| 1. |
- Askling, Johan, et al.
(författare)
-
Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor alpha therapies : does the risk change with the time since start of treatment?
- 2009
-
Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 60:11, s. 3180-3189
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE:To determine the short-term and medium-term risks of cancer in patients receiving anti-tumor necrosis factor alpha (anti-TNFalpha) therapies that have proven effective in the treatment of chronic inflammatory conditions.METHODS:By linking together data from the Swedish Biologics Register, Swedish registers of RA, and the Swedish Cancer Register, we identified and analyzed for cancer occurrence a national cohort of 6,366 patients with RA who first started anti-TNF therapy between January 1999 and July 2006. As comparators, we used a national biologics-naive RA cohort (n = 61,160), a cohort of RA patients newly starting methotrexate (n = 5,989), a cohort of RA patients newly starting disease-modifying antirheumatic drug combination therapy (n = 1,838), and the general population of Sweden. Relative risks (RRs) were estimated using Cox regression analyses, examining overall RR as well as RR by time since the first start of anti-TNF therapy, by the duration of active anti-TNF therapy, and by the anti-TNF agent received.RESULTS:During 25,693 person-years of followup in 6,366 patients newly starting anti-TNF, 240 first cancers occurred, yielding an RR of 1.00 (95% confidence interval 0.86-1.15) versus the biologics-naive RA cohort, and similar RRs versus the other 2 RA comparators. RRs did not increase with increasing time since the start of anti-TNF therapy, nor with the cumulative duration of active anti-TNF therapy. During the first year following the first treatment start, but not thereafter, dissimilar cancer risks for adalimumab, etanercept, and infliximab were observed.CONCLUSION:During the first 6 years after the start of anti-TNF therapy in routine care, no overall elevation of cancer risk and no increase with followup time were observed.
|
|
| 2. |
- Berlin, Lisa, 1973-
(författare)
-
The Role of Inhibitory Control and Executive Functioning in Hyperactivity/ADHD
- 2003
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis examined inhibition, executive functioning and their possible relation to childhood problems of hyperactivity and inattention, in its clinical form referred to as Attention Deficit Hyper-activity Disorder (ADHD). Concurrent as well as longitudinal relations were of interest, and both clinical and non-clinical samples were studied. Study I demonstrated concurrent relations between executive inhibition and both hyperactivity and conduct problems in preschool. However, the relation between inhibition and conduct problems could be attributed to the large overlap between hyperactivity and conduct problems.In Study II, linear relations were found between executive inhibition and hyperactivity, whereas inhibition to the unfamiliar was related to hyperactivity, social initiative, as well as social anxiety. Non-linear analyses showed that children with high levels of both types of inhibition were at risk for developing low social initiative and social anxiety, whereas children with low levels of inhibition were at risk for developing hyperactivity, but at the same time protected from social anxiety. In Study III, executive inhibition was longitudinally related to ADHD symptoms in both school and at home for boys, but only in the school context for girls. Executive inhibition was also related to more general executive functioning deficits, and concurrent relations were found between executive functioning and ADHD symptoms, although in both cases only for boys. Inhibition and executive functioning made independent contributions to the understanding of ADHD symptoms for boys, and together explained about half the variance in inattention problems. In Study IV, group differences were found between ADHD children and controls for both inhibition and various other executive function measures. These measures also discriminated well between groups. The best model, which included measures tapping inhibition, working memory and emotion regulation, classified 86% of the children correctly. In summary, the results of the present thesis were mostly supportive of Barkley’s hybrid model of ADHD, although it should be noted that the question of whether inhibition should be regarded as primary to other executive functions requires further investigation.
|
|
| 3. |
- Eshagh, Mehdi, 1977-
(författare)
-
Spectral combination of spherical gradiometric boundary-value problems: a theoretical study
- 2012
-
Ingår i: Pure and Applied Geophysics. - : Springer Science and Business Media LLC. - 0033-4553 .- 1420-9136. ; 169, s. 2201-2215
-
Tidskriftsartikel (refereegranskat)abstract
- The Earth’s gravity potential can be determined from its second-order partial derivatives using the spherical gradiometric boundary-value problems which have three integral solutions. The problem of merging these solutions by spectral combination is the main subject of this paper. Integral estimators of biased- and unbiased-types are presented for recovering the disturbing gravity potential from gravity gradients. It is shown that only kernels of the biased-type integral estimators are suitable for simultaneous downward continuation and combination of gravity gradients. Numerical results show insignificant practical difference between the biased and unbiased estimators at sea level and the contribution of far-zone gravity gradients remains significant for integration. These contributions depend on the noise level of the gravity gradients at higher levels than sea. In the cases of combining the gravity gradients, contaminated with Gaussian noise, at sea and 250 km levels the errors of the estimated geoid heights are about 10 and 3 times smaller than those obtained by each integral
|
|
| 4. |
- Gruner, Daniel, et al.
(författare)
-
Direct Scanning Electron Microscopy Imaging of Ferroelectric Domains After Ion Milling
- 2010
-
Ingår i: Journal of The American Ceramic Society. - : Wiley. - 0002-7820 .- 1551-2916. ; 93:1, s. 48-50
-
Tidskriftsartikel (refereegranskat)abstract
- A method for directly observing the ferroelectric domain structure by scanning electron microscopy after argon ion milling has been established. Its advantages are exemplified by exposing the domain structure in three widely used ferroelectric ceramics, BaTiO3, (Na,K)NbO3, and Pb(Ti,Zr)O-3. Stable high-resolution images revealing domains with widths <30 nm have been obtained. The domain contrast is caused by electron channeling and is strongly dependent on the sample tilt angle. Owing to a strain- and defect-free surface generated by gentle ion milling, pronounced orientation contrast is observed.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Hakvoort, Ilse, 1960
(författare)
-
Bara bråk? Bygg en pyramid
- 2008
-
Ingår i: Pedagogiska Magasinet. ; :nov 4, s. 40-44
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
- Manca, Gianluca, et al.
(författare)
-
XAIProcessLens: A Counterfactual-Based Dashboard for Explainable AI in Process Industries
- 2023
-
Ingår i: HHAI 2023: AUGMENTING HUMAN INTELLECT. - : IOS PRESS. - 9781643683942 - 9781643683959 ; , s. 401-403
-
Konferensbidrag (refereegranskat)abstract
- We present a novel counterfactual-based dashboard for explainable artificial intelligence (XAI) in process industries, aimed at enhancing the understanding and adoption of machine learning (ML) models by providing transparency, explainability, and performance evaluation. Our dashboard comprises two modules: a statistical analysis module for data visualization and model performance assessment, and an XAI module for exploring counterfactual explanations at varying levels of abstraction. Through a case study of an industrial batch process, we demonstrate the dashboard's applicability and potential to increase trust in ML models among stakeholders, paving the way for confident deployment in process industries.
|
|
