| 1. |
- Llona-Minguez, S, et al.
(author)
-
Chemical strategies for development of ATR inhibitors
- 2014
-
In: Expert reviews in molecular medicine. - : Cambridge University Press (CUP). - 1462-3994. ; 16, s. e10-
-
Journal article (peer-reviewed)abstract
- ATR protein kinase is one of the key players in maintaining genome integrity and coordinating of the DNA damage response and repair signalling pathways. Inhibition of ATR prevents signalling from stalled replication forks and enhances the formation of DNA damage, particularly under conditions of replication stress present in cancers. For this reason ATR/CHK1 checkpoint inhibitors can potentiate the effect of DNA cross-linking agents, as evidenced by ATR inhibitors recently entering human clinical trials. This review aims to compile the existing literature on small molecule inhibitors of ATR, both from academia and the pharmaceutical industry, and will provide the reader with a comprehensive summary of this promising oncology target.
|
|
| 2. |
- Yucel-Lindberg, T, et al.
(author)
-
Inflammatory mediators in the pathogenesis of periodontitis
- 2013
-
In: Expert reviews in molecular medicine. - : Cambridge University Press (CUP). - 1462-3994. ; 15, s. e7-
-
Journal article (peer-reviewed)abstract
- Periodontitis is a chronic inflammatory condition of the periodontium involving interactions between bacterial products, numerous cell populations and inflammatory mediators. It is generally accepted that periodontitis is initiated by complex and diverse microbial biofilms which form on the teeth, i.e. dental plaque. Substances released from this biofilm such as lipopolysaccharides, antigens and other virulence factors, gain access to the gingival tissue and initiate an inflammatory and immune response, leading to the activation of host defence cells. As a result of cellular activation, inflammatory mediators, including cytokines, chemokines, arachidonic acid metabolites and proteolytic enzymes collectively contribute to tissue destruction and bone resorption. This review summarises recent studies on the pathogenesis of periodontitis, with the main focus on inflammatory mediators and their role in periodontal disease.
|
|
