| 1. |
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| 2. |
- Svensson, Bengt, et al.
(författare)
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Test - retest reliability of two instruments for measuring public attitudes towards persons with mental illness
- 2011
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Ingår i: BMC Psychiatry. - : BioMed Central (BMC). - 1471-244X. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Research has identified stigmatization as a major threat to successful treatment of individuals with mental illness. As a consequence several anti-stigma campaigns have been carried out. The results have been discouraging and the field suffers from lack of evidence about interventions that work. There are few reports on psychometric data for instruments used to assess stigma, which thus complicates research efforts. The aim of the present study was to investigate test-retest reliability of the Swedish versions of the questionnaires: FABI and "Changing Minds" and to examine the internal consistency of the two instruments.METHOD: Two instruments, fear and behavioural intentions (FABI) and "Changing Minds", used in earlier studies on public attitudes towards persons with mental illness were translated into Swedish and completed by 51 nursing students on two occasions, with an interval of three weeks. Test-retest reliability was calculated by using weighted kappa coefficient and internal consistency using the Cronbach's alpha coefficient.RESULTS: Both instruments attain at best moderate test-retest reliability. For the Changing Minds questionnaire almost one fifth (17.9%) of the items present poor test-retest reliability and the alpha coefficient for the subscales ranges between 0.19 - 0.46. All of the items in the FABI reach a fair or a moderate agreement between the test and retest, and the questionnaire displays a high internal consistency, alpha 0.80.CONCLUSIONS: There is a need for development of psychometrically tested instruments within this field of research.
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| 3. |
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| 4. |
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| 5. |
- Alehagen, Urban, et al.
(författare)
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Effects of an Intervention with Selenium and Coenzyme Q(10) on Five Selected Age-Related Biomarkers in Elderly Swedes Low in Selenium: Results That Point to an Anti-Ageing Effect-A Sub-Analysis of a Previous Prospective Double-Blind Placebo-Controlled Randomised Clinical Trial
- 2023
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Ingår i: Cells. - : MDPI. - 2073-4409. ; 12:13
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Tidskriftsartikel (refereegranskat)abstract
- Background: Ageing is associated with cardiovascular disease (CVD). As no single biomarker reflects the full ageing process, we aimed to investigate five CVD- and age-related markers and the effects of selenium and coenzyme Q10 intervention to elucidate the mechanisms that may influence the course of ageing. Methods: This is a sub-study of a previous prospective double-blind placebo-controlled randomized clinical trial that included 441 subjects low in selenium (mean age 77, 49% women). The active treatment group (n = 220) received 200 & mu;g/day of selenium and 200 mg/day of coenzyme Q10, combined. Blood samples were collected at inclusion and after 48 months for measurements of the intercellular adhesion molecule (ICAM-1), adiponectin, leptin, stem cell factor (SCF) and osteoprotegerin (OPG), using ELISAs. Repeated measures of variance and ANCOVA evaluations were used to compare the two groups. In order to better understand and reduce the complexity of the relationship between the biomarkers and age, factor analyses and structural equation modelling (SEM) were performed, and a structural model is presented. Results: Correlation analyses of biomarker values at inclusion in relation to age, and relevant markers related to inflammation, endothelial dysfunction and fibrosis, demonstrated the biomarkers association with these pathological processes; however, only ICAM1 and adiponectin were directly correlated with age. SEM analyses showed, however, that the biomarkers ICAM-1, adiponectin, SCF and OPG, but not leptin, all had significant associations with age and formed two independent structural factors, both significantly related to age. While no difference was observed at inclusion, the biomarkers were differently changed in the active treatment and placebo groups (decreasing and increasing levels, respectively) at 48 months (p & LE; 0.02 in all, adjusted), and in the SEM model, they showed an anti-ageing impact. Conclusions: Supplementation with selenium/Q10 influenced the analysed biomarkers in ways indicating an anti-ageing effect, and by applying SEM methodology, the interrelationships between two independent structural factors and age were validated.
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| 6. |
- Alehagen, Urban, 1951-, et al.
(författare)
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Improved cardiovascular health by supplementation with selenium and coenzyme Q10 : applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden
- 2022
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Ingår i: European Journal of Nutrition. - : Springer Heidelberg. - 1436-6207 .- 1436-6215. ; 61:6, s. 3135-3148
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Tidskriftsartikel (refereegranskat)abstract
- Purpose Selenium and coenzyme Q10 have synergistic antioxidant functions. In a four-year supplemental trial in elderly Swedes with a low selenium status, we found improved cardiac function, less cardiac wall tension and reduced cardiovascular mortality up to 12 years of follow-up. Here we briefly review the main results, including those from studies on biomarkers related to cardiovascular risk that were subsequently conducted. In an effort, to explain underlying mechanisms, we conducted a structured analysis of the inter-relationship between biomarkers. Methods Selenium yeast (200 mu g/day) and coenzyme Q10 (200 mg/ day), or placebo was given to 443 elderly community-living persons, for 48 months. Structural Equation Modelling (SEM) was used to investigate the statistical inter-relationships between biomarkers related to inflammation, oxidative stress, insulin-like growth factor 1, expression of microRNA, fibrosis, and endothelial dysfunction and their impact on the clinical effects. The main study was registered at Clinicaltrials.gov at 30th of September 2011, and has the identifier NCT01443780. Results In addition to positive clinical effects, the intervention with selenium and coenzyme Q10 was also associated with favourable effects on biomarkers of cardiovascular risk. Using these results in the SEM model, we showed that the weights of the first-order factors inflammation and oxidative stress were high, together forming a second-order factor inflammation/oxidative stress influencing the factors, fibrosis (beta = 0.74; p < 0.001) and myocardium (beta = 0.65; p < 0.001). According to the model, the intervention impacted fibrosis and myocardium through these factors, resulting in improved cardiac function and reduced CV mortality. Conclusion Selenium reduced inflammation and oxidative stress. According to the SEM analysis, these effects reduced fibrosis and improved myocardial function pointing to the importance of supplementation in those low on selenium and coenzyme Q10.
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| 7. |
- Alehagen, Urban, et al.
(författare)
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Less fibrosis in elderly subjects supplemented with selenium and coenzyme Q10-A mechanism behind reduced cardiovascular mortality?
