, range = 3-9; median total sample = 1,279.5, range = 276-3,512) for high-powered tests of each original finding with both protocols. Overall, following the preregistered analysis plan, we found that the revised protocols produced effect sizes similar to those of the RP:P protocols (Delta r = .002 or .014, depending on analytic approach). The median effect size for the revised protocols (r = .05) was similar to that of the RP:P protocols (r = .04) and the original RP:P replications (r = .11), and smaller than that of the original studies (r = .37). Analysis of the cumulative evidence across the original studies and the corresponding three replication attempts provided very precise estimates of the 10 tested effects and indicated that their effect sizes (median r = .07, range = .00-.15) were 78% smaller, on average, than the original effect sizes (median r = .37, range = .19-.50).
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6.
  • Fresard, Laure, et al. (författare)
  • Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts
  • 2019
  • Ingår i: Nature Medicine. - : NATURE PUBLISHING GROUP. - 1078-8956 .- 1546-170X. ; 25:6, s. 911-919
  • Tidskriftsartikel (refereegranskat)abstract
    • It is estimated that 350 million individuals worldwide suffer from rare diseases, which are predominantly caused by mutation in a single gene(1). The current molecular diagnostic rate is estimated at 50%, with whole-exome sequencing (WES) among the most successful approaches(2-5). For patients in whom WES is uninformative, RNA sequencing (RNA-seq) has shown diagnostic utility in specific tissues and diseases(6-8). This includes muscle biopsies from patients with undiagnosed rare muscle disorders(6,9), and cultured fibroblasts from patients with mitochondrial disorders(7). However, for many individuals, biopsies are not performed for clinical care, and tissues are difficult to access. We sought to assess the utility of RNA-seq from blood as a diagnostic tool for rare diseases of different pathophysiologies. We generated whole-blood RNA-seq from 94 individuals with undiagnosed rare diseases spanning 16 diverse disease categories. We developed a robust approach to compare data from these individuals with large sets of RNA-seq data for controls (n = 1,594 unrelated controls and n = 49 family members) and demonstrated the impacts of expression, splicing, gene and variant filtering strategies on disease gene identification. Across our cohort, we observed that RNA-seq yields a 7.5% diagnostic rate, and an additional 16.7% with improved candidate gene resolution.
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7.
  • Lakens, Daniel, et al. (författare)
  • Justify your alpha
  • 2018
  • Ingår i: Nature Human Behaviour. - : Nature Publishing Group. - 2397-3374. ; 2:3, s. 168-171
  • Tidskriftsartikel (refereegranskat)abstract
    • In response to recommendations to redefine statistical significance to P ≤ 0.005, we propose that researchers should transparently report and justify all choices they make when designing a study, including the alpha level.
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8.
  • Magliocca, Nicholas R., et al. (författare)
  • From meta-studies to modeling: Using synthesis knowledge to build broadly applicable process-based land change models
  • 2015
  • Ingår i: Environmental Modelling & Software. - : Elsevier BV. - 1364-8152. ; 72, s. 10-20
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper explores how meta-studies can support the development of process-based land change models (LCMs) that can be applied across locations and scales. We describe a multi-step framework for model development and provide descriptions and examples of how meta-studies can be used in each step. We conclude that meta-studies best support the conceptualization and experimentation phases of the model development cycle, but cannot typically provide full model parameterizations. Moreover, meta-studies are particularly useful for developing agent-based LCMs that can be applied across a wide range of contexts, locations, and/or scales, because meta-studies provide both quantitative and qualitative data needed to derive agent behaviors more readily than from case study or aggregate data sources alone. Recent land change synthesis studies provide sufficient topical breadth and depth to support the development of broadly applicable process-based LCMs, as well as the potential to accelerate the production of generalized knowledge through model-driven synthesis. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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9.
  • Purcell, Shaun M., et al. (författare)
  • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
  • 2009
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 460:7256, s. 748-752
  • Tidskriftsartikel (refereegranskat)abstract
    • Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%(1,2). We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases.
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10.
  • Sha, Mahesh Kumar, et al. (författare)
  • Validation of methane and carbon monoxide from Sentinel-5 Precursor using TCCON and NDACC-IRWG stations
  • 2021
  • Ingår i: Atmospheric Measurement Techniques. - : Copernicus GmbH. - 1867-1381 .- 1867-8548. ; 14:9, s. 6249-6304
  • Tidskriftsartikel (refereegranskat)abstract
    • The Sentinel-5 Precursor (S5P) mission with the TROPOspheric Monitoring Instrument (TROPOMI) on board has been measuring solar radiation backscattered by the Earth's atmosphere and surface since its launch on 13 October 2017. In this paper, we present for the first time the S5P operational methane (CH4) and carbon monoxide (CO) products' validation results covering a period of about 3 years using global Total Carbon Column Observing Network (TCCON) and Infrared Working Group of the Network for the Detection of Atmospheric Composition Change (NDACC-IRWG) network data, accounting for a priori alignment and smoothing uncertainties in the validation, and testing the sensitivity of validation results towards the application of advanced co-location criteria. We found that the S5P standard and bias-corrected CH4 data over land surface for the recommended quality filtering fulfil the mission requirements. The systematic difference of the bias-corrected total column-averaged dry air mole fraction of methane (XCH4) data with respect to TCCON data is -0.26 +/- 0.56 % in comparison to -0.68 +/- 0.74 % for the standard XCH4 data, with a correlation of 0.6 for most stations. The bias shows a seasonal dependence. We found that the S5P CO data over all surfaces for the recommended quality filtering generally fulfil the missions requirements, with a few exceptions, which are mostly due to co-location mismatches and limited availability of data. The systematic difference between the S5P total column-averaged dry air mole fraction of carbon monoxide (XCO) and the TCCON data is on average 9.22 +/- 3.45 % (standard TCCON XCO) and 2.45 +/- 3.38 % (unscaled TCCON XCO). We found that the systematic difference between the S5P CO column and NDACC CO column (excluding two outlier stations) is on average 6.5 +/- 3.54 %. We found a correlation of above 0.9 for most TCCON and NDACC stations. The study shows the high quality of S5P CH4 and CO data by validating the products against reference global TCCON and NDACC stations covering a wide range of latitudinal bands, atmospheric conditions and surface conditions.
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11.
  • 2019
  • Tidskriftsartikel (refereegranskat)
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12.
  • Ahlberg, Erik, et al. (författare)
  • "Vi klimatforskare stödjer Greta och skolungdomarna"
  • 2019
  • Ingår i: Dagens nyheter (DN debatt). - 1101-2447.
