| 11. |
- Chen, Jiajia, et al.
(författare)
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Passive wide area network solutions : Filterless and semi-filterless optical networks
- 2011
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Ingår i: 13th International Conference on Transparent Optical Networks (ICTON). - 9781457708800
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Konferensbidrag (refereegranskat)abstract
- Advances in optical coherent transmission and electrical compensation technologies (such as coherent receiver and forward error correction FEC) have stimulated ideas for novel optical network architectures. Recently proposed passive wide area network solution, referred to as filterless optical network [1 #x2013;2] eliminates or minimizes the usage of active photonic reconfigurable network elements. In this approach, only the passive splitters and combiners for interconnecting the fiber links are utilized, which makes this network architecture more cost- and energy-effective as well as more reliable compared with networks based on active optical switching. However, the filterless optical network architecture implies some constraints on fiber interconnection design, maximum fiber-tree length and wavelength reuse due to its broadcast nature. Consequently, filterless solution always requires more resources (i.e. number of wavelengths) compared with the active switched optical networks which are allowed to utilize reconfigurable and coloured components. In order to improve the wavelength utilization while maintaining flexibility of resource allocation, this work extends the idea of filterless optical network by introducing some passive coloured components (e.g., fiber Bragg grating FBG, red/blue filters, etc) to drop local signals at some determined nodes. This approach is referred to as semi-filterless optical network. Furthermore, the semi-filterless solution maintains the passive feature, enabling high reliability and efficiency of cost and energy. Meanwhile, its non-broadcast property at some determined nodes has potential to decrease the transmission impairments and hence relax the constraints on fiber interconnection design and the maximal transparent length, which are strict in the filterless optical network. Our preliminary results confirm the advantages of semi-filterless solution.
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| 12. |
- Chen, Leilei, et al.
(författare)
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High-temperature wear mechanisms of TiNbWN films : Role of nanocrystalline oxides formation
- 2023
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Ingår i: Friction. - : Springer. - 2223-7690 .- 2223-7704. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Refractory high/medium entropy nitrides (HENs/MENs) exhibit comprehensive application prospects as protective films on mechanical parts, particularly those subjected to sliding contacts at elevated temperatures. In this study, a new MEN system TiNbWN, forming a single fcc solution, is designed and its wear performance at temperatures ranging from 25 to 750 °C is explored. The wear mechanisms can be rationalized by examining the subsurface microstructural evolutions using the transmission electron microscopy as well as calculating the phase diagrams and interfacial adhesion behavior employing calculation of phase diagram (CALPHAD) and density functional theory (DFT). To be specific, increased wear losses occur in a temperature range of 25–600 °C, being predominantly caused by the thermally-induced hardness degradation; whereas at the ultimate temperature (750 °C), the wear loss is refrained due to the formation of nanocrystalline oxides (WnO3n−2, TiO2, and γTiOx), as synergistically revealed by microscopy and CALPHAD, which not only enhance the mechanical properties of the pristine nitride film, but also act as solid lubricants, reducing the interfacial adhesion. Thus, our work delineates the role of the in situ formed nanocrystalline oxides in the wear mechanism transition of TiNbWN thin films, which could shed light on the high-temperature wear behavior of refractory HEN/MEN films.
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| 13. |
- Ji, Zhenyu, et al.
(författare)
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MITF Modulates Therapeutic Resistance through EGFR Signaling.
- 2015
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Ingår i: Journal of Investigative Dermatology. - : Elsevier BV. - 1523-1747 .- 0022-202X. ; 135:7, s. 1863-1872
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Tidskriftsartikel (refereegranskat)abstract
- Response to targeted therapies varies significantly despite shared oncogenic mutations. Nowhere is this more apparent than in BRAF(V600E)-mutated melanomas where initial drug response can be striking and yet relapse is commonplace. Resistance to BRAF inhibitors have been attributed to the activation of various receptor tyrosine kinases (RTKs) though the underlying mechanisms have been largely uncharacterized. Here, we found that EGFR induced vemurafenib resistance is ligand dependent. We then employed whole-genome expression analysis and discovererd that vemurafenib resistance correlated with the loss of MITF, along with its melanocyte lineage program, and with the activation of EGFR signaling. An inverse relationship between MITF, vemurafenib resistance and EGFR was then observed in patient samples of recurrent melanoma and was conserved across melanoma cell lines and patients' tumor specimens. Functional studies revealed that MITF depletion activated EGFR signaling and consequently recapitulated the resistance phenotype. In contrast, forced expression of MITF in melanoma and colon cancer cells inhibited EGFR and conferred sensitivity to BRAF/MEK inhibitors. These findings indicate that an "autocrine drug resistance loop" is suppressed by melanocyte lineage signal(s), such as MITF. This resistance loop modulates drug response and could explain the unique sensitivity of melanomas to BRAF inhibition.Journal of Investigative Dermatology accepted article preview online, 19 March 2015. doi:10.1038/jid.2015.105.
