| 1. |
- Acosta, Stefan, et al.
(författare)
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Prospective Comparison of Plasma Biomarker and Traditional Risk Factor Profiles for Incident Isolated Atherosclerotic Disease and Incident Isolated Abdominal Aortic Aneurysm
- 2022
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Ingår i: Frontiers in Cardiovascular Medicine. - : Frontiers Media SA. - 2297-055X. ; 8, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Background: Traditional risk factors for atherosclerotic disease (AD) are well-known, of which some are relevant also for abdominal aortic aneurysms (AAA). The present study compares the importance of plasma biomarkers and traditional risk factor profiles for incident AD without concomitant AAA (isolated AD) and AAA without concomitant AD (isolated AAA) during long-term follow-up. Methods: In the Malmö Diet and Cancer Study-cardiovascular cohort, 5,381 participants were free from atrial fibrillation or flutter, AD (coronary artery disease, atherothrombotic ischemic stroke, carotid artery disease, or peripheral artery disease), and AAA underwent blood sampling under standardized fasting conditions between 1991 and 1994. Cox proportional hazards regression analysis was used to calculate hazard ratios (HR) with 95% CIs. Results: During a median follow-up of 23.1 years, 1,152 participants developed isolated AD, and 44 developed isolated AAA. Adjusted HR for lipoprotein-associated phospholipase A2 (mass) (HR 1.53, 95% CI 1.14-2.04 vs. HR 1.05, 95% CI.99-1.12) was higher for incident isolated AAA compared to incident isolated AD, respectively. Mid-regional pro-adrenomedullin (MR-proADM) was associated with incident isolated AD (HR 1.17, 95% CI 1.1-1.25) and incident isolated AAA (HR 1.47, 95% CI 1.15-1.88). MR-proADM was correlated (r = 0.32; p < 0.001) to body mass index (BMI), and BMI was associated with increased risk of incident isolated AAA (HR 1.43, 95% CI 1.02-2). No participant with diabetes mellitus (DM) at baseline developed isolated AAA (0/44), whereas DM was associated with an increased risk of isolated AD (HR 2.57, 95% CI 2.08-3.18). Adjusted HR for male sex (HR 4.8, 95% CI 2.42-9.48, vs. HR 1.76, 95% CI 1.56-1.98) and current smoking (HR 4.79, 95% CI 2.42-9.47 vs. HR 1.97, 95% CI 1.73-2.23) were higher in the incident isolated AAA group compared to the incident isolated AD group, respectively. Conclusions: The data supports the view that components of vascular inflammation and cardiovascular stress drives AAA development, whereas glycated cross-links in abdominal aortic wall tissue may have a plausible role in reducing AAA risk in individuals with DM.
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| 2. |
- Aizawa, S., et al.
(författare)
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Cross-comparison of global simulation models applied to Mercury's dayside magnetosphere
- 2021
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Ingår i: Planetary and Space Science. - : Elsevier. - 0032-0633 .- 1873-5088. ; 198
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Tidskriftsartikel (refereegranskat)abstract
- We present the first comparison of multiple global simulations of the solar wind interaction with Mercury's dayside magnetosphere, conducted in the framework of the international collaborative project SHOTS - Studies on Hermean magnetosphere Oriented Theories and Simulations. Two 3D magnetohydrodynamic and two 3D hybrid simulation codes are used to investigate the global response of the Hermean magnetosphere without its exosphere to a northward-oriented interplanetary magnetic field. We cross-compare the results of the four codes for a theoretical case and a MESSENGER orbit with similar upstream plasma conditions. The models agree on bowshock and magnetopause locations at 2.1 ± 0.11 and 1.4 ± 0.1 Mercury planetary radii, respectively. The latter locations may be influenced by subtle differences in the treatment of the plasma boundary at the planetary surface. The predicted magnetosheath thickness varies less between the codes. Finally, we also sample the plasma data along virtual trajectories of BepiColombo's Magnetospheric and Planetary Orbiter. Our ability to accurately predict the structure of the Hermean magnetosphere aids the analysis of the onboard plasma measurements of past and future magnetospheric missions.
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| 3. |
- Behar, Etienne, et al.
(författare)
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Menura : A code for simulating the interaction between a turbulent solar wind and solar system bodies
- 2022
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Ingår i: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 40:3, s. 281-297
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Tidskriftsartikel (refereegranskat)abstract
- Despite the close relationship between planetary science and plasma physics, few advanced numerical tools allow bridging the two topics. The code Menura proposes a breakthrough towards the self-consistent modelling of these overlapping fields, in a novel two-step approach allowing for the global simulation of the interaction between a fully turbulent solar wind and various bodies of the solar system. This article introduces the new code and its two-step global algorithm, illustrated by a first example: the interaction between a turbulent solar wind and a comet.
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| 4. |
- Dakhel, Ardwan, et al.