- 2018
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Ingår i: Biofactors. - : John Wiley & Sons. - 0951-6433 .- 1872-8081. ; 44:2, s. 137-147
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In an intervention study where 221 healthy elderly persons received selenium and coenzyme Q10 as a dietary supplement, and 222 received placebo for 4 years we observed improved cardiac function and reduced cardiovascular mortality. As fibrosis is central in the aging process, we investigated the effect of the intervention on biomarkers of fibrogenic activity in a subanalysis of this intervention study.MATERIAL AND METHODS: In the present subanalysis 122 actively treated individuals and 101 controls, the effect of the treatment on eight biomarkers of fibrogenic activity were assessed. These biomarkers were: Cathepsin S, Endostatin, Galectin 3, Growth Differentiation Factor-15 (GDF-15), Matrix Metalloproteinases 1 and 9, Tissue Inhibitor of Metalloproteinases 1 (TIMP 1) and Suppression of Tumorigenicity 2 (ST-2). Blood concentrations of these biomarkers after 6 and 42 months were analyzed by the use of T-tests, repeated measures of variance, and factor analyses.RESULTS: Compared with placebo, in those receiving supplementation with selenium and coenzyme Q10, all biomarkers except ST2 showed significant decreased concentrations in blood. The changes in concentrations, that is, effects sizes as given by partial eta2 caused by the intervention were considered small to medium.CONCLUSION: The significantly decreased biomarker concentrations in those on active treatment with selenium and coenzyme Q10 compared with those on placebo after 36 months of intervention presumably reflect less fibrogenic activity as a result of the intervention. These observations might indicate that reduced fibrosis precedes the reported improvement in cardiac function, thereby explaining some of the positive clinical effects caused by the intervention. © 2017 BioFactors, 2017.
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| 8. |
- Alehagen, Urban, et al.
(författare)
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Levels of sP-selectin and hs-CRP Decrease with Dietary Intervention with Selenium and Coenzyme Q10 Combined: A Secondary Analysis of a Randomized Clinical Trial
- 2015
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Ingår i: PLOS ONE. - : PUBLIC LIBRARY SCIENCE. - 1932-6203. ; 10:9, s. e0137680-
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Tidskriftsartikel (refereegranskat)abstract
- Background/Objectives Inflammation and oxidative stress are central in many disease states. The major anti-oxidative enzymes contain selenium. The selenium intake in Europe is low, and supplementation with selenium and coenzyme Q(10) , important anti-oxidants, was evaluated in a previous study. The aim of this study was to evaluate response on the inflammatory biomarkers C-reactive protein, and sP-selectin, and their possible impact on cardiovascular mortality. Subjects/Methods 437 elderly individuals were included in the study. Clinical examination, echocardiography, electrocardiography and blood samples were drawn. The intervention time was 48 months, and median follow-up was 5.2 years. The effects on inflammation/atherosclerosis were evaluated through analyses of CRP and sP-selectin. Evaluations of the effect of the intervention was performed using repeated measures of variance. All mortality was registered, and endpoints of mortality were assessed by Kaplan-Meier plots. Results The placebo group showed a CRP level of 4.8 ng/mL at the start, and 5.1 ng/mL at the study end. The active supplementation group showed a CRP level of 4.1 ng/mL at the start, and 2.1 ng/mL at the study end. SP-selectin exhibited a level of 56.6mg/mL at the start in the placebo group and 72.3 mg/mL at the study end, and in the active group the corresponding figures were 55.9 mg/mL and 58.0 mg/mL. A significantly smaller increase was demonstrated through repeated measurements of the two biomarkers in those on active supplementation. Active supplementation showed an effect on the CRP and sP-selectin levels, irrespective of the biomarker levels. Reduced cardiovascular mortality was demonstrated in both those with high and low levels of CRP and sP-selectin in the active supplementation group. Conclusion CRP and sP-selectin showed significant changes reflecting effects on inflammation and atherosclerosis in those given selenium and coenzyme Q(10) combined. A reduced cardiovascular mortality could be demonstrated in the active group, irrespective of biomarker level. This result should be regarded as hypothesis-generating, and it is hoped it will stimulate more research in the area.
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| 9. |
- Alehagen, Urban, et al.
(författare)
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Natriuretic Peptide Biomarkers as Information Indicators in Elderly Patients With Possible Heart Failure Followed Over Six Years : A Head-to-Head Comparison of Four Cardiac Natriuretic Peptides
- 2007
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Ingår i: Journal of Cardiac Failure. - : Elsevier BV. - 1071-9164 .- 1532-8414. ; 13:6, s. 452-461
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Tidskriftsartikel (refereegranskat)abstract
- Background: Little is known about the differences between natriuretic peptides used to evaluate elderly patients with heart failure. The aim of the study was to evaluate the information and the power to predict cardiovascular mortality derived from an analysis of cardiac natriuretic peptides from the same study population and at the same time. Methods and Results: In all, 415 elderly patients (age 65-82 years) in primary health care were evaluated and followed for 6 years. All patients had symptoms of heart failure and were examined by a cardiologist. An electrocardiogram and chest x-rays were taken, and the systolic and diastolic functions were assessed using Doppler echocardiography. Brain natriuretic peptide (BNP), N-terminal proBNP, atrial natriuretic peptide (ANP), and N-terminal proANP were analyzed. All 4 peptides were associated with age, and only 1 of them showed any gender difference. Three of the 4 peptides (not ANP) provided important information for identifying patients with impaired systolic function and diastolic dysfunction (pseudonormal or restrictive filling pattern), and for assessing the risk of cardiovascular death. Conclusions: Cardiac natriuretic peptides are useful tools for evaluating elderly patients with heart failure. Three of the 4 peptides were very similar. ANP exhibits inferior properties and cannot be recommended in clinical practice. © 2007 Elsevier Inc. All rights reserved.
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| 10. |
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| 11. |
- Andersson, Stefan, FK, bibliotekarie, 1959-, et al.
(författare)
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DiVA : 20 år av unikt samarbete
- 2021
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Ingår i: Uppsala universitetsbibliotek 1621–2021. - Uppsala : Acta Universitatis Upsaliensis. ; , s. 59-66
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Bokkapitel (populärvet., debatt m.m.)
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| 12. |
- Andreasson, Patrik, et al.
(författare)
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A note on a generalized eddy-viscosity hypothesis
- 1992
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Ingår i: Journal of Fluids Engineering. - : ASME International. - 0098-2202 .- 1528-901X. ; 114:3, s. 463-466
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Tidskriftsartikel (refereegranskat)abstract
- The standard eddy-viscosity concept postulates that zero velocity gradient is accompanied by zero shear stress. This is not true for many boundary layer flows: wall jets, asymmetric channel flows, countercurrent flows, for example. The generalized eddy-viscosity hypothesis presented in this paper, relaxes this limitation by recognizing the influence of gradients in the turbulent length scale and the shear. With this new eddy-viscosity concept, implemented into the standard k - ε model, predictions of some boundary layer flows are made. The modelling results agree well with measurements, where predictions with the standard eddy-viscosity concept are known to fail.
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| 13. |
- Arnelo, Urban, et al.
