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- Acosta, Stefan, et al.
(författare)
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Long-term testosterone stimulation induces hyperplasia in the guinea-pig prostate.
- 2004
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Ingår i: Prostate Cancer and Prostatic Diseases. - : Springer Science and Business Media LLC. - 1476-5608 .- 1365-7852. ; 7:3, s. 227-231
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Tidskriftsartikel (refereegranskat)abstract
- The relation between supraphysiologic circulating testosterone levels and prostatic diseases is unclear and difficult to study in men. Animal models may be advantageous. Based on a pilot study, testosterone enantate 50 mg (n=12) or 25 mg (n=12) was administered to guinea-pigs intramuscularly every 3 weeks, for either 7 or 14 months. The histopathology of the prostate was described. Epithelial hyperplasia was found in 14/21 animals receiving testosterone and in 7/12 very old animals, but no such changes were found in the sham or castrated animals. Testosterone stimulation seems to induce epithelial hyperplasia, but not cancer, in the guinea-pig prostate.
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- Debruyne, Frans
(författare)
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Innovators in urology : Introduction
- 2003
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Ingår i: Prostate Cancer and Prostatic Diseases. - : Springer Science and Business Media LLC. - 1365-7852 .- 1476-5608. ; 6:Suppl 1, s. 1-1
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Tidskriftsartikel (refereegranskat)
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6. |
- Soloway, Mark
(författare)
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Innovators in urology
- 2002
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Ingår i: Prostate Cancer and Prostatic Diseases. - : Springer Science and Business Media LLC. - 1365-7852 .- 1476-5608. ; 5, s. 1-1
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Tidskriftsartikel (refereegranskat)
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