| 1. |
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| 2. |
- Hawinkels, L J A C, et al.
(författare)
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Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts
- 2014
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Ingår i: Oncogene. - : Springer Science and Business Media LLC. - 0950-9232 .- 1476-5594. ; 33:1, s. 97-107
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Tidskriftsartikel (refereegranskat)abstract
- The interaction between epithelial cancer cells and cancer-associated fibroblasts (CAFs) has a major role in cancer progression and eventually in metastasis. In colorectal cancer (CRC), CAFs are present in high abundance, but their origin and functional interaction with epithelial tumor cells has not been elucidated. In this study we observed strong activation of the transforming growth factor-β (TGF-β)/Smad signaling pathway in CRC CAFs, accompanied by decreased signaling in epithelial tumor cells. We evaluated the TGF-β1 response and the expression of target genes including matrix metalloproteinases (MMPs) and plasminogen activator inhibitor (PAI)-1 of various epithelial CRC cell lines and primary CAFs in vitro. TGF-β1 stimulation caused high upregulation of MMPs, PAI-1 and TGF-β1 itself. Next we showed that incubation of CAFs with conditioned medium (CM) from epithelial cancer cells led to hyperactivation of the TGF-β signaling pathway, enhanced expression of target genes like PAI-1, and the expression of α-smooth muscle actin (α-SMA). We propose that the interaction of tumor cells with resident fibroblasts results in hyperactivated TGF-β1 signaling and subsequent transdifferentiation of the fibroblasts into α-SMA-positive CAFs. In turn this leads to cumulative production of TGF-β and proteinases within the tumor microenvironment, creating a cancer-promoting feedback loop.
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| 3. |
- Abdesselam, A., et al.
(författare)
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Engineering for the ATLAS SemiConductor Tracker (SCT) end-cap
- 2008
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 3
-
Tidskriftsartikel (refereegranskat)abstract
- The ATLAS SemiConductor Tracker (SCT) is a silicon-strip tracking detector which forms part of the ATLAS inner detector. The SCT is designed to track charged particles produced in proton-proton collisions at the Large Hadron Collider (LHC) at CERN at an energy of 14 TeV. The tracker is made up of a central barrel and two identical end-caps. The barrel contains 2112 silicon modules, while each end-cap contains 988 modules. The overall tracking performance depends not only on the intrinsic measurement precision of the modules but also on the characteristics of the whole assembly, in particular, the stability and the total material budget. This paper describes the engineering design and construction of the SCT end-caps, which are required to support mechanically the silicon modules, supply services to them and provide a suitable environment within the inner detector. Critical engineering choices are highlighted and innovative solutions are presented - these will be of interest to other builders of large-scale tracking detectors. The SCT end-caps will be fully connected at the start of 2008. Further commissioning will continue, to be ready for proton-proton collision data in 2008.
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| 4. |
- Vorobiev, Andrei, 1963, et al.
(författare)
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Composite Ferroelectric FBARs That Are Switchable Between the First and Second Harmonics: Experimental Demonstration
- 2015
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Ingår i: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. - : Institute of Electrical and Electronics Engineers (IEEE). - 0885-3010. ; 62:3, s. 565-575
-
Tidskriftsartikel (refereegranskat)abstract
- Digital switching between the first and second harmonics, in a composite thin-film bulk acoustic wave resonator (FBAR), is demonstrated experimentally. The FBAR consists of two 180-nm-thick paraelectric-phase Ba0.25Sr0.75TiO3 films separated by a 50-nm-thick SrRuO3 conducting layer. The resonant frequency of this composite resonator (with Pt bottom and Al top electrodes) is switched from 3.6 GHz to 7.6 GHz, where the polarity of the 5 V dc bias is reversed on one of the ferroelectric films. The frequency switching ratio (f(2)/f(1) >= 2) depends on the thickness of the electrodes. Some adjustment of f(2)/f(1) is possible by changing the applied dc bias.
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| 5. |
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| 6. |
- Abdesselam, A., et al.
