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| 2. |
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| 3. |
- Alm, Bernt, 1951, et al.
(författare)
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Antibiotics in the first week of life is a risk factor for allergic rhinitis at school age.
- 2014
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Ingår i: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. - : Wiley. - 1399-3038. ; 25:5, s. 468-472
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Tidskriftsartikel (refereegranskat)abstract
- Heredity as well as external factors influences the development of allergic rhinitis. The aim of this study was to analyse early risk factors and protective factors for allergic rhinitis at school age.
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| 4. |
- Alm, Bernt, 1951, et al.
(författare)
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Early introduction of fish decreases the risk of eczema in infants.
- 2009
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Ingår i: Archives of disease in childhood. - : BMJ. - 1468-2044 .- 0003-9888. ; 94:1, s. 11-5
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Atopic eczema in infants has increased in western societies. Environmental factors and the introduction of food may affect the risk of eczema. AIMS: To investigate the prevalence of eczema among infants in western Sweden, describe patterns of food introduction and assess risk factors for eczema at 1 year of age. METHODS: Data were obtained from a prospective, longitudinal cohort study of infants born in western Sweden in 2003; 8176 families were randomly selected and, 6 months after the infant's birth, were invited to participate and received questionnaires. A second questionnaire was sent out when the infants were 12 months old. Both questionnaires were completed and medical birth register data were obtained for 4921 infants (60.2% of the selected population). RESULTS: At 1 year of age, 20.9% of the infants had previous or current eczema. Median age at onset was 4 months. In multivariable analysis, familial occurrence of eczema, especially in siblings (OR 1.87; 95% confidence interval (CI) 1.50 to 2.33) or the mother (OR 1.54; 95% CI 1.30 to 1.84), remained an independent risk factor. Introducing fish before 9 months of age (OR 0.76; 95% CI 0.62 to 0.94) and having a bird in the home (OR 0.35; 95% CI 0.17 to 0.75) were beneficial. CONCLUSIONS: One in five infants suffer from eczema during the first year of life. Familial eczema increased the risk, while early fish introduction and bird keeping decreased it. Breast feeding and time of milk and egg introduction did not affect the risk.
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| 5. |
- Alm, Bernt, 1951, et al.
(författare)
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Early protective and risk factors for allergic rhinitis at age 4½ yr.
- 2011
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Ingår i: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. - : Wiley. - 1399-3038 .- 0905-6157. ; 22:4, s. 398-404
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Tidskriftsartikel (refereegranskat)abstract
- Allergic heredity plays a major role in the development of allergic rhinitis. In addition the introduction of food may influence the risk of subsequent allergic disease. The aim of this study was to analyse early risk factors and protective factors for allergic rhinitis at preschool age. Data were obtained from a prospective, longitudinal study of a cohort of children born in the region of western Sweden in 2003 and 8,176 families (50% of the birth cohort) were randomly selected. The parents answered questionnaires at 6 and 12 months and at 4½ yr of age. The response rate at 4½ yr was 4,496, i.e. 83% of the 5,398 questionnaires distributed at 4½ yr. At 4½ yr of age, 5.5% reported symptoms of allergic rhinitis during the last year. In the multivariate analysis, independent risk factors for allergic rhinitis were: allergic sensitisation to food allergens at 4½ yr (OR 10.21; 95% confidence interval 4.22-24.73), recurrent wheeze at 4½ yr (3.33; 1.56-7.10), doctor-diagnosed eczema at 4½ yr (2.72; 1.62-4.55), parental rhinitis (2.21; 1.39-3.53), eczema first year (1.97; 1.19-3.26) and male gender (1.82; 1.13-2.94). The risk was reduced with fish introduction before 9 months (0.49; 0.29-0.82). In conclusion, we found that previous and present allergic disease, heredity and male gender increased the risk of allergic rhinitis at 4½ yr of age. The introduction of fish before the age of 9 months reduced the risk.
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| 6. |
- Alm, Bernt, 1951, et al.
(författare)
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Föräldrar har tagit till sig råden för att förebygga plötslig spädbarnsdöd : [Parents have accepted the advice on how to prevent sudden infant death]
- 2004
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Ingår i: Läkartidningen. - 0023-7205. ; 101:14, s. 1268-1270
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Tidskriftsartikel (refereegranskat)abstract
- We have compared 430 healthy Swedish infants born between 1991 and 1995 with 599 healthy, six months old infants born in 2002, regarding the prevalence of risk factors for SIDS. Following the introduction of the campaign to reduce the risk of SIDS in Sweden in 1992, we could see a decrease in prone sleeping from 32% to 7% together with an increase in supine sleeping from 35% to 44%. Maternal smoking during pregnancy has gone down from 24% to 10%. The prevalence of breast feeding, already high in Sweden in the 90s, was largely unchanged, 69% at six months of age in 2002. This comparison shows that parents of small infants have accepted the advice on ways to reduce the risk of SIDS, and that information given at infant welfare clinics is still effective ten years later. Further improvements are possible by changing the side sleeping position to supine, and by decreasing tobacco smoking among pregnant mothers.
