1. |
- Bergström, Göran, 1964, et al.
(författare)
-
Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: Results from SCAPIS.
- 2023
-
Ingår i: Atherosclerosis. - : Elsevier BV. - 1879-1484 .- 0021-9150. ; 373, s. 46-54
-
Tidskriftsartikel (refereegranskat)abstract
- Elevated body weight in adolescence is associated with early cardiovascular disease, but whether this association is traceable to weight in early adulthood, weight in midlife or to weight gain is not known. The aim of this study is to assess the risk of midlife coronary atherosclerosis being associated with body weight at age 20, body weight in midlife and body weight change.We used data from 25,181 participants with no previous myocardial infarction or cardiac procedure in the Swedish CArdioPulmonary bioImage Study (SCAPIS, mean age 57 years, 51% women). Data on coronary atherosclerosis, self-reported body weight at age 20 and measured midlife weight were recorded together with potential confounders and mediators. Coronary atherosclerosis was assessed using coronary computed tomography angiography (CCTA) and expressed as segment involvement score (SIS).The probability of having coronary atherosclerosis was markedly higher with increasing weight at age 20 and with mid-life weight (p<0.001 for both sexes). However, weight increase from age 20 until mid-life was only modestly associated with coronary atherosclerosis. The association between weight gain and coronary atherosclerosis was mainly seen in men. However, no significant sex difference could be detected when adjusting for the 10-year delay in disease development in women.Similar in men and women, weight at age 20 and weight in midlife are strongly related to coronary atherosclerosis while weight increase from age 20 until midlife is only modestly related to coronary atherosclerosis.
|
|
2. |
- Oldgren, Jonas, 1964-, et al.
(författare)
-
Systematic Coronary Risk Evaluation estimated risk and prevalent subclinical atherosclerosis in coronary and carotid arteries: A population-based cohort analysis from the Swedish Cardiopulmonary Bioimage Study
- 2021
-
Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 28:3, s. 250-259
-
Tidskriftsartikel (refereegranskat)abstract
- Background It is not clear if the European Systematic Coronary Risk Evaluation algorithm is useful for identifying prevalent subclinical atherosclerosis in a population of apparently healthy individuals. Our aim was to explore the association between the risk estimates from Systematic Coronary Risk Evaluation and prevalent subclinical atherosclerosis. Design The design of this study was as a cross-sectional analysis from a population-based study cohort. Methods From the general population, the Swedish Cardiopulmonary Bioimage Study randomly invited individuals aged 50-64 years and enrolled 13,411 participants mean age 57 (standard deviation 4.3) years; 46% males between November 2013-December 2016. Associations between Systematic Coronary Risk Evaluation risk estimates and coronary artery calcification and plaques in the carotid arteries by using imaging data from a computed tomography of the heart and ultrasonography of the carotid arteries were examined. Results Coronary calcification was present in 39.5% and carotid plaque in 56.0%. In men, coronary artery calcium score >0 ranged from 40.7-65.9% and presence of carotid plaques from 54.5% to 72.8% in the age group 50-54 and 60-65 years, respectively. In women, the corresponding difference was from 17.1-38.9% and from 41.0-58.4%. A doubling of Systematic Coronary Risk Evaluation was associated with an increased probability to have coronary artery calcium score >0 (odds ratio: 2.18 (95% confidence interval 2.07-2.30)) and to have >1 carotid plaques (1.67 (1.61-1.74)). Conclusion Systematic Coronary Risk Evaluation estimated risk is associated with prevalent subclinical atherosclerosis in two major vascular beds in a general population sample without established cardiovascular disease or diabetes mellitus. Thus, the Systematic Coronary Risk Evaluation risk chart may be of use for estimating the risk of subclinical atherosclerosis.
|
|
3. |
- Sundström, Johan, Professor, 1971-, et al.