(författare)
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The barrel modules of the ATLAS semiconductor tracker
- 2006
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 568:2, s. 642-671
-
Tidskriftsartikel (refereegranskat)abstract
- This paper describes the silicon microstrip modules in the barrel section of the SemiConductor Tracker (SCT) of the ATLAS experiment at the CERN Large Hadron Collider (LHC). The module requirements, components and assembly techniques are given, as well as first results of the module performance on the fully assembled barrels that make up the detector being installed in the ATLAS experiment.
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| 7. |
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| 8. |
- Feng, Yan, et al.
(författare)
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Mechanical Activation of Granulated Copper Slag and Its Influence on Hydration Heat and Compressive Strength of Blended Cement
- 2019
-
Ingår i: Materials. - Basel, Switzerland : MDPI. - 1996-1944. ; 12:5
-
Tidskriftsartikel (refereegranskat)abstract
- Mechanical activation of granulated copper slag (GCS) is carried out in the present study for the purposes of enhancing pozzolanic activity for the GCS. A vibration mill mills the GCS for 1, 2, and 3 h to produce samples with specific surface area of 0.67, 1.03 and 1.37 m²/g, respectively. The samples are used to replace 30% cement (PC) to get 3 PC-GCS binders. The hydration heat and compressive strength are measured for the binders and derivative thermogravimetric /thermogravimetric analysis (DTG/TGA), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) are used to characterize the paste samples. It is shown that cumulative heat and compressive strength at different ages of hydration and curing, respectively, are higher for the binders blending the GCS milled for a longer time. The compressive strength after 90 d of curing for the binder with the longest milling time reaches 35.7 MPa, which is higher than the strength of other binders and close to the strength value of 39.3 MPa obtained by the PC pastes. The percentage of fixed lime by the binder pastes at 28 days is correlated with the degree of pozzolanic reaction and strength development. The percentage is higher for the binder blending the GCS with longer milling time and higher specific surface area. The pastes with binders blending the GCS of specific surface area of 0.67 and 1.37 m²/g fix lime of 15.20 and 21.15%, respectively. These results together with results from X-ray diffraction (XRD), FTIR, and SEM investigations demonstrate that the mechanical activation via vibratory milling is an effective method to enhance the pozzolanic activity and the extent for cement substitution by the GCS as a suitable supplementary cementitious material (SCM).
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| 9. |
- Gaiotti, Marco, et al.
(författare)
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A numerical sensitivity analysis on the cohesive parameters of a carbon-steel single lap joint
- 2020
-
Ingår i: Ocean Engineering. - : Elsevier BV. - 0029-8018. ; 198
-
Tidskriftsartikel (refereegranskat)abstract
- One of the key issues concerning the use of composite materials in the construction of steel ships, or vice versa, the use of steel in the construction of composite ships, is related to the ways of joining composite parts to the adjacent steel structure. Carbon-steel joints are of increasing interest for the maritime industry, but knowledge is scarce. Applications of adhesive joints as an alternative method to welding or riveting has numerous advantages. Still, gathering more information about the behaviour of such joints through numerical sensitivity analysis and simulation are necessary to speed up applications on ships and marine structures. The present investigation aims at assessing the sensitivity of the parameters that define the traction separation law on the numerical simulation of the de-bonding of a steel to composite single lap joint, following a previous experimental campaign. The test is intended to induce a mode II separation, although the slight bending moment caused by the misalignment of the two ends leads to mixed mode effects, as well. Two finite element software were compared, ADINA and LS-DYNA. The influence of peak traction, penalty stiffness and energy release rate were investigated, along with the effect of a mixed mode opening behaviour.