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| 7. |
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| 8. |
- Alm, Bernt, 1951, et al.
(författare)
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Neonatal antibiotic treatment is a risk factor for early wheezing.
- 2008
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Ingår i: Pediatrics. - : American Academy of Pediatrics (AAP). - 1098-4275 .- 0031-4005. ; 121:4, s. 697-702
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The use of antibiotics in infancy and subsequent changes in the intestinal bacterial flora have been discussed as risk factors for the development of asthma. However, it has been difficult to exclude the possibility that antibiotics have been given in early episodes of wheezing. As a result, there has been a risk of reverse causation. To minimize the risk of reverse causation, we have focused on the effect of antibiotics that are already administered on the neonatal ward. METHODS: In a cohort study of infants born in western Sweden in 2003, we studied the development of wheezing. The families of the infants were randomly selected and sent a questionnaire at child ages 6 and 12 months. The response rate was 68.5% to the 6-month questionnaire and 68.9% to the 12-month questionnaire. RESULTS: At 12 months, 20.2% of infants had had 1 or more episodes of wheezing, and 5.3% had had 3 or more episodes. Inhaled corticosteroids had been taken by 4.1% of the infants. Independent risk factors for wheezing disorder treated with inhaled corticosteroids were neonatal antibiotic treatment, male gender, gestational age of <37 weeks, having a mother with asthma, having a sibling with asthma or eczema, and breastfeeding for <5 months. CONCLUSIONS: Treatment with antibiotics in the neonatal period was an independent risk factor for wheezing that was treated with inhaled corticosteroids at 12 months of age. These results indirectly support the hypothesis that an alteration in the intestinal flora can increase the risk of subsequent wheezing.
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| 9. |
- Alm, Bernt, 1951, et al.
(författare)
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PD12 - Living on a farm protects from allergic rhinitis at school age.
- 2014
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Ingår i: Clinical and translational allergy. - 2045-7022. ; 4:Suppl 1 3rd Pediatric Allergy and Asthma Meeting
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Tidskriftsartikel (refereegranskat)abstract
- Background Family history plays a major role in the development of allergic rhinitis. External influences, such as a farm childhood and fish introduction have been suggested to play a protective role. The aim was to analyse early risk factors and protective factors for allergic rhinitis at school age. Methods The material is a prospective, longitudinal study of a cohort of children born in the region of western Sweden in 2003 where 8,176 families (50% of the birth cohort) were randomly selected. The parents answered questionnaires at 6 months, 12 months, 4½ years and 8 years of age. The response rate at eight years was 80% (4,051 of 5,044 questionnaires distributed). Results At eight years of age, 441 children (11.3%) had used medicines for allergic rhinitis the past twelve months. The mean onset age was 5.1 year and 61.9% were boys. In a multivariate analysis of factors associated with allergic rhinitis with p<0.1, we found that living on a farm at 4½ years was inversely associated with allergic rhinitis treated with medicines at 8 years (adjusted odds ratio 0.31, 95% confidence interval (0.13, 0.78)). Positive associations were seen with parental allergic rhinitis (2.73 (2.12, 3.52)), food allergy first year (2.45 (1.61, 3.73)), eczema first year (1.97 (1.50, 2.59)), neonatal antibiotics (1.75 (1.03, 2.97)) and male gender (1.35 (1.05, 1.74)). Conclusion In conclusion, we found that a family history of rhinitis, early food allergy, early eczema and male gender increased the risk of rhinitis at school age. Furthermore, we found a protective effect of living on a farm at preschool age, and that antibiotics neonatally increased the risk. Both findings are compatible with the hygiene hypothesis.
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| 10. |
- Alm, Bernt, 1951, et al.