(författare)
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Intraoperative pancreatoscopy can improve the detection of skip lesions during surgery for intraductal papillary mucinous neoplasia : a pilot study
- 2023
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Ingår i: Pancreatology (Print). - : Elsevier. - 1424-3903 .- 1424-3911. ; 23:6, s. 704-711
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Intraoperative pancreatoscopy is a promising procedure that might guide surgical resection for suspected main duct (MD) and mixed type (MT) intraductal papillary mucinous neoplasms (IPMNs). The aim of the present study was to assess the diagnostic yield and clinical impact of intraoperative pancreatoscopy in patients operated on for MD and MT-IPMNs.Methods: This is a retrospective cohort study. Patients undergoing surgery for suspected MD or MT-IPMN underwent intraoperative pancreatoscopy and frozen section analysis. In all patients who required extended resection due to pancreatoscopic findings, we compared the final histology with the results of the intraoperative frozen section analysis.Results: In total, 46 patients, 48% females, mean age (range) 67 years (45–82 years) underwent intraoperative pancreatoscopy. No mortality or procedure related complications were observed. Pancreatoscopy changed the operative course in 30 patients (65%), leading to extended resections in 20 patients (43%) and to parenchyma sparing procedures in 10 patients (22%). Analyzing the group of patients who underwent extended resections, 7 (35%) displayed lesions that needed further surgical treatment (six high grade dysplasia and one with G1 pancreatic neuroendocrine tumor) and among those 7, just 1 (14%) would have been detected exclusively with histological frozen section analysis of the transection margin. The combination of both pancreatoscopy and frozen section analysis lead to 86% sensitivity and 92% specificity for the detection of pathological tissue in the remnant pancreas.Conclusion: Intraoperative pancreatoscopy is a safe and feasible procedure and might allow the detection of skip lesions during surgery for suspect MD-involving IPMNs.
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| 14. |
- Bergmark, Magnus, et al.
(författare)
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Complex Interventions and Interorganisational Relationships : Examining Core Implementation Components of Assertive Community Treatment
- 2018
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Ingår i: International Journal of Integrated Care. - : Ubiquity Press. - 1568-4156 .- 1568-4156. ; 18:4, s. 1-11
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Introduction: There is increasing interest in implementing evidence-based integrated models of care in community-based mental health service systems. Assertive Community Treatment (ACT) is seen as an attractive, and at the same time challenging, model to implement in sectored service settings. This study investigates the implementation process of such an initiative.Methods: Interviews were conducted with ACT team members, the process leader, steering group members, and collaboration partners. The “Sustainable Implementation Scale” helped to identify critical implementation components, and these were further explored using the qualitative interview data. The “Tool for Measuring Assertive Community Treatment” addressed programme fidelity, and the initiative’s sustainability was assessed.Results: High-fidelity implementation of ACT in a sectored service setting is possible. Prominent components that facilitated implementation were careful preparations, team members’ characteristics, and efforts by the process leader and the steering group to improve networking. Implementation was hampered by conflicting goals among the involved authorities and a mismatch between the ACT model’s characteristics and existing organisational traditions and regulations.Discussion and Conclusions: Reducing the uncertainty caused by conflicting goals is an important step in improving the implementation of ACT. In order to facilitate implementation, the goals, regulations, and availability of resources should be aligned horizontally and vertically through the involved organisations.
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| 15. |
- Bergmark, Magnus, et al.
(författare)
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Facilitators and Barriers for Sustainable Implementation of Integrated Support in a Sectored Community Mental Health Service System : Experiences from a Swedish Project
- 2017
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Ingår i: ENMESH - The context of mental health care. ; , s. 134-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Aim: The present research project, reported in several published articles, have studied the implementation of integrated support models (IPS and ACT). Implementation strategies used at several levels have been analyzed, including the national political level, organizational level and team level. This presentation aims to discuss the main findings of barriers and facilitators for sustainable implementation of these interventions in a sectored community mental health service system.Method: Qualitative content analysis was used to analyze political steering strategies. The Sustainable Implementation Scale, based on findings from implementation science, was used to assess effectiveness of implementation. The Supported Employment Fidelity Scale and Tool for Assessment of Assertive Community Treatment was used to assess program fidelity of 15 programs. Data of the selected programs’ target groups and sustainability was used in order to assess the programs establishment in the welfare system’s regular services.Results: Sustainable implementation of the selected models is possible, but several barriers in and between different organizational levels exist. Preparations and collaboration strategies are crucial for teams and organizations. The system level includes several inconsistencies that hamper effective implementation.Conclusions: Political steering, involved agencies’ organizations and the models supposed to be implemented has to be better aligned. A more holistic approach is needed in order to promote supportive horizontal and vertical inter-organizational relationships.
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| 16. |
- Bergmark, Magnus, et al.
(författare)
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Incorporation of evidence-based programs in local contexts : Components of importance for implementation, fidelity and sustainability
- 2015
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The trend toward evidence-based practice has lead to an increased use of internationally tested programs. This development has been questioned because of translation problems, including the lack of fit with national welfare systems and local organizations. This study has followed the implementation process of 14 Individual Placement and Support (IPS) programs that have received national stimulus startup grants. The overarching aim was to explore whether a high fidelity implementation of IPS in a real life Swedish context is possible. The study’s focus was directed towards implementation components at different organizational levels, program fidelity, and the sustainability of the initiatives. Fourteen IPS programs that started during 2012 were selected. Based on research findings that described essential implementation components, an interview protocol and an analysis scale were developed and used. The Sustainable Implementation Scale (SIS) includes components at organizational level, team level, and continuous support. Representatives from the IPS programs were interviewed at baseline, after 12 and 24 months. The 24-month follow-up was conducted 6 months after the disbursement of stimulus grants had ended; therefore questions about the programs sustainability were included. The Supported Employment Fidelity Scale (SEFS) was used to monitor program fidelity after 12 and 24 months. Five of the municipalities with IPS programs had shut them down, while 3 municipalities had partly integrated IPS in regular programs.Six of the programs were fully integrated in the organizations’ regular activities. These 6 programs were characterized by high scores in SIS, primarily on the components concerning recruitment of staff, management, education and access to support structures. There was a significant correlation between the scores on SEFS, SIS, and the sustainability of the program. Collaboration between authorities was a challenge for the programs. An engaged, joint steering group and strategies for local financing were important for the survival of the initiatives. A high fidelity, real-life implementation of IPS in Sweden is possible, but requires a strong focus on essential implementation components and strategies that address contextual barriers. The SIS is a promising tool for monitoring implementation.
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| 17. |
- Billstein, Mats, et al.