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| 10. |
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| 11. |
- Willquist, Petra, 1975
(författare)
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Industrial Safety: Principles for Safety Management based on Emperical Studies
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Although safety management has developed considerably during the last decades, occupational accidents still contribute to work-related health problems worldwide. This thesis investigates occupational accidents in production environments, explores existing safety management and provides some insights into why it fails to function in a satisfactory manner. An abductive approach was used, which implies continuous interplay between the theoretical and empirical world. Empirical studies were performed in the food industry. A systems model was created, three levels of which were studied: conceptual, strategic and operative. An exploration of existing safety management was carried out by means of a literature review of safety analysis methods as well as studies of three case companies. The empirical studies entailed a survey of production systems and interviews at different organisational levels. Finally, a theoretical paper investigated the possibilities of integrating safety and robustness. It was found that companies addressed safety problems by technological solutions and that there were conflicts between safety and other company goals. The actors involved had different mental models of safety and accidents, which led to problems in the operationalisation of goals and policies at conceptual level. Risks and accidents were often addressed by normative approaches, which, however, were not completely applicable to the dynamic systems. This, in combination with e.g. lack of system overview and a strong focus on product rather than production led to tradeoffs at operative level between safety and productivity. The thesis concludes that conflicting goals and mental models should be made explicit. Companies should also aim towards a balance between technological solutions and organisational solutions addressing operators' knowledge and skills. Similarly, the aim should be a balance between normative and decentralised approaches. There is a need to integrate safety and robustness related issues at the strategic level of the system.
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| 12. |
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| 13. |
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| 14. |
- Kianian, Babak, 1985-, et al.
(författare)
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The Role of Additive Manufacturing Technology in job creation : an exploratory case study of suppliers of Additive Manufacturing in Sweden
- 2015
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Ingår i: Procedia CIRP. - : Elsevier. ; , s. 93-98
-
Konferensbidrag (refereegranskat)abstract
- his paper investigates how Additive Manufacturing (AM) technologies, as a process innovation, may contribute to a job creation. Further, the various mechanisms in which AM may contribute to an increase in job creation as well as the types of jobs are analyzed. The analysis also goes beyond AM technologies and incorporates other non-technological factors which foster job creation, i.e. higher wages in BRIC countries, lower quality in BRIC countries, and a rising demand for western-made products. The analysis is based on a case study and the data collected was through interviews with three prominent actors within the AM technologies field in Sweden: technology developers, leading suppliers and users. The main findings indicate that AM (i) contributes to job creation in both the manufacturing sector and in the service sector, (ii) does not bring back mass production jobs from emerging economies such as BRIC, (iii) contributes to job creation in product development stages (e.g. rapid prototyping), and (iv) contributes to job creation in production stages of low-volume batches mainly of complex products. The findings also suggest there are barriers for full exploitation of AM in several areas, including education systems.
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| 15. |
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| 16. |
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| 17. |
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| 18. |
- Kashyap, Shruti
(författare)
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Transparency and Accountability in the European Financial Sector : The Markets in Financial Instruments Directive (MiFID) and Beyond
- 2017. - 1
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Ingår i: Bank Regulation. - : Routledge. - 9781315563893 - 9781138680500 ; , s. 104-129
-
Bokkapitel (refereegranskat)abstract
- This chapter structures the background of inquiry into transparency and accountability in the financial sector is substantiated through an explanation of the interdisciplinary links between banking regulation and practice. In terms of regulatory focus, market efficiency and prudence are two important concerns in the context of financial markets and participants. Regarding market efficiency, market liquidity and information availability are important issues for regulators to consider. In the context of financial markets, transparency may provide the individual merit of promoting market efficiency under certain conditions, although it is generally better understood as a tool for accountability. EU policymakers had long considered how best to enhance market efficiency, and in 1993, they formally adopted the Investment Services Directive of 1993. During the 1980s, regulators were also focused on capital adequacy and the organizational resilience of banks. An important area where regulatory focus on transparency and accountability has risen is the area of internal control and governance within financial institutions.
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| 19. |
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| 20. |
- Brodén Gyberg, Veronica, 1978-
(författare)
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Aiding science? Past and present discourses of Swedish research aid policy.
- 2016
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Ingår i: Panel 2: Where are we now? The past and the future of Swedish development research collaboration (conveners: David Nilsson and Sverker Sörlin).