(författare)
-
Weight gain and blood pressure
- 2020
-
Ingår i: Journal of Hypertension. - : Lippincott Williams & Wilkins. - 0263-6352 .- 1473-5598. ; 38:3, s. 387-394
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Although the causality of the obesity—hypertension association is established, the potential for prevention is not. We hypothesized that weight gain between early adulthood and mid-life is associated with higher mid-life blood pressure.METHODS: We investigated the hypothesis using a large contemporaneous population-based mid-life cohort of men and women aged 50-64 years. Recalled body weight at age 20 years was self-reported, and mid-life body weight and office blood pressures were measured in accordance with a detailed protocol.RESULTS: On average, men had gained 14.9 (95% CI 14.6-15.2) kg of weight, and women 14.6 (95% CI 14.4-14.9) kg, between age 20 years and the mid-life examination, corresponding to 0.40 (95% CI 0.39-0.41) kg/year for men and women. Both weight at age 20 years and weight at the mid-life examination were associated with mid-life blood pressures. On average, a 10 kg weight increase between age 20 years and mid-life was associated with 2.2 (95% CI 0.9-3.5) mmHg higher systolic and 1.7 (95% CI 0.9-2.5) mmHg higher diastolic mid-life blood pressure in men, and 3.2 (2.5-4.0) mmHg higher systolic and 2.4 (1.9-2.9) mmHg higher diastolic mid-life blood pressure in women. Mid-life weight was more closely associated than weight at age 20 years with mid-life blood pressure. For a given mid-life weight, blood pressure was higher in persons with higher weight gain from age 20 years.CONCLUSION: In sum, weight gain between early adulthood and mid-life was associated with higher mid-life blood pressure. The magnitude of the association indicates a potentially great public health impact of strategies to prevent weight gain throughout adulthood.
|
|
4. |
- Wahlström, Annika, 1975, et al.
(författare)
-
Production of deoxycholic acid by low-abundant microbial species is associated with impaired glucose metabolism
- 2024
-
Ingår i: NATURE COMMUNICATIONS. - 2041-1723. ; 15:1
-
Tidskriftsartikel (refereegranskat)abstract
- Alterations in gut microbiota composition are suggested to contribute to cardiometabolic diseases, in part by producing bioactive molecules. Some of the metabolites are produced by very low abundant bacterial taxa, which largely have been neglected due to limits of detection. However, the concentration of microbially produced metabolites from these taxa can still reach high levels and have substantial impact on host physiology. To explore this concept, we focused on the generation of secondary bile acids by 7 alpha-dehydroxylating bacteria and demonstrated that addition of a very low abundant bacteria to a community can change the metabolic output dramatically. We show that Clostridium scindens converts cholic acid into the secondary bile acid deoxycholic acid (DCA) very efficiently even though the abundance of C. scindens is low, but still detectable by digital droplet PCR. We also show that colonization of germ-free female mice with a community containing C. scindens induces DCA production and affects host metabolism. Finally, we show that DCA correlates with impaired glucose metabolism and a worsened lipid profile in individuals with type 2 diabetes, which implies that this metabolic pathway may contribute to the development of cardiometabolic disease. Secondary bile acids are microbially produced metabolites linked to metabolic diseases. A challenge in microbiota research is to understand how bacteria collaborate to produce such bioactive molecules. Here, the authors show that adding a single low-abundance bacterial species to a community can significantly affect the metabolic output and host physiology.
|
|
5. |
- Östgren, Carl Johan, et al.
(författare)
-
Prevalence of atherosclerosis in individuals with prediabetes and diabetes compared to normoglycaemic individuals-a Swedish population-based study.
