| 1. |
- Remberger, Mats, et al.
(author)
-
Improved survival after allogeneic hematopoietic stem cell transplantation in recent years : A single-center study
- 2011
-
In: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 17:11, s. 1688-1697
-
Journal article (peer-reviewed)abstract
- We analyzed the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) over the past 2 decades. Between 1992 and 2009, 953 patients were treated with HSCT, mainly for a hematologic malignancy. They were divided according to 4 different time periods of treatment: 1992 to 1995, 1996 to 2000, 2001 to 2005, and 2006 to 2009. Over the years, many factors have changed considerably regarding patient age, diagnosis, disease stage, type of donor, stem cell source, genomic HLA typing, cell dose, type of conditioning, treatment of infections, use of granulocyte-colony stimulating factor (G-CSF), use of mesenchymal stem cells, use of cytotoxic T cells, and home care. When we compared the last period (2006-2009) with earlier periods, we found slower neutrophil engraftment, a higher incidence of acute graft-versus-host disease (aGVHD) of grades II-IV, and less chronic GVHD (cGHVD). The incidence of relapse was unchanged over the 4 periods (22%-25%). Overall survival (OS) and transplant-related mortality (TRM) improved significantly in the more recent periods, with the best results during the last period (2006-2009) and a 100-day TRM of 5.5%. This improvement was also apparent in a multivariate analysis. When correcting for differences between the 4 groups, the hazard ratio for mortality in the last period was 0.59 (95% confidence interval [CI]: 0.44-0.79; P < .001) and for TRM it was 0.63 (CI: 0.43-0.92; P = .02). This study shows that the combined efforts to improve outcome after HSCT have been very effective. Even though we now treat older patients with more advanced disease and use more alternative HLA nonidentical donors, OS and TRM have improved. The problem of relapse still has to be remedied. Thus, several different developments together have resulted in significantly lower TRM and improved survival after HSCT over the last few years.
|
|
| 2. |
- Ahlman, Therese, et al.
(author)
-
Culling reasons in organic and conventional dairy herds and genotype by environment interaction for longevity
- 2011
-
In: Journal of Dairy Science. - : American Dairy Science Association. - 0022-0302 .- 1525-3198. ; 94, s. 1568-1575
-
Journal article (peer-reviewed)abstract
- Dairy cow longevity combines all functional traits and is thought to be especially important in organic production, which is an established, increasing part of Swedish dairy production, representing approximately 6% of the market. The aim of this study was to compare dynamics in culling reasons between organic and conventional production and to analyze genotype by environment interactions for longevity. The data contained information from all organic herds with information available from official recording (n = 402) and from approximately half of the conventional herds (n = 5,335). Records from Swedish Holsteins (n = 155,379) and Swedish Red cows (n = 160,794) that had their first calf between January 1998 and September 2003 were included. The opportunity period for longevity was at least 6 yr. Six longevity traits were defined: length of productive life; survival through first, second, and third lactations; fertility-determined survival; and udder health-determined survival. Twenty codes were used to describe the cause of culling, and these were divided into 8 groups: udder health, low fertility, low production, leg problems, metabolic diseases, other diseases, other specified causes, and unspecified cause. The main reason for culling cows in organic herds was poor udder health, whereas for cows in conventional herds it was low fertility. Furthermore, the shift in main culling reason from fertility, which was most common in first lactation regardless of production system, to udder health occurred at a lower age in organic production. Heritabilities and genetic correlations for the longevity traits expressed in organic and conventional herds were estimated from a bivariate animal model. The genetic correlations were close to unity (>0.88), except for fertility-determined survival in the Swedish Red breed (0.80). Heritabilities were low to moderate, and no clear pattern was identified for production system or breed. In general, the results indicate that farmers' culling criteria differ between organic and conventional production. Different preferences may influence the need for alternative selection indexes for organic production, with different weightings of traits, or a separate breeding program. However, no genotype by environment interaction of importance was found between the production systems.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Berglund, Britt
(author)
-
Avel för tydlig brunst
- 2012
-
In: Avelsnytt. - 1903-6531. ; , s. s. 18-
-
Journal article (pop. science, debate, etc.)
|
|
| 6. |
- Berglund, Britt, et al.
(author)
-
Genetic Parameters for Endocrine Fertility Traits from In-line Milk Progesterone Records in Dairy Cows
- 2014
-
Other publication (peer-reviewed)abstract
- In-line milk progesterone records (n = 163,145) collected from June 2009 through November 2013 for 2,274 lactations of Holstein-Friesian cows in 12 commercial herds in the Netherlands were analyzed for commencement of luteal activity (CLA), luteal activity during first 60 days in milk (LA60), proportion of samples with luteal activity (PLA), interval from commencement of luteal activity to first service, length of first luteal phase, and number of inter-ovulatory intervals before first service. Heritability (0.13, 0.10, and 0.05) and repeatability estimates (0.26, 0.21, and 0.16) were greatest for CLA, PLA and LA60, respectively, compared with other traits. Genetic correlations were 0.96 to 0.99 between these traits. This study shows that in-line P4 records can be used to define and explore several heritable endocrine fertility traits that can be used in genetic improvement of fertility by selection.
|
|
| 7. |
|
|
| 8. |
- Berglund, Britt
(author)
-
Holstein – med vita öron
- 2012
-
In: Husdjur. - 0046-8339. ; No vol., s. 6-
-
Journal article (pop. science, debate, etc.)
|
|
| 9. |
- Berglund, Britt
(author)
-
Introduction
- 2011
-
In: Reproduction in Domestic Animals. - 0936-6768 .- 1439-0531. ; 46, s. 70-70
-
Conference paper (other academic/artistic)
|
|
| 10. |
|
|