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The purpose of research aid is to contribute to development in different ways through the use of research. Sarec (the Swedish Agency for Research Cooperation with Developing Countries) was one of the pioneers within state research aid, and existed between 1975 and 2008. One of the central questions asked in my dissertation on Sarec’s policy history is how the view of the relationship between research and development has changed over time. One of the conclusions is that there are two main policy discourses that can be traced throughout the entire period studied. They share the starting point that modern science can contribute to development and that national research capacity is an important component in this. The localist discourse represents a more multifaceted view of how research can contribute to development, and what that development consist of. It is more explicitly anti-colonialist and to a greater degree prioritizes the local context as basis for decisions regarding support. The universalist discourse places less emphasis on where knowledge is produced since it can be used anywhere, as long as the right structures and priorities are in place. This historical perspective will be complemented with reflections on current developments in Swedish science aid policy, focusing on the issue of how science aid can contribute to the sustainable development goals and transitions to sustainability (work in progress).
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| 21. |
- Lowry, Stephanie, 1979-, et al.
(författare)
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Lightweight, Viewpoint-Invariant Visual Place Recognition in Changing Environments
- 2018
-
Ingår i: IEEE Robotics and Automation Letters. - : Institute of Electrical and Electronics Engineers (IEEE). - 2377-3766. ; 3:2, s. 957-964
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents a viewpoint-invariant place recognition algorithm which is robust to changing environments while requiring only a small memory footprint. It demonstrates that condition-invariant local features can be combined with Vectors of Locally Aggregated Descriptors (VLAD) to reduce high-dimensional representations of images to compact binary signatures while retaining place matching capability across visually dissimilar conditions. This system provides a speed-up of two orders of magnitude over direct feature matching, and outperforms a bag-of-visual-words approach with near-identical computation speed and memory footprint. The experimental results show that single-image place matching from non-aligned images can be achieved in visually changing environments with as few as 256 bits (32 bytes) per image.
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| 22. |
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| 23. |
- Aad, G., et al.
(författare)
-
- 2014
-
Tidskriftsartikel (refereegranskat)
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| 24. |
- Alexander, Stephen P. H., et al.
(författare)
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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
- 2023
-
Ingår i: BRITISH JOURNAL OF PHARMACOLOGY. - : British pharmacological society. - 0007-1188 .- 1476-5381. ; 180
-
Tidskriftsartikel (refereegranskat)abstract
- The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at . G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
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| 25. |
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| 26. |
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| 27. |
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| 28. |
- Lohmus, Mare, et al.
(författare)
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Climate change : what will it do to fish-parasite interactions?
- 2015
-
Ingår i: Biological Journal of the Linnean Society. - : Oxford University Press (OUP). - 0024-4066 .- 1095-8312. ; 116:2, s. 397-411
-
Forskningsöversikt (refereegranskat)abstract
- Climate change-related factors are predicted to affect aquatic environments in many ways. Fish physiology, immunology, behaviour, and parasite-avoidance strategies are likely to be affected by climate change and this may lead to ecosystem-level changes. Parasitic organisms that exploit fish are also likely to be affected by climate change, both directly and via climate effects on their hosts. It is possible that climate change will alter the prerequisites for parasite transfer, for example, through changes in phenological relationships, and/or change the direction and pressure of selection in host-parasite relationships. Our review indicates strong multifactorial effects of climate change on fish-parasite systems. Increased water temperature is, on the one hand, predicted to enhance parasite metabolism, resulting in more rapid spread of parasites; on the other hand, the occurrence of some parasites could also decrease if the optimal temperature for growth and transmission is exceeded.
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| 29. |
- Moini, Hamid, et al.
(författare)
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The Internet and Internationalization of Smaller Manufacturing Enterprises
- 2005
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Ingår i: Journal of Global Marketing. - 0891-1762. ; 18:3/4, s. 79-94
-
Tidskriftsartikel (refereegranskat)abstract
- One of the most frequently discussed topics in the current international business literature is the impact of the Internet on the internationalization of smaller manufacturing enterprises (SMEs). The study was carried out through a mail survey of the top executives of 125 Wisconsin firms. It examined 10 research hypotheses on internal and external factors which had been identified by previous research to influence the internationalization of SMEs through the Internet. Research findings conclude that the scope of internationalization of SMEs through the Internet is affected by internal factors, such as managements' perceptions of the effectiveness of their web sites as a marketing tool, lack of experience, and SMEs' potential usage of the Internet.
