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| 2. |
- Ahlman, Håkan, 1947, et al.
(författare)
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Adrenocortical carcinoma--diagnostic and therapeutical implications.
- 1993
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Ingår i: The European journal of surgery = Acta chirurgica. - 1102-4151. ; 159:3, s. 149-58
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Tidskriftsartikel (refereegranskat)abstract
- To evaluate the results of treatment of a consecutive series of patients with adrenocortical carcinoma who presented during the six year period 1985 to 1991.
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| 3. |
- Andersson, Arne, et al.
(författare)
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Ottenby fågelstation : Årsrapport 1999
- 1999
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Decenniets, seklets och milleniets sista år blev ett år av stora förändringar vid Ottenby fågelstation. Deföregående tre-fyra åren hade präglats av mycket dålig ekonomi och därtill personalproblem. Under 1998blev situationen akut. Som ett första led i att förbättra situationen ombildades Ottenbykommittén (avSveriges Ornitologiska Förening satt att sköta fågelstationen) under hösten 1998. Den störstaförändringen blev sedan att Jan Pettersson, platschef sedan 1978, sades upp. Därtill kom uppsägning,pensionering, dödsfall (se nedan) och sedan tidigare överflyttade tjänster till OFAB, vilket innebar detatt den “fast” anställda personalstyrkan, som 1992 var 7 personer, reducerades till noll!Ottenbykommittén har nu fått en mycket mer aktiv roll i stationens arbete. Olika verksamhetsdelar haridentifierats och ledamöterna har getts olika ansvarsområden.Kommittén bestod under året av :Åke Lindström (ordförande)Christian Hjort (sekreterare, utlandsverksamheten)Dennis Kraft (ekonomi)Arne Andersson (datafrågor)Dennis Hasselquist (samordning av ansökningar)Anders Hedenström (forskningssamordnare)Niclas Jonzén (personal)Lars Lindell (SOF:s styrelse).Aktiviteterna inom dessa olika områden redovisas nedan och här skallbara de generella linjerna i arbetet läggas fram.Tvivelsutan förbättrades arbetsklimatet för den ideellt arbetandepersonalen på fågelstationen och glädjande nog var tillströmningen storav arbetsvilliga ungdomar. Stationen blev på många sätt öppnare, inteminst mot fågelskådarleden. Fler personer besökte stationen och pådetta sätt kan många fler känna sig delaktiga och trivas. Nackdelen äratt det rent praktiskt blir svårare att driva verksamheten med mångamänniskor närvarande och relativt stor omsättning på personer.Genom mycket hård åtstramning på utgiftssidan kunde ett förväntat rejält underskott i budgeten vändastill en liten vinst. Alla inblandade skall ha stor ära av detta eftersom både stora som små uppoffringarkrävts för att styra ekonomin rätt. Den lilla vinsten användes till att börja täcka det underskott somunder många år ackumulerats. Även om det nu känns som att vi har en god kontroll över den löpandeekonomin så måste vi på lång sikt hitta fler finansieringskällor till stationens verksamhet. Det är tillexempel mycket otillfredsställande att vi nu inte har någon heltidsanställd personal, något som på siktmåste lösas.Fågelstationens gamla dröm om att ha en egen filial söder om Sahara gick i uppfyllelse under 1999 meden månads försöksverksamhet i Nigeria under våren. Denna slog väl ut på alla sätt och verksamhetenskall nu intensifieras under 2000.Datahanteringen fick sig en rejäl skjuts framåt under året och kan vi bara snart förnya maskinparken finnsgrunden för en smidig och effektiv datahantering vid stationen. Detta kommer att underlätta bådeutåtriktad verksamhet (Internet) och eget analysarbete.Ottenby Försäljnings AB (OFAB), som drivit den affärsmässiga delen av stationens verksamhet sedan1995, fortsatte sin verksamhet parallellt med fågelstationens ideella verksamhet. Genom verksamheten iNaturum och restaurang Fågel Blå svarar OFAB för en viktig del av fågelstationens publika aktiviteter.Det är av stor vikt för framtiden att behålla och utveckla det goda samarbetet mellan fågelstationen ochOFAB.Figur 1. Åke LindströmFigur 2. Patrik Rhönnstad, platschef 1999Kontinuiteten i det praktiska arbetet på stationen blev naturligtvis något lidande av att den rutineradepersonalen försvunnit. Situationen hjälptes dock upp signifikant av att OFABs personal fanns på plats(Håkan och Annika Lundkvist, Gösta Friberg) samt att nye platschefen och många av de ideelltarbetande hade erfarenhet från tidigare år.
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| 5. |
- Arnestad, J P, et al.
(författare)
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Isolated hyperthermic liver perfusion with cytostatic-containing perfusate activates the complement cascade.
- 1992
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Ingår i: The British journal of surgery. - 0007-1323. ; 79:9, s. 948-51
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Tidskriftsartikel (refereegranskat)abstract
- Eight patients with advanced liver malignancy undergoing isolated hyperthermic liver perfusion with melphalan and cisplatin were studied with regard to complement activation and formation of anaphylatoxins (C3a and C5a) and terminal C5b-9 complement complexes (TCCs). Blood samples for complement variables (C1-INH, C3, C4, C5, C3a, C5a and TCCs) were taken before surgery, 1 min before the start of perfusion, 1, 2 and 3 h after the start of perfusion, and 24 h after operation. Samples were drawn from the perfusate 1 h after the start of perfusion. Activation of complement was observed during perfusion. Raised plasma concentrations of C3a and TCCs were recorded and high levels of C3a and TCCs were found in the perfusate. In vitro tests indicated that melphalan and cisplatin may activate complement. This activation occurred at 37 and 42 degrees C but was more pronounced at 42 degrees C.
