| 1. |
- Hult, Peter, 1964-, et al.
(författare)
-
A bioacoustic method for timing of the different phases of the breathing cycle and monitoring of breathing frequency
- 2000
-
Ingår i: Medical Engineering and Physics. - 1350-4533 .- 1873-4030. ; 22:6, s. 425-433
-
Tidskriftsartikel (refereegranskat)abstract
- It is well known that the flow of air through the trachea during respiration causes vibrations in the tissue near the trachea, which propagate to the surface of the body and can be picked up by a microphone placed on the throat over the trachea. Since the vibrations are a direct result of the airflow, accurate timing of inspiration and expiration is possible. This paper presents a signal analysis solution for automated monitoring of breathing and calculation of the breathing frequency. The signal analysis approach uses tracheal sound variables in the time and frequency domains, as well as the characteristics of the disturbances that can be used to discriminate tracheal sound from noise. One problem associated with the bioacoustic method is its sensitivity for acoustic disturbances, because the microphone tends to pick up all vibrations, independent of their origin. A signal processing method was developed that makes the bioacoustic method clinically useful in a broad variety of situations, for example in intensive care and during certain heart examinations, where information about both the precise timing and the phases of breathing is crucial.
|
|
| 2. |
- Stasiunas, Antanas, et al.
(författare)
-
A non-linear circuit for simulating OHC of the cochlea
- 2003
-
Ingår i: Medical Engineering and Physics. - London : Elsevier. - 1350-4533 .- 1873-4030. ; 25:7, s. 591-601
-
Tidskriftsartikel (refereegranskat)abstract
- In the present paper, referring to known characteristics of the outer hair cells functioning in the cochlea of the inner ear, a functional model of the outer hair cells is constructed. It consists of a linear feed-forward circuit and a non-linear positive feedback circuit. The feed-forward circuit reflects the contribution of local basilar and tectorial membrane areas and passive outer hair cells’ physical parameters to the forming of low-selectivity resonance characteristics. The non-linear positive feedback circuit reflects the non-linear outer hair cell signal transduction processes and the active role of efferents from the medial superior olive in altering circuit sensitivity and selectivity.Referring to an analytical description of the circuit model and computer simulation results, an explanation is given over the biological meaning of the outer hair cells’ non-linearities in signal transduction processes and the role of the non-linearities in achieving the following: signal compression, the dependency of circuit sensitivity and frequency selectivity upon the input signal amplitude, the compatibility of high-frequency selectivity and short transient response of the biological filtering circuits.
|
|
| 3. |
- Sierpowska, Joanna, et al.
(författare)
-
Effect of human trabecular bone composition on its electrical properties.
- 2007
-
Ingår i: Medical Engineering and Physics. - : Elsevier. - 1350-4533 .- 1873-4030. ; 29:8, s. 845-852
-
Tidskriftsartikel (refereegranskat)abstract
- Mechanical properties of bone are determined not only by bone mineral density (BMD), but also by tissue trabecular structure and organic composition. Impedance spectroscopy has shown potential to diagnose trabecular bone BMD and strength, however, the relationships between organic composition and electrical and dielectric properties have not been systematically investigated. To investigate these issues organic composition of 26 human trabecular bone samples harvested from the distal femur and proximal tibia was determined and compared with relative permittivity, loss factor, conductivity, phase angle, specific impedance and dissipation factor measured at wide range (50 Hz to 5 MHz) of frequencies. A strong linear correlation was found between the relative permittivity at 1.2 MHz and trabecular bone fat content (r = -0.85, p<0.01, n=26). On the other hand, relative permittivity measured at 200 Hz served as a good predictor of water content (r = 0.83). Phase angle, specific impedance and especially conductivity were strongly related to the trabecular bone dry density and water content (|r| > or = 0.69). Variation in bone tissue collagen content was strongly related to the relative permittivity measured at 1.2 MHz (r = 0.64), but only moderately to other parameters. Glycosaminoglycan content showed no significant relations with any investigated electrical parameters. The present study indicates that if the trabecular bone composition is known, the relationships presented in this study could facilitate calculation of current field distribution, e.g. during electrical stimulation of osteogenesis. On the other hand, our results suggest that permittivity measured at low (<1 kHz) or high (>100 kHz) frequencies could be used, e.g. during implant surgery, for prediction of trabecular bone water or fat contents, respectively.
|
|
| 4. |
- Ahmed, Kirstin, 1974, et al.
(författare)
-
Mechanical load applied by Intraosseous Transcutaneous Amputation Prosthesis (ITAP) during walking on level and sloped treadmill: A case study
- 2023
-
Ingår i: Medical Engineering and Physics. - 1350-4533 .- 1873-4030.