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| 30. |
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| 31. |
- Pokutta, Dalia Anna, 1979
(författare)
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Isotopic study of Szczepankowice Early Bronze Age barrow burial ground (southwestern Poland) : Analizy izotopowe wczesnobrazowej nekropoli unietyckiej w Szepankowicach
- 2011
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Ingår i: Silsia Antiqua. - 0080-9594. ; 47:1, s. 70-91
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents the current stage of an ongoing research project regarding isotopic analyses of Únětice culture in Silesia District (southwest Poland). The main core of our undertaking has been divided into several parts, targeting different aspects of diet, migratory patterns and archaeological cultural diversity. These components may be observed on macro- and micro-regional scales in the South West of Poland under the Early Bronze Age period. This study provides a new model of contextual interpretation of barrow burial ground in classic phase of Únětice culture in Central Europe. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 212402. Publication of the Szczepankowice barrows case study sums up the first level of investigation. It has been designed to combine varied elements: archaeological diagnostic, paleopathology, isotopic analyses (local strontium baseline level plus migration case study) and finally radiocarbon dating, which enables us to place the whole structure within a chronological framework. Testing multi-functional tools was one aspect of the investigation, but in general this initial stage has been dedicated to ‘people of the barrows’, the upper class of the Early Bronze Age community.
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| 32. |
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| 33. |
- Thomé, Bibbi
(författare)
-
Att leva med cancer som äldre
- 2004
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Ingår i: Socialmedicinsk tidskrift. - 0037-833X. ; :2, s. 179-179
-
Tidskriftsartikel (refereegranskat)
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| 34. |
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| 35. |
- Adams, Emma, 1989, et al.
(författare)
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Water–gas-shift assisted ammonia formation over Pd/Ce/alumina
- 2018
-
Ingår i: Catalysis Today. - : Elsevier BV. - 0920-5861. ; 307, s. 169-174
-
Tidskriftsartikel (refereegranskat)abstract
- We report experimental results for the water–gas-shift assisted formation of ammonia from nitric oxide over alumina supported palladium, modified with various amounts (0–38 wt.%) of cerium. Static and transient flow reactor experiments were performed in order to identify the effects of temperature and the presence of oxygen on the activity for ammonia formation over the catalysts. The water–gas-shift reaction is enhanced with increasing cerium content, thus providing more hydrogen for ammonia formation. During transient operation at temperatures above 350 °C, a slight delay in ammonia formation is observed over the sample containing the highest cerium loading due to its (relatively) high dynamic oxygen storage capacity. At temperatures below 175 °C, N2O formation is preferred over NH3 formation. This work highlights the importance of balancing the effects that ceria influences when choosing the ceria loading for ammonia formation in passive-SCR applications.
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| 36. |
- Alexander, Steven M., et al.
(författare)
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Untangling the drivers of community cohesion in small-scale fisheries
- 2018
-
Ingår i: International Journal of the Commons. - : Ubiquity Press, Ltd.. - 1875-0281. ; 12:1, s. 519-547
-
Tidskriftsartikel (refereegranskat)abstract
- Sustainable fisheries require strong management and effective governance. However, small-scale fisheries (SSF) often lack formal institutions, leaving management in the hands of local users in the form of various governance approaches (e.g. local, traditional, or co-management). The effectiveness of these approaches inherently relies upon some level of cohesion among resource users to facilitate agreement on common policies and practices regarding common pool fishery resources. Understanding the factors driving the formation and maintenance of community cohesion in SSF is therefore critical if we are to devise more effective participatory governance approaches and encourage and empower decentralized, localized, and community-based resource management approaches. Here, we adopt a social relational network perspective to propose a suite of hypothesized drivers that lead to the establishment of social ties among fishers that build the foundation for community cohesion. We then draw on detailed data from Jamaica's small-scale fishery to empirically test these drivers by employing a set of nested exponential random graph models (ERGMs) based on specific structural building blocks (i.e. network configurations) theorized to influence the establishment of social ties. Our results demonstrate that multiple drivers are at play, but that collectively, gear-based homophily, geographic proximity, and leadership play particularly important roles. We discuss the extent to which these drivers help explain previous experiences, as well as their implications for future and sustained collective action in SSF in Jamaica and elsewhere.