(författare)
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SIDS risk factors and factors associated with prone sleeping in Sweden
- 2006
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Ingår i: Archives of Disease in Childhood. - : BMJ. - 0003-9888 .- 1468-2044. ; 91:11, s. 915-9
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To compare the current prevalence of risk factors for sudden infant death syndrome (SIDS) in Sweden with a decade earlier, and assess factors associated with prone sleeping. METHODS: The results of a cohort study (Infants of Western Sweden) and a population based case-control study (Nordic Epidemiological SIDS Study) were examined. Subjects were 5600 healthy 6 month old infants born in 2003 in the Western Sweden region and 430 healthy Swedish infants born between 1991 and 1995. RESULTS: Prone sleeping decreased from 31.8% to 5.6% and supine sleeping increased from 35.3% to 47.3%. Side or side/supine sleeping increased from 25.2% to 43.8%. Maternal smoking during pregnancy decreased from 23.5% to 9.5%. The risk for prone sleeping increased if the mother was unemployed (OR 2.4, 95% CI 1.5 to 4.0), if she was a heavy smoker in the third trimester (OR 44.1, 95% CI 1.6 to 1199.6), and if the child was irritable (OR 2.5, 95% CI 1.3 to 5.1), shared a bedroom with siblings (OR 2.6, 95% CI 1.0 to 6.6), or never used a dummy (OR 3.2, 95% CI 1.9 to 5.4). CONCLUSIONS: Parents have complied with advice to prevent SIDS given at infant welfare centres for the last 10 years. A change in the preferred sleeping position from side variants to exclusively supine, and reducing the number of pregnant women smoking may be beneficial. Use of a prone sleeping position was associated with maternal employment status, maternal smoking, temperament of the child, dummy use, and sharing a bedroom with siblings.
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| 11. |
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| 12. |
- de Jong, S, et al.
(författare)
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Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
- 2018
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Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 1, s. 163-
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Tidskriftsartikel (refereegranskat)abstract
- Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
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| 13. |
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| 14. |
- Duberg, Ann-Sofi, et al.
(författare)
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The burden of hepatitis C in Sweden : a national study of inpatient care
- 2011
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Ingår i: Journal of Viral Hepatitis. - : Wiley-Blackwell Publishing Inc.. - 1352-0504 .- 1365-2893. ; 18:2, s. 106-118
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Tidskriftsartikel (refereegranskat)abstract
- The spread of hepatitis C virus (HCV) in Sweden in the 1970s indicated that serious liver complications (SLC) would increase in the 2000s. The aim of this study was to analyse the burden of HCV-associated inpatient care in Sweden, to demonstrate the changes over time and to compare the findings with a noninfected population. The HCV-cohort (n: 43 000) was identified from the national surveillance database 1990-2006, and then linked to national registers to produce an age-, sex-, and region-matched noninfected comparison population (n: 215 000) and to obtain information on demographics, cancers, inpatient care and prescriptions. Cox regression was used to estimate the likelihood (hazard ratios) for admission to hospital in the HCV compared with the noninfected cohort. The hazard ratios were 4.03 (95% CI: 3.98-4.08) for all care, 77.52 (71.02-84.60) for liver-related care and 40.74 (30.58-54.27) for liver cancer care. The admission rate in the HCV-cohort compared with the noninfected cohort, the rate ratio (age- and sex-adjusted) for all inpatient care was 5.91 (95% CI: 5.87-5.94), and the rate ratio for liver-related care was 70.05 (66.06-74.28). In the HCV-cohort, 45% of all episodes were for psychiatric, mostly drug-related, care. Inpatient care for SLC increased in the 2000s. To conclude, drug-related care was common in the HCV-infected cohort, the demand for liver-related care was very high, and SLC increased notably in the 2000s, indicating that the burden of inpatient care from serious liver disease in HCV-infected individuals in Sweden is an increasing problem.
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| 15. |
- Enoksson, Staffan, et al.
(författare)
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Marked Re-Utilization of Free Fatty Acids During Activated Lipolysis in Human Skeletal Muscle.
- 2005
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 90:2, s. 1189-1195
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Tidskriftsartikel (refereegranskat)abstract
- Release of glycerol and free fatty acids (FFA) was investigated in human skeletal muscle strips. In the basal state, glycerol and FFA were released at almost equimolar rates (0.3 nmol/ng tissue.90 min). A nonselective beta-adrenoceptor agonist, isoprenaline, caused a concentration-dependent stimulation of glycerol release, whereas FFA release was unaffected. Basal and isoprenaline-induced glycerol release correlated positively with the age of the donors (r = 0.5, P < 0.005) but not with their body mass index (P > or = 0.4). Biochemical experiments with hormone-sensitive lipase (HSL) showed that most enzyme activity was both in the cytosol and mitochondrial fraction and that it constituted the common long and active form of the protein. Electron microscopy studies in rat skeletal muscle using labeled highly specific HSL antibodies verified the cytosolic location of HSL and, furthermore, indicated an accumulation of HSL-adjoining mitochondria. These results suggest that FFA produced in myocytes during catecholamine-induced lipolysis are retained by the muscle and, therefore by inference, reused. It is conceivable that efficient hydrolysis of acylglycerol by HSL located in the cytosol as well as near the mitochondria may facilitate mitochondrial FFA oxidation. In addition, muscle lipolysis activity increases during aging and may be independent of total body fat.
