| 1. |
- Niemi, MEK, et al.
(author)
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- 2021
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swepub:Mat__t
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| 2. |
- Bombarda, F., et al.
(author)
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Runaway electron beam control
- 2019
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In: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 1361-6587 .- 0741-3335. ; 61:1
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Journal article (peer-reviewed)
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| 3. |
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- 2018
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In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:1
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Research review (peer-reviewed)
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| 4. |
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- 2018
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In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:9
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Journal article (peer-reviewed)
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| 5. |
- Meyer, H., et al.
(author)
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Overview of progress in European medium sized tokamaks towards an integrated plasma-edge/wall solution
- 2017
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In: Nuclear Fusion. - : Institute of Physics Publishing (IOPP). - 0029-5515 .- 1741-4326. ; 57:10
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Journal article (peer-reviewed)abstract
- Integrating the plasma core performance with an edge and scrape-off layer (SOL) that leads to tolerable heat and particle loads on the wall is a major challenge. The new European medium size tokamak task force (EU-MST) coordinates research on ASDEX Upgrade (AUG), MAST and TCV. This multi-machine approach within EU-MST, covering a wide parameter range, is instrumental to progress in the field, as ITER and DEMO core/pedestal and SOL parameters are not achievable simultaneously in present day devices. A two prong approach is adopted. On the one hand, scenarios with tolerable transient heat and particle loads, including active edge localised mode (ELM) control are developed. On the other hand, divertor solutions including advanced magnetic configurations are studied. Considerable progress has been made on both approaches, in particular in the fields of: ELM control with resonant magnetic perturbations (RMP), small ELM regimes, detachment onset and control, as well as filamentary scrape-off-layer transport. For example full ELM suppression has now been achieved on AUG at low collisionality with n = 2 RMP maintaining good confinement H-H(98,H-y2) approximate to 0.95. Advances have been made with respect to detachment onset and control. Studies in advanced divertor configurations (Snowflake, Super-X and X-point target divertor) shed new light on SOL physics. Cross field filamentary transport has been characterised in a wide parameter regime on AUG, MAST and TCV progressing the theoretical and experimental understanding crucial for predicting first wall loads in ITER and DEMO. Conditions in the SOL also play a crucial role for ELM stability and access to small ELM regimes.
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| 6. |
- Meyer, H., et al.
(author)
-
Overview of progress in European medium sized tokamaks towards an integrated plasma-edge/wall solution
- 2017
-
In: Nuclear Fusion. - : Institute of Physics Publishing (IOPP). - 0029-5515 .- 1741-4326. ; 57:10
-
Journal article (peer-reviewed)abstract
- Integrating the plasma core performance with an edge and scrape-off layer (SOL) that leads to tolerable heat and particle loads on the wall is a major challenge. The new European medium size tokamak task force (EU-MST) coordinates research on ASDEX Upgrade (AUG), MAST and TCV. This multi-machine approach within EU-MST, covering a wide parameter range, is instrumental to progress in the field, as ITER and DEMO core/pedestal and SOL parameters are not achievable simultaneously in present day devices. A two prong approach is adopted. On the one hand, scenarios with tolerable transient heat and particle loads, including active edge localised mode (ELM) control are developed. On the other hand, divertor solutions including advanced magnetic configurations are studied. Considerable progress has been made on both approaches, in particular in the fields of: ELM control with resonant magnetic perturbations (RMP), small ELM regimes, detachment onset and control, as well as filamentary scrape-off-layer transport. For example full ELM suppression has now been achieved on AUG at low collisionality with n = 2 RMP maintaining good confinement H-H(98,H-y2) approximate to 0.95. Advances have been made with respect to detachment onset and control. Studies in advanced divertor configurations (Snowflake, Super-X and X-point target divertor) shed new light on SOL physics. Cross field filamentary transport has been characterised in a wide parameter regime on AUG, MAST and TCV progressing the theoretical and experimental understanding crucial for predicting first wall loads in ITER and DEMO. Conditions in the SOL also play a crucial role for ELM stability and access to small ELM regimes.
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| 7. |
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| 8. |
- Akkoyun, S., et al.