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • DN DEBATT 15/3. Sedan industrialiseringens början har vi använt omkring fyra femtedelar av den mängd fossilt kol som får förbrännas för att vi ska klara Parisavtalet. Vi har bara en femtedel kvar och det är bråttom att kraftigt reducera utsläppen. Det har Greta Thunberg och de strejkande ungdomarna förstått. Därför stödjer vi deras krav, skriver 270 klimatforskare.
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13.
  • Barredo, José I., et al. (författare)
  • Mapping and assessment of forest ecosystems and their services : Applications and guidance for decision making in the framework of MAES
  • 2015
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • The aim of this report is to illustrate by means of a series of case studies the implementation of mapping and assessment of forest ecosystem services in different contexts and geographical levels. Methodological aspects, data issues, approaches, limitations, gaps and further steps for improvement are analysed for providing good practices and decision making guidance. The EU initiative on Mappingand Assessment of Ecosystems and their Services (MAES), with the support of all Member States, contributes to improve the knowledge on ecosystem services. MAES is one of the building-block initiatives supporting the EU Biodiversity Strategy to 2020.
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14.
  • Bennett, Elena M., et al. (författare)
  • Bright spots : seeds of a good Anthropocene
  • 2016
  • Ingår i: Frontiers in Ecology and the Environment. - : Wiley. - 1540-9295 .- 1540-9309. ; 14:8, s. 441-448
  • Tidskriftsartikel (refereegranskat)abstract
    • The scale, rate, and intensity of humans' environmental impact has engendered broad discussion about how to find plausible pathways of development that hold the most promise for fostering a better future in the Anthropocene. However, the dominance of dystopian visions of irreversible environmental degradation and societal collapse, along with overly optimistic utopias and business-as-usual scenarios that lack insight and innovation, frustrate progress. Here, we present a novel approach to thinking about the future that builds on experiences drawn from a diversity of practices, worldviews, values, and regions that could accelerate the adoption of pathways to transformative change (change that goes beyond incremental improvements). Using an analysis of 100 initiatives, or seeds of a good Anthropocene, we find that emphasizing hopeful elements of existing practice offers the opportunity to: (1) understand the values and features that constitute a good Anthropocene, (2) determine the processes that lead to the emergence and growth of initiatives that fundamentally change human-environmental relationships, and (3) generate creative, bottom-up scenarios that feature well-articulated pathways toward a more positive future.
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15.
  • Berdan, Emma L, 1983, et al. (författare)
  • How chromosomal inversions reorient the evolutionary process
  • 2023
  • Ingår i: Journal of Evolutionary Biology. - 1010-061X .- 1420-9101. ; 36:12, s. 1761-1782
  • Forskningsöversikt (refereegranskat)abstract
    • Inversions are structural mutations that reverse the sequence of a chromosome seg-ment and reduce the effective rate of recombination in the heterozygous state. They play a major role in adaptation, as well as in other evolutionary processes such as spe-ciation. Although inversions have been studied since the 1920s, they remain difficult to investigate because the reduced recombination conferred by them strengthens the effects of drift and hitchhiking, which in turn can obscure signatures of selection. Nonetheless, numerous inversions have been found to be under selection. Given re-cent advances in population genetic theory and empirical study, here we review how different mechanisms of selection affect the evolution of inversions. A key difference between inversions and other mutations, such as single nucleotide variants, is that the fitness of an inversion may be affected by a larger number of frequently interacting processes. This considerably complicates the analysis of the causes underlying the evolution of inversions. We discuss the extent to which these mechanisms can be disentangled, and by which approach.
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16.
  • Brady, Mark, et al. (författare)
  • Jordbrukspolitik för att nå FN:s globala mål?
  • 2021
  • Ingår i: Policy brief / AgriFood Economics Centre.
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Enligt EU-kommissionen är den gemensamma jordbrukspolitiken central för att nå FN:s globala mål för hållbar utveckling. Nästan 40 procent av EU:s budget går till jordbruksstöd, men i vilken utsträckning stöden bidrar till att uppnå FN-målen är oklart. Vi analyserar hur de 551 miljarder kronor som betalades ut i stöd år 2015 fördelades mellan FN:s 17 hållbarhetsmål. Vi finner att:* 60 procent av stöden gick till endast två av FN:s hållbarhetsmål: ingen fattigdom (mål ett) och ingenhunger (mål två).* Kopplingen till mål ett och två är svag eftersom 225 miljarder kronor betalades ut som inkomststöd i regioner där jordbrukare i genomsnitt har högre inkomster än halva EU:s befolkning.* Jordbruksstödens fördelning främjar inte jordbruk med låg klimatpåverkan (mål 13) eller jordbruk som gynnar biologisk mångfald (mål 15) i någon större utsträckning.
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17.
  • Broen, Jasper C A, et al. (författare)
  • The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility.
  • 2011
  • Ingår i: Journal of Rheumatology. - : The Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 38:3, s. 446-449
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.
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18.
  • Cayan, Daniel R., et al. (författare)
  • A 4-week advance in the growing season in Napa Valley, California, USA
  • 2023
  • Ingår i: International Journal of Climatology. - 0899-8418. ; 43:12, s. 5586-5603
  • Tidskriftsartikel (refereegranskat)abstract
    • The growing season start and duration, along with other temperature-related measures of importance to premium wine grapes in Napa Valley, California have changed as climate over the western United States has warmed. The growing season start has varied from year to year with a standard deviation of about 3 weeks, but over the 1958–2016 record a linear fit to the time sequence shows it advanced by more than 4 weeks. Over the study period, advances in the growing season were strongly influenced by temperature increases beginning in the late 1960s with warm anomalies generally persisting through recent years. The date upon which the growing season accumulated 1400 growing degree-days also shifted earlier by about 4 weeks. Other measures swung to a warmer status, including the mean temperature of the last 45 days of the growing season, which warmed by over 1.5°C. Warming days and especially warming nights contributed to the growing season advance as well as trends towards warmer expressions of other viticultural measures. Years with earlier and warmer growing seasons experienced a substantial reduction in the number of daily cool extremes, and an increase in daily warm extremes, including the number of days whose temperature reaches or exceeds 35°C.
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19.
  • Clark, Andrew G., et al. (författare)
  • Evolution of genes and genomes on the Drosophila phylogeny
  • 2007
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
  • Tidskriftsartikel (refereegranskat)abstract
    • Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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20.