(författare)
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A numerical evaluation of air bubbles as a potential explanation to the higher than expected pore pressures in the core of WAC Bennett Dam
- 2002
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Ingår i: Journal of Hydraulic Research. - : Informa UK Limited. - 0022-1686 .- 1814-2079. ; 40:5, s. 623-630
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this study is to numerically evaluate if the Air Hypothesis is a potential explanation of the unusual pressure behaviour of the core at WAC Bennett Dam. Up to now, the pore pressures have exceeded the expected normal steady state distribution for about 25 years. The Air Hypothesis describes the influence of air bubbles on the pressure distribution in the core. An increased water pressure will compress the air bubbles and increases the amount of air that can go into solution at the upstream side of the core. At the downstream side, the situation is reversed, i.e. the air volume will increase and cause a hydraulic blockage. A one-dimensional numerical model, that is based on relevant conservation laws, physical laws (Darcy's, Boyle's, and Henry's laws) and the relationships between the relative hydraulic conductivity and water saturation level, is able to predict the pressure evolution in both a qualitative and quantitative way. The model is applied to both a hypothetical core and the core of WAC Bennett Dam. Results from a plug flow analysis on the dissolution of the air in the hypothetical core are in fair agreement with the numerical results. Comparisons with pressure measurements from WAC Bennett Dam show that the Air Hypothesis is a potential explanation to the unusual pressure distribution in the core
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| 18. |
- Billstein, Mats, et al.
(författare)
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Application and validation of a numerical model of flow through embankment dams with fractures : Comparisons with experimental data
- 1999
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Ingår i: Canadian geotechnical journal (Print). - : Canadian Science Publishing. - 0008-3674 .- 1208-6010. ; 36:4, s. 651-659
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Tidskriftsartikel (refereegranskat)abstract
- The focus of this paper is on the development and validation of a numerical model of flow through simplified embankment dams with fractures. Two laboratory experiments were conducted to provide data for validation of the numerical model, one dealing with steady flow in a Hele-Shaw cell and one with steady flow through a bed of packed glass beads. A horizontal fracture, extending from the upstream boundary to a point within the embankment, was used in both experiments, and it was shown to have a significant influence on the discharge, pressure distribution, height of the seepage face, and free surface profile. Comparisons between numerically determined and experimentally measured results were carried out with respect to the discharge, pressure distribution, height of the seepage face, and free surface profile. In the experiments it is shown that a fracture increases the discharge and that the discharge increases more when a fracture is located far away from the free surface profile than when it is located close to the free surface profile. The height of the seepage face above the tailwater is strongly dependent upon the length of the fracture. The influence on the free surface profile is greater when a fracture is close to the free surface profile than when it is far away from the free surface profile. These effects are also found in the numerical simulations. It is thus concluded that the agreement is generally satisfactory between the experimental and numerical results
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| 19. |
- Billstein, Mats, et al.
(författare)
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Development and Validation of a Numerical Model of Flow Through Embankment Dams – Comparisons with Experimental Data and Analytical Solutions
- 1999
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Ingår i: Transport in Porous Media. - 0169-3913 .- 1573-1634. ; 35:3, s. 395-406
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Tidskriftsartikel (refereegranskat)abstract
- The development and validation of a numerical simulation model of the flow through embankment dams is described. The paper focuses on basic verification studies, that is, comparisons with analytical solutions and data from laboratory experiments. Two experimental studies, one dealing with the flow in a Hele-Shaw cell and the other with the flow through a bed of packed glass beads, are also described. Comparisons are carried out with respect to the phreatic surfaces, pressure profiles, seepage levels and discharges. It is concluded that the agreement between experimental, analytical and numerical results is generally satisfactory.
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| 20. |
- Bilstrup, Urban, et al.
(författare)
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A fault tolerance test enabling QoS in a Bluetooth piconet
- 2004
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Konferensbidrag (populärvet., debatt m.m.)abstract
- An important trend, in personal area networks, is that time critical application becomes more common, e.g., voice over IP, video phone calls, network games. This segment of applications demands for quality of service (QoS) guarantees, to provide the correct functionality. The Bluetooth standard provides an optional interface to support QoS guarantees, but the standard does not suggest any actual implementation. A wireless communication channel is stochastic by nature, providing QoS guarantees with this precondition make traditional deterministic real-time theory obsolete. In this paper a probabilistic fault tolerance test enabling quality of service guarantees in a Bluetooth piconet is given. The basic Bluetooth network architecture is based on a master-slave configuration, i.e., a point to point connection. More advanced network architectures are possible where up to eight Bluetooth equipped units can be active members of one network (piconet). Furthermore, several piconets can interconnect and form a so called scatternet.
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| 21. |
- Bilstrup, Urban, et al.
(författare)
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Capacity limitations in wireless sensor networks
- 2003
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Ingår i: ETFA 2003. - Piscataway, N.J. : IEEE. - 0780379373 ; , s. 529-536
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Konferensbidrag (refereegranskat)abstract
- It is expected that wireless sensor network will be used in home automation and industrial manufacturing in the future. The main driving forces for wireless sensor networks are fault tolerance, energy gain and spatial capacity gain. Unfortunately, an often forgotten issue is the capacity limits that the network topology of a wireless sensor network represents. In this paper we identify gains, losses and limitations in a wireless sensor network, using a simplified theoretical network model. Especially, we want to point out the stringent capacity limitations that this simplified network model provide. Where a comparison between the locality of the performed information exchange and the average capacity available for each node is the main contribution.
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| 22. |
- Bilstrup, Urban, 1971-
(författare)
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Design Space Exploration of Wireless Multihop Networks
- 2005
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis explores the feasible design space of wireless multihop networks and identifies fundamental design parameters. In the process of exploring it is important to ignore all details and instead take a holistic view. This means that all protocol details are overseen, all details of radio wave propagation models are overseen and the system is modelled strictly on an architectural level. From a theoretical information perspective, there is a limit to the capacity that a certain bandwidth and a certain signal-to-noise ratio at the receiver can provide. This limit is approximated as a volume in the time-frequency-space domain. A single transmission is represented as an occupied volume in this domain. A wireless multihop network covers a spatial area, and the question is how multiple numbers of transmission volumes can be fit into a given limited spatial area. This volume fitting should be done in order to maximize the overall performance or to trade available resources to favour a specific characteristic in the wireless multihop network. The volume model is used for the design space exploration of a wireless multihop network. It is argued that the fault tolerance and the energy gain achieved in a multihop topology are its strength as compared to a single-hop architecture. It is further shown that the energy gain is achieved at the expense of delay and a greater end-to-end error probability. This indicates that these parameters must be very carefully balanced in order to gain in the global overall performance perspective. It can further be concluded that the overall spatial capacity is increased as a result of the spatial channel reuse in a multihop topology. On the other hand, it is also shown that the multihop topology introduces a rather stringent geometrical capacity limitation when the number of nodes of a wireless multihop network is increased. The dynamics (e.g. node mobility, changing radio channels etc.) of a large scale wireless multihop network is also a limiting factor. The nodes’ mobility creates a knowledge horizon beyond which very little can be known about the present network topology.
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| 23. |
- Bilstrup, Urban, 1971-, et al.
