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- Persson, Bertil R, et al.
(författare)
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Clinical Studies of EpECT with Bleomycin or Cis-Platin
- 2018
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Ingår i: Electro-Pulse-Enhanced-Chemo-Therapy. - 1651-5013. ; 2018, s. 1-1
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- In recent years several authors have reviewed the clinical results of Electro Enhanced Chemotherapy: • Electro-chemotherapy for primary skin cancer and skin metastasis related to other malignancies (Reinhold, 2011). • Utility of electro-chemotherapy in melanoma treatment (Testori et al., 2012).• Antitumor effectiveness of electro-chemotherapy: A systematic review and meta-analysis (Mali et al., 2013).• Electro-chemotherapy in Breast Cancer: A Review of References (Schmidt et al., 2014).• Treatments of advanced basal cell carcinoma: a review of the literature" (Peris et al., 2016).• Treatment efficacy with electro-chemotherapy: A multi-institutional prospective observational study on 376 patients with superficial tumours"(Campana et al., 2016b).• Basal cell carcinoma: 10-year experience with electro-chemotherapy (Campana et al., 2017b).• Electro-chemotherapy in Breast Cancer - Discussion of the Method and Literature Review (Wichtowski et al., 2017). The treatment results are in most cases reported in terms of following quantities where the fractional response = (No. cases with the actual response / Total No. Cases) CR = Complete response; PR = partial response; SD = stable disease; PD = progressive disease; OR = objective response; CR = fractional complete response; PR = fractional partial response; SD = fractional stable disease; PD = fractional progressive disease; OR = fractional objective responseUsually the sum of complete and partial responses called Objective Response (OR = CR + PR) is used as a general quantity for the response of the treatment in question without considering the responses of stable and progress disease.In order to be able unify all four quantities into a quantity which consider the total response a quantity named “fractional weighting response”, WR is defined as follow:In order to estimate the response considering all four response quantities a quantity named “fractional weighted response”, WR is defined as follow:WR = (3OR + 1PR + 0SD - 3PR)/3;The following sections summarize the published responses of clinical electro-chemotherapy for each specific type of tumour, and estimate the fractional weighting response from the data of each published report.
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