| 1. |
- Abraham, Roshan Mammen, et al.
(författare)
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Tau neutrinos in the next decade : from GeV to EeV
- 2022
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Ingår i: Journal of Physics G. - : Institute of Physics Publishing (IOPP). - 0954-3899 .- 1361-6471. ; 49:11
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Tidskriftsartikel (refereegranskat)abstract
- Tau neutrinos are the least studied particle in the standard model. This whitepaper discusses the current and expected upcoming status of tau neutrino physics with attention to the broad experimental and theoretical landscape spanning long-baseline, beam-dump, collider, and astrophysical experiments. This whitepaper was prepared as a part of the NuTau2021 Workshop.
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| 2. |
- Erjefält, Jonas S., et al.
(författare)
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Diffuse alveolar damage patterns reflect the immunological and molecular heterogeneity in fatal COVID-19
- 2022
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Ingår i: EBioMedicine. - : Elsevier BV. - 2352-3964. ; 83
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Tidskriftsartikel (refereegranskat)abstract
- Background: Severe COVID-19 lung disease exhibits a high degree of spatial and temporal heterogeneity, with different histological features coexisting within a single individual. It is important to capture the disease complexity to support patient management and treatment strategies. We provide spatially decoded analyses on the immunopathology of diffuse alveolar damage (DAD) patterns and factors that modulate immune and structural changes in fatal COVID-19. Methods: We spatially quantified the immune and structural cells in exudative, intermediate, and advanced DAD through multiplex immunohistochemistry in autopsy lung tissue of 18 COVID-19 patients. Cytokine profiling, viral, bacteria, and fungi detection, and transcriptome analyses were performed. Findings: Spatial DAD progression was associated with expansion of immune cells, macrophages, CD8+ T cells, fibroblasts, and (lymph)angiogenesis. Viral load correlated positively with exudative DAD and negatively with disease/hospital length. In all cases, enteric bacteria were isolated, and Candida parapsilosis in eight cases. Cytokines correlated mainly with macrophages and CD8+T cells. Pro-coagulation and acute repair were enriched pathways in exudative DAD whereas intermediate/advanced DAD had a molecular profile of elevated humoral and innate immune responses and extracellular matrix production. Interpretation: Unraveling the spatial and molecular immunopathology of COVID-19 cases exposes the responses to SARS-CoV-2-induced exudative DAD and subsequent immune-modulatory and remodeling changes in proliferative/advanced DAD that occur side-by-side together with secondary infections in the lungs. These complex features have important implications for disease management and the development of novel treatments. Funding: CNPq, Bill and Melinda Gates Foundation, HC-Convida, FAPESP, Regeneron Pharmaceuticals, and the Swedish Heart & Lung Foundation.
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| 3. |
- Benatto, L., et al.
(författare)
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Understanding the effect of solvent additive in polymeric thin film : turning a bilayer into a bulk heterojunction-like photovoltaic device
- 2020
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Ingår i: Journal of Physics D. - : IOP Publishing. - 0022-3727 .- 1361-6463. ; 53:36
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Tidskriftsartikel (refereegranskat)abstract
- Here we report the effect of an additive solvent, 1,8-diiodooctane (DIO), on the performance of a bilayer organic photovoltaic device in which the active layer comprises poly[2,7-(9,9-bis(2 ethylhexyl)-dibenzosilole)-alt-4,7-bis(thiophen-2-yl)benzo-2,1,3-thiadiazole] (PSiF-DBT) as the electron donor material and C60 as the electron acceptor material. We observed that when the donor layer was treated with 1% of DIO the power conversion efficiency (PCE) of the device increased by 138.4% in relation to the device with an untreated donor layer, and 21.3% in relation to the device containing a donor layer submitted to thermal annealing. The main effects that lead to this increase in PCE are the large interfacial area between donor and acceptor materials and the improved conductivity at low voltages. The increase in polymer surface roughness leads to a more effective PSiF-DBT/C60 interface for exciton dissociation. This effect, as well as the increase in the conductivity, raised the short circuit current density (JSC) to 13.89 mA cm−2 and the PCE to 4.84%. Our conclusions are supported by morphological analysis, chemical cross-sectional evaluations with advanced microscopy techniques, charge mobility measurements, as well as by theoretical simulations of the devices in which the changes on the donor/acceptor interfacial area were considered. The outcomes suggest that solvent additives could be an alternative treatment to replace the thermal annealing, which imposes further difficulties in performing lab-to-manufacturing upscaling.
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