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| 37. |
- Alexander, S, et al.
(författare)
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Maternal health outcomes in Europe.
- 2003
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Ingår i: European Journal of Obstet & Gynecol and Repro. Biol.. ; 111, s. 78-
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Tidskriftsartikel (refereegranskat)
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| 38. |
- Alexander, Shovsky, 1978-
(författare)
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Polyelectrolyte complexes of bottle brush copolymers : Solution and adsorption properties
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this thesis work was to systematically investigate the physico-chemical properties of polyelectrolyte complexes (PECs) formed by bottle brush and linear polyelectrolytes in solution and at solid / liquid interfaces. Electrostatic self-assembly of oppositely charged macromolecules in aqueous solution is a versatile strategy to construction of functional nanostructures with easily controlled properties. Bottle brush architecture, introduced into the PEC, generates a number of distinctive properties of the complexes, related to a broad range of application, such as colloidal stability and protein repellency to name a few. To utilize these materials in a wide range of applications e.g. drug delivery, the understanding of the effects of polymer architecture and solution parameters on the properties of bottle brush PECs is of paramount importance. This thesis constitutes a systematic investigation of PECs formed by a series of cationic bottle-brush polyelectrolytes and a series of anionic linear polyelectrolytes in aqueous solution. The focus of the first part of the thesis was primarily on formation and characterization of PECs in solution, whereas the adsorption properties and adsorption kinetics of bottle-brush polyelectrolytes and their complexes was investigated in the second part of the thesis work. In particular, effects of the side-chain density of the bottlebrush polyelectrolyte, concentration, mixing ratio and molecular weigh of the linearpolyelectrolyte on formation, solution properties, stability and adsorption of PECs were addressed. The pronounced effect of the side-chain density of the bottle-brush polyelectrolyte on the properties of stoichiometric and nonstoichiometric PECs was demonstrated. Formation of PECs by bottle-brush copolymers with high density of side-chains results in small, watersoluble, molecular complexes having nonspherical shape, independent of concentration. Whereas formation of PEC-aggregates was revealed by bottle-brush polyelectrolytes with low side chain density, the level of aggregation in these complexes is controlled by polyelectrolyte concentration. The structure of the PECs formed with low molecular weight polyanions is consistent with the picture that several small linear polyelectrolyte molecules associate with the large bottle-brush. In contrast, when complexation occurs between polyanions of high molecular weigh and the bottle-brush polymers considerably larger PECs are formed, consistent with several bottle-brush polymers associating with one high molecular weight polyanion.
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| 39. |
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| 40. |
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| 41. |
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| 42. |
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| 43. |
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| 44. |
- Barabash, Victoria, Dr, et al.
(författare)
-
Development of a competence ecosystem for the future space workforce: strategies, practices and recommendations from international master programs in northern Sweden
- 2022
-
Ingår i: Acta Astronautica. - : Elsevier. - 0094-5765 .- 1879-2030. ; 197, s. 46-52
-
Tidskriftsartikel (refereegranskat)abstract
- Requirements from the global labor market have substantially changed in recent years. Graduate and post-graduate students with excellent subject knowledge, deep understanding of modern working methods, technicaland higher-order thinking, engineering intuition and problem-solving skills are in great demand. They should also have professional skills such as well-developed abilities in communication and teamwork, usually in an international work environment. This review discusses the advantages of multidisciplinary study environment, educational strategies such as student-oriented teaching, project-based learning with its applicability to a“real-world” setting, active learning techniques, development of entrepreneurial skills, lessons learned and best practices from the international Master Program in Spacecraft Design and the Joint Master Program in SpaceScience and Technology – SpaceMaster at Luleå University of Technology in northern Sweden. The importance of complementarity between formal, informal and non-formal learning methods for science and engineering studentshas been specifically highlighted. Connections to the world of work, through active industry involvementin the education in a systematic way, e.g. External Advisory Board, shared services and facilities, joint projectsand supervision of Master and PhD students, is recognised as a key success factor for professional training. A structural combination of modern pedagogical tools, strategic partnership with industry, business entities, academic partners and up-to-date multidisciplinary labs creates the conceptual framework for a CompetenceEcosystem for fostering a new generation of space scientists and engineers.