  • Clark, Kyle H., et al. (författare)
  • Introducing urban food forestry: a multifunctional approach to increase food security and provide ecosystem services
  • 2013
  • Ingår i: Landscape Ecology. - : Springer Science and Business Media LLC. - 1572-9761 .- 0921-2973. ; 28:9, s. 1649-1669
  • Tidskriftsartikel (refereegranskat)abstract
    • We examine the potential role of perennial woody food-producing species ("food trees") in cities in the context of urban sustainable development and propose a multifunctional approach that combines elements of urban agriculture, urban forestry, and agroforestry into what we call "urban food forestry" (UFF). We used four approaches at different scales to gauge the potential of UFF to enhance urban sustainability and contribute to food security in the context of urbanization and climate change. First, we identified 37 current initiatives based around urban food trees, and analyzed their activities in three categories: planting, mapping, and harvesting, finding that the majority (73 %) only performed one activity, and only 8 % performed all three. Second, we analyzed 30 urban forestry master plans, finding that only 13 % included human food security among their objectives, while 77 % included habitat for wildlife. Third, we used Burlington, Vermont as a case study to quantify the potential fruit yield of publicly accessible open space if planted with Malus domestica (the common apple) under nine different planting and yield scenarios. We found that 108 % of the daily recommended minimum intake of fruit for the entire city's population could be met under the most ambitious planting scenario, with substantial potential to contribute to food security even under more modest scenarios. Finally, we developed a Climate-Food-Species Matrix of potential food trees appropriate for temperate urban environments as a decision-making tool. We identified a total of 70 species, 30 of which we deemed "highly suitable" for urban food forestry based on their cold hardiness, drought tolerance, and edibility. We conclude that substantial untapped potential exists for urban food forestry to contribute to urban sustainability via increased food security and landscape multifunctionality.
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21.
  • Coates, Brad S., et al. (författare)
  • A draft Diabrotica virgifera virgifera genome : insights into control and host plant adaption by a major maize pest insect
  • 2023
  • Ingår i: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 24:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Adaptations by arthropod pests to host plant defenses of crops determine their impacts on agricultural production. The larval host range of western corn rootworm, Diabrotica virgifera virgifera (Coleoptera: Chrysomelidae), is restricted to maize and a few grasses. Resistance of D. v. virgifera to crop rotation practices and multiple insecticides contributes to its status as the most damaging pest of cultivated maize in North America and Europe. The extent to which adaptations by this pest contributes to host plant specialization remains unknown. Results: A 2.42 Gb draft D. v. virgifera genome, Dvir_v2.0, was assembled from short shotgun reads and scaffolded using long-insert mate-pair, transcriptome and linked read data. K-mer analysis predicted a repeat content of ≥ 61.5%. Ortholog assignments for Dvir_2.0 RefSeq models predict a greater number of species-specific gene duplications, including expansions in ATP binding cassette transporter and chemosensory gene families, than in other Coleoptera. A majority of annotated D. v. virgifera cytochrome P450s belong to CYP4, 6, and 9 clades. A total of 5,404 transcripts were differentially-expressed between D. v. virgifera larvae fed maize roots compared to alternative host (Miscanthus), a marginal host (Panicum virgatum), a poor host (Sorghum bicolor) and starvation treatments; Among differentially-expressed transcripts, 1,908 were shared across treatments and the least number were between Miscanthus compared to maize. Differentially-expressed transcripts were enriched for putative spliceosome, proteosome, and intracellular transport functions. General stress pathway functions were unique and enriched among up-regulated transcripts in marginal host, poor host, and starvation responses compared to responses on primary (maize) and alternate hosts. Conclusions: Manual annotation of D. v. virgifera Dvir_2.0 RefSeq models predicted expansion of paralogs with gene families putatively involved in insecticide resistance and chemosensory perception. Our study also suggests that adaptations of D. v. virgifera larvae to feeding on an alternate host plant invoke fewer transcriptional changes compared to marginal or poor hosts. The shared up-regulation of stress response pathways between marginal host and poor host, and starvation treatments may reflect nutrient deprivation. This study provides insight into transcriptomic responses of larval feeding on different host plants and resources for genomic research on this economically significant pest of maize.
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22.
  • Collen, Wain Anthony, et al. (författare)
  • Building local institutions for national conservation programs: lessons for developing Reducing Emissions from Deforestation and Forest Degradation (REDD+) programs
  • 2016
  • Ingår i: Ecology and Society. - 1708-3087. ; 21:2
  • Tidskriftsartikel (refereegranskat)abstract
    • ABSTRACT. For programs that aim to promote forest conservation and poverty alleviation, such as Reducing Emissions from Deforestation and Forest Degradation (REDD+), the participation of indigenous communities is essential to meet program goals. Using Ostrom's theory of collective action for common pool resource management, we evaluated the institutions governing indigenous participation in the Programa Socio Bosque incentive-based conservation program in Ecuador. We conducted structured interviews with 94 members in 4 communities to assess community institutions for 6 of Ostrom's principles, using 12 measures we developed for the principles. We found substantial variation between communities in terms of their institutional performance. The best-performing community performed well (>50% of interviewees reported successfully meeting the measure) on 8 of the 12 measures. The weakest performed well on only 2 out of 12 measures. Overall, our results indicate that there is stronger performance for constitutional-levelinstitutions, which determine who gets to make the rules, and some collective-choice institutions, which determine how local rules are made. We identified specific challenges with the day-to-day operational institutions that arise from participation in nation state–community conservation programs, such as restricted resource appropriation, monitoring and compliance, and conflict resolution. We found that top-down policy making has an important role to play in supporting communities to establish constitutional-level and some collective-choice institutions. However, developing operational institutions may take more time and depend on local families’ day-today use of resources, and thus may require a more nuanced policy approach. As some countries and donors find a jurisdictional REDD+ approach increasingly attractive, complementing top-down policy measures with bottom-up institutional development could provide a stronger platform to achieve the shift from current land use driving deforestation to a lower-carbon-emissions land management trajectory.
  •  
23.
  • Crossfield, Ian J. M., et al. (författare)
  • 197 CANDIDATES AND 104 VALIDATED PLANETS IN K2's FIRST FIVE FIELDS
  • 2016
  • Ingår i: Astrophysical Journal Supplement Series. - : American Astronomical Society. - 0067-0049 .- 1538-4365. ; 226:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present 197 planet candidates discovered using data from the first year of the NASA K2 mission (Campaigns 0-4), along with the results of an intensive program of photometric analyses, stellar spectroscopy, high-resolution imaging, and statistical validation. We distill these candidates into sets of 104 validated planets (57 in multi-planet systems), 30 false positives, and 63 remaining candidates. Our validated systems span a range of properties, with median values of R-P = 2.3 R-circle plus, P = 8.6 days, T-eff = 5300 K, and Kp = 12.7 mag. Stellar spectroscopy provides precise stellar and planetary parameters for most of these systems. We show that K2 has increased by 30% the number of small planets known to orbit moderately bright stars (1-4 R-circle plus, Kp = 9-13. mag). Of particular interest are 76 planets smaller than 2 R-circle plus, 15 orbiting stars brighter than Kp = 11.5. mag, 5 receiving Earth-like irradiation levels, and several multi-planet systems-including 4 planets orbiting the M dwarf K2-72 near mean-motion resonances. By quantifying the likelihood that each candidate is a planet we demonstrate that our candidate sample has an overall false positive rate of 15%-30%, with rates substantially lower for small candidates (<2 R-circle plus) and larger for candidates with radii >8 R-circle plus and/or with P < 3 days. Extrapolation of the current planetary yield suggests that K2 will discover between 500 and 1000 planets in its planned four-year mission, assuming sufficient follow-up resources are available. Efficient observing and analysis, together with an organized and coherent follow-up strategy, are essential for maximizing the efficacy of planet-validation efforts for K2, TESS, and future large-scale surveys.
