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- Chen, H.Y., et al.
(författare)
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Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study
- 2023
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Ingår i: European Heart Journal. - : Oxford University Press. - 0195-668X .- 1522-9645. ; 44:21, s. 1927-1939
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Tidskriftsartikel (refereegranskat)abstract
- Aims Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype data to identify mechanisms of AS. Methods and results A genome-wide meta-analysis of 11.6 million variants in 10 cohorts involving 653 867 European ancestry participants (13 765 cases) was performed. Seventeen loci were associated with AS at P ≤ 5 × 10−8, of which 15 replicated in an independent cohort of 90 828 participants (7111 cases), including CELSR2–SORT1, NLRP6, and SMC2. A genetic risk score comprised of the index variants was associated with AS [odds ratio (OR) per standard deviation, 1.31; 95% confidence interval (CI), 1.26–1.35; P = 2.7 × 10−51] and aortic valve calcium (OR per standard deviation, 1.22; 95% CI, 1.08–1.37; P = 1.4 × 10−3), after adjustment for known risk factors. A phenome-wide association study indicated multiple associations with coronary artery disease, apolipoprotein B, and triglycerides. Mendelian randomization supported a causal role for apolipoprotein B-containing lipoprotein particles in AS (OR per g/L of apolipoprotein B, 3.85; 95% CI, 2.90–5.12; P = 2.1 × 10−20) and replicated previous findings of causality for lipoprotein(a) (OR per natural logarithm, 1.20; 95% CI, 1.17–1.23; P = 4.8 × 10−73) and body mass index (OR per kg/m2, 1.07; 95% CI, 1.05–1.9; P = 1.9 × 10−12). Colocalization analyses using the GTEx database identified a role for differential expression of the genes LPA, SORT1, ACTR2, NOTCH4, IL6R, and FADS. Conclusion Dyslipidemia, inflammation, calcification, and adiposity play important roles in the etiology of AS, implicating novel treatments and prevention strategies. © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.
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| 2. |
- D’Amico, Valeria, et al.
(författare)
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EU FP7 INFSO-ICT-247223 ARTIST4G, D1.2 Innovative advanced signal processing algorithms for interference avoidance
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This document provides an overview of the proposed innovations and activities in Task 1.1 of Work Package 1 (WP1) of the ARTIST4G project, related to interference avoidance. Focus is on the technical approaches applicable at the physical layer, which are grouped into four different classes of innovations related to single-cell multi-user MIMO schemes, multi-cell multi-user MIMOschemes, advanced 3D beamforming and enabling functionalities. Descriptions of the proposed innovations are given including basic ideas, potential of performance, simulation results, realization options and possible implementation restrictions.
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| 5. |
- Steenholt Olesen, Rikke
(författare)
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Runes about a Snow-White Woman : The Lund Gaming-Piece Revisited
- 2013
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Ingår i: Futhark. - 1892-0950 .- 2003-296X. ; 3, s. 89-104
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Tidskriftsartikel (refereegranskat)abstract
- A small, well-preserved, wooden runic object was found in a well in the city of Lund in Scania (Skåne) in 2004 and has puzzled researchers ever since. It is presumably a gaming-piece for a board game. The dating of the archaeological layer in which the object was found suggests that it ended in the well between c. 1220 and 1235. The reading of the individual runes is in almost every case certain. The reading order of the lines, the interpretation of the linguistic content and the provenance, however, have caused disagreement among those who have studied the object. The inscription was tentatively discussed in the author’s Ph.D. dissertation from 2007, but many questions remained unsolved. This paper reviews the discussion so far, and offers a more coherent linguistic interpretation. It also suggests a probable provenance for the object.
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| 6. |
- Steenholt Olesen, Rikke
(författare)
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Runic Amulets from Medieval Denmark
- 2010
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Ingår i: Futhark: International Journal of Runic Studies. - Oslo, Uppsala : University of Oslo, Uppsala University. - 1892-0950. ; 1, s. 161-176
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Tidskriftsartikel (refereegranskat)
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| 7. |
- Wejse, Christian, et al.
(författare)
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Serum 25-hydroxyvitamin D in a West African population of tuberculosis patients and unmatched healthy controls
- 2007
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Ingår i: American Journal of Clinical Nutrition. - 1938-3207. ; 86:5, s. 1376-1383
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Tidskriftsartikel (refereegranskat)abstract
- Background: Little is known regarding vitamin D deficiency (VDD) in African populations and in tuberculosis (TB) patients. VDD has been shown to be associated with TB. Objective: We aimed to compare the degree of vitamin D insufficiency (VDI) and VDD in TB patients and healthy adult controls in a West African population. Design: An unmatched case-control study was performed at a Demographic Surveillance Site in Guinea-Bissau. Serum 25-hydroxyvitamin D-3 [25(OH)D-3] concentrations were measured in 362 TB patients and in 494 controls. Results: Hypovitammosis D [25(OH)D-3 <= 75 nmol/L] was more common in TB patients, but VDD [25(OH)D-3 <= 50 nmol/L] was more common and more severe in controls. We observed hypovitaminosis D in 467o (167/362) of the TB patients and in 39% (193/494) of the controls: the relative risk (RR) of hypovitaminosis D was 1.18 (95% Cl: 1.01. 1.38). VDD was observed in 8.5% (31/362) of the TB patients and in 13.2% (65/494) of the controls. The RR was 0.65 (95% Cl: 0.43,0.98), mainly because severe VDD [25(OH)D-3 <= 25 nmol/L] was observed in only I of 362 TB patients (0.2%) and in 24 of 494 controls (4.9%). After adjustment for background factors, hypovitaminosis D was not more frequent in TB patients than in healthy controls, but the mean serum 25(OH)D3 concentration remained lower. Conclusions: Hypovitammosis D was highly prevalent in TB patients and in healthy controls living at 12 degrees N; severe VDD was rare in TB patients. The finding indicates that the serum 25(OH)D3 concentration is associated with TB infection, but whether this role is a symptom or is causal was not established.
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