| 1. |
- Jiang, Zeyu, et al.
(författare)
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Enhanced Interface Charge Transfer of Z-Scheme Photocatalyst by Br Substitution at the Bay Position in Perylene Tetracarboxylic Diimide
- 2020
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Ingår i: Solar RRL. - : WILEY-V C H VERLAG GMBH. - 2367-198X. ; 4:10
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Tidskriftsartikel (refereegranskat)abstract
- Z-scheme heterojunction photocatalysts (ZsHP) have attracted significant attention due to their excellent carrier recombination suppression and charge potential enhancement properties. However, the photocatalytic performance of ZsHP is limited by inefficient charge transfer at the heterojunction interface, mainly due to electron trapping by O-2 or H+ in part B and the large energy gap between its conduction band (CB) and the valence band (VB) of part A. Herein, perylene tetracarboxylic diimide (PTCDI, part B) and g-C3N4 (part A) are used to fabricate an organic ZsHP (PI-g-C3N4) as a novel strategy to significantly improve interfacial charge transfer efficiency by tailoring the Br substitution at the PTCDI bay position. Br substitution at the bay position reduce electron trapping in part B and bring the CB of part B closer to the VB of part A. Moreover, Br substitution enhance the electric field from g-C3N4 to PTCDI, enhancing the interfacial charge transfer of the ZsHP. These findings enable the design of ZsHP with tunable interface electron-transfer efficiencies.
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| 2. |
- Xu, Changdan, et al.
(författare)
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CTCs Detection and Whole-exome Sequencing Might Be Used to Differentiate Benign and Malignant Pulmonary Nodules
- 2023
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Ingår i: Chinese Journal of Lung Cancer. - 1009-3419. ; 26:6, s. 449-460
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Tidskriftsartikel (refereegranskat)abstract
- Background and objective Low-density computed tomography (LDCT) improved early lung cancer diagnosis but introduces an excess of false-positive pulmonary nodules data. Hence, accurate diagnosis of early-stage lung cancer remains challenging. The purpose of the study was to assess the feasibility of using circulating tumour cells (CTCs) to differentiate malignant from benign pulmonary nodules. Materials and methods 122 patients with suspected malignant pulmonary nodules detected on chest CT in preparation for surgery were prospectively recruited. Peripheral blood samples were collected before surgery, and CTCs were identified upon isolation by size of epithelial tumour cells and morphological analysis. Laser capture microdissection, MALBAC amplification, and whole-exome sequencing were performed on 8 samples. The diagnostic efficacy of CTCs counting, and the genomic variation profile of benign and malignant CTCs samples were analysed. Results Using 2.5 cells/5 mL as the cut-off value, the area under the receiver operating characteristic curve was of 0.651 (95% confidence interval: 0.538-0.764), with a sensitivity and specificity of 0.526 and 0.800, respectively, and positive and negative predictive values of 91.1% and 30.3%, respectively. Distinct sequence variations differences in DNA damage repair-related and driver genes were observed in benign and malignant samples. TP53 mutations were identified in CTCs of four malignant cases; in particular, g.7578115T>C, g.7578645C>T, and g.7579472G>C were exclusively detected in all four malignant samples. Conclusion CTCs play an ancillary role in the diagnosis of pulmonary nodules. TP53 mutations in CTCs might be used to identify benign and malignant pulmonary nodules.
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| 3. |
- Li, Guohui, et al.
(författare)
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Efficient heat dissipation perovskite lasers using a high-thermal-conductivity diamond substrate
- 2023
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Ingår i: SCIENCE CHINA Materials. - : Springer Science and Business Media LLC. - 2095-8226 .- 2199-4501. ; 66:6, s. 2400-2407
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Tidskriftsartikel (refereegranskat)abstract
- Efficient heat dissipation that can minimize temperature increases in device is critical in realizing electrical injection lasers. High-thermal-conductivity diamonds are promising for overcoming heat dissipation limitations for perovskite lasers. In this study, we demonstrate a perovskite nanoplatelet laser on a diamond substrate that can efficiently dissipate heat generated during optical pumping. Tight optical confinement is also realized by introducing a thin SiO2 gap layer between nanoplatelets and the diamond substrate. The demonstrated laser features a Q factor of ∼1962, a lasing threshold of 52.19 µJ cm−2, and a low pump-density-dependent temperature sensitivity (∼0.56 ± 0.01 K cm2 µJ−1) through the incorporation of the diamond substrate. We believe our study could inspire the development of electrically driven perovskite lasers. [Figure not available: see fulltext.].
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| 4. |
- Liu, Caifeng, et al.
(författare)
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A Zebrafish Model Discovers a Novel Mechanism of Stromal Fibroblast-Mediated Cancer Metastasis
- 2017
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Ingår i: Clinical Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 1078-0432 .- 1557-3265. ; 23:16, s. 4769-4779
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Cancer metastasis can occur at the early stage of tumor development when a primary tumor is at the microscopic size. In particular, the interaction of malignant cells with other cell types including cancer-associated fibroblasts (CAF) in promoting metastasis at the early stage of tumor development remains largely unknown. Here, we investigated the role of CAFs in facilitating the initial events of cancer metastasis when primary tumors were at microscopic sizes. Experimental Design: Multicolor-coded cancer cells and CAFs were coimplanted into the transparent zebrafish body and metastasis at a single-cell level was monitored in living animals. Healthy fibroblasts, tumor factor-educated fibroblasts, and CAFs isolated from various tumors were tested for their ability to facilitate metastasis. Results: We showed that CAFs promoted cancer cell metastasis at the very early stage during primary tumor development. When a primary tumor was at the microscopic size consisting of a few hundred cells, CAFs were able to hijack cancer cells for dissemination from the primary site. Surprisingly, a majority of metastatic cancer cells remained in tight association with CAFs in the circulation. Furthermore, stimulation of non-metastasis-promoting normal fibroblasts with TGF-B, FGF-2, HGF, and PDGF-BB led to acquisition of their metastatic capacity. Conclusions: Cancer metastasis occurs at the very early stage of tumor formation consisting of only a few hundred cells. CAFs are the key cellular determinant for metastasis. Our findings provide novel mechanistic insights on CAFs in promoting cancer metastasis and targeting CAFs for cancer therapy should be aimed at the early stage during cancer development. (C) 2017 AACR.
