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- Batista, N, et al.
(författare)
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Phase II study of capecitabine in combination with paclitaxel in patients with anthracycline-pretreated advanced/metastatic breast cancer.
- 2004
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Ingår i: Br J Cancer. - 0007-0920. ; 90:9, s. 1740-6
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Tidskriftsartikel (refereegranskat)abstract
- The addition of oral capecitabine to docetaxel improves response rate, time to progression (TTP) and overall survival in anthracycline-pretreated metastatic breast cancer (MBC). This phase II study evaluates the efficacy and safety of a 21-day cycle of oral capecitabine (1000 mg m(-2) twice daily, days 1-14) plus i.v. paclitaxel (175 mg m(-2), day 1) in anthracycline-pretreated advanced/MBC. In all, 73 patients were enrolled at 13 Swedish and Spanish centres. The objective response rate was 52% (95% confidence interval (CI): 40-63%) in the intent-to-treat population, including complete responses in 11%. Disease was stabilised in a further 29%. The median time to disease progression (TTP) was 8.1 months and the median overall survival was 16.5 months. The combination was generally well tolerated with a predictable safety profile. The most common treatment-related nonhaematological adverse events were hand-foot syndrome (42%), alopecia (30%) and diarrhoea (26%). The only treatment-related Grade 3/4 adverse events occurring in >5% of patients were alopecia (22%) and hand-foot syndrome (11%). Grade 3/4 neutropenia and lymphocytopenia were reported in 12 and 14% of patients, respectively. Capecitabine plus paclitaxel is highly active with a favourable safety profile in anthracycline-pretreated MBC.
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- Wernemyr, Claes, 1949, et al.
(författare)
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Users’ experience of a virtual reality architectural model compared with users’ experience of the completed building
- 2003
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Ingår i: Proceedings of the 1st international conference on advanced research in virtual and rapid prototyping. ; , s. 363-370, s. 363-370
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Konferensbidrag (refereegranskat)abstract
- This research investigated how the employees of a company experienced a VR-model of an office building that was to be their future work place and how that VR-experience com¬pared with the employees’ experience of the completed building. About two years after the VR-showings the building was completed and the staff had moved into the building. The results for the employees who saw the VR-presentation for the Semantic environment de¬scrip¬tion scale (SMB) comparing the experiences of the VR-model with the experiences of the completed real building suggested that the experience of the VR-model gave a fairly accurate representation of the experience of the real building However, the reactions to the VR-model were more appreciative after the VR-show as compared with when the VR-model was compared with the real building.
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