(author)
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AGATA - Advanced GAmma Tracking Array
- 2012
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In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002 .- 0167-5087 .- 1872-9576. ; 668, s. 26-58
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Journal article (peer-reviewed)abstract
- The Advanced GAmma Tracking Array (AGATA) is a European project to develop and operate the next generation γ-ray spectrometer. AGATA is based on the technique of γ-ray energy tracking in electrically segmented high-purity germanium crystals. This technique requires the accurate determination of the energy, time and position of every interaction as a γ ray deposits its energy within the detector volume. Reconstruction of the full interaction path results in a detector with very high efficiency and excellent spectral response. The realisation of γ-ray tracking and AGATA is a result of many technical advances. These include the development of encapsulated highly segmented germanium detectors assembled in a triple cluster detector cryostat, an electronics system with fast digital sampling and a data acquisition system to process the data at a high rate. The full characterisation of the crystals was measured and compared with detector- response simulations. This enabled pulse-shape analysis algorithms, to extract energy, time and position, to be employed. In addition, tracking algorithms for event reconstruction were developed. The first phase of AGATA is now complete and operational in its first physics campaign. In the future AGATA will be moved between laboratories in Europe and operated in a series of campaigns to take advantage of the different beams and facilities available to maximise its science output. The paper reviews all the achievements made in the AGATA project including all the necessary infrastructure to operate and support the spectrometer. © 2011 Elsevier B.V. All rights reserved.
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| 9. |
- Lieder, R M, et al.
(author)
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Gamma-ray tracking arrays
- 2001
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In: PROGRESS IN PARTICLE AND NUCLEAR PHYSICS, VOL 46. ; , s. 399-407
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Conference paper (peer-reviewed)abstract
- The next generation of 4 pi arrays for high-precision gamma -ray spectroscopy will involve "gamma -ray tracking front-end on digital signal processing techniques, which allows to extract energy, timing and spatial information on the interactions of a gamma -ray in the Ge detector by pulse shape analysis of its signals. Utilizing the information on the positions of the interaction points and the energies released at each point the tracks of the gamma -rays in a Ge shell can be reconstructed in three dimensions.
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| 10. |
- De Angeli, M., et al.
(author)
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Cross machine investigation of magnetic tokamak dust : Morphological and elemental analysis
- 2021
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In: Fusion engineering and design. - : Elsevier BV. - 0920-3796 .- 1873-7196. ; 166
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Journal article (peer-reviewed)abstract
- The presence of magnetic dust can be an important issue for future fusion reactors where plasma breakdown is critical. Magnetic dust has been collected from contemporary fusion devices (FTU, Alcator C-Mod, COMPASS and DIII-D) that feature different plasma facing components. The results of morphological and elemental analysis are presented. Magnetic dust is based on steel or nickel alloys and its magnetism is generated by intense plasma material interactions. In spite of the strong similarities in terms of morphology and composition, X-ray diffraction analysis revealed differences in the structural evolution that leads to non-trivial magnetic responses.
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| 11. |
- Ratynskaia, Svetlana V., et al.
(author)
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Interaction of adhered beryllium proxy dust with transient and stationary plasmas
- 2018
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In: Nuclear Materials and Energy. - : ELSEVIER SCIENCE BV. - 2352-1791. ; 17, s. 222-227
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Journal article (peer-reviewed)abstract
- Tungsten (W) substrates with adhered beryllium (Be) proxy dust-copper, chromium, aluminium -have been exposed in the Magnum-PSI linear device. Their interaction with transient and stationary plasmas has been systematically studied under varying heat fluxes and magnetic field topologies. The dust remobilization activities, macro-morphological changes and chemical modifications induced by the plasma incidence are documented. Aluminium is identified to be the most suitable surrogate material due to the similar binary phase diagram and nearly identical evaporation rates. Extrapolation suggests that Be dust cannot survive on hot W surfaces but it can trigger mixed Be/W effects prior to its plasma removal.
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| 12. |
- Ratynskaia, Svetlana V., et al.
(author)
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Tungsten dust remobilization under steady-state and transient plasma conditions
- 2017
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In: NUCLEAR MATERIALS AND ENERGY. - : Elsevier. - 2352-1791. ; 12, s. 569-574
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Journal article (peer-reviewed)abstract
- Remobilization is one of the most prominent unresolved fusion dust-relevant issues, strongly related to the lifetime of dust in plasma-wetted regions, the survivability of dust on hot plasma-facing surfaces and the formation of dust accumulation sites. A systematic cross-machine study has been initiated to investigate the remobilization of tungsten micron-size dust from tungsten surfaces implementing a newly developed technique based on controlled pre-adhesion by gas dynamics methods. It has been utilized in a number of devices and has provided new insights on remobilization under steady-state and transient conditions. The experiments are interpreted with contact mechanics theory and heat conduction models.
