| 1. |
- Almhagen, Erik, et al.
(author)
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Plan robustness and RBE influence for proton dose painting by numbers for head and neck cancers
- 2023
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In: Physica medica (Testo stampato). - : Elsevier. - 1120-1797 .- 1724-191X. ; 115, s. 103157-
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Journal article (peer-reviewed)abstract
- PurposeTo investigate the feasibility of dose painting by numbers (DPBN) with respect to robustness for proton therapy for head and neck cancers (HNC), and to study the influence of variable RBE on the TCP and OAR dose burden.Methods and materialsData for 19 patients who have been scanned pretreatment with PET-FDG and subsequently treated with photon therapy were used in the study. A dose response model developed for photon therapy was implemented in a TPS, allowing DPBN plans to be created. Conventional homogeneous dose and DPBN plans were created for each patient, optimized with either fixed RBE = 1.1 or a variable RBE model. Robust optimization was used to create clinically acceptable plans. To estimate the maximum potential loss in TCP due to actual SUV variations from the pre-treatment imaging, we applied a test case with randomized SUV distribution.ResultsRegardless of the use of variable RBE for optimization or evaluation, a statistically significant increase (p < 0.001) in TCP was found for DPBN plans as compared to homogeneous dose plans. Randomizing the SUV distribution decreased the TCP for all plans. A correlation between TCP increase and variance of the SUV distribution and target volume was also found.ConclusionDPBN for protons and HNC is feasible and could lead to a TCP gain. Risks associated with the temporal variation of SUV distributions could be mitigated by imposing minimum doses to targets. The correlation found between TCP increase and SUV variance and target volume may be used for patient selection.
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| 2. |
- Andruszkiewicz, Aneta, et al.
(author)
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Perovskite and quantum dot tandem solar cells with interlayer modification for improved optical semitransparency and stability
- 2021
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In: Nanoscale. - : Royal Society of Chemistry. - 2040-3364 .- 2040-3372. ; 13:12, s. 6234-6240
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Journal article (peer-reviewed)abstract
- In this work, four-terminal (4T) tandem solar cells were fabricated by using a methylammonium lead iodide (MAPbI3) perovskite solar cell (PSC) as the front-cell and a lead sulfide (PbS) colloidal quantum dot solar cell (CQDSC) as the back-cell. Different modifications of the tandem interlayer, at the interface between the sub-cells, were tested in order to improve the infrared transparency of the perovskite sub-cell and consequently increase the utilization of infrared (IR) light by the tandem system. This included the incorporation of a semi-transparent thin gold electrode (Au) on the MAPbI3 solar cell, followed by adding a molybdenum(VI) oxide (MoO3) layer or a surlyn layer. These interlayer modifications resulted in an increase of the IR transmittance to the back cell and improved the optical stability, compared to that in the reference devices. This investigation shows the importance of the interlayer, connecting the PSC with a strong absorption in the visible region and the CQDSC with a strong infrared absorption to obtain efficient next-generation tandem photovoltaics (PVs).
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| 3. |
- Axelsson, Erland, et al.
(author)
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Psychological treatments for irritable bowel syndrome : a comprehensive systematic review and meta-analysis
- 2023
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In: Cognitive Behaviour Therapy. - : Routledge. - 1650-6073 .- 1651-2316. ; 52:6, s. 565-584
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Research review (peer-reviewed)abstract
- A wide range of psychological treatments have been found to reduce the symptoms of irritable bowel syndrome (IBS) but their relative effects are unclear. In this systematic review and meta-analysis, we determined the effects of psychological treatments for IBS, including subtypes of cognitive behavior therapy, versus attention controls. We searched 11 databases (March 2022) for studies of psychological treatments for IBS, reported in journal articles, books, dissertations, and conference abstracts. The resulting database comprised 9 outcome domains from 118 studies published in 1983–2022. Using data from 62 studies and 6496 participants, we estimated the effect of treatment type on improvement in composite IBS severity using random-effects meta-regression. In comparison with the attention controls, there was a significant added effect of exposure therapy (g = 0.52, 95% CI = 0.17–0.88) and hypnotherapy (g = 0.36, 95% CI = 0.06–0.67) when controlling for the pre- to post-assessment duration. When additional potential confounders were included, exposure therapy but not hypnotherapy retained a significant added effect. Effects were also larger with a longer duration, individual treatment, questionnaire (non-diary) outcomes, and recruitment outside of routine care. Heterogeneity was substantial. Tentatively, exposure therapy appears to be a particularly promising treatment for IBS. More direct comparisons in randomized controlled trials are needed. OSF.io identifier: 5yh9a.