(författare)
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Vasoactive Biomarkers Associated With Long-Term Incidence of Symptomatic Peripheral Arterial Disease and Mortality
- 2021
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Ingår i: Angiology. - : SAGE Publications. - 0003-3197 .- 1940-1574. ; 72:6, s. 550-555
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Tidskriftsartikel (refereegranskat)abstract
- We evaluated if plasma biomarkers can predict incident peripheral arterial disease (PAD) and mortality in a longitudinal cohort study. Men (n = 3618) and women (n = 1542) were included in the Malmö Preventive Project and underwent analysis of: C-terminal endothelin-1 (CT-proET-1), N-Terminal prosomatostatin (NT-proSST), midregional proatrial natriuretic peptide (MR-proANP), procalcitonin (PCT), and copeptin. Participants were followed up for incident PAD and mortality until December 31, 2016. Median follow-up was 11.2 years (interquartile range 9.4-12.2). Cumulative incidence of PAD was 4.3% (221/5160), 4.5% in men (164/3618) and 3.7% in women (57/1542; P =.174). In an adjusted Cox proportional hazards regression model, higher CT-proET-1 (hazard ratio [HR] 1.8; 95% confidence interval [CI] 1.4-2.3), NT-proSST (HR 1.5; 95% CI 1.2-2.0), and MR-proANP (HR 1.7; 95% CI 1.3-2.3) were independently associated with incident PAD, and higher CT-proET-1 (HR 1.3; 95% CI 1.2-1.5), NT-proSST (HR 1.2; 95% CI 1.1-1.3), MR-proANP (HR 1.4; 95% CI 1.3-1.6), PCT (HR 1.1; 95% CI 1.0-1.2), and copeptin (HR 1.2; 95% CI 1.1-1.4) were independently associated with mortality. Increased levels of CT-proET-1, NT-proSST, and MR-proANP were independently associated with incident PAD, whereas all the vasoactive biomarkers were independently associated with mortality during follow-up.
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| 5. |
- Farrell, William M., et al.
(författare)
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The dust, atmosphere, and plasma at the moon
- 2024
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Ingår i: Reviews in Mineralogy and Geochemistry, Mineralogical Society of America. - : Walter de Gruyter. - 1529-6466 .- 1943-2666. ; 89, s. 563-609
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Fatemi, Shahab, et al.
(författare)
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Circulating Biomarkers Predict Symptomatic but Not Asymptomatic Carotid Artery Stenosis
- 2022
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Ingår i: Cerebrovascular Diseases. - : S. Karger AG. - 1015-9770 .- 1421-9786. ; 51:5, s. 623-629
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Tidskriftsartikel (refereegranskat)abstract
- Background: Subjects exposed to risk factors such as age, gender, hypertension, diabetes mellitus, and smoking are prone to atherosclerotic events. Aims: The main aim of this longitudinal cohort study was to determine whether the role of novel plasma biomarkers for atherosclerotic carotid artery disease is different in subjects developing symptomatic carotid artery stenosis (CAS), as opposed to those with incident asymptomatic CAS. Methods: The following biomarkers were measured in 5,550 middle-aged subjects in a population-based cohort study: C-reactive protein (CRP), lipoprotein-associated phospholipase A2 mass and activity, proneurotensin, midregional proadrenomedullin (MR-proADM), midregional proatrial natriuretic peptide (MR-proANP), N-terminal pro-B-type natriuretic peptide (NT pro-BNP), copeptin, and cystatin C. After exclusion of those with prevalent CAS, subjects were thereafter followed in national patient registers for 23.4 (interquartile range 19.5-24.3) years regarding incident symptomatic and asymptomatic CAS. Results: Among 110 patients with confirmed incident CAS, 56 were symptomatic and 54 were asymptomatic. When including conventional risk markers in a Cox regression analysis, NT pro-BNP (hazard ratio [HR] 1.59; 95% confidence interval [CI]: 1.20-2.11), MR-proADM (HR 1.40; CI: 1.13-1.73), cystatin C (HR 1.21; CI: 1.02-1.43), and CRP (HR 1.53; CI: 1.13-1.73) were independently associated with incident symptomatic CAS, whereas no plasma biomarker was associated with incident asymptomatic CAS. Conclusion: Plasma biomarkers NT pro-BNP, MR-proADM, cystatin C, and CRP were independently associated with incident symptomatic CAS, whereas no such association could be demonstrated with incident asymptomatic CAS. As these biomarkers indicate future development of clinically relevant atherosclerotic CAS, their potential utility in relation to intensified preventive measures and selection of potential candidates for carotid surgery should be further evaluated.
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| 7. |
- Fatemi, Shahab, et al.
