1. |
- Middeldorp, Christel M., et al.
(author)
-
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia : design, results and future prospects
- 2019
-
In: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 34:3, s. 279-300
-
Journal article (peer-reviewed)abstract
- The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
|
|
2. |
- Yu, Xia, et al.
(author)
-
Nanostructure core fiber with enhanced performances: Design, fabrication and devices
- 2009
-
In: Journal of Lightwave Technology. - : IEEE. - 0733-8724 .- 1558-2213. ; 27:11, s. 1548-1555
-
Journal article (peer-reviewed)abstract
- We report a new type of silica-based all-solid fiber with a 2-D nanostructure core. The nanostructure core fiber (NCF) is formed by a 2-D array of high-index rods of sub-wavelength dimensions. We theoretically study the birefringence property of such fibers over a large wavelength range. Large-mode-area (LMA) structure with a typical high birefringence in the order of 10 -4 can be easily realized. The attenuation of the fabricated NCF is as low as 3.5 dB/km at 1550 nm. Higher macro- and micro-bending losses compared with those of the single-mode fiber (SMF) due to the reduced index difference have been observed experimentally, which suggests that the NCF is potentially useful for curvature and strain sensing applications. A fiber Bragg grating (FBG) inscribed in such a novel fiber is side-polished to make use of its evanescent field for refractive index sensing. The refractive index sensitivity obtained is one order of magnitude higher than that of the side-polished FBG in SMF, while the temperature and strain performances are comparable with those of the SMF-based FBG.
|
|