1. |
- Castellanos-Jankiewicz, A., et al.
(author)
-
Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity
- 2021
-
In: Cell Metabolism. - : Elsevier BV. - 1550-4131. ; 33:7
-
Journal article (peer-reviewed)abstract
- Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implicated in body weight control and obesity pathophysiology remains unknown. Here we show that hypothalamic BA content is reduced in diet-induced obese mice. Central administration of BAs or a specific TGR5 agonist in these animals decreases body weight and fat mass by activating the sympathetic nervous system, thereby promoting negative energy balance. Conversely, genetic downregulation of hypothalamic TGR5 expression in the mediobasal hypothalamus favors the development of obesity and worsens established obesity by blunting sympathetic activity. Lastly, hypothalamic TGR5 signaling is required for the anti-obesity action of dietary BA supplementation. Together, these findings identify hypothalamic TGR5 signaling as a key mediator of a top-down neural mechanism that counteracts diet induced obesity.
|
|
2. |
- Soffel, M., et al.
(author)
-
The IAU 2000 Resolutions for Astrometry, Celestial Mechanics, and Metrology in the Relativistic Framework: Explanatory Supplement
- 2003
-
In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X. ; 126:6, s. 2687-2706
-
Journal article (peer-reviewed)abstract
- We discuss the IAU resolutions B1.3, B1.4, B1.5, and B1.9 that wereadopted during the 24th General Assembly in Manchester, 2000, andprovides details on and explanations for these resolutions. It isexplained why they present significant progress over the correspondingIAU 1991 resolutions and why they are necessary in the light of presentaccuracies in astrometry, celestial mechanics, and metrology. In fact,most of these resolutions are consistent with astronomical models andsoftware already in use. The metric tensors and gravitational potentialsof both the Barycentric Celestial Reference System and the GeocentricCelestial Reference System are defined and discussed. The necessity andrelevance of the two celestial reference systems are explained. Thetransformations of coordinates and gravitational potentials arediscussed. Potential coefficients parameterizing the post-Newtoniangravitational potentials are expounded. Simplified versions of the timetransformations suitable for modern clock accuracies are elucidated.Various approximations used in the resolutions are explicated andjustified. Some models (e.g., for higher spin moments) that serve thepurpose of estimating orders of magnitude have actually never beenpublished before.
|
|