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24.
  • Dickson-Hoyle, Sarah, et al. (författare)
  • Towards meaningful youth participation in science-policy processes : A case study of the Youth in Landscapes Initiative
  • 2018
  • Ingår i: Elementa. - : University of California Press. - 2325-1026. ; 6
  • Tidskriftsartikel (refereegranskat)abstract
    • In the context of complex intergenerational challenges such as climate change and sustainable development, it is increasingly important for scientists and policy-makers to actively engage with and support the meaningful participation of youth in policy and decision-making. This research evaluates the effectiveness and impact of the Youth in Landscapes Initiative in supporting the active participation and leadership development of youth (aged 18-30 years old) participants at the 2014 Global Landscapes Forum (GLF), an international science-policy forum. This 'youth program' comprised a Youth Session, skills workshops and mentoring programs to empower youth through leadership and capacity building opportunities. Results show a high demand for youth participation: 34% of GLF conference delegates expressed interest to attend the Youth Session, over 22% of GLF session organisers requested youth to take on leadership roles, and the youth program itself received over 770 applications for the 'facilitator' and 'pitcher' leadership positions. The skills-based 'masterclasses' successfully built the confidence and knowledge of youth participants, as shown by post-evaluation survey responses. This translated into active and substantive youth participation throughout the forum. Senior professionals connected to the program praised it highly, seeing it as an opportunity for mutual, intergenerational learning. The Youth in Landscape Initiative is presented as a model and distilled into a framework to inform future youth engagement strategies in international conferences and associated science-policy processes.
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25.
  • Dooley, Kate, et al. (författare)
  • Co-producing climate policy and negative emissions: trade-offs for sustainable land-use
  • 2018
  • Ingår i: Global Sustainability. - : Cambridge University Press (CUP). - 2059-4798. ; 1
  • Tidskriftsartikel (refereegranskat)abstract
    • Under the Paris Agreement, nations have committed to preventing dangerous global warming. Scenarios for achieving net-zero emissions in the second half of this century depend on land (forests and bioenergy) to remove carbon from the atmosphere. Modelled levels of land-based mitigation could reduce the availability of productive agricultural land, and encroach on natural land, with potentially significant social and environmental consequences. However, these issues are poorly recognized in the policy-uptake of modelled outputs. Understanding how science and policy interact to produce expectations about mitigation pathways allows us to consider the trade-offs inherent in relying on land for mitigation.
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26.
  • Dornelles, Andre Z., et al. (författare)
  • Towards a bridging concept for undesirable resilience in social-ecological systems
  • 2020
  • Ingår i: Global Sustainability. - : Cambridge University Press (CUP). - 2059-4798. ; 3
  • Tidskriftsartikel (refereegranskat)abstract
    • Non-technical summary Resilience is a cross-disciplinary concept that is relevant for understanding the sustainability of the social and environmental conditions in which we live. Most research normatively focuses on building or strengthening resilience, despite growing recognition of the importance of breaking the resilience of, and thus transforming, unsustainable social-ecological systems. Undesirable resilience (cf. lock-ins, social-ecological traps), however, is not only less explored in the academic literature, but its understanding is also more fragmented across different disciplines. This disparity can inhibit collaboration among researchers exploring interdependent challenges in sustainability sciences. In this article, we propose that the term lock-in may contribute to a common understanding of undesirable resilience across scientific fields. Technical summary Resilience is an extendable concept that bridges the social and life sciences. Studies increasingly interpret resilience normatively as a desirable property of social-ecological systems, despite growing awareness of resilient properties leading to social and ecological degradation, vulnerability or barriers that hinder sustainability transformations (i.e., 'undesirable' resilience). This is the first study to qualify, quantify and compare the conceptualization of 'desirable' and 'undesirable' resilience across academic disciplines. Our literature analysis found that various synonyms are used to denote undesirable resilience (e.g., path dependency, social-ecological traps, institutional inertia). Compared to resilience as a desirable property, research on undesirable resilience is substantially less frequent and scattered across distinct scientific fields. Amongst synonyms for undesirable resilience, the term lock-in is more frequently and evenly used across academic disciplines. We propose that lock-in therefore has the potential to reconcile diverse interpretations of the mechanisms that constrain system transformation - explicitly and coherently addressing characteristics of reversibility and plausibility - and thus enabling integrative understanding of social-ecological system dynamics. Social media summary 'Lock-in' as a bridging concept for interdisciplinary understanding of barriers to desirable sustainability transitions.
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27.
  • Dornelles, André Zuanazzi, et al. (författare)
  • Transformation archetypes in global food systems
  • 2022
  • Ingår i: Sustainability Science. - : Springer Science and Business Media LLC. - 1862-4065 .- 1862-4057. ; 17:5, s. 1827-1840
  • Tidskriftsartikel (refereegranskat)abstract
    • Food systems are primary drivers of human and environmental health, but the understanding of their diverse and dynamic co-transformation remains limited. We use a data-driven approach to disentangle different development pathways of national food systems (i.e. ‘transformation archetypes’) based on historical, intertwined trends of food system structure (agricultural inputs and outputs and food trade), and social and environmental outcomes (malnutrition, biosphere integrity, and greenhouse gases emissions) for 161 countries, from 1995 to 2015. We found that whilst agricultural total factor productivity has consistently increased globally, a closer analysis suggests a typology of three transformation archetypes across countries: rapidly expansionist, expansionist, and consolidative. Expansionist and rapidly expansionist archetypes increased in agricultural area, synthetic fertilizer use, and gross agricultural output, which was accompanied by malnutrition, environmental pressures, and lasting socioeconomic disadvantages. The lowest rates of change in key structure metrics were found in the consolidative archetype. Across all transformation archetypes, agricultural greenhouse gases emissions, synthetic fertilizer use, and ecological footprint of consumption increased faster than the expansion of agricultural area, and obesity levels increased more rapidly than undernourishment decreased. The persistence of these unsustainable trajectories occurred independently of improvements in productivity. Our results underscore the importance of quantifying the multiple human and environmental dimensions of food systems transformations and can serve as a starting point to identify potential leverage points for sustainability transformations. More attention is thus warranted to alternative development pathways able of delivering equitable benefits to both productivity and to human and environmental health.
