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| 3. |
- Nguyen, Thanh N, et al.
(author)
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Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up.
- 2023
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In: Neurology. - 1526-632X. ; 100:4
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Journal article (peer-reviewed)abstract
- Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases.There were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1-6.9]; p < 0.0001). ICH volumes declined from 29,585 to 28,156 (4.8% [5.1-4.6]; p < 0.0001) and IVT volume from 24,584 to 23,077 (6.1% [6.4-5.8]; p < 0.0001). Larger declines were observed at high-volume compared with low-volume centers (all p < 0.0001). There was no significant change in mechanical thrombectomy volumes (0.7% [0.6-0.9]; p = 0.49). Stroke was diagnosed in 1.3% [1.31-1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82-2.97], 5,656/195,539) of all stroke hospitalizations.There was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year.This study is registered under NCT04934020.
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- Algora, A., et al.
(author)
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Pronounced Shape Change Induced by Quasiparticle Alignment
- 2000
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In: Physical Review C (Nuclear Physics). - 0556-2813 .- 1089-490X. ; 61:3
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Journal article (peer-reviewed)abstract
- Mean lifetimes of high-spin states of Kr-74 have been determined using the Doppler-shift attenuation method. The high-spin states were studied using the Ca-40(Ca-40, alpha 2p) reaction at a beam energy of 160 MeV with the GASP gamma-ray spectrometer. The ground-state band and negative parity side band show the presence of three different configurations in terms of transitional quadrupole deformations. A dramatic shape change was found along the ground-state band after the S-band crossing. The deduced quadrupole deformation changes are well reproduced by cranked Woods-Saxon Strutinsky calculations.
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| 5. |
- Weiszflog, M., et al.
(author)
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High-spin Spectroscopy of 63Ga and 65Ga
- 2001
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In: European Physical Journal A. Hadrons and Nuclei. - 1434-6001. ; 11, s. 25-38
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Journal article (peer-reviewed)abstract
- High-spin states in the nuclei Ga-63 and Ga-65 were studied following the reaction S-32 + Ca-40 at a reaction energy of 125 MeV and using the GASP gamma -ray spectrometer in combination with the ISIS charged-particle detector system. In addition to low-lying negative-parity states with single-particle character, rotational-like cascades built on the 9/2(+) and 19/2(-) states have been observed in both nuclei. Sidebands with negative parity in Ga-63 and positive parity in Ga-65 could be established. The experimental results are compared with Total Routhian Surface calculations which describe the nuclei as moderately deformed (beta (2) approximate to 0.25) and gamma soft at low rotational frequencies. The highest experimentally observed positive-parity state in Ga-65 (41/2(+)) is in good agreement with the calculated crossing of the collective band with a non-collective one terminating at this spin.
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| 6. |
- Weiszflog, M., et al.
(author)
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High-spin spectroscopy of Ga-63(31)32 and Ga-65(31)34
- 2001
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In: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 11:1, s. 25-38
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Journal article (peer-reviewed)abstract
- High-spin states in the nuclei Ga-63 and Ga-65 were studied following the reaction S-32 + Ca-40 at a reaction energy of 125 MeV and using the GASP gamma -ray spectrometer in combination with the ISIS charged-particle detector system. In addition to low-lying negative-parity states with single-particle character, rotational-like cascades built on the 9/2(+) and 19/2(-) states have been observed in both nuclei. Sidebands with negative parity in Ga-63 and positive parity in Ga-65 could be established. The experimental results are compared with Total Routhian Surface calculations which describe the nuclei as moderately deformed (beta (2) approximate to 0.25) and gamma soft at low rotational frequencies. The highest experimentally observed positive-parity state in Ga-65 (41/2(+)) is in good agreement with the calculated crossing of the collective band with a non-collective one terminating at this spin.
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| 7. |
- Borcan, C, et al.
(author)
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First identification of excited states in the N = Z nucleus Br-70
- 1999
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In: EUROPEAN PHYSICAL JOURNAL A. - : SPRINGER VERLAG. ; 5:3, s. 243-246
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Journal article (other academic/artistic)abstract
- Excited states in the T-z = 0 nucleus Br-70 have been investigated using the reaction Ni-58(O-16,1p3n). gamma rays were detected with one EUROBALL CLUSTER detector and three single HPGe detectors. Charged particles and neutrons were registered with the Ro
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| 9. |
- Kaasinen, E, et al.
(author)
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Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans
- 2019
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 1252-
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Journal article (peer-reviewed)abstract
- Clonal hematopoiesis driven by somatic heterozygous TET2 loss is linked to malignant degeneration via consequent aberrant DNA methylation, and possibly to cardiovascular disease via increased cytokine and chemokine expression as reported in mice. Here, we discover a germline TET2 mutation in a lymphoma family. We observe neither unusual predisposition to atherosclerosis nor abnormal pro-inflammatory cytokine or chemokine expression. The latter finding is confirmed in cells from three additional unrelated TET2 germline mutation carriers. The TET2 defect elevates blood DNA methylation levels, especially at active enhancers and cell-type specific regulatory regions with binding sequences of master transcription factors involved in hematopoiesis. The regions display reduced methylation relative to all open chromatin regions in four DNMT3A germline mutation carriers, potentially due to TET2-mediated oxidation. Our findings provide insight into the interplay between epigenetic modulators and transcription factor activity in hematological neoplasia, but do not confirm the putative role of TET2 in atherosclerosis.
