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| 2. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 4. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 13. |
- Sanguedolce, F, et al.
(författare)
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Are We Ready to Implement Molecular Subtyping of Bladder Cancer in Clinical Practice? Part 2: Subtypes and Divergent Differentiation
- 2022
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Ingår i: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 23:14
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Tidskriftsartikel (refereegranskat)abstract
- Following several attempts to achieve a molecular stratification of bladder cancer (BC) over the last decade, a “consensus” classification has been recently developed to provide a common base for the molecular classification of bladder cancer (BC), encompassing a six-cluster scheme with distinct prognostic and predictive characteristics. In order to implement molecular subtyping (MS) as a risk stratification tool in routine practice, immunohistochemistry (IHC) has been explored as a readily accessible, relatively inexpensive, standardized surrogate method, achieving promising results in different clinical settings. The second part of this review deals with the pathological and clinical features of the molecular clusters, both in conventional and divergent urothelial carcinoma, with a focus on the role of IHC-based subtyping.
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| 14. |
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| 15. |
- Ammendola, M., et al.
(författare)
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Mast Cells Density Positive to Tryptase Correlate with Microvascular Density in both Primary Gastric Cancer Tissue and Loco-Regional Lymph Node Metastases from Patients That Have Undergone Radical Surgery
- 2016
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Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1422-0067. ; 17:11
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Tidskriftsartikel (refereegranskat)abstract
- Mast Cells (MCs) play a role in immune responses and more recently MCs have been involved in tumoral angiogenesis. In particular MCs can release tryptase, a potent in vivo and in vitro pro-angiogenic factor via proteinase-activated receptor-2 (PAR-2) activation and mitogen-activated protein kinase (MAPK) phosphorylation. MCs can release tryptase following c-Kit receptor activation. Nevertheless, no data are available concerning the relationship among MCs Density Positive to Tryptase (MCDPT) and Microvascular Density (MVD) in both primary gastric cancer tissue and loco-regional lymph node metastases. A series of 75 GC patients with stage T2-3N2-3M0 (by AJCC for Gastric Cancer Seventh Edition) undergone to radical surgery were selected for the study. MCDPT and MVD were evaluated by immunohistochemistry and by image analysis system and results were correlated each to other in primary tumor tissue and in metastatic lymph nodes harvested. Furthermore, tissue parameters were correlated with important clinico-pathological features. A significant correlation between MCDPT and MVD was found in primary gastric cancer tissue and lymph node metastases. Pearson t-test analysis (r ranged from 0.74 to 0.79; p-value ranged from 0.001 to 0.003). These preliminary data suggest that MCDPT play a role in angiogenesis in both primary tumor and in lymph node metastases from GC. We suggest that MCs and tryptase could be further evaluated as novel targets for anti-angiogenic therapies.
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| 16. |
- Favuzza, S., et al.
(författare)
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An Analysis of the Intertial Response of Small Isolated Power Systems in Presence of Generation from Renewable Energy Sources
- 2018
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Ingår i: 2018 IEEE 4th International Forum on Research and Technology for Society and Industry (RTSI). - 9781538662823
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Konferensbidrag (refereegranskat)abstract
- Renewable Energy Sources are posing critical issues related to the mining of power systems stability, essentially due to a decrement of the inertial response during system's contingencies. As a consequence, to preserve the security and the reliability of the system, it is necessary to adopt new frequency adjustments mechanisms. This issue becomes particularly critical in isolated power systems, like those of small islands not supplied by the main grid, in the case of high shares of production from unpredictable renewabies such as photovoitaic and wind sources. In this framework, the present work deals with the analysis of the variation of the inertia time constant of a small island in various scenarios characterized by a different share of renewable energy. The study represents the first step of a more extended feasibility study for the conversion of a traditional power system based on fossil fuel towards a renewable energy-based power system.
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| 17. |
- Favuzza, S., et al.
(författare)
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System Stability of a Small Island's Network with Different Levels of Wind Power Penetration
- 2018
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Ingår i: 2018 IEEE 4th International Forum on Research and Technology for Society and Industry (RTSI). - 9781538662823
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Konferensbidrag (refereegranskat)abstract
- The reduction of the inertial response of the generation system has been one of the main obstacles to the penetration of high sharing of renewable energy sources in islanded systems. This issue can be solved thanks to innovative control that makes wind turbines able to provide the so-named synthetic inertia. The paper investigates some scenarios with different levels of wind power penetration in a small island whose grid is not supplied by the main grid, by the use of the software NEPLAN 360, simulating the wind power plants accordingly to the standard IEC 61400-27. The aim of the paper is to assess the maximum level of penetration in the island of wind generation, with traditional control systems, that does not threaten the stability of the system.
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| 18. |
- Sanguedolce, F, et al.
