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Träfflista för sökning "WFRF:(Bohl E) srt2:(2000-2004)"

Search: WFRF:(Bohl E) > (2000-2004)

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1.	Bohl E, Carlsson J, Edwards K, Sjöberg S, Gedda L (author) SLT-particles for twostep targeting in boron neutron capture therapy 2001 In: Frontiers in neutron capture therapy. - : New York Plenum Publisher. ; , s. 1069-1075 Journal article (other academic/artistic)
2.	Bohl, E., et al. (author) SLT-particles for two step targeting in boron neutron capture therapy 2001 In: Frontiers in Neutron Capture Therapy. - New York : Kluwer Academic/Plenum Publishers, New York. ; , s. 70- Book chapter (other academic/artistic)
3.	Bohl Kullberg E, Carlsson J, Edwards K, Capala J, Sjöberg S, Gedda L. (author) Introductory Experiments On Ligand Liposomes as Delivery Agents for Boron Neutron Capture Therapy 2003 In: International Journal of Oncology. ; :23, s. 461-467 Journal article (other academic/artistic)
4.	Bohl Kullberg, E, et al. (author) Introductory experiments on ligand liposomes as delivery agents for boronneutron capture therapy 2003 In: International Journal of Oncology. - 1019-6439 .- 1791-2423. ; 23:2, s. 461-467 Journal article (peer-reviewed)abstract Liposomes are, when coupled to receptor ligands, candidates for receptor mediated delivery of boron for tumour therapy since they have capacity to deliver large amounts of boron per receptor interaction. With EGF-liposomes we present a pegylated ligand liposome delivery vehicle, containing water soluble boronated phenanthridine, WSP1, or water soluble boronated acridine, WSA1, for EGFR targeting. In the case of WSA1 a ligand dependent uptake was obtained and the boron uptake was as good as if free WSA1 was given. No ligand dependent boron uptake was seen for WSP1 containing liposomes. Thus, WSA1 is a candidate for further studies. Approximately 10(5) boron atoms were in each liposome. A critical assessment indicates that after optimization up to 10(6) boron atoms can be loaded. Since it is known that, for therapeutic effect, approximately 10(8)-10(9) boron atoms are needed in a single tumour cell it is realized that 10(2)-10(3) receptor interactions are needed to meet the demand. Tests applying cultured glioma cells indicate, without optimization of the delivery conditions, a boron uptake in the ppm range, which is necessary for successful BNCT. Thus, it seems possible to kill micro-invasive tumour cells with targeted liposomes if the delivery conditions are optimal.
5.	Carlsson, J, et al. (author) Cellular spheroids as a micrometastasis model in preclinical tests of boron neutron capture therapy 2001 In: Frontiers in Neutron Capture Therapy, volume 1. - 030646442X ; , s. 109- Conference paper (other academic/artistic)
6.	Lundqvist, H, et al. (author) Preclinical research on Auger therapy 2003 Conference paper (other academic/artistic)
7.	Orlova, Anna, et al. (author) Synthesis of [211At] N-[8-(acridin-9-ylamino)-octyl]-3- astatobenzamide, an astatinated DNA intercalator 2000 In: European Journal of Nuclear Medicine. - 0340-6997 .- 1432-105X. ; 27:8, s. 317- Review (other academic/artistic)

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Result 1-7 of 7

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Type of publication: journal article (3); conference paper (2); book chapter (1); review (1)

Type of content: other academic/artistic (6); peer-reviewed (1)

Author/Editor: Sjöberg, S (5); Bohl, E. (4); Edwards, Katarina (3); Gedda, Lars (3); Carlsson, J (3); Gedda, L. (2); show more...; Nilsson, P. (1); Lundqvist, Hans (1); Tolmachev, Vladimir (1); Tolmachev, V. (1); Orlova, A. (1); Orlova, Anna (1); Carlsson, Jörgen (1); Lundqvist, H (1); Bohl E, Carlsson J, ... (1); Bohl Kullberg E, Car ... (1); Bohl Kullberg, E (1); Capala, J (1); Bruskin, A. (1); Sjöström, A (1); Lebeda, Ondrej (1); Ghaneolhosseino, H. (1); show less...

University: Uppsala University (7)

Language: English (7)

Research subject (UKÄ/SCB): Natural sciences (3)

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