| 1. |
- Agren, J, et al.
(författare)
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Aquaporin-1 and -3 in perinatal skin
- 1999
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Ingår i: PEDIATRIC RESEARCH. - : Springer Science and Business Media LLC. - 0031-3998 .- 1530-0447. ; 45:4, s. 47A-47A
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Johannsson, Oscar Thor, et al.
(författare)
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Founding BRCA1 Mutations in Hereditary Breast and Ovarian Cancer in Southern Sweden
- 1996
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Ingår i: American Journal of Human Genetics. - 0002-9297. ; 58:3, s. 441-450
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Tidskriftsartikel (refereegranskat)abstract
- Nine different germ-line mutations in the BRCA1 breast and ovarian cancer susceptibility gene were identified in 15 of 47 kindreds from southern Sweden, by use of SSCP and heteroduplex analysis of all exons and flanking intron region and by a protein-truncation test for exon 11, followed by direct sequencing. All but one of the mutations are predicted to give rise to premature translation termination and include seven frameshift insertions or deletions, a nonsense mutation, and a splice acceptor site mutation. The remaining mutation is a missense mutation (Cys61Gly) in the zinc-binding motif. Four novel Swedish founding mutations were identified: the nucleotide 2595 deletion A was found in five families, the C 1806 T nonsense mutation in three families, the 3166 insertion TGAGA in three families, and the nucleotide 1201 deletion 11 in two families. Analysis of the intragenic polymorphism D17S855 supports common origins of the mutations. Eleven of the 15 kindreds manifesting BRCA1 mutations were breast-ovarian cancer families, several of them with a predominant ovarian cancer phenotype. The set of 32 families in which no BRCA1 alterations were detected included 1 breast-ovarian cancer kindred manifesting clear linkage to the BRCA1 region and loss of the wild-type chromosome in associated tumors. Other tumor types found in BRCA1 mutation/haplotype carriers included prostatic, pancreas, skin, and lung cancer, a malignant melanoma, an oligodendroglioma, and a carcinosarcoma. In all, 12 of 16 kindreds manifesting BRCA1 mutation or linkage contained ovarian cancer, as compared with only 6 of the remaining 31 families (P < .001). The present study confirms the involvement of BRCA1 in disease predisposition for a subset of hereditary breast cancer families often characterized by ovarian cancers.
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| 3. |
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| 4. |
- Baudin, K, et al.
(författare)
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Sputtering of large size clusters from solids bombarded by high energy cluster ions and fullerenes
- 1996
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Ingår i: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS. - : ELSEVIER SCIENCE BV. - 0168-583X. ; 112:1-4, s. 59-63
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- It is shown that polyatomic ions at high energy (MeV) are able to emit large size cluster ions with a high yield when they bombard solid surfaces. Results on sputtering of clusters ejected from inorganic and organic targets as well as sputtering of C-n(-)
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| 5. |
- Bromark, M, et al.
(författare)
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Influence of recoating on the mechanical and tribological performance of TiN-coated HSS
- 1995
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Ingår i: SURFACE & COATINGS TECHNOLOGY. - : ELSEVIER SCIENCE SA LAUSANNE. - 0257-8972. ; 77:1-3, s. 481-486
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In the manufacturing industry, there is a pronounced economic interest in the recoating of used tools. The influence of recoating on the mechanical (composite hardness, scratch test response and residual stress) and tribological (intrinsic abrasive wear r
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| 6. |
- Buijs, J, et al.
(författare)
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Conformational stability of adsorbed insulin studied with mass spectrometry and hydrogen exchange
- 1999
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Ingår i: ANALYTICAL CHEMISTRY. - : AMER CHEMICAL SOC. - 0003-2700. ; 71:15, s. 3219-3225
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A new method is described for direct monitoring of the conformational stability of proteins that are physically adsorbed from solution onto a solid substrate. The adsorption-induced conformational changes of insulin are studied using a combination of hydr
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| 7. |
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| 8. |
- Daya, DDNB, et al.
(författare)
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Radiation damage features on mica and L-valine probed by scanning force microscopy
- 1995
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Ingår i: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS. - : ELSEVIER SCIENCE BV. - 0168-583X. ; 106:1-4, s. 38-42
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The radiation damage tracks on the surface of muscovite mica due to single 78.2 MeV I-127 ions from the Uppsala EN tandem accelerator have been studied using tapping mode scanning force microscopy (TM-SFM). Conically-shaped hillocks having nearly circular
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| 9. |
- Gahlin, R, et al.
(författare)
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Properties of TiN and CrN coatings deposited at low temperature using reactive arc-evaporation
- 1995
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Ingår i: SURFACE & COATINGS TECHNOLOGY. - : ELSEVIER SCIENCE SA LAUSANNE. - 0257-8972. ; 76:1-3, s. 174-180
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- PVD TiN and CrN coatings were deposited at both low (approximate to 200 degrees C) and standard temperatures (approximate to 400 degrees C) using reactive arc-evaporation Variations in microstructure (obtained by TEM and XRD), morphology (studied using SE
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| 10. |
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