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| 16. |
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| 17. |
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| 18. |
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| 19. |
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| 20. |
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| 21. |
- Fryknäs, Mårten, et al.
(författare)
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STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines
- 2007
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 120:1, s. 189-195
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Tidskriftsartikel (refereegranskat)abstract
- The myeloma cell line RPMI 8226/S and its doxorubicin resistant subline 8226/Dox40 were used as models to explore the potential importance of the STAT1 signaling pathway in drug and radiation resistance. The 40-fold doxorubicin resistant subline 8226/Dox40 was found to be crossresistant to single doses of 4 and 8 Gy of radiation. A genome-wide mRNA expression study comparing the 8226/Dox40 cell line to its parental line was performed to identify the underlying molecular mechanisms. Seventeen of the top 50 overexpressed genes have previously been implicated in the STAT1 signaling pathway. STAT1 was over expressed both at the mRNA and protein level. Moreover, analyses of nuclear extracts showed higher abundance of phosphorylated STAT1 (Tyr 701) in the resistant subline. Preexposure of the crossresistant cells to the STAT1 inhibiting drug fludarabine reduced expression of overexpressed genes and enhanced the effects of both doxorubicin and radiation. These results show that resistance to doxorubicin and radiation is associated with increased STAT1 signaling and can be modulated by fludarabine. The data support further development of therapies combining fludarabine and radiation.
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| 22. |
- Goksör, Emma, 1974, et al.
(författare)
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Early fish introduction and neonatal antibiotics affect the risk of asthma into school age.
- 2013
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Ingår i: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. - : Wiley. - 1399-3038. ; 24:4, s. 339-344
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The early introduction of fish has been reported to reduce the risk of wheezing disorder in early childhood, while broad-spectrum antibiotics in the first week have been associated with an increased risk. However, it is uncertain whether the effects remain into school age. The aim was to explore these risk factors for doctor-diagnosed asthma at 8years. METHODS: Data were obtained from a prospective, longitudinal study of a cohort of children born in western Sweden. The parents answered questionnaires at 6months and 1, 4.5 and 8years of age. The response rate at 8years was 80% of the questionnaires distributed (4051/5044), that is, 71% of the families entering the study (4051/5654). RESULTS: At 8years, 5.7% reported current doctor-diagnosed asthma. Of these, 65% had atopic asthma and 35% non-atopic asthma. In the multivariate analysis, atopic heredity, male gender and own allergic disease during infancy were risk factors for doctor-diagnosed asthma at 8years. In addition, the introduction of fish before the age of 9months independently reduced the risk (adjusted OR 0.6; 95% CI 0.4-0.96), while broad-spectrum antibiotics in the first week independently increased the risk of current asthma at school age (aOR 2.3; 1.2-4.2). Regarding types of asthma, the effects were significant in atopic asthma but not in non-atopic asthma. CONCLUSION: The early introduction of fish and neonatal antibiotic treatment influence the risk of asthma into school age. The significant effect on atopic asthma is of particular importance, as this phenotype is of major clinical significance.
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| 23. |
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| 24. |
- Goksör, Emma, 1974, et al.
(författare)
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Preschool wheeze - impact of early fish introduction and neonatal antibiotics.
- 2011
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Ingår i: Acta paediatrica (Oslo, Norway : 1992). - : Wiley. - 1651-2227 .- 0803-5253.
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Tidskriftsartikel (refereegranskat)abstract
- Aim: The aim of this study was to analyse the risk factors for preschool wheeze with special reference to the early introduction of fish and early antibiotic treatment. To avoid reverse causation regarding antibiotics, we focused on the influence of broad-spectrum antibiotics given during the first week of life. Methods: Data were obtained from a prospective, longitudinal study of a cohort of children born in western Sweden where 50% of the birth cohort was randomly selected. The parents answered questionnaires at 6 and 12months and at 4.5years of age. The response rate at 4.5years was 83% (4496 of 5398 questionnaires distributed). Results: In the multivariate analysis, broad-spectrum antibiotics in the first week increased the risk of recurrent wheeze (≥3 episodes) during the last 12months at age 4.5years (adjusted OR 2.2; 95% CI 1.3-3.8) and multiple-trigger wheeze (aOR, 2.8; 1.3-6.1). The introduction of fish before the age of 9months reduced the risk of recurrent wheeze (aOR, 0.6; 0.4-0.8). Conclusion: Treatment with broad-spectrum antibiotics during the first week of life increased the risk of recurrent wheeze and multiple-trigger wheeze at preschool age. The early introduction of fish reduced the risk of recurrent wheeze.
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| 25. |
- Golman, Klaes, et al.
(författare)
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13C-angiography.
