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- Eklund, Johan
(författare)
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Searching for genetical cancer risks using a database of familial cancer : part I
- 1999
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- A method to estimate cancer risks, when a recessive genetic defect is assumed to influence the risk to develop cancer, is presented. The proportion of the recessive defect is also estimated. The method uses cancer diagnosis data from a large sample of biological families. A family is here parents and two children. The information used is the frequencies of cancer diagnoses among siblings. Estimations are performed with the method of moments. The work is methodological, meaning that no specific type of cancer is considered.
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