-
Tidskriftsartikel (refereegranskat)abstract
- This proof of concept study presents a method to collect and analyse kinetic data from one participant with a transfemoral amputation fitted with a percutaneous osseointegrated implant walking on a level and sloped treadmill. We describe the construction of and results from a bespoke wireless six axis load cell built into one participant’s prosthetic assembly. The load cell does not clinically compromise the participant in any way and is an initial milestone in the development of a light-weight wireless load cell for use with percutaneous osseointegrated implants. In this case, it is the first time that kinetic data from a participant fitted with an Intraosseous Transcutaneous Amputation Prosthesis has been published. We propose that the data can be used to model the load transfer to the host bone, with several clinically significant applications. The raw dynamic data are made available and quasi-static load cases for each functional phase of gait are presented. Peak forces obtained in the medio-lateral (X), cranio-caudal (Y) and antero-posterior (Z) axes over level ground respectively were -243.8 N (0.24 BW), 1321.5 N (1.31 BW) and -421.8 N (0.42 BW); uphill were -141.0 N (0.14 BW), 1604.2 N (1.59 BW), -498.1 (0.49 BW); downhill were -206.0 N (0.20 BW), 1103.9 N (1.09 BW), -547.2 N (0.54 BW). The kinetics broadly followed non-amputated gait patterns with some gait strategies consistent in participants with other implant designs or prosthetic socket connections, for example offloading the artificial limb downhill.
|
|
| 5. |
- Alegre-Martínez, C., et al.
(författare)
-
On the axial distribution of plaque stress : Influence of stenosis severity, lipid core stiffness, lipid core length and fibrous cap stiffness
- 2019
-
Ingår i: Medical Engineering and Physics. - : Elsevier. - 1350-4533 .- 1873-4030. ; 68, s. 76-84
-
Tidskriftsartikel (refereegranskat)abstract
- Numerical simulations of blood flow through a partially-blocked axisymmetric artery are performed to investigate the stress distributions in the plaque. We show that the combined effect of stenosis severity and the stiffness of the lipid core can drastically change the axial stress distribution, strongly affecting the potential sites of plaque rupture. The core stiffness is also an important factor when assessing plaque vulnerability, where a mild stenosis with a lipid-filled core presents higher stress levels than a severe stenosis with a calcified plaque. A shorter lipid core gives rise to an increase in the stress levels. However, the fibrous cap stiffness does not influence the stress distributions for the range of values considered in this work. Based on these mechanical analyses, we identify potential sites of rupture in the axial direction for each case: the midpoints of the upstream and downstream regions of the stenosis (for severe, lipid-filled plaques), the ends of the lipid core (for short cores), and the middle of the stenosis (for mild stenoses with positive remodelling of the arterial wall).
|
|
| 6. |
- Atashipour, Rasoul, 1983, et al.
(författare)
-
Mechanical characterization of human skin—A non-invasive digital twin approach using vibration-response integrated with numerical methods
- 2023
-
Ingår i: Medical Engineering and Physics. - 1350-4533 .- 1873-4030. ; 121
-
Tidskriftsartikel (refereegranskat)abstract
- This paper proposes an innovative approach to identify elastic material properties and mass density of soft tissues based on interpreting their mechanical vibration response, externally excited by a mechanical indenter or acoustic waves. A vibration test is performed on soft sheets to measure their response to a continuous range of excitation frequencies. The frequency responses are collected with a pair of high-speed cameras in conjunction with 3-D digital image correlation (DIC). Two cases are considered, including suspended/fully-free rectangular neoprene sheets as artificial tissue cutout samples and continuous layered human skin vibrations. An efficient theoretical model is developed to analytically simulate the free vibrations of the neoprene artificial sheet samples as well as the continuous layered human skins. The high accuracy and validity of the presented analytical simulations are demonstrated through comparison with the DIC measurements and the conducted frequency tests, as well as a number of finite element (FE) modeling. The developed analytical approach is implemented into a numerical algorithm to perform an inverse calculation of the soft sheets' elastic properties using the imported experimental vibration results and the predicted system's mass via the system equivalent reduction/expansion process (SEREP) method. It is shown that the proposed frequency-dependent inverse approach is capable of rapidly predicting the material properties of the tested samples with high accuracy.
|
|
| 7. |
- Buendia, Ruben, 1983-, et al.
(författare)
-
Influence of electrode mismatch on Cole parameter estimation from Total Right Side Electrical Bioimpedance Spectroscopy measurements
- 2012
-
Ingår i: Medical Engineering and Physics. - : Elsevier BV. - 1350-4533 .- 1873-4030. ; 34:7, s. 1024-1028
-
Tidskriftsartikel (refereegranskat)abstract
- Applications based on measurements of Electrical Bioimpedance (EBI) spectroscopy analysis, like assessment of body composition, have proliferated in the past years. Currently Body Composition Assessment (BCA) based in Bioimpedance Spectroscopy (BIS) analysis relays on an accurate estimation of the Cole parameters R-0 and R-infinity. A recent study by Bogonez-Franco et al. has proposed electrode mismatch as source of remarkable artefacts in BIS measurements. Using Total Right Side BIS measurements from the aforementioned study, this work has focused on the influence of electrode mismatch on the estimation of R-0 and R-infinity using the Non-Linear Least Square curve fitting technique on the modulus of the impedance. The results show that electrode mismatch on the voltage sensing electrodes produces an overestimation of the impedance spectrum leading to a wrong estimation of the parameters R-0 and R-infinity, and consequently obtaining values around 4% larger that the values obtained from BIS without electrode mismatch. The specific key factors behind electrode mismatch or its influence on the analysis of single and spectroscopy measurements have not been investigated yet, no compensation or correction technique is available to overcome the deviation produced on the EBI measurement. Since textile-enabled EBI applications using dry textrodes, i.e. textile electrodes with dry skin-electrode interfaces and potentially large values of electrode polarization impedance are more prone to produce electrode mismatch, the lack of a correction or compensation technique might hinder the proliferation of textile-enabled EBI applications for personalized healthcare monitoring.
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