- 2002
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Ingår i: Academic Radiology. - 1878-4046. ; 9:Suppl 2, s. 507-510
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Tidskriftsartikel (refereegranskat)
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| 26. |
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| 27. |
- Hodapp, Klaus W., et al.
(författare)
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The New EXor Outburst of ESO-H alpha 99 Observed by Gaia ATLAS and TESS
- 2019
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Ingår i: Astronomical Journal. - : IOP PUBLISHING LTD. - 0004-6256 .- 1538-3881. ; 158:6
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Tidskriftsartikel (refereegranskat)abstract
- We report photometry and spectroscopy of the outburst of the young stellar object ESO-H?99. The outburst was first noticed in Gaia alert Gaia18dvc and later by the Asteroid Terrestrial-impact Last Alert System (ATLAS). We have established the outburst light curve with archival ATLAS orange filter photometry, Gaia data, new V-band photometry, and J, H, and K-s photometry from the Infrared Imaging System (IRIS) and the United Kingdom Infrared Telescope (UKIRT). The brightness has fluctuated several times near the light curve maximum. The Transiting Exoplanet Survey Satellite (TESS) satellite observed ESO-H99 with high cadence during one of these minor minima and found brightness fluctuations on timescales of days and hours. Imaging with UKIRT shows the outline of an outflow cavity, and we find one knot of emission, now named MHO 1520, on the symmetry axis of this nebula, indicating recent collimated outflow activity from ESO-H99. Its pre-outburst SED shows a flat far-infrared spectrum, confirming its early evolutionary state and its similarity to other deeply embedded objects in the broader EXor class. The pre-outburst luminosity is 34 L, a much higher luminosity than typical EXors, indicating that ESO-H alpha 99 may be a star of intermediate mass. Infrared and optical spectroscopy show a rich emission-line spectrum, including H i lines, strong red Ca ii emission, as well as infrared CO bandhead emission, all characteristic EXors in the broadest sense. Comparison of the present spectra with an optical spectrum obtained in 1993, presumably in the quiescent state of the object, shows that during the present outburst the continuum component of the spectrum has increased notably more than the emission lines. The H alpha equivalent width during the outburst is down to one-half of its 1993 level, and shock-excited emission lines are much less prominent.
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| 28. |
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| 29. |
- Lindahl, Bertil, et al.
(författare)
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Autoantibodies to cardiac troponin in acute coronary syndromes
- 2010
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Ingår i: Clinica Chimica Acta. - : Elsevier BV. - 0009-8981 .- 1873-3492. ; 411:21-22, s. 1793-1798
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Tidskriftsartikel (refereegranskat)abstract
- Backgrounds In a recent small study, patients with autoantibodies to cardiac troponin (cTnaAb) had higher cardiac troponin 1 (cTnl) release during an episode of acute coronary syndrome (ACS) than patients without cTnaAb and continued to have higher long-term levels of cTnl However, the prognostic importance of the occurrence of cTnaAb is unknown Methods In 957 nonST-elevation ACS patients cTnaAb and cTnl were analyzed at randomization and after 6 months. Outcomes were assessed through 5 years Results. Seven and 11% of the patients were cTnaAb positive at inclusion and 6 months, respectively The cardiac troponin I (cTnl) concentration at inclusion was independently associated with the development of cTnaAb (OR 1 53, 95% Cl 1 25-1 88) The presence of cTnaAb was associated with an increased cTnl level at 6 months (OR 2 39, 95% CI 1 50-381) cTnaAb was not independently associated with death and AMI during follow-up (HR 0 97. 95% Cl 0.61-1 54) Conclusion Development of cTnaAb after an episode of nonST-elevation ACS is associated with the acute myocardial damage, but occurs only in a minority of patients Furthermore, the presence of cTnaAb is associated with chronically elevated cTnl concentrations However, the occurrence of cTnaAb is not associated with an adverse long-term prognosis.
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| 30. |
- Lindholm, Eva, et al.