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| 45. |
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| 46. |
-
Darwin-Inspired Learning
- 2015
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Charles Darwin has been extensively analysed and written about as a scientist, Victorian, father and husband. However, this is the first book to present a carefully thought out pedagogical approach to learning that is centred on Darwin's life and scientific practice. The ways in which darwin developed his scientific ideas, and their far-reaching effects continue to challenge and provoke contemporary teachers and learners, inspiring them to consider both how scientists work and how humans 'read nature'.
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| 47. |
- Fulda, S., et al.
(författare)
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Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
- 1997
-
Ingår i: Cancer Research. - : American Association for Cancer Research. - 0008-5472 .- 1538-7445. ; 57:21, s. 4956-4964
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Tidskriftsartikel (refereegranskat)abstract
- Betulinic acid CBA), a melanoma-specific cytotoxic agent, induced apoptosis in neuroectodermal tumors, such as neuroblastoma, medulloblastoma, and Ewing's sarcoma, representing the most common solid tumors of childhood. BA triggered an apoptosis pathway different from the one previously identified for standard chemotherapeutic drugs. BA-induced apoptosis was independent of CD95-ligand/receptor interaction and accumulation of wild-type p53 protein, but it critically depended on activation of caspases (interleukin 1 beta-converting enzyme/Ced-3-like proteases), FLICE/MACH (caspase-8), considered to be an upstream protease in the caspase cascade, and the downstream caspase CPP32/YAMA/Apopain (caspase-3) were activated, resulting in cleavage of the prototype substrate of caspases PARP. The broad-spectrum peptide inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone, which blocked cleavage of FLICE and PARP, also completely abrogated BA-triggered apoptosis. Cleavage of caspases was preceded by disturbance of mitochondrial membrane potential and by generation of reactive oxygen species. Overexpression of Bcl-2 and Bcl-x(L) conferred resistance to BA at the level of mitochondrial dysfunction, protease activation, and nuclear fragmentation. This suggested that mitochondrial alterations were involved in BA-induced activation of caspases. Furthermore, pax and Bcl-x(s), two death-promoting proteins of the Bcl-2 family, were up-regulated following BA treatment. Most importantly, neuroblastoma cells resistant to CD95- and doxorubicin-mediated apoptosis were sensitive to treatment with BA, suggesting that BA may bypass some forms of drug resistance. Because BA exhibited significant antitumor activity on patients' derived neuroblastoma cells ex vivo, BA may be a promising new agent for the treatment of neuroectodermal tumors in vivo.
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| 48. |
- Heymowski, Andreas
(författare)
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Den mäktiga Rikssalen
- 2011
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Ingår i: Kulturvärden. - Stockholm : Statens fastighetsverk (SFV). - 1654-8582. ; :1, s. 30-36
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 49. |
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| 50. |
- Klofsten, Magnus, et al.
(författare)
-
An Integrated Approach to Measuring the Development of High Technology Firms
- 2013
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Ingår i: High Technology Entrepreneurship: A Festschrift for Ray Oakey. - Linköping : VU University Press. - 9789086596461 ; , s. 53-69
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Bokkapitel (refereegranskat)abstract
- Small high-technology firms are a central element in technological innovation and economic growth; as such, they have attracted the attention of scholars and practitioners. In the last 20 years Ray Oakey has become an undisputed authority in this field. This volume of conceptual and empirical studies provides an overview of Ray Oakey’s exceptional career and work and of the most important topics in the field of high-technology entrepreneurship. It discusses the intricate dynamics between entrepreneurs, venture, and networks, as well as the issue of university-entrepreneurship interactions and other forms of public private partnerships in the field of high technology. The present volume contains diverse contributions in terms of both the methodology applied—from case studies to large scale surveys—as well as the fields and countries investigated and the theoretical frameworks applied, reflecting the broad scope of Ray Oakey’s thinking and writing.
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