| 1. |
- Batut, Jacques, et al.
(author)
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The evolution of chronic infection strategies in the α-proteobacteria
- 2004
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In: Nature Reviews Microbiology. - : Springer Science and Business Media LLC. - 1740-1526 .- 1740-1534. ; 2, s. 933-945
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Research review (peer-reviewed)abstract
- Many of the -proteobacteria establish long-term, often chronic, interactions with higher eukaryotes. These interactions range from pericellular colonization through facultative intracellular multiplication to obligate intracellular lifestyles. A common feature in this wide range of interactions is modulation of host-cell proliferation, which sometimes leads to the formation of tumour-like structures in which the bacteria can grow. Comparative genome analyses reveal genome reduction by gene loss in the intracellular -proteobacterial lineages, and genome expansion by gene duplication and horizontal gene transfer in the free-living species. In this review, we discuss -proteobacterial genome evolution and highlight strategies and mechanisms used by these bacteria to infect and multiply in eukaryotic cells.
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| 2. |
- Lundberg, JO, et al.
(author)
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Nitrate, bacteria and human health
- 2004
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In: Nature reviews. Microbiology. - : Springer Science and Business Media LLC. - 1740-1526 .- 1740-1534. ; 2:7, s. 593-602
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Journal article (peer-reviewed)
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| 3. |
- Oyston, Petra C F, et al.
(author)
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Tularaemia : bioterrorism defence renews interest in Francisella tularensis.
- 2004
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In: Nature Reviews Microbiology. - : Springer Science and Business Media LLC. - 1740-1526 .- 1740-1534. ; 2:12, s. 967-78
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Journal article (peer-reviewed)abstract
- Francisella tularensis is a highly infectious aerosolizable intracellular pathogen that is capable of causing a debilitating or fatal disease with doses as low as 25 colony-forming units. There is no licensed vaccine available. Since the 1950s there has been concern that F. tularensis could be used as a biological threat agent, and it has received renewed attention recently owing to concerns about bioterrorism. The International Conference on Tularaemia in 2003 attracted more than 200 delegates, twice the number of participants as previous meetings. This is a reflection of the increased funding of research on this pathogen, particularly in the United States.
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| 4. |
- Turner, Anthony P. F., et al.
(author)
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Electronic noses and disease diagnostics
- 2004
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In: Nature Reviews Microbiology. - : Nature Publishing Group. - 1740-1526 .- 1740-1534. ; 2:2, s. 161-166
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Research review (peer-reviewed)abstract
- Rapid developments in sensor technology have facilitated the production of devices known as electronic noses - that can detect and discriminate the production profiles of volatile compounds from microbial infections in situ. Such qualitative and semi-quantitative approaches could have a significant role in the early diagnosis and detection of microbial diseases. Using artificial intelligence and web-based knowledge systems, electronic noses might also have a valuable role in monitoring disease epidemiology
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