(författare)
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Knowledge Horizon - Dynamic limitations in a wireless ad hoc network
- 2003
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Ingår i: SNCNW 2003 Swedish National Computer Networking Workshop 2003 on-line proceedings. ; , s. 1-3
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Konferensbidrag (refereegranskat)abstract
- In this paper we investigate the impact of node mobility in a wireless ad hoc network (WAHN). Especially we investigate the possibility to provide guaranteed services in a WAHN, i.e., the network topology predictability. We combine link expiration time (LET) estimation with information propagation speed (IPS) in a time-space diagram and as result an operation area is revealed. The result gives that a WAHN, where the nodes are mobile, has a knowledge horizon (KH), the distance of which is dependent on the mobility of the nodes. Beyond the KH, knowledge about the network state is impossible to achieve. Thus, we can not predict long distance network topology state when the node mobility is high.
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| 24. |
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| 25. |
- Bilstrup, Urban, et al.
(författare)
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The use of clustered wireless multihop networks in industrial settings
- 2007
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Ingår i: ETFA 2007. - Piscataway, NJ : IEEE Press. - 9781424408252 ; , s. 211-218
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Konferensbidrag (refereegranskat)abstract
- This paper suggests a cluster collision avoidance mechanism and a dual transceiver architecture to be used in a clustered wireless multihop network. These two contributions make the clustered wireless multihop network the preferred architecture for future industrial wireless networks. The wireless multihop cluster consists of one master and several slaves, where some of the slaves will act as gateways between different clusters. Frequency hopping spread spectrum is used on a cluster level and to avoid frequency collisions between clusters a "neighbor cluster collision avoidance mechanism" is proposed and evaluated through simulations. To break up the dependence between the clusters, introduced by the gateway nodes, each node is equipped with two transceivers. The paper is concluded with a suggestion to use a clustered wireless multihop network with orthogonal hopping sequences for an industrial setting.
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| 26. |
- Bilstrup, Urban, et al.
(författare)
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Using Dual-Radio Nodes to Enable Quality of Service in a Clustered Wireless Mesh Network
- 2006
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Ingår i: IEEE Conference on Emerging Technologies and Factory Automation, 2006. ETFA '06. - Piscataway, N.J. : IEEE Press. - 0780397584 ; , s. 54-61
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Konferensbidrag (refereegranskat)abstract
- In this paper some well established wireless technologies are merged into a new concept solution for a future industrial wireless mesh network. The suggested clustered wireless mesh network can handle probabilistic quality of service guarantees and is based on a dual-radio node architecture using synchronized frequency hopping spread spectrum Bluetooth radios. The proposed architecture gives a heuristic solution to the inter-cluster scheduling problem of gateway nodes in clustered architectures and breaks up the dependence between the local medium access schedules of adjacent clusters. The dual-radio feature also enables higher network connectivity, implying, for example, that a higher link redundancy can be achieved.
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| 27. |
- Borgegard, Tomas, et al.
(författare)
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Alzheimers Disease: Presenilin 2-Sparing gamma-Secretase Inhibition Is a Tolerable A beta Peptide-Lowering Strategy
- 2012
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Ingår i: Journal of Neuroscience. - : Society for Neuroscience. - 0270-6474 .- 1529-2401. ; 32:48, s. 17297-17305
-
Tidskriftsartikel (refereegranskat)abstract
- gamma-Secretase inhibition represents a major therapeutic strategy for lowering amyloid beta (A beta) peptide production in Alzheimers disease (AD). Progress toward clinical use of gamma-secretase inhibitors has, however, been hampered due to mechanism-based adverse events, primarily related to impairment of Notch signaling. The gamma-secretase inhibitor MRK-560 represents an exception as it is largely tolerable in vivo despite displaying only a small selectivity between A beta production and Notch signaling in vitro. In exploring the molecular basis for the observed tolerability, we show that MRK-560 displays a strong preference for the presenilin 1(PS1) over PS2 subclass of gamma-secretases and is tolerable in wild-type mice but causes dose-dependent Notch-related side effect in PS2-deficient mice at drug exposure levels resulting in a substantial decrease in brain A beta levels. This demonstrates that PS2 plays an important role in mediating essential Notch signaling in several peripheral organs during pharmacological inhibition of PS1 and provide preclinical in vivo proof of concept for PS2-sparing inhibition as a novel, tolerable and efficacious gamma-secretase targeting strategy for AD.
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| 28. |
- Borgegård, Tomas, et al.
(författare)
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Alzheimer's Disease : Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy
- 2012
-
Ingår i: Journal of Neuroscience. - 0270-6474 .- 1529-2401. ; 32:48, s. 17297-17305
-
Tidskriftsartikel (refereegranskat)abstract
- γ-Secretase inhibition represents a major therapeutic strategy for lowering amyloid β (Aβ) peptide production in Alzheimer's disease (AD). Progress toward clinical use of γ-secretase inhibitors has, however, been hampered due to mechanism-based adverse events, primarily related to impairment of Notch signaling. The γ-secretase inhibitor MRK-560 represents an exception as it is largely tolerable in vivo despite displaying only a small selectivity between Aβ production and Notch signaling in vitro. In exploring the molecular basis for the observed tolerability, we show that MRK-560 displays a strong preference for the presenilin 1 (PS1) over PS2 subclass of γ-secretases and is tolerable in wild-type mice but causes dose-dependent Notch-related side effect in PS2-deficient mice at drug exposure levels resulting in a substantial decrease in brain Aβ levels. This demonstrates that PS2 plays an important role in mediating essential Notch signaling in several peripheral organs during pharmacological inhibition of PS1 and provide preclinical in vivo proof of concept for PS2-sparing inhibition as a novel, tolerable and efficacious γ-secretase targeting strategy for AD.
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| 29. |
- Carlsson, Georg, et al.
(författare)
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Alternativa skötselmetoder för ängs- och betesmarker och användning av skördat växtmaterial
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Ängs- och betesmarker utgör unika livsmiljöer och är mycket värdefulla för den biologiska mångfalden. I dagsläget är utmaningarna stora i Sverige för att kunna hävda ängs- och betesmarkerna med hög kvalitet, till stor del beroende på det minskande antalet betesdjur och minskat behov av fodermarker. Denna rapport sammanställer aktuell kunskap kring möjliga nya skötselmetoder för våra ängs- och betesmarker samt hur skördat material kan användas som en resurs i samhället. Sammanställningen bygger på vetenskaplig och populärvetenskaplig litteratur, författarnas erfarenheter inom området, samt information om pågående teknikutveckling och praktisk tillämpning. Utmaningarna för att utveckla hävden av ängs- och betesmarker består i huvudsak i att hitta rationella system, dels för hantering av betesdjur och dels för effektiv insamling och användning av biomassa. Vi har identifierat följande skötselmetoder och användningsområden som särskilt intressanta för vidare analyser: 1. Flexibel hävd genom till exempel extensivt bete, varierad hävd genom olika skötselmetoder olika år (hävdföljd), kombination av olika metoder genom till exempel maskinell skörd och bränning eller slåtter i kombination med bete. 2. Maskinanpassad hävd av skogsbeten och lövängar – kombinationen av ängsväxter och träd för såväl biologisk mångfald som kolinlagring och produktion av biomassa (både gräs och träd). 3. Småskalig och situationsanpassad teknik – slåtter och borttransport av biomassa från små och hinderrika fält genom en kombination av motormanuella och rationella lösningar. Detta kräver viss metodutveckling och logistik lämpad för avslagning, uppsamling och transport. 4. Samordning och utveckling av avsättning för biomassan för bioenergiändamål. Användning av ängsbiomassa som biogassubstrat har särskilt stor miljönytta och möjliggör effektivt resursutnyttjande genom att man både utvinner energi och en växtnäringsrik rötrest (biogödsel) samtidigt som markerna hävdas. Flera nya studier visar på små eller inga skillnader när slåtter genomförs med skärande eller klippande redskap (lie och knivslåtterbalk) jämfört med roterande redskap (rotorslåttermaskiner med vassa knivar eller röjsnöre). Denna kunskap öppnar upp för maskinell skötsel av slåtterängar som annars hotas av utebliven hävd.
