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- Aspenberg, Per, et al.
(författare)
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Bone graft proteins influence osteoconduction. A titanium chamber study in rats
- 1996
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Ingår i: Acta Orthopaedica Scandinavica. - : Medical Journals Sweden AB. - 0001-6470. ; 67:4, s. 377-382
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Tidskriftsartikel (refereegranskat)abstract
- Although it is often emphasized that the matrix of bone grafts contains several growth factors, it is not known if these factors become activated and play a role in bone grafting. We therefore compared ground defatted bone which had or had not been deproteinized by heating with water to 270 degrees C at an autogenic pressure of 55 bar. This is a careful ceramic procedure which leaves the mineral unchanged. Deproteinized and non-deproteinized bone granulae derived from cortical rat bone were placed in titanium bone conduction chambers implanted bilaterally in rat tibiae. Ingrowing bone could enter the cylindrical interior of the chamber only at one end. It then penetrated the material in the chamber, but due to the length of the cylinder, it never reached the other end. The mean distance which the ingrown bone had reached in the material was then measured on histological slides. The bone formation activity was measured by TcMDP scintimetry. With the protein-containing granulae, the mean bone ingrowth distance and the scintimetric activity were increased by 41% and 31%, respectively (p < 0.01). We conclude that there is a limited favourable effect of proteins in a graft. Our grounded material had a large fracture surface area with no osteoid lining. The leakage of growth factors from such areas may explain the extraordinarily good clinical incorporation of morselized compacted allografts.
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- Atroshi, Isam, et al.
(författare)
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Radial tunnel release. Unpredictable outcome in 37 consecutive cases with a 1-5 year follow-up
- 1995
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Ingår i: Acta Orthopaedica Scandinavica. - : Medical Journals Sweden AB. - 0001-6470. ; 66:3, s. 255-257
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Tidskriftsartikel (refereegranskat)abstract
- 37 consecutive patients with radial tunnel syndrome treated by decompression of the posterior interosseous nerve and application of a free fat transplant were retrospectively evaluated 3.5 (1-5) years post-operatively by an independent observer. Substantial pain relief was reported by 13 patients and 15 patients were satisfied with the outcome. 16 of 35 patients returned to their preoperative employment. There were complications in 12 cases, including two radial nerve pareses. Preoperative and operative findings did not correlate to the outcome. Judging from this study, the symptoms and signs used as diagnostic criteria for radial tunnel syndrome may be unreliable and the results of posterior interosseous nerve decompression unpredictable.
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- Atroshi, Isam, et al.
(författare)
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Self-administered outcome instrument in carpal tunnel syndrome. Reliability, validity and responsiveness evaluated in 102 patients
- 1998
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Ingår i: Acta Orthopaedica Scandinavica. - : Medical Journals Sweden AB. - 0001-6470. ; 69:1, s. 82-88
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Tidskriftsartikel (refereegranskat)abstract
- We evaluated a Swedish version of a self-administered disease-specific outcome questionnaire for carpal tunnel syndrome regarding reliability, validity and responsiveness to clinical change. It consists of multi-item scales assessing symptom severity, function, patient satisfaction and quality of life. It was given to 102 patients before and 3 months after carpal tunnel release. Test-retest reliability, studied in a subsample of 22 patients on two occasions with a 1-3-week interval, showed good agreement between the scores. Internal consistency of the scales was high (Cronbach alpha 0.80-0.95). Validity of the scales was evaluated using the SF-36 general health questionnaire in a subgroup of 48 patients as well as items concerning patient satisfaction, showing the expected relationships between these measures. Responsiveness of the scales to clinical change, estimated by the effect size and standardized response mean, was large (0.94-1.7). We conclude that this questionnaire can provide a standardized measure of symptom severity and functional status, as well as patient satisfaction and quality of life in the carpal tunnel syndrome.
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