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| 4. |
- Bohgard, Mats, et al.
(author)
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Nu krävs satsning på forskning för ett hållbart arbetsliv
- 2021
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In: Dagens Medicin. - 1104-7488.
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Journal article (pop. science, debate, etc.)abstract
- Debatt: Vi vill att forskningsråden skapar tvärvetenskapliga regionala forskningscentrum för arbetslivsforskning, som är internationellt konkurrenskraftiga och ger nationellt och regionalt kunskapsstöd. Dessa centrum ska ge kunskaper för både befintliga och framtida utmaningar. Stora vinster kan fås om forskning om folkhälsa och yttre miljö samordnas i centrumen. Arbetslivet är grunden för hälsa, välstånd och ett välfungerande samhälle. För att säkra att framtidens arbetsliv bidrar till hälsa och välstånd behövs både kunskap om hur det ska utformas och en uthållig infrastruktur för forskning. Tyvärr saknas detta. Gammal kunskap faller i glömska.
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| 5. |
- Dreyer, Joshua, et al.
(author)
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Constraining the Positive Ion Composition in Saturn's Lower Ionosphere with the Effective Recombination Coefficient
- 2021
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In: The Planetary Science Journal. - : American Astronomical Society. - 2632-3338. ; 2:1
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Journal article (peer-reviewed)abstract
- The present study combines Radio and Plasma Wave Science/Langmuir Probe and Ion and Neutral Mass Spectrometer data from Cassini's last four orbits into Saturn's lower ionosphere to constrain the effective recombination coefficient α300 from measured number densities and electron temperatures at a reference electron temperature of 300 K. Previous studies have shown an influx of ring material causes a state of electron depletion due to grain charging, which will subsequently affect the ionospheric chemistry. The requirement to take grain charging into account limits the derivation of α300 to upper limits. Assuming photochemical equilibrium and using an established method to calculate the electron production rate, we derive upper limits for α300 of ≲ 3 × 10−7 cm3 s−1 for altitudes below 2000 km. This suggests that Saturn's ionospheric positive ions are dominated by species with low recombination rate coefficients like HCO+. An ionosphere dominated by water group ions or complex hydrocarbons, as previously suggested, is incompatible with this result, as these species have recombination rate coefficients > 5 × 10−7 cm3 s−1 at an electron temperature of 300 K.
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| 6. |
- Dreyer, Joshua, et al.
(author)
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Identifying Shadowing Signatures of C Ring Ringlets and Plateaus in Cassini Data from Saturn's Ionosphere
- 2022
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In: The Planetary Science Journal. - : Institute of Physics (IOP). - 2632-3338. ; 3:7
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Journal article (peer-reviewed)abstract
- For orbits 288 and 292 of Cassini's Grand Finale, clear dips (sharp and narrow decreases) are visible in the H-2(+) densities measured by the Ion and Neutral Mass Spectrometer (INMS). In 2017, the southern hemisphere of Saturn was shadowed by its rings and the substructures within. Tracing a path of the solar photons through the ring plane to Cassini's position, we can identify regions in the ionosphere that were shadowed by the individual ringlets and plateaus (with increased optical depths) of Saturn's C ring. The calculated shadowed altitudes along Cassini's trajectory line up well with the dips in the H-2(+) data when adjusting the latter based on a detected evolving shift in the INMS timestamps since 2013, illustrating the potential for verification of instrument timings. We can further estimate the mean optical depths of the ringlets/plateaus by comparing the dips to inbound H-2(+) densities. Our results agree well with values derived from stellar occultation measurements. No clear dips are visible for orbits 283 and 287, whose periapsides were at higher altitudes. This can be attributed to the much longer chemical lifetime of H2+ at these higher altitudes, which in turn can be further used to estimate a lower limit for the flow speed along Cassini's trajectory. The resulting estimate of similar to 0.3 km s(-1) at an altitude of similar to 3400 km is in line with prior suggestions. Finally, the ringlet and plateau shadows are not associated with obvious dips in the electron density, which is expected due to their comparatively long chemical (recombination) lifetime.