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| 30. |
- Cousins, Sara, et al.
(författare)
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I nattviolens hage
- 2008
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Ingår i: Olsson, R. (red), Mångfaldsmarker. - Uppsala : Centrum för biologisk mångfald. - 9789189232297 ; , s. 9-28
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- I en svensk naturbetesmark kan man hitta över 40 växtarter inom en enda kvadratmeter. Det är världsrekord. En stor del av de arter som finns i betesmarkerna förekommer inte i andra naturtyper. Idag återstår inte mer än en tiondel av den areal naturbetesmarker som fanns i Sverige för drygt 100 år sedan. Igenväxningen hotar inte bara en lång rad arter. Också stora kulturhistoriska värden och vårt vackra, variationsrika odlingslandskap står på spel. Fortsatt hävd förutsätter att det finns en levande landsbygd med bärkraftiga jordbruksföretag.
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| 31. |
- Cousins, Sara, et al.
(författare)
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I nattviolens hage
- 2008
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Ingår i: Olsson, R. (red), Mångfaldsmarker. - Uppsala : Centrum för biologisk mångfald. ; , s. 9-28
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- I en svensk naturbetesmark kan man hitta över 40 växtarter inom en enda kvadratmeter. Det är världsrekord. En stor del av de arter som finns i betesmarkerna förekommer inte i andra naturtyper. Idag återstår inte mer än en tiondel av den areal naturbetesmarker som fanns i Sverige för drygt 100 år sedan. Igenväxningen hotar inte bara en lång rad arter. Också stora kulturhistoriska värden och vårt vackra, variationsrika odlingslandskap står på spel. Fortsatt hävd förutsätter att det finns en levande landsbygd med bärkraftiga jordbruksföretag.
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| 32. |
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| 33. |
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| 34. |
- Engelmark, Helen, et al.
(författare)
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Numerical modelling of phase change in freezing and thawing unsaturated soil
- 1993
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Ingår i: Nordic Hydrology. - : IWA Publishing. - 0029-1277 .- 1996-9694. ; 24:2-3, s. 95-110
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Tidskriftsartikel (refereegranskat)abstract
- Problems associated with seasonal freezing and thawing processes occur in natural and man modified soil environments. To optimize various technical solutions in such areas, the importance of accurately predicting heat and water flow in seasonally freezing and thawing soils becomes obvious. A phase change between water and ice occurs in moist soils subjected to freezing and thawing. In concentrating on water transport phenomena in frozen soil, it can be demonstrated that the heat and moisture flow relationships are coupled to relationships for mass balance and phase change. A new numerical model was developed for handling the phase change process. In the new method, heat and mass transfer equations for soils subjected to both freezing and thawing (but without heaving and transport of mass in the air phase), are solved numerically. This new method for handling the phase change process is based on a total energy balance together with soil-water-freezing-characteristics (SWFC). The total energy balance of the frozen zone includes sensible and latent heat components. The phase change during a time increment is calculated, without any iteration, after the heat and water flow equations are solved for the same time increment (i.e., a two-step approach). Simulations of the three tests with the proposed new method were carried out with abrupt boundary conditions from time zero. Little difference between measured and calculated temperature and moisture content profiles resulted. However, a difference in the results at the cold end, between simulations with the new model and a previously developed model, shows that without any exact measurement of the moisture content at the cold end, no final conclusion about the real magnitude of the moisture content at the cold end can be drawn. A supercooling of the pore water was needed before ice formation could begin. This was due to moderate initial moisture content. The water flow toward the freezing front caused the moisture content to decrease in the unfrozen part of the soil column. Lesser amounts of water in this part, then required even lower temperatures before ice formation could start. Frost depths were not detectable with only temperature measurements. (See also W93-08925) (Lantz-PTT)
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| 35. |
- Fahlström, Karl, et al.
(författare)
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Distortion Analysis in Laser Welding of Ultra High Strength Steel
- 2014
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Ingår i: Proceedings of the 6th International Swedish Production Symposium 2014. - 9789198097412 ; , s. 1-9
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Konferensbidrag (refereegranskat)abstract
- Due to increased demands on reduced weight in automotive industries, the use of ultra high strength steels (UHSS) has increased. When laser welding UHSS sheets, heating and cooling of the material will cause geometrical distortions and may cause low joint quality. 700 mm long U-beam structures of 1 mm thick boron steel simulating structural pillars in body-in-white constructions have been welded along the flanges with different welding speeds to investigate distortions and weld quality. The results show that final distortions appear in the range of 0-8 mm. FE simulation methods have also been presented which generally predict the distribution of welding distortions.
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| 36. |
- Felton, Adam, et al.
(författare)
-
Correction to: Keeping pace with forestry : Multi-scale conservation in a changing production forest matrix (vol 49, pg 1050, 2020)
- 2020
-
Ingår i: Ambio. - : Springer. - 0044-7447 .- 1654-7209. ; 49:5, s. 1065-1066
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Tidskriftsartikel (refereegranskat)abstract
- In the original published article, the sentence “Nevertheless, semi-natural forest remnants continue to be harvested and fragmented (Svensson et al. 2018; Jonsson et al. 2019), and over 2000 forest-associated species (of 15 000 assessed) are listed as threatened on Sweden’s red-list, largely represented by macro-fungi, beetles, lichens and butterflies (Sandström 2015).”under the section Introduction was incorrect. The correct version of the sentence is “Nevertheless, semi-natural forest remnants continue to be harvested and fragmented (Svensson et al. 2018; Jonsson et al. 2019), and approximately 2000 forest-associated species (of 15 000 assessed) are on Sweden’s red-list, largely represented by macro-fungi, beetles, lichens and butterflies (Sandström 2015).”
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| 37. |
- Felton, Adam, et al.