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28.
  • Feola, Giuseppe, et al. (författare)
  • Researching farmer behaviour in climate change adaptation and sustainable agriculture: Lessons learned from five case studies
  • 2015
  • Ingår i: Journal of Rural Studies. - : Elsevier BV. - 0743-0167. ; 39, s. 74-84
  • Tidskriftsartikel (refereegranskat)abstract
    • Understanding farmer behaviour is needed for local agricultural systems to produce food sustainably while facing multiple pressures. We synthesize existing literature to identify three fundamental questions that correspond to three distinct areas of knowledge necessary to understand farmer behaviour: 1) decision-making model; 2) cross-scale and cross-level pressures; and 3) temporal dynamics. We use this framework to compare five interdisciplinary case studies of agricultural systems in distinct geographical contexts across the globe. We find that these three areas of knowledge are important to understanding farmer behaviour, and can be used to guide the interdisciplinary design and interpretation of studies in the future. Most importantly, we find that these three areas need to be addressed simultaneously in order to understand farmer behaviour. We also identify three methodological challenges hindering this understanding: the suitability of theoretical frameworks, the trade-offs among methods and the limited timeframe of typical research projects. We propose that a triangulation research strategy that makes use of mixed methods, or collaborations between researchers across mixed disciplines, can be used to successfully address all three areas simultaneously and show how this strategy has been achieved in the case studies. The framework facilitates interdisciplinary research on farmer behaviour by opening up spaces of structured dialogue on assumptions, research questions and methods employed in investigation. (C) 2015 Elsevier Ltd. All rights reserved.
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29.
  • Forouzanfar, Mohammad H, et al. (författare)
  • Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.
  • 2015
  • Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 386:10010, s. 2287-2323
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol.FINDINGS: All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8-58·5) of deaths and 41·6% (40·1-43·0) of DALYs. Risks quantified account for 87·9% (86·5-89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa.INTERPRETATION: Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks.FUNDING: Bill & Melinda Gates Foundation.
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30.
  • Gerhardt, Karin, et al. (författare)
  • Nog nu, politiker – ta klimatkrisen på allvar
  • 2022
  • Ingår i: Aftonbladet Debatt. - 1103-9000. ; -:-
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • 1944 svenska forskare och anställda i forskarvärlden: Vad är det ni inte förstår?
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31.
  • Guillen-Royo, Monica, et al. (författare)
  • Flight-intensive practices and wellbeing: current evidence and future research
  • Ingår i: Consumption and Society. - 2752-8499.
  • Tidskriftsartikel (refereegranskat)abstract
    • This article draws on social practice theory and wellbeing perspectives to outline a research framework for the study of flight-intensive practices. The framework is then used to discuss, through a non-systematic review, the social science air travel literature and to propose avenues for future research. We study both the work and leisure domains, with sub-cases for travel in academia and visiting family and friends. We find insights of a complex relationship between flight-intensive practices and wellbeing. On one hand, currently flight-intensive practices are linked to human need fulfilment, particularly in the family and social domains. Leisure-related air travel often enhances subjective wellbeing, as it contributes to positive moods and life satisfaction, but may not be sustained in the long term. On the other hand, flying, particularly frequent flying, hinders wellbeing by increasing levels of stress and health-related issues, and by straining work/life balance. Overall, the study suggests that policies to reduce the demand for air travel may not significantly compromise wellbeing if accompanied by infrastructural and sociocultural changes that support specific groups to still meet their needs for relatedness, participation, or understanding through low carbon transport, videoconferencing, or reducing the total amount of travel. We identify avenues for future research, both to consolidate our understanding of the practice elements that will support a shift away from flight-intensive practices, and to understand their direct effects on wellbeing.
  •  
32.
  • Halldórsdóttir, Thorhildur Ósk, et al. (författare)
  • Local food in Iceland : Identifying behavioral barriers to increased production and consumption
  • 2016
  • Ingår i: Environmental Research Letters. - : IOP Publishing. - 1748-9326. ; 11:11
  • Tidskriftsartikel (refereegranskat)abstract
    • Increased production and consumption of local food may reduce the negative environmental, social, and economic impacts of industrialized and globalized food production. Here we examined potential barriers to increasing production and consumption of food produced in Iceland. First, we developed a new framework to address the behaviors of production and consumption simultaneously, to comprehensively analyze their potential barriers. We examined structural barriers by estimating the food production capacity of Iceland, and cultural and personal barriers through survey data on cultural norms and purchasing behavior from Matís, a research and development company. We found no structural barriers preventing Iceland from increasing production of local cereals, which would compliment current local production of meat and dairy and reduce reliance on imports, currently at 50% of the daily caloric intake. However, if food production became entirely local without changing the current mix of crops grown, there would be a 50% reduction in diversity (from 50 to 25 items in eight out of ten food categories). We did not identify any cultural barriers, as survey results demonstrated that consumers hold generally positive worldviews towards local food, with 88% satisfied with local food they had purchased. More than two-thirds of consumers regarded supporting the local farmer and considerations such as environmentally friendly production, fewer food miles, lower carbon footprint as important. However, they rated the local food they have access to as lower in meeting sustainability criteria, showing that they make justifications for not choosing local food in practice. This is a personal barrier to increased consumption of local food, and implies that marketing strategies and general knowledge connected to local food in Iceland might be improved. Although the results apply to the case of Iceland, the method of identifying behavioral barriers to change is applicable to other countries, regions, or foodsheds interested in assessing their food security through an analysis of local food.
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33.
  • Hillier, Ladeana W, et al. (författare)
  • Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
  • 2004
  • Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 432:7018, s. 695-716
  • Tidskriftsartikel (refereegranskat)abstract
    • We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome--composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes--provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.
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34.