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| 14. |
- Ji, Zhenyu, et al.
(författare)
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Vemurafenib Synergizes with Nutlin-3 to Deplete Survivin and Suppresses Melanoma Viability and Tumor Growth
- 2013
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Ingår i: Clinical Cancer Research. - 1078-0432. ; 19:16, s. 4383-4391
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: For patients with advanced melanoma, primary and secondary resistance to selective BRAF inhibition remains one of the most critically compelling challenges. One rationale argues that novel biologically informed strategies are needed to maximally cripple melanoma cells up front before compensatory mechanisms emerge. As p53 is uncommonly mutated in melanoma, restoration of its function represents an attractive adjunct to selective BRAF inhibition. Experimental Design: Thirty-seven BRAF(V600E)-mutated melanoma lines were subjected to synergy studies in vitro using a combination of vemurafenib and nutlin-3 (Nt-3). In addition, cellular responses and in vivo efficacy were also determined. We also analyzed changes in the levels of canonical apoptotic/survival factors in response to vemurafenib. Results: Dual targeting of BRAF(V600E) and Hdm2 with vemurafenib and Nt-3, respectively, synergistically induced apoptosis and suppressed melanoma viability in vitro and tumor growth in vivo. Suppression of p53 in melanoma cells abrogated Nt-3's effects fully and vemurafenib's effects partially. A survey of canonical survival factors revealed that both vemurafenib and Nt-3 independently attenuated levels of the antiapoptotic protein, survivin. Genetic depletion of survivin reproduces the cytotoxic effects of the combination strategy. Conclusion: These results show preclinical feasibility for overcoming primary vemurafenib resistance by restoring p53 function. Moreover, it identifies survivin as one downstream mediator of the observed synergism and a potential secondary target. (C)2013 AACR.
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| 15. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
- 2008
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Ingår i: Autophagy. - : Landes Bioscience. - 1554-8627 .- 1554-8635. ; 4:2, s. 151-175
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Forskningsöversikt (refereegranskat)abstract
- Research in autophagy continues to accelerate,1 and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring macroautophagy in different organisms. Recent reviews have described the range of assays that have been used for this purpose.2,3 There are many useful and convenient methods that can be used to monitor macroautophagy in yeast, but relatively few in other model systems, and there is much confusion regarding acceptable methods to measure macroautophagy in higher eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers of autophagosomes versus those that measure flux through the autophagy pathway; thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from fully functional autophagy that includes delivery to, and degradation within, lysosomes (in most higher eukaryotes) or the vacuole (in plants and fungi). Here, we present a set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes. This set of guidelines is not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response.
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| 16. |
- Kristan, Matej, et al.
(författare)
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The Visual Object Tracking VOT2016 Challenge Results
- 2016
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Ingår i: COMPUTER VISION - ECCV 2016 WORKSHOPS, PT II. - Cham : SPRINGER INT PUBLISHING AG. - 9783319488813 - 9783319488806 ; , s. 777-823
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2016 aims at comparing short-term single-object visual trackers that do not apply pre-learned models of object appearance. Results of 70 trackers are presented, with a large number of trackers being published at major computer vision conferences and journals in the recent years. The number of tested state-of-the-art trackers makes the VOT 2016 the largest and most challenging benchmark on short-term tracking to date. For each participating tracker, a short description is provided in the Appendix. The VOT2016 goes beyond its predecessors by (i) introducing a new semi-automatic ground truth bounding box annotation methodology and (ii) extending the evaluation system with the no-reset experiment.
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| 17. |
- Liao, Yaoming, et al.
(författare)
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Downscaling of future precipitation in china’s beijing-tianjin-hebei region using a weather generator
- 2022
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Ingår i: Atmosphere. - : MDPI AG. - 2073-4433. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- To project local precipitation at the existing meteorological stations in China’s Beijing-Tianjin-Hebei region in the future, local daily precipitation was simulated for three periods (2006–2030, 2031–2050, and 2051–2070) under RCP 4.5 and RCP 8.5 emission scenarios. These projections were statistically downscaled using a weather generator (BCC/RCG-WG) and the output of five global climate models. Based on the downscaled daily precipitation at 174 stations, eight indices describing mean and extreme precipitation climates were calculated. Overall increasing trends in the frequency and intensity of the mean and extreme precipitation were identified for the majority of the stations studied, which is in line with the GCMs’ output. However, the downscaling approach enables more local features to be reflected, adding value to applications at the local scale. Compared with the baseline during 1961–2005, the regional average annual precipitation and its intensity are projected to increase in all three future periods under both RCP 4.5 and RCP 8.5. The projected changes in the number of days with precipitation are relatively small across the Beijing-Tianjin-Hebei region. The regional average annual number of days with precipitation would increase by 0.2~1.0% under both RCP 4.5 and RCP 8.5, except during 2031–2050 under RCP 8.5 when it would decrease by 0.7%. The regional averages of annual days with precipitation ≥25 mm and ≥40 mm, the greatest one-day and five-day precipitation in the Beijing-Tianjin-Hebei region, are projected to increase by 8~30% during all the three periods. The number of days with daily precipitation ≥40 mm was projected to increase most significantly out of the eight indices, indicating the need to consider increased flooding risk in the future. The average annual maximum number of consecutive days without precipitation in the Beijing-Tianjin-Hebei region is projected to decrease, and the drought risk in this area is expected to decrease.