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| 13. |
- Tolias, Panagiotis, 1984-, et al.
(author)
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Diffusion bonding effects on the adhesion of tungsten dust on tungsten surfaces
- 2020
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In: Nuclear Materials and Energy. - : Elsevier BV. - 2352-1791. ; 24
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Journal article (peer-reviewed)abstract
- High temperature excursions have the potential to strongly enhance the room temperature adhesion of tokamak dust. Planar tungsten substrates containing adhered nearly monodisperse spherical tungsten dust have been exposed to linear plasmas and vacuum furnaces. Prolonged thermal treatments of varying peak temperature and constant duration were followed by room temperature adhesion measurements with the electrostatic detachment method. Adhesive forces have been observed to strongly depend on the thermal pre-history, greatly increasing above a threshold temperature. Adhesive forces have been measured up to an order of magnitude larger than those of untreated samples. This enhancement has been attributed to atomic diffusion that slowly eliminates the omnipresent nanometer-scale surface roughness, ultimately switching the dominant interaction from long-range weak van der Waals forces to short-range strong metallic bonding.
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| 14. |
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| 15. |
- Carvalho, Marcelo, et al.
(author)
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Analysis of a set of missense, frameshift, and in-frame deletion variants of BRCA1
- 2009
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In: Mutation research. - : Elsevier BV. - 0027-5107 .- 1873-135X .- 1879-2871. ; 660:1-2, s. 1-11
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Journal article (peer-reviewed)abstract
- Germline mutations that inactivate BRCA1 are responsible for breast and ovarian cancer susceptibility. One possible outcome of genetic testing for BRCA1 is the finding of a genetic variant of uncertain significance for which there is no information regarding its cancer association. This outcome leads to problems in risk assessment, counseling and preventive care. The purpose of the present study was to functionally evaluate seven unclassified variants of BRCA1 including a genomic deletion that leads to the in-frame loss of exons 16/17 (Delta exons 16/17) in the mRNA, an insertion that leads to a frameshift and an extended carboxy-terminus (5673insC), and five missense variants (K1487R, S1613C, M1652I, Q1826H and V1833M). We analyzed the variants using a functional assay based on the transcription activation property of BRCA1 combined with supervised learning computational models. Functional analysis indicated that variants S1613C, Q1826H, and M1652I are likely to be neutral, whereas variants V1833M, Delta exons 16/17, and 5673insC are likely to represent deleterious variants. In agreement with the functional analysis, the results of the computational analysis also indicated that the latter three variants are likely to be deleterious. Taken together, a combined approach of functional and bioinformatics analysis, plus structural modeling, can be utilized to obtain valuable information pertaining to the effect of a rare variant on the structure and function of BRCA1. Such information can, in turn, aid in the classification of BRCA1 variants for which there is a lack of genetic information needed to provide reliable risk assessment.
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| 16. |
- De Angeli, M., et al.
(author)
-
Cross machine investigation of magnetic tokamak dust; structural and magnetic analysis
- 2021
-
In: Nuclear Materials and Energy. - : Elsevier BV. - 2352-1791. ; 28
-
Journal article (peer-reviewed)abstract
- Magnetic dust collected from multiple fusion devices (FTU, Alcator C-Mod, COMPASS) that feature different plasma-facing components (PFCs) and toroidal magnetic fields has been analyzed by means of the X-ray diffraction technique aiming to investigate the nature and origin of dust magnetism. Analysis led to the conclusion that the main mechanism of ferromagnetic dust formation is the change of iron crystalline phase from austenitic to ferritic during the re-solidification of stainless steel droplets. Analysis also revealed differences in the collected dust structure and an unexpectedly high amount of stainless steel based dust in its native austenitic phase. Theoretical estimates showed that the magnetic moment force can also mobilize strongly paramagnetic adhered dust prior to the establishment of proper tokamak discharges. The post-mortem analysis of dust collected during pure magnetic discharges in FTU confirmed these estimates.
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| 17. |
- De Angeli, M., et al.
