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- Wang, Li-San, et al.
(författare)
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Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States.
- 2015
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Ingår i: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 72:2
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Tidskriftsartikel (refereegranskat)abstract
- Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of this variant in AD cases and cognitively normal controls to determine whether this variant will significantly contribute to risk assessment in individuals in the United States.
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- Jones, Lesley, et al.
(författare)
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Convergent genetic and expression data implicate immunity in Alzheimer's disease
- 2015
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Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 11:6, s. 658-671
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Tidskriftsartikel (refereegranskat)abstract
- Background: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis. Methods: The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain. Results: ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 X 10(-12) after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 X 10(-11)), cholesterol transport (P = 2.96 X 10(-9)), and proteasome-ubiquitin activity (P = 1.34 X 10(-6)). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected P = .002-.05). Conclusions: The immime response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics.
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- Larsson, Oscar, et al.
(författare)
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Measurements of heavy-ion anisotropy and dose rates in the Russian section of the International Space Station with the Sileye-3/Alteino detector
- 2015
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Ingår i: Journal of Physics G. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 42:2, s. 025002-
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Tidskriftsartikel (refereegranskat)abstract
- In this work we present data on linear energy transfer (LET), dose and dose equivalent rates from different locations of the Russian part of the International Space Station (ISS) measured by the Sileye-3/Alteino detector. Data were taken as part of the ESA ALTCRISS project from late 2005 through 2007. The LET rate data shows a heavy-ion (LET > 50 keV/mu m) anisotropy. From the heavy-ion LET rate in the Zvezda service module we find ISS (y) over cap (Starboard) and (z) over cap (Nadir) to be about 10-15 times higher than in (x) over cap (Forward). The situation is similar for dose and dose equivalent rates, ranging from 25-40 mu Gy d(-1) in (x) over cap to about 75 mu Gy d(-1) in (z) over cap, whereas for the dose equivalent the rate peaks in (y) over cap with around 470 mu Sv d(-1). The heavy-ion anisotropy confirms what has been reported by the ALTEA collaboration. Measurements using two sets of passive detectors, DLR-TLDs and PADLES (TLD+CR-39), have also been performed in conjunction with Alteino measurements, both shielded and unshielded. The passive detectors register a dose rate about 3-5 times as high as Alteino, 260-280 mu Gy d(-1) for PADLES and 200-260 mu Gy d(-1) for DLR-TLDs. For the dose equivalent PADLES measurements ranges from 560-740 mu Sv d(-1).
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