| 11. |
- Fäldt, R., et al.
(författare)
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Tumor‐associated humoral cytotoxicity in patients with acute myelogenous leukemia before and after chemotherapy
- 1977
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 20:6, s. 824-833
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Tidskriftsartikel (refereegranskat)abstract
- Sera of eight unselected adult patients with acute myelogenous leukemia obtained before and after chemotherapy were repeatedly tested for specific complement‐dependent cytotoxicity against autochthonous peripheral white blood cells from the acute leukemia stage and from the remission stage, respectively. Complement‐dependent cytotoxicity against white blood cells from the acute leukemia stage was demonstrated in all of the eight patients, while none of three patients' sera were reactive against white blood cells from the remission stage tested in parallel. The cytotoxicity was increased after chemotherapy, also in those patients in whom remission was not achieved.
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| 12. |
- Johansson, C, et al.
(författare)
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Interaction by cholestyramine on the uptake of hydrocortisone in the gastrointestinal tract.
- 1978
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Ingår i: Acta medica Scandinavica. - 0001-6101. ; 204:6, s. 509-12
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Tidskriftsartikel (refereegranskat)abstract
- An absolute reduction of the plasma cortisol levels and a delay of the peak concentrations were recorded in 10 healthy subjects, when a bile-sequestering anionic exchange resin, cholestyramine, was given prior to a single oral hydrocortisone dose, indicating that the resin interferes with the uptake of a neutral sterol in the human gastrointestinal tract. The possibility of a direct binding of drug to resin is supported by the affinity of hydrocortisone to cholestyramine in vitro, which was uninfluenced by the presence of sodium taurocholate. Cholestyramine significantly delayed the gastric emptying of a glucose solution, indicating that the resin not only decreases but also delays hydrocortisone absorption. Careful supervision is recommended when treatment with cholestyramine is given concomitant to neutral sterol drugs.
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| 13. |
- Jonsson, Nils, et al.
(författare)
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Studies on adenovirus type 9‐induced mammary fibroadenomas in rats and their malignant transformation
- 1977
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Ingår i: Cancer. - 0008-543X. ; 39:6, s. 2513-2519
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Tidskriftsartikel (refereegranskat)abstract
- After inoculating newborn W/Fu rats with adenovirus type 9,27 of 27 females developed mammary fibroadenomas with a latency period of 14–25 weeks. No tumors were observed after inoculation with adenovirus type 5 or in males with the type 9 inoculation. After persistence of the tumors for 3–14 months, malignant transformation of the stroma resulted in different types of sarcoma in three rats: fibrosarcoma, round‐cell liposarcoma, osteosarcoma and malignant mes‐enchymoma. In another animal the stroma of a fibroadenoma was highly cellular, suggesting a transition into fibrosarcoma. Malignant transformation of the epithelial component was not observed. Tumor cells contained adenovirus type 9‐specific T‐antigen, and rats with transplanted tumors were immunized to T‐antigen. Mammary fibroadenomas without signs of malignant transformation developed in eight of nine female rats inoculated with adenovirus type 9 at an adult age. Neonatal thymectomy and total body x‐irradiation neither significantly shortened the induction time of adenovirus 9‐induced fibroadenomas nor increased the frequency of malignant transformation in females. One lipoma and one highly differentiated liposarcoma, however, appeared in two male rats. The results provide an example of the progression of a virus‐induced benign tumor into a malignant neoplasm.
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| 14. |
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| 15. |
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| 16. |
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| 17. |
- Nelson, K, et al.
(författare)
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Separation of rat leukocytes by countercurrent distribution in aqueous two-phase systems. II. Subpopulations which mediate selective and nonselective lysis of normal and colon carcinoma target cells in vitro
- 1978
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Ingår i: Cellular Immunology. - : Elsevier BV. - 0008-8749. ; 37:2, s. 422-431
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Tidskriftsartikel (refereegranskat)abstract
- Spleen cells from WF rats immunized to allogeneic lymphoid cells or to syngeneic colon carcinomas and from unimmunized controls were separated by countercurrent distribution in aqueous two-phase systems. The cells were assayed for cytotoxicity to allogeneic fibroblasts or syngeneic colon carcinoma cells and to syngeneic fibroblasts in a 24-hr 51Cr-release assay. Cells from immunized rats which selectively lysed the specific target cells were repeatedly found in one area of the distribution separate from the majority of cells, which nonselectively lysed syngeneic fibroblasts as well. A similar subpopulation which nonselectively lysed all target cells assayed was recovered from the spleens of unimmunized rats. The cells were also assayed for the ability to lyse antibody-coated thymocytes in a 4-hr 51Cr-release assay. The peak of K cells was found to overlap partially that of cells with nonselective cytotoxicity.
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| 18. |
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| 19. |
- Olsson, H., et al.
(författare)
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Relief of Pruritus as an Early Sign of Spinal Cord Compression in Hodgkin's Disease
- 1979
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0001-6101. ; 206:1-6, s. 319-320
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Tidskriftsartikel (refereegranskat)abstract
- ABSTRACT In a patient with advanced Hodgkin's disease (HD) associated with generalized pruritus, an unexpected relief of itching was found to be an early sign of spinal cord compression. Following irradiation of an extradural mass at the Th II level, itching recurred. Although the mechanisms bringing about itching in HD are unknown, the relief and recurrence of the symptom in our patient are in line with a peripheral origin of pruritus in the disease. Spontaneous relief of pruritus in HD despite other signs of active disease should prompt a neurological examination, since early recognition and treatment of spinal cord compression in lymphoma are important to avoid residual neurological disability. 1979 Association for the Publication of the Journal of Internal Medicine
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| 20. |
- Steele, G., et al.
(författare)
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Absorption of blocking activity from human tumor‐bearer sera by staphylococcus aureus, cowan I
- 1975
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 15:2, s. 180-189
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Tidskriftsartikel (refereegranskat)abstract
- Staphylococcus aureus, strain Cowan I, contains a cell‐wall substance, protein A, which combines with the Fc part of IgG in most mammalian species. It can therefore be used as a solid‐phase immunoabsorbant for elimination of the reacting immunoglobulins. Since it has been shown that Cowan I could absorb out the blocking activity of sera from rats bearing isografts of polyoma‐virus‐induced sarcomas or chemically induced colon carcinomas, we investigated what effects Cowan I absorption of human tumor‐bearer sera might have. In all tumor‐bearer sera tested, from patients with melanomas or colon carcinomas, treatment with protein‐A‐containing staphylococci decreased the sera's ability to inhibit lymphocyte‐mediated cytotoxicity in vitro. Cowan‐I‐treated sera from healthy controls had no effect on lymphocyte cytotoxicity. Nor did Cowan‐I‐treated tumor‐bearer sera potentiate or „arm” normal lymphocytes against tumor target cells. There was no evidence of complement‐dependent cytotoxicity with added human complement in sera from melanoma and colon carcinoma bearing patients either before or after absorption with Staphylococcus aureus, Cowan I. The concentrations of IgA, IgG and IgM were determined in sera used for in vitro tests of blocking activity and complement‐dependent cytotoxicity before and after absorption. No reduction of IgA, reduction to undetectable levels of IgG and 20–30% reduction of IgM immunoglobulins as compared to unabsorbed sera were demonstrated.
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