(författare)
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Reconstruction of ancestral haplotypes in a 12-generation schizophrenia pedigree
- 2004
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Ingår i: Psychiatric Genetics. - Philadelphia : Lippincott Williams & Wilkins. - 0955-8829 .- 1473-5873. ; 14:1, s. 1-8
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Tidskriftsartikel (refereegranskat)abstract
- We searched for candidate chromosomal regions inherited identical by descent in 19 patients suffering from schizophrenia or schizoaffective disorder that are related 12 generations back, to an ancestral couple born in the middle of the seventeenth century. To accomplish this goal, we constructed complete chromosomal haplotypes for each patient using genotype data from 450 markers. In total, 12 haplotype regions (with sizes ranging from 0.6 to 10.9 cM) constituted by three markers each were identical in three or more of the affected individuals. The largest genomic segment was located on 6q25, a region previously shown to be significantly more frequent in patients than controls, and proposed to contain a schizophrenia susceptibility locus. For the remaining 11 candidate haplotypes, we estimated haplotype frequencies from all the 43 affected members collected from the same family and 46 unrelated control individuals. This analysis indicated that at least four of the 11 candidate haplotypes are ancestral, since the frequencies were significantly higher in patients than in controls. Five additional haplotypes showed higher estimated frequencies in the patients but the differences were not significant. Interestingly, five of these 11 genomic regions are located in, or close to, candidate regions previously suggested to contain susceptibility genes for schizophrenia. The regions are 5q21-23, 8p21-22, 1 0p13-15, 13q12-13 and 22q12-13. Several of these haplotypes are probably ancestral linkage disequilibrium blocks inherited from the original couple. There exists, however, the possibility that one or more of these regions harbour schizophrenia susceptibility loci that may have epistatic interactions among them.
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| 31. |
- Loid, Petra, et al.
(författare)
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A persistently high body mass index increases the risk of atopic asthma at school age.
- 2015
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Ingår i: Acta paediatrica (Oslo, Norway : 1992). - : Wiley. - 1651-2227 .- 0803-5253. ; 104:7, s. 707-712
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Tidskriftsartikel (refereegranskat)abstract
- Being overweight has been associated with the risk of developing childhood asthma, but studies have produced conflicting results, for example with regard to possible links to allergic diseases. This study aimed to explore the relationship between body mass index (BMI) and school age asthma.
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| 32. |
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| 33. |
- Lundin, Björn, et al.
(författare)
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Compatible scales for progressive and additive MRI assessments of haemophilic arthropathy.
- 2005
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Ingår i: Haemophilia. - : Wiley. - 1351-8216 .- 1365-2516. ; 11:2, s. 109-115
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Tidskriftsartikel (refereegranskat)abstract
- Summary. The international MRI expert subgroup of the International Prophylaxis Study Group (IPSG) has developed a consensus for magnetic resonance imaging (MRI) scales for assessment of haemophilic arthropathy. A MRI scoring scheme including a 10 step progressive scale and a 20 step additive scale with identical definitions of mutual steps is presented. Using the progressive scale, effusion/haemarthrosis can correspond to progressive scores of 1, 2, or 3, and synovial hypertrophy and/or haemosiderin deposition to 4, 5, or 6. The progressive score can be 7 or 8 if there are subchondral cysts and/or surface erosions, and it is 9 or 10 if there is loss of cartilage. Using the additive scale, synovial hypertrophy contributes 1–3 points to the additive score and haemosiderin deposition contributes 1 point. For osteochondral changes, 16 statements are evaluated as to whether they are true or false, and each true statement contributes 1 point to the additive score. The use of these two compatible scales for progressive and additive MRI assessments can facilitate international comparison of data and enhance the accumulation of experience on MRI scoring of haemophilic arthropathy.
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| 34. |
- Lundin, Björn, et al.
(författare)
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Gadolinium Contrast Agent is of Limited Value for Magnetic Resonance Imaging Assessment of Synovial Hypertrophy in Hemophiliacs.
- 2007
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Ingår i: Acta Radiologica. - : SAGE Publications. - 1600-0455 .- 0284-1851. ; 48:5, s. 520-530
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To examine the influence of different doses of gadolinium contrast agent on synovial enhancement, to compare magnetic resonance imaging (MRI) findings of synovial hypertrophy and radiographic joint changes in hemophiliacs, and to investigate the value of gadolinium in MRI assessment of synovial hypertrophy in hemophiliacs using dynamic MRI and MRI scoring. Material and Methods: Twenty-one hemophiliacs on prophylactic factor treatment without recent bleeds were subjected to radiography and gadolinium contrast-enhanced dynamic and static MRI of the knee using a standard dose of 0.1 mmol/kg b.w. gadoteridol. In 17 of the patients, the MRI procedure was repeated after a triple dose of gadoteridol. Results: MRI findings of synovial hypertrophy were significantly correlated with Pettersson radiographic scores. In 19 of the 21 MRI investigated joints, administration of contrast agent did not alter the result of the evaluation of synovial hypertrophy. Conclusion: The optimal time interval for volume assessment of synovial hypertrophy after injection of gadolinium contrast agent is dose dependent. Hemophiliacs without recent bleeds have minor to abundant synovial hypertrophy in joints with pronounced radiographic changes. Dynamic MRI is not useful for evaluating hemophilic arthropathy, and gadolinium contrast agent is not routinely indicated for MRI scoring of joints in hemophiliacs.
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| 35. |
- Lundin, Björn, et al.