(author)
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Evidence for high-velocity solid dust generation induced by runaway electron impact in FTU
- 2023
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In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 63:1
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Journal article (peer-reviewed)abstract
- Post-mortem and in situ evidence is presented in favor of the generation of high-velocity solid dust during the explosion-like interaction of runaway electrons with metallic plasma-facing components in FTU. The freshly-produced solid dust is the source of secondary de-localized wall damage through high-velocity impacts that lead to the formation of craters, which have been reproduced in dedicated light gas gun impact tests. This novel mechanism, of potential importance for ITER and DEMO, is further supported by surface analysis, multiple theoretical arguments and dust dynamics modeling.
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| 18. |
- De Angeli, M., et al.
(author)
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Post-mortem and in-situ investigations of magnetic dust in ASDEX Upgrade
- 2023
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In: Nuclear Materials and Energy. - : Elsevier BV. - 2352-1791. ; 36
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Journal article (peer-reviewed)abstract
- Pre-plasma mobilization of magnetic dust can be an important issue for future fusion reactors where plasma breakdown is critical. A combined on-line and off-line study of magnetic dust in ASDEX Upgrade is reported. Post-mortem collection revealed similar composition and morphology compared to other tokamaks, but the overall amount was much smaller. Optical and IR camera diagnostics excluded dust flybys prior to plasma start-up. The negative detection is discussed in light of the magnetic dust properties, the strength of mobilizing forces and the temporal evolution of the magnetic field.
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| 19. |
- De Angeli, M., et al.
(author)
-
Remobilization of tungsten dust from castellated plasma-facing components
- 2017
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In: NUCLEAR MATERIALS AND ENERGY. - : Elsevier BV. - 2352-1791. ; 12, s. 536-540
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Journal article (peer-reviewed)abstract
- Studies of tungsten dust remobilization from castellated plasma-facing components can shed light to whether gaps constitute a dust accumulation site with important implications for monitoring but also removal. Castellated structures of ITER relevant geometry that contained pre-adhered tungsten dust of controlled deposition profile have been exposed in the Pilot-PSI linear device. The experiments were performed under steady state and transient plasma conditions, as well as varying magnetic field topologies. The results suggest that dust remobilization from the plasma-facing monoblock surface can enhance dust trapping in the gaps and that tungsten dust is efficiently trapped inside the gaps.
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| 20. |
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| 21. |
- Maxwell, Christopher A., et al.
(author)
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Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer
- 2011
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In: PLoS Biology. - : Public Library of Science (PLoS). - 1545-7885 .- 1544-9173. ; 9:11
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Journal article (peer-reviewed)abstract
- Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest that BRCA1 regulates stem/progenitor cell proliferation and differentiation. However, the function of BRCA1 in this process and its link to carcinogenesis remain unknown. Here we depict a molecular mechanism involving BRCA1 and RHAMM that regulates apicobasal polarity and, when perturbed, may increase risk of breast cancer. Starting from complementary genetic analyses across families and populations, we identified common genetic variation at the low-penetrance susceptibility HMMR locus (encoding for RHAMM) that modifies breast cancer risk among BRCA1, but probably not BRCA2, mutation carriers: n = 7,584, weighted hazard ratio ((w)HR) = 1.09 (95% CI 1.02-1.16), p(trend) = 0.017; and n = 3,965, (w)HR = 1.04 (95% CI 0.94-1.16), p(trend) = 0.43; respectively. Subsequently, studies of MCF10A apicobasal polarization revealed a central role for BRCA1 and RHAMM, together with AURKA and TPX2, in essential reorganization of microtubules. Mechanistically, reorganization is facilitated by BRCA1 and impaired by AURKA, which is regulated by negative feedback involving RHAMM and TPX2. Taken together, our data provide fundamental insight into apicobasal polarization through BRCA1 function, which may explain the expanded cell subsets and characteristic tumor type accompanying BRCA1 mutation, while also linking this process to sporadic breast cancer through perturbation of HMMR/RHAMM.
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| 22. |
- Ratynskaia, Svetlana, et al.
(author)
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Elastic-plastic adhesive impacts of tungsten dust with metal surfaces in plasma environments
- 2015
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In: Journal of Nuclear Materials. - : Elsevier BV. - 0022-3115 .- 1873-4820. ; 463, s. 877-880
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Journal article (peer-reviewed)abstract
- Dust-surface collisions impose size selectivity on the ability of dust grains to migrate in scrape-off layer and divertor plasmas and to adhere to plasma-facing components. Here, we report first experimental evidence of dust impact phenomena in plasma environments concerning low-speed collisions of tungsten dust with tungsten surfaces: re-bouncing, adhesion, sliding and rolling. The results comply with the predictions of the model of elastic-perfectly plastic adhesive spheres employed in the dust dynamics code MIGRAINe for sub- to several meters per second impacts of micrometer-range metal dust.
