| 1. |
- Bengtsson, BE, et al.
(författare)
-
Reproductive disturbances in Baltic fish: A synopsis of the FiRe project
- 1999
-
Ingår i: AMBIO. - : ROYAL SWEDISH ACAD SCIENCES. - 0044-7447. ; 28:1, s. 2-8
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Research within the Swedish FiRe project Reproductive Disturbances in Baltic Fish has focused mainly on the M74 syndrome, which has caused high mortality in fry of sea-run Atlantic salmon (Salmo salar) from the Baltic Sea. At the end of the 4-year project
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Bahrami, Fariba, et al.
(författare)
-
Localization and comparative toxicity of methylsulfonyl-2,5-and 2,6-dichlorobenzene in the olfactory mucosa of mice
- 1999
-
Ingår i: Toxicological Sciences. - 1096-6080 .- 1096-0929. ; 49:1, s. 116-123
-
Tidskriftsartikel (refereegranskat)abstract
- Several methylsulfonyl (MeSO2) metabolites formed from chlorinated aromatic hydrocarbons have been identified in human milk, lung, and body fat, as well as in the tissues of Baltic grey seals and arctic polar bears. The tissue localization and nasal toxicity of two methylsulfonyl-substituted dichlorobenzenes (diCl-MeSO2-B), with the chlorine atoms in the 2,5-, and 2,6- positions, were investigated in female NMRI and C57B1 mice. Using tape-section autoradiography, animals dosed i.v. with 14C-labeled 2,5-, or 2,6-(diCl-MeSO2-B) showed a preferential uptake of radioactivity in the olfactory mucosa and the tracheobronchial epithelium. Histopathology showed that 2,6-(diCl-MeSO2- B) is a potent toxicant that induces necrosis in the olfactory mucosa following a single dose as low as 4 mg/kg (i.p. injection), whereas 2,5- (diCl-MeSO2-B) induced no signs of toxicity in the olfactory mucosa at doses as high as 130 mg/kg (i.p. injection). Necrosis of the Bowman's glands was the first sign of 2,6-(diCl-MeSO2-B)-induced toxicity followed by degeneration of the neuroepithelium, which implies that the Bowman's gland may be the primary site of toxicity and degeneration of the neuroepithelium may be a secondary effect. Administration of the parent compounds, 1,3-dichlorobenzene and 1,4-dichlorobenzene, or the chlorinated analog 1,2,3-trichlorobenzene (85, 85, and 105 mg/kg, respectively; i.p. injection), induced no signs of toxicity in the olfactory mucosa. These and previous results suggest that 2,6- positioned chlorine atoms and an electron withdrawing substituent in the primary position is an arrangement that predisposes for toxicity in the olfactory mucosa.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Holm, M., et al.
(författare)
-
A New Method for Analysis of Atrial Activation during Chronic Atrial Fibrillation in Man
- 1996
-
Ingår i: IEEE Transactions on Biomedical Engineering. - : Institute of Electrical and Electronics Engineers (IEEE). - 1558-2531 .- 0018-9294. ; 43:2, s. 198-210
-
Tidskriftsartikel (refereegranskat)abstract
- To further clarify the mechanisms maintaining chronic atrial fibrillation (CAF), a method identifying preferable activation patterns of the atria during fibrillation, by time averaging of multiple discrete excitation vectors, was developed. Repeated recordings, each of 56 atrial bipolar electrograms simultaneously acquired during 8 s, were made at multiple sites in the right atrial free wall and the left atrial appendage in 16 patients with CAF using a 2.17/spl times/3.54 cm electrode array. The local activation times (LAT's) in each recording were estimated as the median activation time at the respective measurement point. By calculating the time difference between the LAT's at adjacent measurement points in two spatial dimensions, a direction vector was created for each activation wave passing each set of measurement points, a total of 42 sets. By time averaging of the individual direction vectors (typically n=55) at each set of measurement points, preferable activation patterns were determined. Three types of activation patterns were found: 1) inconsistent activation (n=5), 2) consistent activation with preferential propagation directions (n=7) and 3) consistent activation with impulses originating from a localizable site within the recording area (n=4). All activation patterns were reproducible and the two latter patterns were proven significant using statistical tests. It is concluded that this new method is useful in further clarification of the mechanisms involved in the maintenance of atrial fibrillation.
|
|