(författare)
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MRI scores of ankle joints in children with haemophilia--comparison with clinical data.
- 2005
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Ingår i: Haemophilia. - : Wiley. - 1351-8216 .- 1365-2516. ; 11:2, s. 116-122
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Tidskriftsartikel (refereegranskat)abstract
- Summary. Fifty-six ankle joints in 38 haemophilic boys were investigated by magnetic resonance imaging (MRI) and the findings were classified according to both the Denver- and the European scoring schemes. The different MRI scores were compared with each other and with clinical data on number of joint bleeds and the orthopaedic joint score. MRI changes that were more advanced than a small effusion were found in 33 (59%) of the ankles and osteochondral changes were observed in 20 (36%). The total number of bleeds in individual ankles ranged from 0 to 80 (mean: 11). The orthopaedic joint score was 0 for 49 ankles and ranged from one to four for seven ankles. There was a significant and strong correlation between the assessment results obtained with the two MRI scoring methods (correlation coefficients ranged from 0.80 to 0.95, P < 0.001), and both types of MRI scores were weakly but significantly correlated with the clinical data on the number of joint bleeds and the orthopaedic joint score (correlation coefficients: 0.32–0.39, P < 0.01 or P < 0.05). MRI is useful for evaluating early joint changes in patients with haemophilia. The European scoring method differentiates the arthropathic changes further than the Denver scale does, but the two different scoring methods have similar correlation to the number of joint bleeds and the orthopaedic joint score.
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| 36. |
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| 37. |
- Matson, Inga-Lill, 1951-
(författare)
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Grus i maskineriet? : Några kommunala tjänstemäns, politikers, föräldrars och lärares syn på en skola för alla
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overall aim of this thesis is to investigate experiences, perceptions and experiences of "a school for all" in one municipality by means of a case study. The municipality is medium-sized and, for many years, has had a clearly expressed intention of providing "a school for all". This means that all pupils are included in regular comprehensive school classes, where no separate schools or groups are available for pupils with intellectual disabilities.The empirical material consists of three studies. The pilot study is a licentiate thesis published in 2007, with a societal bias and is based on web-based documentation and interviews with politicians and civil servants (n=5). This study describes regional administrators’ initiatives to promote the implementation of ”a school for all” within the entire municipality. A major finding was the importance of committed and engaged leadership. Bronfenbrenner’s (1979) model for ecological systems constitutes the theoretical starting point. The respondents in sub-studies I and II, which are the focus in this section of the thesis, are parents (n=14) and teachers (n=8). The common denominator is children/pupils who have an intellectual disability, and study according to the curriculum for special schooling but are taught in regular comprehensive school classes. Previous research into inclusion and national policy documents are of central concern to this thesis. Interpretative Phenomenological Analysis is employed as an interpretative tool for the interviews.Parents discuss the benefits of "a school for all"; good role models, social relationships and opportunities for the child to develop both socially and intellectually. They also describe how they must always be prepared to fight for their child, "keeping a watchful eye" on the school, and they imply that it is never possible to "become complacent". Teachers' attitudes and knowledge are described as crucial. A few parents wanted to have the opportunity to choose a special school for children with intellectual disabilities (ID). Their arguments are presented. In the teacher interviews, a conviction emerges about the importance of "a school for all" for the pupils' self-image, social and academic development. Organizational support, in-service training and skills’ development are seen as the prerequisites for successful inclusion, as well as educational strategies such as family groups and model learning. Respondents indicate that inclusion works most satisfactorily between years 1 and 6 in the comprehensive school and is viewed more detrimentally between years 7 and 9, in order to be better viewed again in the upper secondary school (senior high school) and the reasons for this are discussed. The case study contributes to a broader understanding of the processes of implementation and change regarding inclusion of pupils with special school status and the importance of understanding the connections and relationships between the levels within Bronfenbrenner’s ecological systems theory which directly or indirectly affect the child’s/pupil’s development and well-being.
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| 38. |
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| 39. |
- Pettersson, Anders, et al.
(författare)
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Analysis of Linear L1 Adaptive Control Architectures for Aerospace Applications
- 2012
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Ingår i: IEEE 51st Annual Conference on Decision and Control (CDC), 2012. - 0743-1546. - 9781467320658 ; , s. 1136-1141
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Konferensbidrag (refereegranskat)abstract
- In some situations the closed-loop system obtained by L1 adaptive control is equivalent to linear systems. The architectures of these systems are investigated and compared with internal model control and the input observer architecture. The analysis is focused on aerospace application. An effort has been made to understand and describe what fundamental control characteristic of flying applications that make L1 adaptive controllers suitable for the task.
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| 40. |
- Pettersson, Anders, et al.
