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Sökning: L773:1179 1608 > (2010-2014)

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  • Tegelberg, Åke, et al. (författare)
  • Improved cognitive functions after treatment with an oral appliance in obstructive sleep apnea
  • 2012
  • Ingår i: Nature and Science of Sleep. - : Dove Press. - 1179-1608. ; 4, s. 89-96
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: The objective of this study was to evaluate the effect of oral appliance (OA) treatment on cognitive functions in patients with obstructive sleep apnea (OSA). Materials and methods: In a prospective study, 50 male patients with verified moderate-to-severe OSA received an OA with mandibular advancement. The cognitive functions assessed included working memory, vigilance, executive functioning, and mental pace, measured before as well as after 6 months of treatment. Somnography was used to measure physiological treatment effects. Forty-three patients completed the 6-month follow-up study. Results: All domains of cognitive functioning measured improved after 6 months of treatment with an OA (P < 0.001). The apnea/hypopnea- and oxygen desaturation-indices decreased significantly after treatment (P < 0.01). An obvious treatment response was reached in 60% of the patients, and 54% of the patients had recovered ie, had normalized breathing during sleep. Conclusion: OA with mandibular advancement is a treatment modality for the physiological symptoms of OSA, and may have a positive impact on cognitive functions, after only 6 months of treatment.
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