(författare)
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Hybrid Simulations of Solar Wind Proton Precipitation to the Surface of Mercury
- 2020
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Ingår i: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 125:4
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Tidskriftsartikel (refereegranskat)abstract
- We examine the effects of the interplanetary magnetic field (IMF) orientation and solar wind dynamic pressure on the solar wind proton precipitation to the surface of Mercury using a hybrid-kinetic model. We use our model to explain observations of Mercury's neutral sodium exosphere and compare our results with MESSENGER observations. For the typical solar wind dynamic pressure at Mercury our model shows a high proton flux precipitates through the magnetospheric cusps to the high latitudes on both hemispheres on the dayside, centered near the noon meridian with ∼11° latitudinal extent in the north and ∼21° latitudinal extent in the south, which is consistent with MESSENGER observations. We show that this two-peak pattern is controlled by the radial component (Bx) of the IMF and not the Bz. Our model suggests that the southward IMF and its associated magnetic reconnection do not play a major role in controlling plasma precipitation to the surface of Mercury through the cusps. We found that the total precipitation rate through both of the cusps remain constant and independent of the IMF orientation. We also show that the solar wind proton incidence rate to the entire surface of Mercury is higher when the IMF has a northward component and nearly half of the incidence flux impacts the low latitudes on the nightside. During extreme solar events (e.g., coronal mass ejections), our model suggests that over 70 nPa solar wind dynamic pressure is required for the entire surface of Mercury to be exposed to the solar wind plasma.
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| 8. |
- Fatemi, Shahab, et al.
(författare)
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Ion Dynamics at the Magnetopause of Ganymede
- 2022
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Ingår i: Journal of Geophysical Research - Space Physics. - : John Wiley & Sons. - 2169-9380 .- 2169-9402. ; 127:1
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Tidskriftsartikel (refereegranskat)abstract
- We study the dynamics of the thermal O+ and H+ ions at Ganymede's magnetopause when Ganymede is inside and outside of the Jovian plasma sheet using a three-dimensional hybrid model of plasma (kinetic ions, fluid electrons). We present the global structure of the electric fields and power density (E ⋅ J) in the magnetosphere of Ganymede and show that the power density at the magnetopause is mainly positive and on average is +0.95 and +0.75 nW/m3 when Ganymede is inside and outside the Jovian plasma sheet, respectively, but locally it reaches over +20 nW/m3. Our kinetic simulations show that ion velocity distributions at the vicinity of the upstream magnetopause of Ganymede are highly non-Maxwellian. We investigate the energization of the ions interacting with the magnetopause and find that the energy of those particles on average increases by a factor of 8 and 30 for the O+ and H+ ions, respectively. The energy of these ions is mostly within 1–100 keV for both species after interaction with the magnetopause, but a few percentages reach to 0.1–1 MeV. Our kinetic simulations show that a small fraction ((Formula presented.) 25%) of the corotating Jovian plasma reach the magnetopause, but among those >50% cross the high-power density regions at the magnetopause and gain energy. Finally, we compare our simulation results with Galileo observations of Ganymede's magnetopause crossings (i.e., G8 and G28 flybys). There is an excellent agreement between our simulations and observations, particularly our simulations fully capture the size and structure of the magnetosphere.
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| 9. |
- Fatemi, Shahab, et al.
(författare)
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Pro B-type Natriuretic Peptide and Midregional Proadrenomedullin are Associated with Incident Carotid Stenosis During Long Term Follow-up
- 2021
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Ingår i: Journal of Stroke and Cerebrovascular Diseases. - : Elsevier BV. - 1052-3057. ; 30:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Plasma biomarkers may be useful to detect healthy individuals at increased risk for atherosclerotic manifestations, such as carotid artery stenosis. The aim of this longitudinal cohort study was to evaluate new biomarkers in relation to C-reactive protein and conventional risk factors for carotid artery stenosis during long term follow-up Methods: The following markers were measured in 5550 middle-aged subjects: C-reactive protein, lipoprotein-associated phospholipase A2, proneurotensin, midregional pro-adrenomedullin, midregional pro-atrial natriuretic peptide, N-terminal pro B-type natriuretic peptide, copeptin, and cystatin C. Subjects with prevalent carotid artery stenosis were excluded. Subjects were followed in national patient registers for 23.4 (interquartile range 19.5–24.3) years regarding incident carotid artery stenosis, both operated and non-operated. Results: When including conventional risk markers in Cox regression, N-terminal pro B-type natriuretic peptide (Hazard ratio 1.36; 95% confidence interval 1.12–1.65; p = 0.002) was independently associated with incident carotid artery stenosis, whereas there were trends for C-reactive protein (HR 1.20; 95% confidence interval 0.98–1.48; p = 0.071), and midregional pro-adrenomedullin (Hazard ratio 1.21; 95% confidence interval 0.99–1.47; p = 0.061). Midregional pro-adrenomedullin (Hazard ratio 1.30; 95% confidence interval 1.03–1.65; p = 0.029) was independently associated with incident surgery for carotid artery stenosis, whereas there was a trend for N-terminal pro B-type natriuretic peptide (Hazard ratio 1.31; 95% confidence interval 1.00–1.72; p = 0.052). Conclusions: N-terminal pro B-type natriuretic peptide and midregional pro-adrenomedullin can be used as predictors for clinically detected carotid artery stenosis during long-term follow-up of healthy subjects.
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