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- Rizzoli, René, et al.
(author)
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Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis.
- 2008
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In: Bone. - : Elsevier BV. - 8756-3282. ; 42:5, s. 841-7
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Journal article (peer-reviewed)abstract
- A potential side effect associated with bisphosphonates, a class of drugs used in the treatment of osteoporosis, Paget's disease and metastatic bone disease, is osteonecrosis of the jaw (ONJ). The incidence of ONJ in the general population is unknown; this rare condition also may occur in patients not receiving bisphosphonates. Case reports have discussed ONJ development in patients with multiple myeloma or metastatic breast cancer receiving bisphosphonates as palliation for bone metastases. These patients are also receiving chemotherapeutic agents that might impair the immune system and affect angiogenesis. The incidence or prevalence of ONJ in patients taking bisphosphonates for osteoporosis seems to be very rare. No causative relationship has been unequivocally demonstrated between ONJ and bisphosphonate therapy. A majority of ONJ occurs after tooth extraction. Furthermore, the underlying risk of developing ONJ may be increased in osteoporotic patients by comorbid diseases. Treatment for ONJ is generally conservative.
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- Thoma, Markus H., et al.
(author)
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PK-4 : Complex plasmas in space - The next generation
- 2007
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In: IEEE Transactions on Plasma Science. - 0093-3813 .- 1939-9375. ; 35:2, s. 255-259
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Journal article (peer-reviewed)abstract
- PK-4 is an experiment designed to investigate complex plasmas in a combined dc/RF discharge under microgravity conditions on board of the International Space Station. The dc,discharge is produced in a glass tube with a length of 35 cm and, a diameter of 3 cm. In addition, an RF discharge can be applied by external RF coils. The setup is especially suited for studying the liquid phase of the complex plasmas, e.g., flow phenomena such as turbulence or nozzles, and forces acting on the microparticles. Experiments in the laboratory and in parabolic flights have been used to determine the charge of the microparticles as well as the ion drag force acting on them.
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