  • Jacobs, Alan M., et al. (författare)
  • The Qualitative Transparency Deliberations : Insights and Implications
  • 2021
  • Ingår i: Perspectives on Politics. - 1537-5927 .- 1541-0986. ; 19:1, s. 171-208
  • Tidskriftsartikel (refereegranskat)abstract
    • In recent years, a variety of efforts have been made in political science to enable, encourage, or require scholars to be more open and explicit about the bases of their empirical claims and, in turn, make those claims more readily evaluable by others. While qualitative scholars have long taken an interest in making their research open, reflexive, and systematic, the recent push for overarching transparency norms and requirements has provoked serious concern within qualitative research communities and raised fundamental questions about the meaning, value, costs, and intellectual relevance of transparency for qualitative inquiry. In this Perspectives Reflection, we crystallize the central findings of a three-year deliberative process-the Qualitative Transparency Deliberations (QTD)-involving hundreds of political scientists in a broad discussion of these issues. Following an overview of the process and the key insights that emerged, we present summaries of the QTD Working Groups' final reports. Drawing on a series of public, online conversations that unfolded at www.qualtd.net, the reports unpack transparency's promise, practicalities, risks, and limitations in relation to different qualitative methodologies, forms of evidence, and research contexts. Taken as a whole, these reports-the full versions of which can be found in the Supplementary Materials-offer practical guidance to scholars designing and implementing qualitative research, and to editors, reviewers, and funders seeking to develop criteria of evaluation that are appropriate-as understood by relevant research communities-to the forms of inquiry being assessed. We dedicate this Reflection to the memory of our coauthor and QTD working group leader Kendra Koivu.(1)
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35.
  • Jelenkovic, Aline, et al. (författare)
  • Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age : A Study of the CODATwins Project
  • 2015
  • Ingår i: Twin Research and Human Genetics. - : Cambridge University Press. - 1832-4274 .- 1839-2628. ; 18:5, s. 557-570
  • Tidskriftsartikel (refereegranskat)abstract
    • A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m(2) in childhood and adolescence and up to 0.2 kg/m(2) in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.
  •  
36.
  • Johansson, Emma Li, et al. (författare)
  • Green and blue water demand from large-scale land acquisitions in Africa
  • 2016
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 113:41, s. 11471-11476
  • Tidskriftsartikel (refereegranskat)abstract
    • In the last decade, more than 22 million ha of land have been contracted to large-scale land acquisitions in Africa, leading to increased pressures, competition, and conflicts over freshwater resources. Currently, 3% of contracted land is in production, for which we model site-specific water demands to indicate where freshwater appropriation might pose high socioenvironmental challenges. We use the dynamic global vegetation model Lund-Potsdam-Jena managed Land to simulate green (precipitation stored in soils and consumed by plants through evapotranspiration) and blue (extracted from rivers, lakes, aquifers, and dams) water demand and crop yields for seven irrigation scenarios, and compare these data with two baseline scenarios of staple crops representing previous water demand. We find that most land acquisitions are planted with crops that demand large volumes of water (>9,000 m3·ha-1) like sugarcane, jatropha, and eucalyptus, and that staple crops have lower water requirements (<7,000 m3·ha-1). Blue water demand varies with irrigation system, crop choice, and climate. Even if the most efficient irrigation systems were implemented, 18% of the land acquisitions, totaling 91,000 ha, would still require more than 50% of water from blue water sources. These hotspots indicate areas at risk for transgressing regional constraints for freshwater use as a result of overconsumption of blue water, where socioenvironmental systems might face increased conflicts and tensions over water resources.
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37.
  • Jouffray, Jean-Baptiste, et al. (författare)
  • Parsing human and biophysical drivers of coral reef regimes
  • 2019
  • Ingår i: Proceedings of the Royal Society of London. Biological Sciences. - : The Royal Society. - 0962-8452 .- 1471-2954. ; 286:1896
  • Tidskriftsartikel (refereegranskat)abstract
    • Coral reefs worldwide face unprecedented cumulative anthropogenic effects of interacting local human pressures, global climate change and distal social processes. Reefs are also bound by the natural biophysical environment within which they exist. In this context, a key challenge for effective management is understanding how anthropogenic and biophysical conditions interact to drive distinct coral reef configurations. Here, we use machine learning to conduct explanatory predictions on reef ecosystems defined by both fish and benthic communities. Drawing on the most spatially extensive dataset available across the Hawaiian archipelago-20 anthropogenic and biophysical predictors over 620 survey sites-we model the occurrence of four distinct reef regimes and provide a novel approach to quantify the relative influence of human and environmental variables in shaping reef ecosystems. Our findings highlight the nuances of what underpins different coral reef regimes, the overwhelming importance of biophysical predictors and how a reef's natural setting may either expand or narrow the opportunity space for management interventions. The methods developed through this study can help inform reef practitioners and hold promises for replication across a broad range of ecosystems.
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38.
  • Kattge, Jens, et al. (författare)
  • TRY plant trait database - enhanced coverage and open access
  • 2020
  • Ingår i: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188
  • Tidskriftsartikel (refereegranskat)abstract
    • Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
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39.
  • Khagram, Sanjeev, et al. (författare)
  • Thinking about knowing: conceptual foundations for interdisciplinary environmental research
  • 2010
  • Ingår i: Environmental Conservation. - 0376-8929. ; 37:4, s. 388-397
  • Tidskriftsartikel (refereegranskat)abstract
    • Working across knowledge-based research programmes, rather than institutional structures, should be central to interdisciplinary research. In this paper, a novel framework is proposed to facilitate interdisciplinary research, with the goals of promoting communication, understanding and collaborative work. Three core elements need to be addressed to improve interdisciplinary research: the types (forms and functions) of theories, the underlying philosophies of knowledge and the combination of research styles; these three elements combine to form the research programme. Case studies from sustainability science and environmental security illustrate the application of this research programme-based framework. This framework may be helpful in overcoming often oversimplified distinctions, such as qualitative/quantitative, deductive/inductive, normative/descriptive, subjective/objective and theory/practice. Applying this conceptual framework to interdisciplinary research should foster theoretical advances, more effective communication and better problem-solving in increasingly interdisciplinary environmental fields.
  •  
40.
  • Kramer, Daniel Boyd, et al. (författare)
  • Top 40 questions in coupled human and natural systems (CHANS) research
  • 2017
  • Ingår i: Ecology and Society. - 1708-3087. ; 22:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Understanding and managing coupled human and natural systems (CHANS) is a central challenge of the 21st century, but more focus is needed to pursue the most important questions within this vast field given limited research capacity and funding. We present 40 important questions for CHANS research, identified through a two-part crowdsourcing exercise within the CHANS community. We solicited members of the International Network of Research on Coupled Human and Natural Systems (CHANS-Net) to submit up to three questions that they considered transformative, receiving 540 questions from 207 respondents. After editing for clarity and consistency, we asked the network’s members to each evaluate a random subset of 20 questions in importance on a scale from 1 (least important) to 7 (extremely important). Questions on land use and agriculture topped the list, with a median importance ranking of 5.7, followed by questions of scale, climate change and energy, sustainability and development, adaptation and resilience, in addition to seven other categories. We identified 40 questions with a median importance of 6.0 or above, which we highlight as the current view of researchers active in the field as research questions to pursue in order to maximize impact on understanding and managing coupled human and natural systems for achieving sustainable development goals and addressing emerging global challenges.
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41.
