| 1. |
- Acatauassu, Diogo, et al.
(author)
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KHM cable model parameters for ITU-T G.Fast reference loops
- 2016
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In: 2015 IEEE Conference on Standards for Communications and Networking, CSCN 2015. - 9781479989287 ; , s. 168-173
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Conference paper (peer-reviewed)abstract
- G.Fast is a new standard for fixed broadband access that aims at achieving bit rates of 1 Gb/s over short copper loops. In order to give support to simulation, design and performance evaluation tests, the G.Fast recommendation presents examples of some wiring topologies and reference loops describing configurations expected to be found in real G.Fast deployments. Our work describes results of modeling some types of lines adopted in these reference loops by means of a low complexity and causal parametric cable model. The results indicate that the modeling approach proposed in this work is accurate for all the analyzed cases, which include high quality, medium quality and low quality cables.
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| 2. |
- Berg, Aase, et al.
(author)
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Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria
- 2015
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In: The Internet Journal of Infectious Diseases. - : Oxford University Press (OUP). - 1528-8366 .- 0022-1899 .- 1537-6613. ; 212:11, s. 1835-1840
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Journal article (peer-reviewed)abstract
- The impact of complement activation and its possible relation to cytokine responses during malaria pathology was investigated in plasma samples from patients with confirmed Plasmodium falciparum malaria and in human whole-blood specimens stimulated with malaria-relevant agents ex vivo. Complement was significantly activated in the malaria cohort, compared with healthy controls, and was positively correlated with disease severity and with certain cytokines, in particular interleukin 8 (IL-8)/CXCL8. This was confirmed in ex vivo-stimulated blood specimens, in which complement inhibition significantly reduced IL-8/CXCL8 release. P. falciparum malaria is associated with systemic complement activation and complement-dependent release of inflammatory cytokines, of which IL-8/CXCL8 is particularly prominent.
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| 3. |
- Boer, Christa, et al.
(author)
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2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery.
- 2018
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In: Journal of Cardiothoracic and Vascular Anesthesia. - : Elsevier BV. - 1532-8422 .- 1053-0770. ; 32:1, s. 88-120
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Journal article (peer-reviewed)abstract
- Authors/Task Force Members: Christa Boer (EACTA Chairperson)(Netherlands), Michael I. Meesters (Netherlands), Milan Milojevic (Netherlands), Umberto Benedetto (UK), Daniel Bolliger (Switzerland), Christian von Heymann (Germany), Anders Jeppsson (Sweden), Andreas Koster (Germany), Ruben L. Osnabrugge (Netherlands), Marco Ranucci (Italy), Hanne Berg Ravn (Denmark), Alexander B.A. Vonk (Netherlands), Alexander Wahba (Norway), Domenico Pagano (EACTS Chairperson)(UK), Document Reviewers: Moritz W.V. Wyler von Ballmoos (USA), Mate Petricevic (Croatia), Arie Pieter Kappetein (Netherlands), Miguel Sousa-Uva (Portugal), Georg Trummer (Germany), Peter M. Rosseel (Netherlands), Michael Sander (Germany), Pascal Colson (France), Adrian Bauer (Germany).
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| 4. |
- Engert, Andreas, et al.
(author)
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The European Hematology Association Roadmap for European Hematology Research : a consensus document
- 2016
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In: Haematologica. - Pavia, Italy : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
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Journal article (peer-reviewed)abstract
- The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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| 5. |
- Fertner, Antoni, et al.
(author)
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Applications of Backscattering for the Study of Twisted Pair Transmission Lines
- 2018
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In: IEEE Transactions on Microwave Theory and Techniques. - 0018-9480. ; 66:12, s. 5230-5237
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Journal article (peer-reviewed)abstract
- The phenomenon of backscattering in copper cables has been recently observed and initially explicated. It can provide promising techniques to address the problem of loop diagnostic and maintenance. The backscattering is analyzed both in frequency and time domains. To demonstrate the practical use of the phenomenon, we estimate certain properties of the loop using wideband, high-frequency $\selevenf(f)$ measurements performed in the laboratory on real cables. The results corroborate the usefulness and accuracy of the investigated method.
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| 6. |
- Fertner, Antoni, et al.