- 2023
-
Ingår i: Cardiovascular diabetology. - : BioMed Central (BMC). - 1475-2840. ; 22:1
-
Tidskriftsartikel (refereegranskat)abstract
- Patients with type 2 diabetes have an increased risk of death and cardiovascular events and people with diabetes or prediabetes have been found to have increased atherosclerotic burden in the coronary and carotid arteries. This study will estimate the cross-sectional prevalence of atherosclerosis in the coronary and carotid arteries in individuals with prediabetes and diabetes, compared with normoglycaemic individuals in a large population-based cohort.The 30,154 study participants, 50-64years, were categorized according to their fasting glycaemic status or self-reported data as normoglycaemic, prediabetes, and previously undetected or known diabetes. Prevalence of affected coronary artery segments, severity of stenosis and coronary artery calcium score (CACS) were determined by coronary computed tomography angiography. Total atherosclerotic burden was assessed in the 11 clinically most relevant segments using the Segment Involvement Score and as the presence of any coronary atherosclerosis. The presence of atherosclerotic plaque in the carotid arteries was determined by ultrasound examination.Study participants with prediabetes (n=4804, 16.0%) or diabetes (n=2282, 7.6%) had greater coronary artery plaque burden, more coronary stenosis and higher CACS than normoglycaemic participants (all, p<0.01). Among male participants with diabetes 35.3% had CACS≥100 compared to 16.1% among normoglycaemic participants. For women, the corresponding figures were 8.9% vs 6.1%. The prevalence of atherosclerosis in the coronary arteries was higher in participants with previously undetected diabetes than prediabetes, but lower than in patients with known diabetes. The prevalence of any plaque in the carotid arteries was higher in participants with prediabetes or diabetes than in normoglycaemic participants.In this large population-based cohort of currently asymptomatic people, the atherosclerotic burden in the coronary and carotid arteries increased with increasing degree of dysglycaemia. The finding that the atherosclerotic burden in the coronary arteries in the undetected diabetes category was midway between the prediabetes category and patients with known diabetes may have implications for screening strategies and tailored prevention interventions for people with dysglycaemia in the future.
|
|
6. |
- Bergström, Annika, 1964, et al.
(författare)
-
E-books: In the shadow of print
- 2020
-
Ingår i: Convergence. The International Journal of Research into New Media Technologies. - : SAGE Publications. - 1354-8565 .- 1748-7382. ; 26:4, s. 895-911
-
Tidskriftsartikel (refereegranskat)abstract
- The e-book has gained a large number of readers in many countries. However, the growth rate, as well as the market penetration of e-books, varies considerably between countries and language areas. In the United States and other English-speaking countries, the use of e-books is more widespread than in many European countries, such as Sweden. In both the United States and Swedish markets, the growth rate has slowed down during the latest 2 years, and the majority of readers still seem to prefer printed books. This article aims to reveal the relationship between attitudes and use of e-books and to contextualize this in relation to socio-demographic background, library use and reading habits. The results, based on national, representative surveys in Sweden during 2013 and 2014, show that people’s attitudes are a significant and important factor for the choice of e-books instead of print, but this is probably a two-way relationship. It is also evident that e-books serve a complementary rather than displacement function in relation to print.
|
|
7. |
- Bergström, Annika, 1964
(författare)
-
Exploring digital divides in older adults’ news consumption
- 2020
-
Ingår i: Nordicom Review. - : Walter de Gruyter GmbH. - 1403-1108 .- 2001-5119. ; 41:2, s. 163-177
-
Tidskriftsartikel (refereegranskat)abstract
- Media structure is rapidly steering towards digital formats and distribution. Meanwhile, many Western societies have ageing populations, where older adults are less digitally active than the population at large. This, combined with the fact that the news media are crucial in providing information and fostering engagement and cohesion, means that the news consumption of older adults deserves scholarly attention. Based on national representative surveys, this article analyses the use of traditional and digital news among people aged 66 to 85 between 2014 and 2018. The findings show that the overall reading of newspapers is decreasing among pensioners of all ages, whereas radio and television news both have rather stable audience shares. Despite the overall decline of newspaper reading, the reading of digital newspapers is becoming more common, and digital newspapers seem, to some extent, to have replaced printed newspapers. Concerning factors explaining digital news consumption among the 65+ group, general Internet habits, sex, and political interest are shown to be the most important.
|
|
8. |
- Bergström, Annika, 1964, et al.