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| 5. |
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| 6. |
- Shen, Xiaoling, et al.
(författare)
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Enhancing Photocatalytic Activity of NO Removal through an In Situ Control of Oxygen Vacancies in Growth of TiO2
- 2019
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Ingår i: Advanced Materials Interfaces. - : WILEY. - 2196-7350. ; 6:19
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Tidskriftsartikel (refereegranskat)abstract
- Although defects play an important role in the photocatalytic activity of TiO2, the mechanism of the photocatalytic activity related to different defects remains disputable. Moreover, the reported methods to introduce defects raise the preparation cost. In this work, different types of defects including O-vacancy cluster, surface O-vacancy, and bulk O-vacancy defects are in situ introduced in TiO2 by controlling the crystallization temperature. The medium-degree crystallinity TiO2 sample mainly containing surface O-vacancies exhibits the best NO removal activity. The systematic study of photocatalytic mechanism demonstrates that the surface O-vacancies significantly promote the adsorption of H2O molecules and improve charge transfer to the adsorbed H2O forming center dot OH, thus dramatically enhancing the photocatalytic NO removal activity. On the contrary, bulk O-vacancies neither help the adsorption of H2O molecules, nor improve the charge transfer to H2O.
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| 7. |
- Xu, Fengqin, et al.
(författare)
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Effects of an Innovative Training Program for New Graduate Registered Nurses : A Comparison Study
- 2021
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Ingår i: SAGE Open. - : SAGE Open. - 2158-2440. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- New graduate registered nurses (NGRNs) face a great challenge during the transition from school to clinical practice. We conducted a quasi-randomized controlled study to evaluate the effects of a new training mode for newly recruited NGRNs in a Chinese teaching hospital. A total of 150 NGRNs were recruited from a teaching hospital and assigned into two groups. The conventional training and a new training program were taken for the control group and the research group, respectively. At the end of the training, the two groups were evaluated and compared for theoretical knowledge and operation skills using a mutual-evaluation examination and the Chinese Registered Nurse Core Competency Scale. The scores of theoretical knowledge (88.4 vs. 81.7, p < .001) and operation skills (94.8 vs. 90.3, p < .001), and the total core competencies score (156.2 vs. 148.8, p < .05) in the research group were statistically significantly higher than those in the control group. Compared with the control group, the research group also had statistically significantly higher scores in education and consultation (2.47 vs. 2.40), clinical nursing (2.87 vs. 2.62), interpersonal relationship (2.56 vs. 2.43), and critical thinking and scientific research (2.78 vs. 2.61). The innovative pre-job training program for NGRNs conducted in Chinese clinical nursing skill training bases might significantly improve the training effects and is worthy of broader implementation.
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| 8. |
- Zhao, Kefan, et al.
(författare)
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High-Quality Solution-Processed Quasi-2D Perovskite for Low-Threshold Lasers
- 2024
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Ingår i: ACS Applied Materials and Interfaces. - 1944-8244. ; 16:17, s. 22361-22368
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Tidskriftsartikel (refereegranskat)abstract
- Spin-coated quasi-two-dimensional halide perovskite films, which exhibit superior optoelectronic properties and environmental stability, have recently been extensively studied for lasers. Crystallinity is of great importance for the laser performance. Although some parameters related to the spin-coating process have been studied, the in-depth understanding and effective control of the acceleration rate on two-dimensional perovskite crystallization during spin-coating are still unknown. Here we investigate the effect of solvent evaporation on the microstructure of the final perovskite films during the spin-coating process. The crystallization quality of the film can be significantly improved by controlling solvent evaporation. As a result, the prepared quasi-2D perovskite film exhibits a stimulated emission threshold (pump: 343 nm, 6 kHz, 290 fs) of 550 nm as low as 16.2 μJ/cm2. Transient absorption characterization shows that the radiative biexciton recombination time is reduced from 738.5 to 438.3 ps, benefiting from the improved crystallinity. The faster biexciton recombination significantly enhanced the photoluminescence efficiency, which is critical for population inversion. This work could contribute to the development of low-threshold lasers.
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| 9. |
- Zhou, Meng, et al.
(författare)
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Photocatalytic removal of NO by intercalated carbon nitride: The effect of group IIA element ions
- 2020
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Ingår i: Applied Catalysis B. - : ELSEVIER. - 0926-3373 .- 1873-3883. ; 273
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Tidskriftsartikel (refereegranskat)abstract
- In this study, Group IIA element ion-doped g-C3N4 samples were synthesized to eliminate above two disadvantages and increase photocatalytic NO removal activity. The experimental results showed that the Group IIA element ions could form coordination bonds with the nitrogen atoms in the triazine rings of g-C3N4 that distorted the g-C3N4 structure because of uneven force. The structure distortion destroyed the surface electronic delocalization and suppressed the recombination of surface charge carriers. Additionally, the formed coordinate bonds connected two adjacent layers and served as interlayer electron channels, which could significantly improve the electron transport between two layers. Additionally, structural distortions created more amino and imino groups, which are the chemisorption sites of O-2. Therefore, the modified g-C3N4 samples produced more reactive oxygen species to remove NO. The degree of distortion and the NO removal activity increased as the Group IIA atomic number increased.
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