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| 23. |
- Ratynskaia, S., et al.
(author)
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Interaction of metal dust adhered on castellated substrates with the ELMy H-mode plasmas of ASDEX-Upgrade
- 2018
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In: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 58:10
-
Journal article (peer-reviewed)abstract
- Castellated substrates with adhered micron dust have been exposed in the outer ASDEX-Upgrade divertor to ELMy H-mode discharges. Beryllium proxy (chromium, copper) and refractory metal (tungsten, molybdenum) dust has been deposited on the plasma-facing and plasma-shadowed sides of the monoblocks as well as the bottom of the gaps. Interaction with time-averaged transient heat loads up to 5 MWm(-2) led to dust remobilization, clustering, melting and wetting-induced coagulation. The amount of dust released in the vessel has been quantified and remobilized dust trajectories inferred. Gaps can efficiently trap locally adhered dust, but dust detaching from adjacent monoblocks does not preferentially move inside the gaps implying that they do not constitute a dust accumulation site. Heat transfer simulations of melting events are also reported taking into account heat constriction due to the finite contact area and the presence of surface roughness.
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| 24. |
- Ratynskaya, Svetlana, et al.
(author)
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Dust-surface collisions in adhesion regime for tokamak relevant materials
- 2013
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In: Journal of Nuclear Materials. - : Elsevier BV. - 0022-3115 .- 1873-4820. ; 438:Suppl., s. S796-S799
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Journal article (peer-reviewed)abstract
- Empirical studies of dust-surface collisions for metal and carbon projectiles impacting on metal targets in the velocity range from a few m/s to those in excess of 1 km/s have been carried out with the use of a modified pellet injection system. The selected projectile/target shapes, sizes and materials are mimicking the scenario of dust colliding with plasma facing components (PFCs) of a metal machine. The low velocities (10's m/s) reported here, characteristic for dust motion in tokamak scrape-off layer plasmas, are in the range of sticking phenomenon; the critical velocity and size for bouncing off are essential and timely inputs for the dust dynamics codes and statistical models aiming to predict dust transport and redepo-sition on PFCs.
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| 25. |
- Tolias, Panagiotis, et al.
(author)
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Dust remobilization in fusion plasmas under steady state conditions
- 2016
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In: Plasma Physics and Controlled Fusion. - : Institute of Physics (IOP). - 0741-3335 .- 1361-6587. ; 58:2
-
Journal article (peer-reviewed)abstract
- The first combined experimental and theoretical studies of dust remobilization by plasma forces are reported. The main theoretical aspects of remobilization in fusion devices under steady state conditions are analyzed. In particular, the dominant role of adhesive forces is highlighted and generic remobilization conditions-direct lift-up, sliding, rolling-are formulated. A novel experimental technique is proposed, based on controlled adhesion of dust grains on tungsten samples combined with detailed mapping of the dust deposition profile prior and post plasma exposure. Proof-of-principle experiments in the TEXTOR tokamak and the EXTRAP-T2R reversed-field pinch are presented. The versatile environment of the linear device Pilot-PSI allowed for experiments with different magnetic field topologies and varying plasma conditions that were complemented with camera observations.
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| 26. |
- Tolias, Panagiotis, 1984-, et al.
(author)
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The adhesion of tungsten dust on plasma-exposed tungsten surfaces
- 2019
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In: Nuclear Materials and Energy. - : ELSEVIER SCIENCE BV. - 2352-1791. ; 18, s. 18-22
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Journal article (peer-reviewed)abstract
- The adhesion of tungsten dust is measured on plasma-exposed and non-exposed tungsten substrates with the electrostatic detachment method. Tungsten substrates of comparable surface roughness have been exposed to the deuterium plasmas of the GyM linear device and the argon plasmas of rf glow discharges under conditions which invariably modify the surface composition due to physical sputtering. The adhesion has been systematically characterized for different spherical nearly monodisperse dust populations. Independent of the dust size, an approximate 50% post-exposure reduction of the average and spread of the adhesive force has been consistently observed and attributed to surface chemistry modifications.
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