(författare)
-
Keeping pace with forestry : Multi-scale conservation in a changing production forest matrix
- 2020
-
Ingår i: Ambio. - : Springer. - 0044-7447 .- 1654-7209. ; 49:5, s. 1050-1064
-
Tidskriftsartikel (refereegranskat)abstract
- The multi-scale approach to conserving forest biodiversity has been used in Sweden since the 1980s, a period defined by increased reserve area and conservation actions within production forests. However, two thousand forest-associated species remain on Sweden's red-list, and Sweden's 2020 goals for sustainable forests are not being met. We argue that ongoing changes in the production forest matrix require more consideration, and that multi-scale conservation must be adapted to, and integrated with, production forest development. To make this case, we summarize trends in habitat provision by Sweden's protected and production forests, and the variety of ways silviculture can affect biodiversity. We discuss how different forestry trajectories affect the type and extent of conservation approaches needed to secure biodiversity, and suggest leverage points for aiding the adoption of diversified silviculture. Sweden's long-term experience with multi-scale conservation and intensive forestry provides insights for other countries trying to conserve species within production landscapes.
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| 38. |
- Gråsjö, Urban, 1962-, et al.
(författare)
-
Experience Design : Understanding the Role of Technology for Virtual Experiences
- 2005
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Ingår i: WSEAS Transactions on Information Science and Applications.
-
Konferensbidrag (refereegranskat)abstract
- Abstract: New technologies have always teased the imagination of avant-garde artists on how to challenge existing cultural paradigms. For instance, experience design for the creative industries of today provides exciting challenges with a potential to innovate practices and creating new ways of interaction between the artist and her audience. In an ongoing research project we aim at framing the design space for virtual experiences. The paper presents and discusses the role of technology in such context and use three ongoing case studies where ICT has been used to augment and support consumers of cultural experiences. The analysis shows how technology-driven interventions are less oriented towards radical change compared to interventions that are rooted in their nondigital origins. 1.
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| 39. |
- Gråsjö, Urban, 1962-, et al.
(författare)
-
Experience Design : Understanding the Role of Technology for Virtual Experiences
- 2006
-
Ingår i: Proceedings of 29th Information System Research Seminar in Scandinavia, IRIS 29.
-
Konferensbidrag (refereegranskat)abstract
- New technologies have always teased the imagination of avant-garde artists on how to challenge existing cultural paradigms. For instance, experience design for the creative industries of today provides exciting challenges with a potential to innovate practices and creating new ways of interaction between the artist and her audience. In an ongoing research project we aim at framing the design space for virtual experiences. The paper presents and discusses the role of technology in such context and use three ongoing case studies where ICT has been used to augment and support consumers of cultural experiences. The analysis shows how technology-driven interventions are less oriented towards radical change compared to interventions that are rooted in their nondigital origins.
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| 40. |
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| 41. |
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| 42. |
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| 43. |
- Hedenas, Henrik, et al.
(författare)
-
Changes Versus Homeostasis in Alpine and Sub-Alpine Vegetation Over Three Decades in the Sub-Arctic
- 2012
-
Ingår i: Ambio. - : Springer Verlag (Germany). - 0044-7447 .- 1654-7209. ; 41, s. 187-196
-
Tidskriftsartikel (refereegranskat)abstract
- Plant species distributions are expected to shift and diversity is expected to decline as a result of global climate change, particularly in the Arctic where climate warming is amplified. We have recorded the changes in richness and abundance of vascular plants at Abisko, sub-Arctic Sweden, by re-sampling five studies consisting of seven datasets; one in the mountain birch forest and six at open sites. The oldest study was initiated in 1977–1979 and the latest in 1992. Total species number increased at all sites except for the birch forest site where richness decreased. We found no general pattern in how composition of vascular plants has changed over time. Three species, Calamagrostis lapponica, Carex vaginata and Salix reticulata, showed an overall increase in cover/frequency, while two Equisetum taxa decreased. Instead, we showed that the magnitude and direction of changes in species richness and composition differ among sites.
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| 44. |
- Hedenås, Henrik, et al.
(författare)
-
Changes Versus Homeostasis in Alpine and Sub-Alpine Vegetation Over Three Decades in the Sub-Arctic
- 2012
-
Ingår i: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 41:Suppl 3, s. 187-196
-
Tidskriftsartikel (refereegranskat)abstract
- Plant species distributions are expected to shift and diversity is expected to decline as a result of global climate change, particularly in the Arctic where climate warming is amplified. We have recorded the changes in richness and abundance of vascular plants at Abisko, sub-Arctic Sweden, by re-sampling five studies consisting of seven datasets; one in the mountain birch forest and six at open sites. The oldest study was initiated in 1977-1979 and the latest in 1992. Total species number increased at all sites except for the birch forest site where richness decreased. We found no general pattern in how composition of vascular plants has changed over time. Three species, Calamagrostis lapponica, Carex vaginata and Salix reticulata, showed an overall increase in cover/frequency, while two Equisetum taxa decreased. Instead, we showed that the magnitude and direction of changes in species richness and composition differ among sites.
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| 45. |
- Hellström, Magnus, et al.
(författare)
-
A population-based 220,014- injury event cohort 1993-2014 Umeå, Sweden
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Injury kills more people than AIDS, malaria, and tuberculosis—together. In rich countries fall injuries dominate quantitatively, while other mechanisms as traffic and occupational injuries decrease. This is a descriptive macro-perspective of the entire injury as a data repository and reference to further more comprehensive studies, e.g., socio-demography, comorbidity, drugs and trauma recidivism.A population-based registration of patients admitted to an emergency department was done 1993-2014.Of the 220,014 injury events, 43% were fall injuries, 12% transportation injuries; assault 4%; 18% were hospitalized; 0.2% were fatal. Young men and old women were at the highest risk for injury. There were 23% fractures in the entire material, increasing to 40% in senescence, whereof 40% hip fractures. With age, fracture locations changed from distal to proximal, and from upper to lower extremity. Fall injuries accounted for 80% of all trauma-related hospital days, mostly old people. The spatial distribution of the population is heavily skewed, spanning from urban core areas to rural peripheries.This is a description of a population-based injury panorama to further studies linking cause, mechanism and type of injury to available medical, sociologic and economic information. Age and sex affected the type, soft tissue injury/fracture and anatomic location, i.e., proximal/distal and upper/lower extremity. At the beginning and end of life, endogenic risk factors are more dominant than in adulthood where exogenic factors dominate. It therefore seems reasonable to believe that it should be possible to substantially prevent injuries by using multipronged analyses to design specific interventions. Injuries are not accidents.