  • Krause, Torsten, et al. (författare)
  • Evaluating safeguards in a conservation incentive program : participation, consent, and benefit sharing in indigenous communities of the Ecuadorian Amazon
  • 2013
  • Ingår i: Ecology & Society. - 1708-3087. ; 18:4, s. 1-16
  • Tidskriftsartikel (refereegranskat)abstract
    • Critics suggest that Reducing Emissions from Deforestation and forest Degradation (REDD+) may not generate improvements in well-being for participating stakeholders, and may in fact undermine indigenous rights. To ensure positive social benefits from REDD+ projects, the United Nations REDD Programme has proposed core safeguards, including local stakeholder participation; free, prior, and informed consent; and equitable distribution of benefits. However, there is little experience to date in implementing and evaluating these safeguards. We apply these core safeguards as a framework to study how people in indigenous communities in the Ecuadorian Amazon perceive and benefit from Programa Socio Bosque, a conservation incentive program in Ecuador’s national REDD+ Programme portfolio. We interviewed 101 individuals in five communities that had participated in the Programa Socio Bosque for at least 18 months. Close to 80% of respondents reported that the decision to join Socio Bosque was made democratically, that they were familiar with the conservation goals of Socio Bosque, and that they were aware which area their community had selected for conservation. However, only 17% were familiar with the overall terms of the conservation agreement, implying that they were either not fully informed of or did not fully understand what they were consenting to in joining the program. Although the terms of the program require a community investment plan to be democratically developed by community members, less than half of respondents were aware of the existence of the investment plan, and fewer than 20% had participated in its development. The majority of respondents (61%) reported that they did not know the amount of incentives that their community currently receives, and only 44% stated that incentives were managed democratically in communal assemblies. Moreover, although a slight majority (53%) said they had noticed benefits to the community from participating in Socio Bosque, the majority (57%) said their family had not received any benefits. These results demonstrate a need to strengthen inclusive participation, better inform participants about program design, and improve the management of incentives within communities if incentive-based conservation programs are to achieve their social development and environmental goals.
  •  
42.
  • Kuss, Paula, et al. (författare)
  • A dozen effective interventions to reduce car use in European cities : Lessons learned from a meta-analysis and transition management
  • 2022
  • Ingår i: Case Studies on Transport Policy. - : Elsevier BV. - 2213-624X. ; 10:3, s. 1494-1513
  • Tidskriftsartikel (refereegranskat)abstract
    • Transitioning to fossil-free transport and reducing car use are necessary to meet European and national climate goals. Cities are promising leverage points to facilitate system transitions by promoting local innovation and policy experimentation. Building on transition management, we developed a knowledge base for the implementation of transition experiments to reduce city-level car use. From screening nearly 800 peer-reviewed studies and case studies, including in-depth analysis of 24 documents that met quality criteria and quantitatively estimated car use reduction, we identify 12 intervention types combining different measures and policy instruments that were effective in reducing car use in European cities. The most effective at reducing overall car use were the Congestion Charge, Parking & Traffic Congrol, and Limited Traffic Zone. Most interventions were led by local government, planned and decided in collaboration with different urban stakeholders. We evaluated the potential of the identified intervention types to be implemented in a pilot study of Lund, Sweden, using three criteria from Transition Management of novelty, feasibility, and suitability, as assessed by interviews with local experts. We recommend three transition experiments to reduce local car use in Lund: Parking and Traffic Control, Workplace Parking Charge, and Mobility Services for Commuters. We suggest practitioners follow our method to identify effective and locally suitable interventions to reduce car use, and future research quantify the effectiveness of interventions to reduce car use using the standardised outcome measure of daily passenger kilometres travelled by car.
  •  
43.
  • Levis, Brooke, et al. (författare)
  • Comparison of major depression diagnostic classification probability using the SCID, CIDI, and MINI diagnostic interviews among women in pregnancy or postpartum : An individual participant data meta-analysis
  • 2019
  • Ingår i: International Journal of Methods in Psychiatric Research. - : WILEY. - 1049-8931 .- 1557-0657. ; 28:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives: A previous individual participant data meta-analysis (IPDMA) identified differences in major depression classification rates between different diagnostic interviews, controlling for depressive symptoms on the basis of the Patient Health Questionnaire-9. We aimed to determine whether similar results would be seen in a different population, using studies that administered the Edinburgh Postnatal Depression Scale (EPDS) in pregnancy or postpartum.Methods: Data accrued for an EPDS diagnostic accuracy IPDMA were analysed. Binomial generalised linear mixed models were fit to compare depression classification odds for the Mini International Neuropsychiatric Interview (MINI), Composite International Diagnostic Interview (CIDI), and Structured Clinical Interview for DSM (SCID), controlling for EPDS scores and participant characteristics.Results Among fully structured interviews, the MINI (15 studies, 2,532 participants, 342 major depression cases) classified depression more often than the CIDI (3 studies, 2,948 participants, 194 major depression cases; adjusted odds ratio [aOR] = 3.72, 95% confidence interval [CI] [1.21, 11.43]). Compared with the semistructured SCID (28 studies, 7,403 participants, 1,027 major depression cases), odds with the CIDI (interaction aOR = 0.88, 95% CI [0.85, 0.92]) and MINI (interaction aOR = 0.95, 95% CI [0.92, 0.99]) increased less as EPDS scores increased.Conclusion Different interviews may not classify major depression equivalently.
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44.
  • Liski, Anja Helena, et al. (författare)
  • Governance and stakeholder perspectives of managed re-alignment: adapting to sea level rise in the Inner Forth estuary, Scotland
  • 2019
  • Ingår i: Regional Environmental Change. - : Springer Science and Business Media LLC. - 1436-378X .- 1436-3798. ; 19:8, s. 2231-2243
  • Tidskriftsartikel (refereegranskat)abstract
    • With climate change, coastal areas are faced with unprecedented sea level rise and flooding, raising questions as to how societies will choose to adapt. One option is to strengthen existing sea walls to maintain current land uses; however, scientists, policy-makers and conservationists increasingly see the benefits of managed realignment, which is a nature-based coastal adaptation that involves the conversion of reclaimed farmland back to wetlands, allowing periodic local flooding in designated areas to reduce the risk of flooding downstream. We interviewed 16 local organisations, landowners and farmers and held workshops with 109 citizens living the Inner Forth estuary in eastern Scotland, to examine how managed realignment is supported by stakeholder attitudes and their engagement. Most of the farmers we interviewed prefer strengthened sea walls, to maintain their livelihoods and agricultural heritage. Citizens and local organisations were mainly supportive of managed realignment, because it provided wildlife and flood regulation benefits. However, we identified several barriers that could present obstacles to implementing managed realignment, for example, uncertainty whether it would support their principles of economic and rational decision-making. Our findings suggest that the local capacity to cope with rising sea levels is limited by lack of engagement with all relevant stakeholder groups, the limited scope of existing stakeholder partnerships and poor short-term funding prospects of landscape partnerships that would facilitate collaboration and discussion. We suggest that including citizens, landowners, farmers and industries would strengthen existing stakeholder deliberation and collaboration, and support the Inner Forth’s transition towards a more sustainable future shoreline.
