| 1. |
- Lindnér, Per, 1956, et al.
(författare)
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Blood flow in liver tumors--effects of vasoactive drugs estimated with xenon (133Xe) clearance.
- 2004
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Ingår i: Hepato-gastroenterology. - 0172-6390. ; 51:57, s. 781-6
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present study was to identify in a standardized experimental rat liver tumor system the drugs which are most appropriate in influencing the relationship between liver tumor and normal liver parenchyma blood flow as estimated with 133Xe washout clearance method, and thereby positively influencing the kinetics of chemotherapeutic drugs. A battery of vasoactive drugs, which according to a literature review were considered to be active, were tested.
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| 2. |
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| 3. |
- Oman, M, et al.
(författare)
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Treatment of non-resectable pancreatic cancer with intraperitoneal 5-FU and leucovorin IV.
- 2001
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Ingår i: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. - : Elsevier BV. - 0748-7983. ; 27:5, s. 477-81
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Tidskriftsartikel (refereegranskat)abstract
- To explore the feasibility of intraperitoneal (IP) 5-fluorouracil (5-FU) and (IV) leucovorin for patients with advanced pancreatic carcinoma.
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| 4. |
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| 5. |
- Öman, Mikael, et al.
(författare)
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133Xe clearance estimates the effect of vasopressin on peritoneal blood flow in rats.
- 2004
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Ingår i: Hepato-gastroenterology. - 0172-6390. ; 51:58, s. 1037-41
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Tidskriftsartikel (refereegranskat)abstract
- When assessing the peritoneal microcirculation with invasive methods, interference with the mechanisms of vaso-regulation may occur. The 133Xe clearance technique renders the possibility, by minimal invasiveness, to estimate the influence of a vasoactive agent on the peritoneal microcirculation.
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| 6. |
- Öman, Mikael, et al.
(författare)
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Effect of carcinomatosis and intraperitoneal 5-fluorouracil on peritoneal blood flow modulated by vasopressin in the rat as measured with the 133Xe-clearance technique.
- 2004
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Ingår i: Cancer chemotherapy and pharmacology. - : Springer Science and Business Media LLC. - 0344-5704 .- 1432-0843. ; 54:3, s. 213-8
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Tidskriftsartikel (refereegranskat)abstract
- Intraperitoneal administration of 5-fluorouracil for the treatment of gastrointestinal malignancies results in a greater total drug exposure in the peritoneal fluid than in plasma. Drugs are eliminated from the peritoneal cavity mainly by capillaries leading to the portal venous system and to a lesser extent by lymphatics. The drug itself and the presence of peritoneal carcinomatosis may affect elimination of the drug. The 133Xe-clearance technique allows the influence of a vasoactive agent on the peritoneal blood flow to be estimated with minimal invasiveness. The aim of the present study was to explore whether intraperitoneal 5-FU or peritoneal carcinomatosis affects the peritoneal blood flow and its reactivity to intravenous vasopressin, as measured indirectly with the 133Xe-clearance technique.
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