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| 10. |
- Malekkhaiat Häffner, S., et al.
(author)
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Composition effects on photooxidative membrane destabilization by TiO2 nanoparticles
- 2021
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In: Journal of Colloid and Interface Science. - : Elsevier BV. - 0021-9797. ; 584, s. 19-33
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Journal article (peer-reviewed)abstract
- Membrane interactions and photooxidative membrane destabilization of titanium dioxide (TiO2) nanoparticles were investigated, focusing on the effects of membrane composition, notably phospholipid headgroup charge and presence of cholesterol. For this, we employed a battery of state-of-the-art methods for studies of bilayers formed by zwitterionic palmitoyloleoylphosphatidylcholine (POPC) containing also polyunsaturated palmitoylarachidonoylphosphocholine (PAPC), as well as its mixtures with anionic palmitoyloleoylphosphatidylglycerol (POPG) and cholesterol. It was found that the TiO2 nanoparticles display close to zero charge at pH 7.4, resulting in aggregation. At pH 3.4, in contrast, the 6 nm TiO2 nanoparticles are well dispersed due to a strongly positive ζ-potential. Mirroring this pH dependence, TiO2 nanoparticles were observed to bind to negatively charged lipid bilayers at pH 3.4, but much less so at pH 7.4. While nanoparticle binding has some destabilizing effect alone, illumination with ultraviolet (UV) light accentuates membrane destabilization, a result of oxidative stress caused by generated reactive oxygen species (ROS). Neutron reflectivity (NR), quartz crystal microbalance (QCM), and small-angle X-ray scattering (SAXS) results all demonstrate that membrane composition strongly influences membrane interactions and photooxidative destabilization of lipid bilayers. In particular, the presence of anionic POPG makes the bilayers more sensitive to oxidative destabilization, whereas a stabilizing effect was observed in the presence of cholesterol. Also, structural aspects of peroxidation were found to depend strongly on membrane composition, notably the presence of anionic phospholipids. The results show that membrane interactions and UV-induced ROS generation act in concert and need to be considered together to understand effects of lipid membrane composition on UV-triggered oxidative destabilization by TiO2 nanoparticles, e.g., in the context of oxidative damage of bacteria and cells.
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| 11. |
- Nouhi, Shirin, et al.
(author)
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Sticking particles to solid surfaces using Moringa oleifera proteins as a glue
- 2018
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In: Colloids and Surfaces B: Biointerfaces. - : Elsevier BV. - 0927-7765 .- 1873-4367. ; 168, s. 68-75
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Journal article (peer-reviewed)abstract
- Experimental studies have been made to test the idea that seed proteins from Moringa oleifera which are novel, natural flocculating agents for many particles could be used to promote adhesion at planar interfaces and hence provide routes to useful nanostructures. The proteins bind irreversibly to silica interfaces. Surfaces that had been exposed to protein solutions and rinsed were then exposed to dispersions of sulfonated polystyrene latex. Atomic force microscopy was used to count particle density and identified that the sticking probability was close to 1. Measurements with a quartz crystal microbalance confirmed the adhesion and indicated that repeated exposures to solutions of Moringa seed protein and particles increased the coverage. Neutron reflectivity and scattering experiments indicate that particles bind as a monolayer. The various results show that the 2S albumin seed protein can be used to fix particles at interfaces and suggest routes for future developments in making active filters or improved interfaces for photonic devices.
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| 13. |
- Rudolph, Dirk, et al.
(author)
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The 3701 keV Neutron g9/2 Single-particle State in 57Ni
- 1999
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In: European Physical Journal A. Hadrons and Nuclei. - 1434-6001. ; 6, s. 377-380
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Journal article (peer-reviewed)abstract
- The neutron g(9/2) single-particle state in Ni-57 has been unambiguously identified in a combined measurement of the linear polarization, angular distribution, and angular correlation of gamma rays following the fusion-evaporation reaction Si-28(S-32,2pn)Ni-57 at a beam energy of 90 MeV. The linear polarization was measured with a EUROBALL cluster detector and a prototype of an encapsulated six-fold segmented hexaconical Ge-detector. The spin of the 3701 keV level in Ni-57 was confirmed to be I = 9/2 and its parity determined to be positive.
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| 14. |
- Weiszflog, M., et al.
(author)
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High-spin States in 89Mo
- 1993
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In: Conference Series. - 0951-3248. - 0750302623 ; 132, s. 631-633
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Conference paper (peer-reviewed)
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