(author)
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Backscattering in Twisted-Pair Nonhomogeneous Transmission Lines
- 2018
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In: IEEE Transactions on Microwave Theory and Techniques. - 0018-9480. ; 66:6, s. 2674-2682
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Journal article (peer-reviewed)abstract
- The development of the communication networks tends gradually toward exploiting higher frequencies, sometimes even reaching the lowest microwave band (P-band). As the signal bandwidth used for transmission over twisted-pairs increases, as recommended by G.fast and other broadband systems, new phenomenon was observed, namely, backscattering. Motivated by the measurements of copper cables in frequency band up to 400 MHz, we propose a novel backscattering model. It may be productively applied to the problem of loop diagnostics. The methods to accurately and reliable determine the relevant transmission-line parameters are sine qua non condition to appropriately exploit the potential of short-to-medium range access lines. In this paper, a recursive formulation of the frequency-domain response of the backscattering is used for a space-time characterization. To confirm the practical use of the finding, we evaluate the properties of a loop using wideband, high-frequency S₁₁ measurements of the real cables. These laboratory results confirm the effectiveness and accuracy of the proposed method.
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| 7. |
- Fonseca, Maria Nilma, et al.
(author)
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DCT-based compression scheme for OFDM baseband signals
- 2018
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In: 2018 Wireless Days, WD 2018. - 9781538656327 ; 2018-April, s. 92-97
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Conference paper (peer-reviewed)abstract
- The requirements on the data rates of communication systems increase roughly an order of a magnitude at each new generation. This increase can be especially noticeable for the new centralized radio access networks (C-RAN) scenarios, considered for meeting the requirements of the fifth generation (5G) wireless systems. The general C-RAN architecture normally assumes data transmission in the form of digitized baseband, i.e. I/Q samples. This paper proposes a relatively low-complexity compression scheme for LTE OFDM baseband samples based on transform coding, using the discrete cosine transform (DCT). The compression method is evaluated in both downlink and uplink. The results show that this process can be configured to achieve compression ratio according with the load, for example, in the range of 5:1 to 31:1, with error vector magnitudes (EVMs) lower than 2.8%.
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| 8. |
- Hollestelle, Antoinette, et al.
(author)
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No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
- 2016
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In: Gynecologic Oncology. - : Elsevier BV. - 0090-8258 .- 1095-6859. ; 141:2, s. 386-401
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Journal article (peer-reviewed)abstract
- Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. Methods Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). Results We found no association with risk of ovarian cancer (OR = 0.99, 95% CI 0.94-1.04, p = 0.74) or breast cancer (OR = 0.98, 95% CI 0.94-1.01, p = 0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR = 1.09, 95% CI 0.97-1.23, p = 0.14, breast cancer HR = 1.04, 95% CI 0.97-1.12, p = 0.27; BRCA2, ovarian cancer HR = 0.89, 95% CI 0.71-1.13, p = 0.34, breast cancer HR = 1.06, 95% CI 0.94-1.19, p = 0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR = 0.94, 95% CI 0.83-1.07, p = 0.38), breast cancer (HR = 0.96, 95% CI 0.87-1.06, p = 0.38), and all other previously-reported associations. Conclusions rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.
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| 9. |
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| 10. |
- Huang, Yezi, et al.
(author)
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Functional Split of Zero-Forcing Based Massive MIMO for Fronthaul Load Reduction
- 2018
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In: IEEE Access. - 2169-3536. ; 6, s. 6350-6359
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Journal article (peer-reviewed)abstract
- The evolution towards centralized radio access network (C-RAN) for 5G is driven by the need for improved network performance and reduced total-cost-of-ownership (TCO). In CRAN, physically separated remote radio units (RRUs) and baseband units (BBUs) are connected via fronthaul (FH) links, which are capacity constrained. When base-station antennas are upgraded to support massive MIMO techniques, an intra PHY split between RRU and BBU becomes favorable to avoid the dramatic rate growth on the FH links. In this paper, we present a new uplink functional split alternative that decomposes the massive MIMO processing, on the basis of zero-forcing (ZF) equalization, into two phases: dimension-reduction phase and interference cancellation phase, which are implemented in RRU and BBU respectively. Compared with the traditional C-RAN architecture having all baseband processing in the BBU, the new scheme largely alleviates the FH load by reducing the number of FH streams to be equal to the number of MIMO user layers. Compared with an existing split that places all MIMO processing in RRU, the new scheme reduces the RRU complexity without compromising the post-processing performances.
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