(författare)
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Augmenting L1 Adaptive Control of Piecewise Constant Type to a Fighter Aircraft. Performance and Robustness Evaluation for Rapid Maneuvering
- 2012
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Ingår i: AIAA Guidance, Navigation, and Control Conference, 13 - 16 August 2012.
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Konferensbidrag (refereegranskat)abstract
- An L1 adaptive controller of piecewise constant type has been applied to a fighter aircraft by augmenting it to a linear state-feedback controller. Angle of attack and sideslip as well as velocity vector roll rate is demanded and controlled. It is relatively easy to design a controller augmentation this way; few parameters need to be tuned. To design an L1-controller for roll/pitch/yaw-motion of an aircraft, a five-state reference system with desired dynamics is created and three bandwidths of low-pass filters are chosen. The L1-controller activates when the aircraft aided by the feedback controller deviates from the reference dynamics. Load disturbance rejection is improved when the L1-controller is active. Results from simulations with different kinds of deviations from the nominal aircraft are presented. Special non-linear design elements need to be introduced if actuator dynamics, including rate limits, interfere with reference system dynamics. Since an L1 adaptive controller of piecewise constant type in its original form is linear time invariant, frequency domain analysis is presented, including comparisons to a typical linear state-feedback controller.
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| 41. |
- Pettersson, Anders, et al.
(författare)
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Nonlinear Feedforward and Reference Systems for Adaptive Flight Control
- 2013
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Ingår i: 2013 AIAA Guidance, Navigation, and Control Conference. - Reston, Virginia : American Institute of Aeronautics and Astronautics.
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Konferensbidrag (refereegranskat)abstract
- Use of feedforward can alleviate feedback and adaptive actions. Feedforward signals can be generated from reference models and the same models can also be used as reference models in adaptive control. A method for designing the reference models is presented in the paper. By exploiting the structure of the equations describing air vehicles it is possible to find reference models that scale to the present flight condition and vehicle configuration. Such reference systems are derived for flying vehicles in a generic manner, suitable for both winged aircraft and missiles. The same type of reference systems are also used to create trajectories for feedforward signals that compensate known plant non-linearities.
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| 42. |
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| 43. |
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| 44. |
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| 45. |
- Pettersson, Rolf, 1937
(författare)
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On Boundedness of Higher Velocity Moments for the Linear Boltzmann Equation with Diffuse Boundary Conditions
- 2012
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Ingår i: Transport Theory and Statistical Physics. - : Informa UK Limited. - 0041-1450 .- 1532-2424. ; 41:5-6, s. 345-355
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Konferensbidrag (refereegranskat)abstract
- This article considers the time and space-dependent linear Boltzmann equation for elastic or inelastic (granular) collisions. First, in the angular cut-off case or with hard sphere collisions, mild L-1-solutions are constructed as limits of iterate functions. Then, in the case of hard potentials together with diffuse boundary conditions, global boundedness in time of higher velocity moments is proved, using our old collision velocity estimates together with a Jensen inequality.
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| 46. |
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| 47. |
- Pettersson, Rolf, 1937
(författare)
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On global boundedness of higher velocity moments for solutions to the linear Boltzmann equation with hard sphere collisions
- 2010
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Ingår i: Nuovo Cimento della Societa Italiana di Fisica C. - 1124-1896. ; 33:1, s. 189-197
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Tidskriftsartikel (refereegranskat)abstract
- This paper considers the time- and space-dependent linear Boltzmann equation for elastic or inelastic (granular) collisions. First, in the angular cut-off case or with hard sphere collisions, mild L 1-solutions are constructed as limits of iterate functions. Then, in the case of hard sphere collisions together with, e.g., specular boundary conditions, global boundedness in time of higher velocity moments is proved, using our old collision velocity estimates together with a Jensen inequality. This generalizes our earlier results for hard inverse collision forces, and also results given by other authors from the space-homogeneous case to our space-dependent one.
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| 48. |
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| 49. |
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| 50. |
- Pettersson, Rolf, 1937
(författare)
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On solutions to the linear boltzmann equation with inelastic granular collisions and infinite range forces
- 2009
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Ingår i: AIP Conference Proceedings. - 1551-7616 .- 0094-243X. ; 1084, s. 135-139
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Konferensbidrag (refereegranskat)abstract
- This paper considers the time- and space-dependent linear Boltzmann equation with general boundary conditions in the case of inelastic (granular) collisions. First, in the angular cut-off case, mild L 1-solutions are constructed as limits of iterate functions, and boundedness of higher velocity moments are studied in the case of inverse power collision forces. Then the problem with inelastic collisions in the infinite range case (without cut-off) will be studied in an integral weak form, combining methods from our earlier papers, and using an H-theorem for a relative entropy functional.
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