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| 7. |
- Folkersen, Lasse, et al.
(author)
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Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
- 2020
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In: Nature metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 2:10, s. 1135-1148
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Journal article (peer-reviewed)abstract
- Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtain trans-pQTL gene and regulatory designations. We substantiate these regulatory findings with orthogonal evidence for trans-pQTLs using mouse knockdown experiments (ABCA1 and TRIB1) and clinical trial results (chemokine receptors CCR2 and CCR5), with consistent regulation. Finally, we evaluate known drug targets, and suggest new target candidates or repositioning opportunities using Mendelian randomization. This identifies 11 proteins with causal evidence of involvement in human disease that have not previously been targeted, including EGF, IL-16, PAPPA, SPON1, F3, ADM, CASP-8, CHI3L1, CXCL16, GDF15 and MMP-12. Taken together, these findings demonstrate the utility of large-scale mapping of the genetics of the proteome and provide a resource for future precision studies of circulating proteins in human health.
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| 8. |
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| 9. |
- Frykholm, Erik, 1985-, et al.
(author)
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Applicability of a supramaximal high-intensity interval training program for older adults previously not engaged in regular exercise : analyses of secondary outcomes from the Umeå HIT Study
- 2024
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In: Psychology of Sport And Exercise. - : Elsevier. - 1469-0292 .- 1878-5476. ; 73
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Journal article (peer-reviewed)abstract
- This analysis of secondary outcomes investigated the applicability of supramaximal high-intensity interval training (HIT) with individually prescribed external intensity performed on stationary bicycles. Sixty-eight participants with a median (min; max) age of 69 (66; 79), at the time not engaged in regular exercise were randomized to 25 twice-weekly sessions of supramaximal HIT (20-min session with 10 × 6-s intervals) or moderate-intensity training (MIT, 40-min session with 3 × 8-min intervals). The primary aim was outcomes on applicability regarding; adherence to prescribed external interval intensity, participant reported positive and negative events, ratings of perceived exertion (RPE 6–20), and affective state (Feeling Scale, FS -5–5). A secondary aim was to investigate change in exercise-related self-efficacy (Exercise Self-Efficacy Scale) and motivation (Behavioural Regulations in Exercise Questionnaire-2). Total adherence to the prescribed external interval intensity was [median (min; max)] 89 % (56; 100 %) in supramaximal HIT, and 100 % (95; 100 %) in MIT. The supramaximal HIT group reported 60 % of the positive (112 of 186) and 36 % of the negative (52 of 146) events. At the end of the training period, the median (min; max) session RPE was 15 (12; 17) for supramaximal HIT and 14 (9; 15) for MIT. As for FS, the median last within-session rating was 3 (−1; 5) for supramaximal HIT and 3 (1; 5) for MIT. Exercise-related motivation increased (mean difference in Relative Autonomy Index score = 1.54, 95 % CI [0.69; 2.40]), while self-efficacy did not change (mean difference = 0.55, 95 % CI [-0.75; 1.82]), regardless of group. This study provide support for supramaximal HIT in supervised group settings for older adults.
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| 10. |
- Furukawa, Toshi A., et al.
(author)
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Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression : a systematic review and component network meta-analysis using individual data
- 2021
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In: Lancet psychiatry. - London, United Kingdom : Elsevier. - 2215-0374 .- 2215-0366. ; 8:6, s. 500-511
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Research review (peer-reviewed)abstract
- Findings We identified 76 RCTs, including 48 trials contributing individual participant data (11 704 participants) and 28 trials with aggregate data (6474 participants). The participants' weighted mean age was 42.0 years and 12 406 (71%) of 17 521 reported were women. There was suggestive evidence that behavioural activation might be beneficial (iMD -1.83 [95% credible interval (CrI) -2.90 to -0.80]) and that relaxation might be harmful (1.20 [95% CrI 0.17 to 2.27]). Baseline severity emerged as the strongest prognostic factor for endpoint depression. Combining human and automated encouragement reduced dropouts from treatment (incremental odds ratio, 0.32 [95% CrI 0.13 to 0.93]). The risk of bias was low for the randomisation process, missing outcome data, or selection of reported results in most of the included studies, uncertain for deviation from intended interventions, and high for measurement of outcomes. There was moderate to high heterogeneity among the studies and their components. 511
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