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| 18. |
- Marinins, Aleksandrs, et al.
(författare)
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Photostable Polymer/Si Nanocrystal Bulk Hybrids with Tunable Photoluminescence
- 2016
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Ingår i: ACS Photonics. - : American Chemical Society (ACS). - 2330-4022. ; 3:9, s. 1575-1580
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Tidskriftsartikel (refereegranskat)abstract
- Solid polymer/Si nanocrystal bulk nanocomposites were fabricated from solutions of alkene- and hydride-terminated silicon nanocrystals (NCs) in toluene. The photoluminescence peak position of hydride-terminated SiNCs before polymerization was tuned by photoassisted hydrofluoric acid etching. Optical properties of obtained PMMA/NC hybrids, such as quantum yield, luminescence lifetime, and dispersion factor, were evaluated over time. Photostability of these transparent bulk polymer/SiNC hybrids over months was confirmed. The emission covers the visible to near-infrared range with a quantum yield of similar to 30-40% for yellow-red nanocomposites.
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| 19. |
- Miao, Yuchen, et al.
(författare)
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TouchKey : Touch to Generate Symmetric Keys by Skin Electric Potentials Induced by Powerline Radiation
- 2023
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Ingår i: Proceedings of the ACM on Interactive Mobile Wearable and Ubiquitous Technologies-Imwut. - : Association for Computing Machinery (ACM). - 2474-9567. ; 7:2
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Tidskriftsartikel (refereegranskat)abstract
- Secure device pairing is important to wearables. Existing solutions either degrade usability due to the need of specific actions like shaking, or they lack universality due to the need of dedicated hardware like electrocardiogram sensors. This paper proposes TOUCHKEY, a symmetric key generation scheme that exploits the skin electric potential (SEP) induced by powerline electromagnetic radiation. The SEP is ubiquitously accessible indoors with analog-to-digital converters widely available on Internet of Things devices. Our measurements show that the SEP has high randomness and the SEPs measured at two close locations on the same human body are similar. Extensive experiments show that TOUCHKEY achieves a high key generation rate of 345 bit/s and an average success rate of 99.29%. Under a range of adversary models including active and passive attacks, TOUCHKEY shows a low false acceptance rate of 0.86%, which outperforms existing solutions. Besides, the overall execution time and energy usage are 0.44 s and 2.716 mJ, which make it suitable for resource-constrained devices.
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| 20. |
- Ning, Rui, et al.
(författare)
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Assessing progression limits in different grades of keratoconus from a novel perspective : precision of measurements of the corneal epithelium
- 2024
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Ingår i: Eye and Vision. - 2326-0254. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: To assess repeatability and reproducibility of corneal epithelium thickness (ET) measured by a spectral-domain optical coherence tomographer (SD-OCT)/Placido topographer (MS-39, CSO, Florence, Italy) in keratoconus (KC) population at different stages, as well as to determine the progression limits for evaluating KC progression. Methods: A total of 149 eyes were enrolled in this study, with 29 eyes in the forme fruste keratoconus (FFKC) group, 34 eyes in the mild KC group, 40 eyes in the moderate KC group, and 46 eyes in the severe KC group. Employing the within-subject standard deviation (Sw), test-retest variability (TRT), coefficient of variation (CoV), and intraclass correlation coefficient (ICC) to evaluate intraoperator repeatability and interoperator reproducibility. Results: The repeatability and reproducibility of MS-39 in patients with KC were acceptable, according to ICC values ranging from 0.732 to 0.954. However, patients with more severe KC and progressive peripheralization of the measurement points had higher TRTs but a thinning trend. The current study tended to set the cut-off values of mild KC, moderate KC, and severe KC to 4.9 µm, 5.2 µm, and 7.4 µm for thinnest epithelium thickness (TET). When differences between follow-ups are higher than those values, progression of the disease is possible. As for center epithelium thickness (CET), cut-off values for mild KC, moderate KC, and severe KC should be 2.8 µm, 4.4 µm, and 5.3 µm. This might be useful in the follow-up and diagnosis of keratoconus. Conclusions: This study demonstrated that the precision of MS-39 was reduced in measuring more severe KC patients and more peripheral corneal points. In determining disease progression, values should be differentiated between disease-related real changes and measurement inaccuracies. Due to the large difference in ET measured by MS-39 between various stages of disease progression, it is necessary to accurately grade KC patients to avoid errors in KC clinical decision-making.
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