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| 7. |
- Bosaeus, Ingvar, 1950, et al.
(författare)
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Comparison of methods to estimate body fat in growth hormone deficient adults.
- 1996
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Ingår i: Clinical endocrinology. - 0300-0664. ; 44:4, s. 395-402
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Tidskriftsartikel (refereegranskat)abstract
- All of the presently used methods for in-vivo determination of body composition have inherent methodological errors and depend on various assumptions. We have therefore compared several different methods used to measure body fat in adult GH deficiency during GH treatment.Comparison of body composition data from a two-phase trial with an initial placebo-controlled, double-blind 6-month period, followed by open treatment with GH until all patients had received GH for 12 months.Twenty-five patients with known GH deficiency entered the study. Baseline examinations were complete in 23 patients, and 22 patients (16 males, 6 females) completed all examinations after treatment.Body fat calculated from total body potassium (TBK) by whole-body 40K counting, total body water (TBW) by tritium dilution, total body nitrogen (TBN) by neutron activation, and bioelectric impedance (BIA) measurements were compared to body fat determinations by dual-energy X-ray absorptiometry (DEXA) in two-compartment and multicompartment body composition models.At baseline, DEXA fat mass agreed well at group level with measurements based on TBW or TBK alone, in a four-compartment model based on TBK and TBW, and a multicompartment model based on bone mineral (by DEXA), TBN and TBW. Body fat by BIA agreed less well. After 12 months of GH treatment, body fat decreased by all methods used. This decrease was smaller by DEXA than by the other methods. The four-compartment model based on TBK and TBW, and TBW alone, showed the best agreement with changes in DEXA fat.All methods showed a decrease of body fat with GH treatment, but variation between methods was considerable.
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| 8. |
- Janson, Per-Olof, 1940, et al.
(författare)
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Acromegaly and Cushing's syndrome due to ectopic production of GHRH and ACTH by a thymic carcinoid tumour: in vitro responses to GHRH and GHRP-6.
- 1998
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Ingår i: Clinical endocrinology. - 0300-0664. ; 48:2, s. 243-50
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Tidskriftsartikel (refereegranskat)abstract
- A 50-year-old male presented with diabetes mellitus and Cushing's syndrome associated with a large mediastinal mass. The levels of serum cortisol were high (1500-1800 nmol/l) without diurnal variation. Plasma ACTH levels (200-250 ng/l) and urinary excretion of cortisol were also increased. The levels of these hormones did not change in response to stimulation with corticotrophin releasing hormone (CRH) or suppression with high doses of dexamethasone. The patient had an elevated baseline GH level (7.3 mU/l), and the levels of immunoreactive GH-releasing hormone (GHRH) in eight plasma samples were markedly increased (600-1500 ng/l). Circulating levels of IGF-1, chromogranin A and neuropeptide Y (NPY) were also increased. Computer-assisted tomography and octreotide scintigraphy revealed a large mediastinal tumour and metastases in the left supraclavicular fossa. During treatment with octreotide, the baseline GH level was decreased (to 4.4 mU/l), while the GH pulse height was unchanged. Surgical removal of most of the tumour tissue resulted in a further decrease in the baseline serum GH level to a value (1.6 mU/l) about 20% of that before treatment, while the pulse height and mean GH were affected to a lesser extent. Postoperatively, circulating levels of cortisol and IGF-1 decreased, and the patient exhibited clinical improvement. Histological examination showed a neuroendocrine tumour with characteristics consistent with a foregut carcinoid of thymic origin. Immunoreactive GHRH, ACTH and NPY, but not immunoreactive GH, were detected in 80-90% of the tumour cells and the three peptides appeared to be co-localized. In primary culture, cells from this tumour displayed calcium influx in response to GHRH or GH releasing peptide-6 (GHRP-6), while there were not such responses by cells from another carcinoid not producing GHRH, ACTH or NPY. These results demonstrate a rare case of ectopic production of GHRH, ACTH and NPY, and indicate that the tumour cells were responsive to GHRH and GHRP-6 as well as octreotide.
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| 10. |
- Johannsson, Gudmundur, 1960, et al.
(författare)
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Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency.
- 1996
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Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 81:8, s. 2865-73
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Tidskriftsartikel (refereegranskat)abstract
- The main purpose of this trial was to determine the effects of 2 yr of GH treatment on bone mineral density (BMD) and bone metabolism in patients with adult-onset GH deficiency. Forty-four patients (24 men and 20 women; aged 23-66 yr) participated in a 2-yr open treatment trial with recombinant human GH. BMD was assessed with dual energy x-ray absorptiometry, and serum concentrations of osteocalcin, carboxy-terminal propeptide of type I procollagen (PICP), and carboxy-terminal cross-linked telopeptide of type I collagen (ICTP) were measured. After 2 yr of GH treatment, the BMD increased in the lumbar spine L2-L4 by 3.8% [95% confidence interval (CI), 2.1-5.5], in the femoral neck by 4.1% (CI, 2.1-6.1) in the femoral trochanter by 5.6% (CI, 3.8-7.4) and in Ward's triangle by 4.9% (CI, 2.2-7.6) compared with baseline. Patients with a z-score (difference in SD from the mean of age- and sex-matched subjects) below -1 SD responded with the most marked BMD increment. The serum concentrations of osteocalcin, PICP, and ICTP remained higher throughout the 2 yr of treatment. Women demonstrated a more marked increase in total body BMD and a less pronounced initial increment in osteocalcin, PICP, and ICTP than men. Two years of GH treatment induced a sustained increase in overall bone remodeling activity, which resulted in a net gain in BMD that was more marked in those subjects with a low pretreatment z-score.
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