| 1. |
- Bergström, Christel, 1973-, et al.
(författare)
-
Biorelevant intrinsic dissolution profiling in early drug development : Fundamental, methodological, and industrial aspects
- 2019
-
Ingår i: European journal of pharmaceutics and biopharmaceutics. - : Elsevier. - 0939-6411 .- 1873-3441. ; 139, s. 101-114
-
Forskningsöversikt (refereegranskat)abstract
- Intrinsic dissolution rate (IDR) is the surface specific dissolution rate of a drug. In early drug development, this property (among other parameters) is measured in order to compare different polymorphs and salt forms, guide formulation decisions, and to provide a quality marker of the active pharmaceutical ingredient (API) during production. In this review, an update on different methods and small-scale techniques that have recently evolved for determination of IDR is provided. The importance of biorelevant media and the hydrodynamic conditions of dissolution are also discussed. Different preparation techniques for samples are presented with a focus on disc, particle- and crystal-based methods. A number of small-scale techniques are then described in detail, and their applicability domains are identified. Finally, an updated industrial perspective is provided about IDR's place in the early drug development process.
|
|
| 2. |
- Box, Marcus, 1972-, et al.
(författare)
-
Företagsnedläggningar : Olika perspektiv och forskningsmetoder
- 2018
-
Ingår i: Insolvensrättslig tidskrift. - : Föreningen Insolvensrättslig Tidskrift. - 2002-3014 .- 2002-6315. ; 3:1, s. 12-31
-
Tidskriftsartikel (refereegranskat)abstract
- Uppsatsen redogör för förklaringar till företagsdödlighet i såväl offentliga utredningar som inom ekonomisk och sociologisk forskning och teoribildning. Två fundamentalt olika föreställningar om hur och varför företag beter sig på ett visst sätt har dominerat de flesta studier. Ett perspektiv förutsätter en central roll för företagsledningens beslutsfattande och kompetens. Ett andra och motsatt perspektiv ser företags beteenden bestämda av externa krafter över vilka företagsledningen saknar kontroll. De olika föreställningarna påverkar resultat och slutsatser inom forskningen och har också betydelse för utformningen av den ekonomiska politiken.
|
|
| 3. |
|
|
| 4. |
- Box, Marcus, 1972-, et al.
(författare)
-
Konkurs och konjunktur i Sverige 1830-2010
- 2016
-
Ingår i: Insolvensrättslig tidskrift. - : Föreningen Insolvensrättslig Tidskrift. - 2002-3014 .- 2002-6315. ; :1, s. 20-36
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Ekonomer betraktar vanligtvis konkursutvecklingen som en konjunkturindikator och därmed beroende av förändringar på ekonomins efterfrågesida: konkurserna förväntas öka i tider av ekonomisk nedgång och minska under högkonjunkturer. Flertalet analyser är emellertid kortsiktiga. I denna uppsats presenterar vi ny och unik empiri där vi analyserar det långsiktiga sambandet mellan konjunkturväxlingar och konkurser i Sverige mellan år 1830 och år 2010. I uppsatsen diskuteras också problem som kan uppstå i tolkningen av konkursstatistiken, både historiskt och i vår samtid. Den statistiska analysen visar att det delvis går att fastställa ett samband mellan makroekonomiska svängningar och förändringar i konkursmängden.
|
|
| 5. |
- Box, Marcus, 1972-, et al.
