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Träfflista för sökning "WFRF:(Fredlund E.) srt2:(2010-2014)"

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1.	Orth, M, et al. (author) Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY 2011 In: Journal of neurology, neurosurgery, and psychiatry. - : BMJ. - 1468-330X .- 0022-3050. ; 82:12, s. 1409- Journal article (other academic/artistic)
2.	Cepeda, D., et al. (author) CDK-mediated activation of the SCFFBXO28 ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer 2013 In: EMBO Molecular Medicine. - : EMBO. - 1757-4676 .- 1757-4684. ; 5:7, s. 999-1018 Journal article (peer-reviewed)abstract SCF (Skp1/Cul1/F-box) ubiquitin ligases act as master regulators of cellular homeostasis by targeting key proteins for ubiquitylation. Here, we identified a hitherto uncharacterized F-box protein, FBXO28 that controls MYC-dependent transcription by non-proteolytic ubiquitylation. SCFFBXO28 activity and stability are regulated during the cell cycle by CDK1/2-mediated phosphorylation of FBXO28, which is required for its efficient ubiquitylation of MYC and downsteam enhancement of the MYC pathway. Depletion of FBXO28 or overexpression of an F-box mutant unable to support MYC ubiquitylation results in an impairment of MYC-driven transcription, transformation and tumourigenesis. Finally, in human breast cancer, high FBXO28 expression and phosphorylation are strong and independent predictors of poor outcome. In conclusion, our data suggest that SCFFBXO28 plays an important role in transmitting CDK activity to MYC function during the cell cycle, emphasizing the CDK-FBXO28-MYC axis as a potential molecular drug target in MYC-driven cancers, including breast cancer. FBXO28 is identified as part of a SCF complex acting as a regulator of tumor cell proliferation and an important modifier of MYC function. FBXO28 may be a new prognostic factor in breast cancer and a new potential drug target in MYC- driven tumors.
3.	Fredlund, Erik, et al. (author) Neuroblastoma: Role of hypoxia and hypoxia inducible factors in tumor progression 2012 In: Tumors of the central nervous system. - 9789400724174 ; 1st edition, XXVI Book chapter (peer-reviewed)
4.	Fredlund, H, et al. (author) A case of diphtheria in Sweden, October 2011 2011 In: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. - 1560-7917. ; 16:50, s. 10-11 Journal article (peer-reviewed)

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Type of publication: journal article (3); book chapter (1)

Type of content: peer-reviewed (3); other academic/artistic (1)

Author/Editor: Widschwendter, M (1); Nielsen, J. (1); Sanchez, J. (1); Richter, S. (1); Salvatore, E. (1); Petersen, A. (1); show more...; Silva, M. (1); Schmidt, S. (1); Svenningsson, P (1); Barker, RA (1); Poewe, W (1); Hoffmann, R. (1); Miller, J. (1); Al-Khalili Szigyarto ... (1); Pontén, Fredrik (1); Edwards, M. (1); Taylor, R. (1); Mason, S. (1); Peterson, M. (1); Smith, P. (1); Thompson, J. (1); Weindl, A. (1); Goodman, A (1); Wiedemann, A (1); Roth, J. (1); Rudolf, G (1); Mariotti, C. (1); Stokholm, J (1); Uhlén, Mathias (1); Massaro, F. (1); Johansson, A (1); Hughes, M (1); Wright, J (1); Wojcik, M. (1); Krawczyk, M. (1); Peter, M. (1); Clayton, C. (1); Barth, K. (1); Fredlund, H (1); Patel, A (1); Evans, C (1); Foster, J (1); Wikstrom, B (1); Ladurner, G (1); Szczudlik, A (1); Nilsson, H (1); Paucar, M (1); Olofsson, C (1); Påhlman, Sven (1); Magnusson, Kristina (1); show less...

University: Karolinska Institutet (3); Lund University (2); Royal Institute of Technology (1); Uppsala University (1); Marie Cederschiöld högskola (1)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (3)

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