| 1. |
- Boström, Barbro, et al.
(författare)
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A comparison of pain and health-related quality of life between two groups of cancer patients with differing average levels of pain
- 2003
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Ingår i: Journal of Clinical Nursing. - Chichester : Wiley-Blackwell Publishing Inc.. - 0962-1067 .- 1365-2702. ; 12:5, s. 726-735
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Tidskriftsartikel (refereegranskat)abstract
- A study was performed to describe and compare pain and Health-Related Quality of Life (HRQOL) in two groups of cancer patients in palliative care as well as to describe the correlation between pain and HRQOL. ○ Forty-seven patients with mild average pain [Visual Analogue Scale (VAS) < 3] and 28 patients with moderate to severe average pain (VAS > 3) were included. Medical Outcomes Study Short Form (SF-36) was used to evaluate HRQOL, pain intensity levels were measured with the VAS on Pain-O-Meter. ○ Compared to patients with mild pain, patients with moderate to severe pain had statistically significant, higher pain intensity for the items 'pain at time of interview', 'worst pain in the past 24 hours' and 'pain interrupting sleep.' They also had the lowest scores of the SF-36 dimensions: physical functioning, role-physical, and bodily pain. Patients with moderate to severe pain had statistically significant, fewer months of survival. There were statistically significant positive correlations between pain items and negative correlation between pain and SF-36 dimensions. ○ The conclusion is that pain has a negative impact on HRQOL, especially on physical health and that pain increases towards the final stages of life. Even if patients have to endure symptoms such as fatigue and anxiety during their short survival time, dealing with pain is an unnecessary burden, which can be prevented.
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| 2. |
- Boström, Barbro, et al.
(författare)
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Cancer patients' experiences of care related to pain management before and after palliative care referral
- 2004
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Ingår i: European Journal of Cancer Care. - : Wiley-Blackwell. - 0961-5423 .- 1365-2354. ; 13:3, s. 238-245
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Tidskriftsartikel (refereegranskat)abstract
- Pain is the main problem for patients with cancer referred to palliative care (PC). Pain management in PC requires a multidimensional approach. A questionnaire was used to determine cancer patients' experiences of care related to pain management, before and after being referred to PC, and to also discover possible correlations between pain control and other aspects of care. Seventy-five consecutive patients from two PC teams were included in the study. The patients had experienced a statistically significant (P < 0.01) improvement in care after being referred to PC, despite the fact that pain control had not been optimized. Patients' description of 'pain control' after being referred to PC had a statistically significant correlation with their 'feeling of security' and 'continuity of care' throughout the same period. The conclusion is that care provided in PC is vital to successful pain management. Pain control depends not only on analgesics but also on many other aspects of care provided by the nurse. Continuity of care and the opportunity to talk increases the patients' feeling of security, which is also of utmost importance to successful pain management.
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| 3. |
- Boström, Barbro, et al.
(författare)
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Cancer-related pain in palliative care : patients' perceptions of pain management
- 2004
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Ingår i: Journal of Advanced Nursing. - : Blackwell Publishing. - 0309-2402 .- 1365-2648. ; 45:4, s. 410-419
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Tidskriftsartikel (refereegranskat)abstract
- Background: Pain is still a significant problem for many patients with cancer, despite numerous, clear and concise guidelines for the treatment of cancer-related pain. The impact of pain cognition on patients' experiences of cancer-related pain remains relatively unexplored. Aim: The aim of this study was to describe how patients with cancer-related pain in palliative care perceive the management of their pain. Method: Thirty patients were strategically selected for interviews with open-ended questions, designed to explore the pain and pain management related to their cancer. The interviews were analysed using a phenomenographic approach. Findings: Patients described 10 different perceptions of pain and pain management summarized in the three categories: communication, planning and trust. In terms of communication, patients expressed a need for an open and honest dialogue with health care professionals about all problems concerning pain. Patients expressed an urgent need for planning of their pain treatment including all caring activities around them. When they felt trust in the health care organization as a whole, and in nurses and physicians in particular, they described improved ability and willingness to participate in pain management. While the findings are limited to patients in palliative care, questions are raised about others with cancer-related pain without access to a palliative care team. Conclusion: The opportunity for patients to discuss pain and its treatment seems to have occurred late in the course of disease, mostly not until coming in contact with a palliative care team. They expressed a wish to be pain-free, or attain as much pain relief as possible, with as few side effects as possible.
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| 4. |
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| 5. |
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| 6. |
- Boström, Barbro, et al.