(författare)
-
Linking Entrepreneurship and Economic Growth in Sweden, 1850–2000
- 2016. - 1
-
Ingår i: Contemporary Entrepreneurship. - Cham : Springer. - 9783319281322 - 9783319281346 ; , s. 31-49
-
Bokkapitel (refereegranskat)abstract
- Recent developments in entrepreneurship suggest a causal link between entrepreneurial activity and economic growth: entrepreneurship precedes economic growth. A positive effect from entrepreneurship on economic development in advanced, innovation-driven economies in the most recent decades is often maintained. Self-employment is one of the most common indicators of entrepreneurship. The present study uses very long series of non-interrupted data on self-employment in Sweden (1850–2000). It analyzes the relationship between variations in self-employment and economic growth. For the entire period, variations in self-employment had a significant, instantaneous positive correlation with GDP growth. However, no causal relationship could be discovered: variations in self-employment did not (Granger) cause GDP growth. We discovered a structural break in GDP growth as early as in the year of 1948. Up until 1948, (Granger) causality between self-employment and GDP could not be established for any direction. For the other segment (1949–2000), GDP growth (Granger) caused self-employment growth, but not the other way around. For the period 1949–2000, but not for the previous period, selfemployment lagged with respect to GDP growth. Consequently, GDP growth preceded self-employment growth, but self-employment growth did not precede GDP growth. Given that self-employment is a suitable indicator, the empirical results in this study are, in several respects, in disagreement with dominating assumptions in mainstream research.
|
|
| 6. |
- Box, Marcus, 1972-, et al.
(författare)
-
New-Firm Survival in Sweden : New Methods and Results
- 2017
-
Ingår i: International Review of Entrepreneurship. - : Senate Hall Academic Publishing. - 2009-2822. ; :4, s. 431-464
-
Tidskriftsartikel (refereegranskat)abstract
- We analyse firm survival and focus on several levels of analysis (both firm level and macro-level). We employ a unique longitudinal data set, recorded at the firm-level and covering nine complete entry cohorts of Swedish companies. The companies were founded between 1899 and 1992, and each firm is followed over nearly a decade. We adopt the semi-parametric complementary log-log (cloglog) model. The main novelty of our approach is that, unlike extant studies so far, we are able to distinguish between the impact on the hazard rate of founding conditions and contemporaneous, post-entry conditions. Using our new approach we test several hypotheses derived from the Industrial Organization and Organizational Ecology literatures.
|
|
| 7. |
- Box, Marcus, 1972-, et al.
(författare)
-
The Asymmetric Effect of Bankruptcy Fraud in Sweden : A Long-Term Perspective
- 2019
-
Ingår i: Journal of quantitative criminology. - : Springer. - 0748-4518 .- 1573-7799. ; 35:2, s. 287-312
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: The knowledge of the effects of white-collar crimes is incomplete. In the article, we operationalize white-collar crimes as bankruptcy frauds. Economic models maintain that interlinkages between firms may give ‘domino effects’: bankruptcy events could lead to ‘bankruptcy chains’ in which a bankruptcy spreads to other firms. Analogously, criminologists assert that social and economic networks can be a major source of fraud diffusion, with the potential to drive other firms bankrupt. Recent empirical results show that crimes may have detrimental and even asymmetric (nonlinear) effects on economic activity. We analyze the diffusion and the aggregate development of bankruptcy frauds in Sweden over nearly two hundred years, specifically focusing on the relationship between bankruptcy frauds and the bankruptcy volume. We also consider linkages between bankruptcy frauds, bankruptcies, and the macroeconomic cycle. Methods: We use long, aggregate time series, collected from several different historical and contemporary sources. Applying the recently developed cointegrating nonlinear autoregressive distributed lag (NARDL) model, we investigate whether the bankruptcy volume reacts asymmetrically to increases and decreases in bankruptcy frauds, both in the short and the long run. Results: Bankruptcy frauds reveal a causal effect on bankruptcies, showing an asymmetric (nonlinear) diffusion effect from economic frauds to the bankruptcy volume. Increases in bankruptcy frauds have a positive and significant effect on the bankruptcy volume. However, decreases in bankruptcy frauds show no significant effect. No causal relationship between the macroeconomic cycle and bankruptcy frauds is found. Conclusions: Our data and research approach demonstrate how previously generated hypotheses in both criminology and economic research on the relationship between (economic) crimes, economic activity, and the diffusion of white-collar crime can be tested at an aggregate level. © 2018 The Author(s)
|
|