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| 46. |
- Hillborg, Helene, 1968-
(författare)
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Erfarenheter av rehabiliteringsprocessen mot ett arbetsliv : brukarens och de professionellas perspektiv
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Erfarenheter av rehabiliteringsprocessen mot ett arbetsliv - brukarens och de professionellas perspektiv. Örebro, Studies from the Swedish Institute of Disability Research No 34, 107 pp.The overall aim of this dissertation is to (1) describe and analyse perceived barriers and opportunities from the perspective of the individual receiving vocational rehabilitation services as a result of unemployment and psychiatric disability (2) describe and analyse perceived barriers and opportunities in services for unemployed people with psychiatric disabilities from the perspective of professionals working in the area of vocational rehabilitation and (3) utilize empowerment theory to explore and develop a deeper understanding of the experiences and perceptions described by these individuals and professionals. The data consists of open-ended interviews with service users and professionals’ working in the area of vocational rehabilitation. A content analysis together with an interpretive approach was used to analyse the data. The results revealed that support and the psychosocial work environment are important factors that influence the rehabilitation process for the individual. These factors can facilitate opportunities to develop skills in contacts with fellow employees, increase belief in one’s own abilities, and can contribute to the achievement of specified goals. These factors are also seen as supporting empowerment and active participation in the rehabilitation process. However, the results also revealed that the rehabilitation process is negatively effected by environmental factors to which the professionals and their organizations contributed. Barriers related to interagency collaboration contributed to barriers to a successful rehabilitation for the individual. The professionals were consistent in what they viewed as enabling factors in the rehabilitation process but the results also showed how difficult it was for the service system to create a rehabilitation context in line with their knowledge and experience.Keywords: Psychiatric disabilities, vocational rehabilitation, empowerment, interagency collaboration, support system.
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| 47. |
- Hofmann, Robin, et al.
(författare)
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Oxygen therapy in suspected acute myocardial infarction
- 2017
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Ingår i: New England Journal of Medicine. - : MASSACHUSETTS MEDICAL SOC. - 0028-4793 .- 1533-4406. ; 377:13, s. 1240-1249
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The clinical effect of routine oxygen therapy in patients with suspected acute myocardial infarction who do not have hypoxemia at baseline is uncertain. METHODS: In this registry-based randomized clinical trial, we used nationwide Swedish registries for patient enrollment and data collection. Patients with suspected myocardial infarction and an oxygen saturation of 90% or higher were randomly assigned to receive either supplemental oxygen (6 liters per minute for 6 to 12 hours, delivered through an open face mask) or ambient air. RESULTS: A total of 6629 patients were enrolled. The median duration of oxygen therapy was 11.6 hours, and the median oxygen saturation at the end of the treatment period was 99% among patients assigned to oxygen and 97% among patients assigned to ambient air. Hypoxemia developed in 62 patients (1.9%) in the oxygen group, as compared with 254 patients (7.7%) in the ambient-air group. The median of the highest troponin level during hospitalization was 946.5 ng per liter in the oxygen group and 983.0 ng per liter in the ambient-air group. The primary end point of death from any cause within 1 year after randomization occurred in 5.0% of patients (166 of 3311) assigned to oxygen and in 5.1% of patients (168 of 3318) assigned to ambient air (hazard ratio, 0.97; 95% confidence interval [CI], 0.79 to 1.21; P=0.80). Rehospitalization with myocardial infarction within 1 year occurred in 126 patients (3.8%) assigned to oxygen and in 111 patients (3.3%) assigned to ambient air (hazard ratio, 1.13; 95% CI, 0.88 to 1.46; P=0.33). The results were consistent across all predefined subgroups. CONCLUSIONS: Routine use of supplemental oxygen in patients with suspected myocardial infarction who did not have hypoxemia was not found to reduce 1-year all-cause mortality. (Funded by the Swedish Heart–Lung Foundation and others; DETO2X-AMI ClinicalTrials.gov number, NCT01787110.)
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| 48. |
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| 49. |
- Iraola, Aitor, et al.
(författare)
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Microtomography-based Inter-Granular Network for the simulation of radionuclide diffusion and sorption in a granitic rock
- 2017
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Ingår i: Journal of Contaminant Hydrology. - : Elsevier BV. - 0169-7722 .- 1873-6009. ; 207, s. 8-16
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Tidskriftsartikel (refereegranskat)abstract
- Field investigation studies, conducted in the context of safety analyses of deep geological repositories for nuclear waste, have pointed out that in fractured crystalline rocks sorbing radionuclides can diffuse surprisingly long distances deep into the intact rock matrix; i.e. much longer distances than those predicted by reactive transport models based on a homogeneous description of the properties of the rock matrix. Here, we focus on cesium diffusion and use detailed micro characterisation data, based on micro computed tomography, along with a grain-scale Inter-Granular Network model, to offer a plausible explanation for the anomalously long cesium penetration profiles observed in these in-situ experiments. The sparse distribution of chemically reactive grains (i.e. grains belonging to sorbing mineral phases) is shown to have a strong control on the diffusive patterns of sorbing radionuclides. The computed penetration profiles of cesium agree well with an analytical model based on two parallel diffusive pathways. This agreement, along with visual inspection of the spatial distribution of cesium concentration, indicates that for sorbing radionuclides the medium indeed behaves as a composite system, with most of the mass being retained close to the injection boundary and a non-negligible part diffusing faster along preferential diffusive pathways.
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| 50. |
- Janson, Martin S., et al.
(författare)
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Hydrogen in the wide bandgap semiconductor silicon carbide
- 2004
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Ingår i: Physica Scripta. - 0031-8949 .- 1402-4896. ; T108, s. 99-112
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we give a review of our recent results related to the incorporation of hydrogen (H) in silicon carbide (SiC) and its interaction with acceptor doping atoms and implantation induced defects. Hydrogen is an abundant impurity in the growth of epitaxial SiC since it is present in the precursor gases and since H-2 is used as the carrier gas. High concentrations of hydrogen are indeed incorporated into highly doped p-type epi-layers and it is shown that the main source is the carrier gas. Furthermore, it is revealed that the entire substrate becomes homogeneously filled with hydrogen during growth and that this hydrogen is more thermally stable than that in the epi-layer. Incorporation of hydrogen from an H-2 ambient, at temperatures considerably lower than those used for epitaxy, is also demonstrated in p-type samples coated with a catalytic metal film. This effect is most likely the cause for the increased series resistance observed in p-type SiC Schottky sensor devices using a catalytic metal gate after annealing at 600 degrees C in a H-2 containing ambient. Hydrogen is found to passivate the acceptors Al and B by forming electrically neutral H-acceptor complexes. Unlike in Si and GaAs, the two H-acceptor complexes in SiC exhibit very different dissociation energies, suggesting that the atomic configurations of the complexes are significantly different. The migration of mobile hydrogen in the presence of externally applied, or internal built-in, electric fields further reveals that hydrogen is present as H+ in p-type SiC. Finally, the redistribution and subsequent out-diffusion of low energy implanted H-1 and H-2 is investigated. Two annealing phases for the redistribution are observed, and the activation energies for the processes are extracted.
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