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- Schael, S, et al.
(författare)
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Precision electroweak measurements on the Z resonance
- 2006
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Ingår i: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
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Forskningsöversikt (refereegranskat)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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- Shah, S, et al.
(författare)
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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 163-
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Tidskriftsartikel (refereegranskat)abstract
- Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies.
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- Wang, HD, et al.
(författare)
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Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015
- 2016
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Ingår i: Lancet (London, England). - : Elsevier. - 1474-547X .- 0140-6736. ; 388:10053, s. 1725-1774
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Tidskriftsartikel (refereegranskat)
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- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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- Caplan, A, et al.
(författare)
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Author Accountability in Biomedical Research
- 2018
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Ingår i: Stem cells and development. - : Mary Ann Liebert Inc. - 1557-8534 .- 1547-3287. ; 27:24, s. 1671-1673
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Large, DJ, et al.
(författare)
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The influence of climate, hydrology and permafrost on Holocene peat accumulation at 3500 m on the eastern Qinghai-Tibetan plateau
- 2009
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Ingår i: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791 .- 1873-457X. ; 28:27-28, s. 3303-3314
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Tidskriftsartikel (refereegranskat)abstract
- Peatland of the eastern Qinghai–Tibetan Plateau lies at the convergence of the East Asian and Indian monsoon systems in eastern Asia. To understand the evolution of this peatland and its potential to provide new insights into the Holocene evolution of the East Asian monsoon a 6 m peat core was collected from the undisturbed central part of a peat deposit near Hongyuan. The age-depth profile was determined using 16 14C-AMS age dates, the peat analysed for a range of environmental variables including carbon, nitrogen and hydrogen concentration, bulk density, δ13C and the associated spring water analysed for hydrogen and oxygen isotopes. The age-depth profile of the recovered peat sequence covers the period from 9.6 to 0.3 kyr BP and is linear indicating that the conditions governing productivity and decay varied little over the Holocene. Using changes in carbon density, organic carbon content and its δ13C, cold dry periods of permafrost characterised by low density and impeded surface drainage were identified. The low δ18O and δD values of the spring water emanating around the peat deposit, down to −13.8 and −102‰ (VSMOW), respectively, with an inverse relationship between electrical conductivity and isotopic composition indicate precipitation under colder and drier conditions relative to the present day. In view of the current annual mean air temperature of 1 °C this suggests conditions in the past have been conducive to permafrost. Inferred periods of permafrost correspond to independently recognised cold periods in other Holocene records from across China at 8.6, 8.2–7.8, 5.6–4.2, 3.1 and 1.8–1.5 kyr BP. The transition to a cold dry climate appears to be more rapid than the subsequent recovery and cold dry periods at Hongyuan are of longer duration than equivalent cold dry periods over central and eastern China. Light–dark banding peat on a scale of 15–30 years from 9.6 to 5.5 kyr BP may indicate a strong influence of decadal oscillations possibly the Pacific Decadal Oscillation and a potential link between near simultaneous climatic changes in the northwest Pacific, ENSO, movement of the Intertropical Convergence Zone and the East Asian Monsoon.
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- Wacker, A, et al.
(författare)
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Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy
- 2020
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Ingår i: Nucleic acids research. - : Oxford University Press (OUP). - 1362-4962 .- 0305-1048. ; 48:22, s. 12415-12435
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Tidskriftsartikel (refereegranskat)abstract
- The current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2) highlights the need for coordinated research to combat COVID-19. A particularly important aspect is the development of medication. In addition to viral proteins, structured RNA elements represent a potent alternative as drug targets. The search for drugs that target RNA requires their high-resolution structural characterization. Using nuclear magnetic resonance (NMR) spectroscopy, a worldwide consortium of NMR researchers aims to characterize potential RNA drug targets of SCoV2. Here, we report the characterization of 15 conserved RNA elements located at the 5′ end, the ribosomal frameshift segment and the 3′-untranslated region (3′-UTR) of the SCoV2 genome, their large-scale production and NMR-based secondary structure determination. The NMR data are corroborated with secondary structure probing by DMS footprinting experiments. The close agreement of NMR secondary structure determination of isolated RNA elements with DMS footprinting and NMR performed on larger RNA regions shows that the secondary structure elements fold independently. The NMR data reported here provide the basis for NMR investigations of RNA function, RNA interactions with viral and host proteins and screening campaigns to identify potential RNA binders for pharmaceutical intervention.
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