(författare)
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Pain and health-related quality of life among cancer patients in final stage of life : a comparison between two palliative care teams
- 2003
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Ingår i: Journal of Nursing Management. - Chichester, West Sussex : Blackwell Publishing. - 0966-0429 .- 1365-2834. ; 11:3, s. 189-196
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Tidskriftsartikel (refereegranskat)abstract
- A two-centred descriptive study was performed in order to describe and compare pain and health-related quality of life (HRQOL) among cancer patients, in their final stage of life. The patients were cared for by either a nurse-led palliative care team I (PCT I) or a physician-led palliative care team II (PCT II). Forty-six consecutive, stratified patients (PCT I, n = 21 and PCT II, n = 25) participated. The medical outcomes study short form 36 (SF-36) was used for evaluating HRQOL and the Pain-O-Meter for assessing pain. Patients' pain intensity, pain quality and HRQOL showed no significant difference between the two groups PCT I and PCT II. The patients from PCT I had significantly longer survival time (P = 0.017) than those from PCT II. The different composition of the teams being led by nurses or physicians is worth further research; both from the patient's and staff's viewpoint, there may also be cost-benefits worth examining.
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| 7. |
- Gustafsson, Bengt, et al.
(författare)
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Astronomi och rymdvetenskap
- 2001
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Ingår i: Vetenskapens framsteg.
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Bokkapitel (populärvet., debatt m.m.)
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| 8. |
- Haglund, Ann-Louise, 1972-
(författare)
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Attached Bacterial Communities in Lakes – Habitat-Specific Differences
- 2004
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- For many years, the importance of microorganisms attached to surfaces in littoral zones and wetlands has been disregarded when describing aquatic ecosystem dynamics. Supporting evidence is scarce but convincing that these microbial communities are not only very productive but can often serve as major regulators of nutrient and carbon dynamics in many freshwaters. In order to determine the quantitative importance of epiphytic bacteria for the overall carbon turnover, I compared the relative contribution of epiphytic bacteria on the submerged macrophyte Ranunculus circinatus, sediment and free-living bacteria to the total bacterial production. Sediment bacteria generally dominated total bacterial biomass in the littoral zone. Although the epiphytic biomass on R. circinatus was ten times lower than the biomass of sediment bacteria, it often contributed at least equally to the total bacterial production. Thus, the results presented in this thesis confirm that most bacterial biomass and production in shallow lakes is associated with surfaces, and that in littoral zones with dense macrophyte stands, epiphytic bacteria can contribute significantly to the overall carbon turnover. There is increasing evidence that not all cells in natural bacterial communities are metabolically active. In Lake Erken, there were large differences in the fraction of active bacteria between different habitats, while the within-habitat differences were small. The sediments had the largest bacterial fraction, followed by epiphytic bacteria, while in the water column only a few percent of the bacteria were active. In this thesis the fraction of active bacteria is connected to environmental fluctuations. I hypothesize that smaller fluctuations in chemical, biological or physical factors result in large active bacterial fractions. Thus, small environmental fluctuations within a habitat allow large active bacterial fractions, while the active fraction is constrained when the environmental fluctuations are large.
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| 9. |
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| 10. |
- Linder, Birgitta, et al.
(författare)
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In vitro growth of human endolymphatic sac cells : a transmission electron microscopic and immunohistochemical study in patients with vestibular schwannoma and Ménière's Disease
- 2001
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Ingår i: Otology and Neurotology. - 1531-7129 .- 1537-4505. ; 22:6, s. 938-943
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Tidskriftsartikel (refereegranskat)abstract
- HYPOTHESIS:Human endolymphatic sac cells have been notoriously difficult to maintain in culture. It was hypothesized that an in vitro environment intended for growth of keratinocytes would also be suitable for human endolymph sac cells.BACKGROUND:Studies on cell physiology of human endolymphatic sac cells have been hampered by difficulties in maintaining them in culture.METHODS:Human endolymphatic sac cells were taken from 10 patients during translabyrinthine skull base surgery for vestibular schwannoma, one of whom also had Ménière's disease. Cell lines of proliferating epithelial cells were obtained after trypsinization and growth in a 3:1 mixture of Dulbecco's modified Eagle medium and Ham's F12 medium supplemented with 10% fetal calf serum. Fibroblast overgrowth was counteracted by the use of so-called cloning rings. During various stages, cells were investigated with transmission electron microscopy and/or immunohistochemistry.RESULTS:Proliferation took place after 2 to 3 days of primary cell culture. The cells were cytokeratin-positive and pleomorphic, and they had abundant polarized microvillus-like projections, numerous coated cytoplasmic pits and vesicles, and a well-developed rough endoplasmic reticulum.CONCLUSION:Cell lines of proliferating human endolymphatic sac cells can be produced with the technique described here and may be a valid tool in studies of human endolymph sac physiology.
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