(författare)
-
Får äldre vara med i mediesamhället? Rapport 19 Delegationen för senior arbetskraft S 2018:10
- 2020
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Den bild som medierna ger av äldre har betydelse för hur vi förstår och hanterar livets senare skeden. Medier kan bekräfta, förstärka eller utmana stereotypa föreställningar om människor, och detta gäller inte minst synen på ålder och äldres roll i samhället. En fjärdedel av befolkningen är över 60 år, men i det breda medieutbudet förekommer de sällan. Osynliggörandet är något som kan påverka självbilden hos äldre, men också andra generationers synsätt och attityder. Huvudslutsatsen i rapporten är att mediebilden av äldre är problematisk och riskerar att bidra till diskriminering. Medierna pratar ofta om äldre som en svag och homogen grupp, när det i själva verket finns stora variationer inom gruppen. En förklaring till den ensidiga mediebilden kan vara att journalisters och medieproducenters kunskapsnivå kring äldre är låg. Vidare är ålder en av de viktigaste faktorerna när det gäller att förstå hur digitala klyftor uppstår och vidmakthålls. Digitaliseringen ger tillgång till ett ständigt ökande utbud av tjänster via nätet, vilket kan underlätta människors vardag, men också skapa stress om den upplevs som dyr, otillgänglig och komplicerad. Utifrån den äldre medborgarens perspektiv kan digitaliseringen innebära fördelar om man själv är aktiv och har möjlighet att skaffa sig de varor och tjänster man är intresserad av. För vissa äldre kan digitaliseringen däremot innebära nackdelar om krav ställs på att samhällsservice ska ske på sådant sätt som kräver dator, internetuppkoppling och smartphone. Rapporten är fri att ladda ner, open access.
|
|
9. |
- Bergström, Annika, 1964
(författare)
-
Internet – en kompanjon i vardagen
- 2020
-
Ingår i: Digitala är vi allihopa?. - Göteborg : SOM-institutet, Göteborgs universitet. - 0284-4788. - 9789189673489 ; , s. 35-44
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Nästan alla använder internet men vi vet förhållandevis lite om hur de ser på nätet och på sin egen användning. Att vara digital kan ju vara en konsekvens av att man finner nytta och nöje i användningen, men det kan också finnas grupper av användare som i grunden ser problem och där användningen är en följd av försämrad service och tillgänglighet på analoga sätt. Uppfattningar om internet och användningen av digitala medier förknippas med såväl egna erfarenheter som traditionella sociodemografiska bakgrundsfaktorer. Den västsvenska SOM-undersökningen 2019 visar att användare överlag är positiva till internet och sin egen användning. Internet ses tveklöst som en bra källa till lärdom, medan uppfattningarna om hur tekniken tar plats i vardagslivet varierar. Mer frekventa användare har mer positiv inställning, men de yngsta, som är de mest frekventa användarna, står i störst utsträckning bakom funderingar kring om internet tar för mycket tid och om användningen skulle begränsas.
|
|
10. |
- Bergström, Annika, 1964
(författare)
-
Internet perceptions among older adults in Sweden
- 2023
-
Ingår i: Frontiers in Human Dynamics. - 2673-2726. ; 5
-
Tidskriftsartikel (refereegranskat)abstract
- The digital inequality is still present after decades of development and diffusion of digital media. Age is one of the most important factors predicting access, use, skills, and outcomes, which is somewhat paradoxical as information and communication technologies can create opportunities for older adults to sustain independent living. To increase understanding of older adults' online engagement, this study focuses on perceptions of the internet usage and how it can be a useful tool in everyday life. Based on representative survey (n=841), analyses point to decreasing support for the internet with increasing age -also within the group of 66 to 85 years old. There are significant correlations between perceptions and internet experience, whereas sociodemographic factors have weak explanatory power. Interestingly, large shares of older adults do not have any opinion of the internet, which could partly explain the persistence of the digital divide and difficulties to increase digital literacy.
|
|