(författare)
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Are We Ready to Implement Molecular Subtyping of Bladder Cancer in Clinical Practice? Part 1: General Issues and Marker Expression
- 2022
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Ingår i: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 23:14
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Tidskriftsartikel (refereegranskat)abstract
- Bladder cancer (BC) is a heterogeneous disease with highly variable clinical and pathological features, and resulting in different outcomes. Such heterogeneity ensues from distinct pathogenetic mechanisms and may consistently affect treatment responses in single patients. Thus, over the last few years, several groups have developed molecular classification schemes for BC, mainly based on their mRNA expression profiles. A “consensus” classification has recently been proposed to combine the published systems, agreeing on a six-cluster scheme with distinct prognostic and predictive features. In order to implement molecular subtyping as a risk-stratification tool in routine practice, immunohistochemistry (IHC) has been explored as a readily accessible, relatively inexpensive, standardized surrogate method, achieving promising results in different clinical settings. The first part of this review deals with the steps resulting in the development of a molecular subtyping of BC, its prognostic and predictive implications, and the main features of immunohistochemical markers used as surrogates to stratify BC into pre-defined molecular clusters.
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| 19. |
- Bongiorno, Massimo, 1976, et al.
(författare)
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Inertial response of isolated power networks with wind power plants
- 2019
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Ingår i: 2019 IEEE Milan PowerTech, PowerTech 2019.
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Konferensbidrag (refereegranskat)abstract
- The constant increase of power generation provided by renewable energy source (RES) power plants is causing a progressive reduction of the overall inertia of the power systems. Especially in the case of small, isolated power networks, the replacement of conventional generation plants with RES power plants can affect significantly the frequency response of the system. The critical low-inertia conditions can be improved by the introduction of specific additional controls to the RES power converters. These control schemes are known as 'synthetic inertia' or 'virtual inertia' controls. The paper analyzes the impact of a derivative-based inertial control on a small, isolated power system, with a relevant share of power supplied by a wind power plant. The inertial response control is added to the standard IEC wind turbine active power controller of type WT4A. Simulations performed on the dynamic model of the system indicate the appearance of frequency oscillations in response to the applied power unbalance. A comprehensive analysis of the observed phenomenon is given, and a tuning of the inertial control parameters is then proposed. Simulations repeated with the proposed tuning of the controller prove the validity of the applied modifications, and show a satisfactory transient response of the system, even in the case of critical low-inertia conditions.
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| 20. |
- Ippolito, M. G., et al.
(författare)
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Damping Provision by Different Virtual Synchronous Machine Schemes
- 2020
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Ingår i: Proceedings - 2020 IEEE International Conference on Environment and Electrical Engineering and 2020 IEEE Industrial and Commercial Power Systems Europe, EEEIC / I and CPS Europe 2020.
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Konferensbidrag (refereegranskat)abstract
- The adoption of virtual synchronous machine (VSM) schemes for the control of power converters is gaining more and more attention both in academia and industry. The VSM control strategies fall into the category of grid-forming converter controls, and they are intended for a range of different applications, providing specific services and different kinds of support to the grid. The paper investigates the possibility of damping provision to the system by VSM power converters. Different schemes are considered and compared, showing the opportunity of the investigated solutions through combined modal and time domain analyses. A specific modification of the power synchronization loop is recognized as the most suitable method to contain the power oscillations and increase the damping level in the system.
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| 21. |
- Ippolito, M. G., et al.
(författare)
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Extension and Tuning of Virtual Synchronous Machine to Avoid Oscillatory Instability in Isolated Power Networks
- 2020
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Ingår i: 12th AEIT International Annual Conference, AEIT 2020.
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Konferensbidrag (refereegranskat)abstract
- The risk of oscillatory instability introduced by virtual synchronous machines (VSM) control in isolated power networks is investigated. The considered control is a common scheme widely studied in literature, in several configurations and for different case studies. The impact of the VSM control on the system stability is examined for the existing power network of a Mediterranean island. The VSM control is implemented within the power converters interfacing the energy storage systems (ESS) installed in the network. Simulations and analysis show the occurrence of oscillatory instability in the system, with the ESS-VSM and the synchronous machines of the network progressively swinging against each other. The reasons of the instability are identified as the lack of damping in the system and the adverse interaction between the VSM converter control and the synchronous machine dynamics. The possibility of extending the VSM control with a corrective action for the stabilization of the system is analyzed and discussed. A proper tuning procedure of the extended control is also provided.
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| 22. |
- Ranieri, G., et al.
(författare)
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A model of study for human cancer : Spontaneous occurring tumors in dogs. Biological features and translation for new anticancer therapies
- 2013
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Ingår i: Critical reviews in oncology/hematology. - : Elsevier BV. - 1040-8428 .- 1879-0461. ; 88:1, s. 187-197
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Forskningsöversikt (refereegranskat)abstract
- Murine cancer models have been extremely useful for analyzing the biology of pathways involved in cancer initiation, promotion, and progression. Interestingly, several murine cancer models also exhibit heterogeneity, genomic instability and an intact immune system. However, they do not adequately represent several features that define cancer in humans, including long periods of latency, the complex biology of cancer recurrence and metastasis and outcomes to novel therapies. Therefore, additional models that better investigate the human disease are needed. In the pet population, with special references to the dog, cancer is a spontaneous disease and dogs naturally develop cancers that share many characteristics with human malignancies More than 40 years ago, optimization of bone marrow transplantation protocols was undertaken in dogs and recently novel targeted therapies such as liposomal muramyl tripeptide phosphatidylethanolamine and several tyrosine kinase inhibitors, namely masitinib (AB1010) and toceranib phosphate (SU11654), have been developed to treat dog tumors which have then been translated to human clinical trials. In this review article, we will analyze biological data from dog tumors and comparative features with human tumors, and new therapeutic approaches translated from dog to human cancer.
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