  •  
45.
  • Macgregor, Finlay, et al. (författare)
  • Problems with Firm-Led Voluntary Sustainability Schemes: The Case of Direct Trade Coffee
  • 2017
  • Ingår i: Sustainability. - : MDPI AG. - 2071-1050. ; 9:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Ensuring sustainable consumption and production is one of the United Nations’ Sustainable Development Goals. Sustainable consumption can be supported through regulatory processes. Voluntary private regulatory schemes claiming to contribute to sustainability are a rapidly growing form of regulation. We study one such voluntary sustainability scheme in order to look at the opportunities and challenges this type of regulatory process poses using Abbot and Snidal’s regulatory standard-setting framework (2009). Specifically, we examine direct trade voluntary schemes in the coffee industry. To do this, we selected six leading direct trade firms in the US and Scandinavia, analyzed firms’ websites in 2015 and 2016 and conducted interviews with four of the firms. We found direct trade as a voluntary scheme was an attempt to market and codify good sourcing practices. US-based founding firms have distanced themselves from the term due to perceived co-optation, which we conceptualize as the failure of industry to self-regulate and argue was enabled by the re-negotiation of standards without the power to enforce or penalize misuse of the term. Firms reacted to co-optation by releasing data to consumers directly; we argue this puts too much responsibility on consumers to monitor and enforce standards. By contrast, Scandinavian firms maintained standards enforced through trademark nationally. Both US and Scandinavian contexts demonstrate a weakness of firm-led agenda-setting for sustainable development in that schemes may be optimized for a particular business concern—in this case quality—rather than to achieve sustainable development goals. This is problematic if schemes are marketed on contribution to the public good when incentives within the scheme are not aligned to produce an optimal result for the public good.
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46.
  • Mastrángelo, Matías E., et al. (författare)
  • Key knowledge gaps to achieve global sustainability goals
  • 2019
  • Ingår i: Nature Sustainability. - : Springer Science and Business Media LLC. - 2398-9629. ; 2:12, s. 1115-1121
  • Tidskriftsartikel (refereegranskat)abstract
    • Regional and global assessments periodically update what we know, and highlight what remains to be known, about the linkages between people and nature that both define and depend upon the state of the environment. To guide research that better informs policy and practice, we systematically synthesize knowledge gaps from recent assessments of four regions of the globe and three key themes by the Intergovernmental Science-Policy Platform for Biodiversity and Ecosystem Services. We assess their relevance to global sustainability goals and trace their evolution relative to those identified in the Millennium Ecosystem Assessment. We found that global sustainability goals cannot be achieved without improved knowledge on feedbacks between social and ecological systems, effectiveness of governance systems and the influence of institutions on the social distribution of ecosystem services. These top research priorities have persisted for the 14 years since the Millennium Ecosystem Assessment. Our analysis also reveals limited understanding of the role of indigenous and local knowledge in sustaining nature’s benefits to people. Our findings contribute to a policy-relevant and solution-oriented agenda for global, long-term social-ecological research.
  •  
47.
  • Mechiche-alami, Altaaf, et al. (författare)
  • Agricultural land acquisitions unlikely to address the food security needs of African countries
  • 2021
  • Ingår i: World Development. - : Elsevier BV. - 0305-750X. ; 141
  • Tidskriftsartikel (refereegranskat)abstract
    • In recent years, Large Scale Land Acquisitions (LSLA), direct land tenure changes have been gaining momentum in developing countries. In this study, we evaluate the potential extent to which agricultural land deals in Africa are able to address the host countries’ food security needs, a commonly cited motivation for their establishment. First, we develop a framework to evaluate the priority food security needs of 38 African countries in 2000 based on indicators of food availability, accessibility, stability, and utilization. Second, we estimate whether the crops from land deals would be sold on export or local food markets based on the origin of investments (domestic, foreign or mixed), type of investors (eg. agribusiness, finance, or government) and the intended crops (eg. food, cash crop, or biofuel). This enables us to estimate how likely the investment is to improve in-country food security, versus serving other purposes (e.g., speculation, enclosure of natural resources). Third, we account for the characteristics of the locations where the deals happen (population density, land cover and distance to markets) in order to estimate the level of conflict and deforestation that they could exacerbate. We find that LSLA are only likely to address the identified food security needs of 7 countries. LSLA are also at risk of increasing land pressures and conflicts or deforestation on 83% of the acquired area, including in countries where they could meet food security needs. We also find that the more productive lands are most often allocated to flex crops, while food crops are produced on more marginal lands. We thus argue that even when their purpose is agricultural production, most LSLA are not likely to improve food security; rather, they often serve the financial interests of transnational companies and local elites with the support of host governments. Finally, we recommend agricultural investments to be elaborated in consultation with local communities and marginalized groups to sustainably support their socio-ecological systems.
  •  
48.
  • Mechiche-alami, Altaaf, et al. (författare)
  • Transnational land acquisitions beyond the food and financial crises
  • 2019
  • Ingår i: Environmental Research Letters. - : IOP Publishing. - 1748-9326. ; 14:8
  • Tidskriftsartikel (refereegranskat)abstract
    • Large-scale land acquisitions (LSLA) in resource-rich countries came to global attention after the food and financial crises of 2008. Previous research has assessed the magnitude of these land investments in terms of land areas acquired. In this study, we analyze the trends in the evolution of LSLA by framing the latter as virtual land trade network with land transactions occurring between 2000 and 2015, in order to shed light on the development and evolution of this system. Based on an index we introduce to represent both the number of countries and size of deals, we discover three main phases of trade activity: a steady increase from 2000 until 2007 (Phase 1) followed by a peak coinciding with the food and financial crises between 2008 and 2010 (Phase 2) and concluded by a decline from 2011 to 2015 (Phase 3). We identify 73 countries that remained active in land trading during all three phases and form a core of land traders much larger than previously thought. Using network analysis methods, we group countries with similar trade patterns into categories of competitive, preferential, diversified, and occasional importers or exporters. Finally, in exploring the changes in investors and their interests in land throughout the phases, we attribute the evolution of LSLA to the different stages in the globalization and financialization of different industries. By showing that land investments seem fully integrated as investment strategies across industries we argue for the urgency of better regulation of LSLA so that they also benefit local populations without damaging the environment regardless of their primary purpose.
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